[Hub]/) : Traits : Neuroticism :

chr16:30,347,731-31,892,919

Best TWAS P=1.11e-09 · Best GWAS P=3.51e-09 conditioned to 0.244

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HSD3B7 0.05 0.06 lasso 4 0.07 5.5e-09 -5.8 -5.8 5.0e-09 0.97 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous RP11-196G11.2 0.23 0.20 lasso 9 0.21 4.2e-17 -5.7 -5.8 4.9e-09 0.99 0.03 0.97 FALSE
3 GTEx Adrenal Gland HSD3B7 0.21 0.17 lasso 4 0.13 2.9e-05 -5.8 -5.3 1.5e-07 0.95 0.03 0.93 FALSE
4 GTEx Artery Aorta STX1B 0.17 0.18 lasso 6 0.15 1.9e-08 -5.8 -5.8 5.1e-09 0.96 0.02 0.98 FALSE
5 GTEx Artery Aorta RP11-196G11.2 0.10 0.16 lasso 2 0.14 7.1e-08 -5.6 -5.7 1.1e-08 0.97 0.03 0.97 FALSE
6 GTEx Artery Coronary RP11-196G11.2 0.12 0.06 lasso 6 0.06 3.4e-03 -5.7 -5.9 4.7e-09 0.96 0.03 0.91 FALSE
7 GTEx Artery Tibial RP11-196G11.2 0.08 0.04 lasso 4 0.03 3.8e-03 -5.6 -5.3 1.2e-07 0.96 0.03 0.96 FALSE
8 GTEx Brain Cerebellar Hemisphere STX1B 0.13 0.11 lasso 5 0.10 1.5e-03 -5.6 -5.8 6.8e-09 0.96 0.03 0.75 FALSE
9 GTEx Brain Cerebellar Hemisphere RP11-196G11.2 0.18 0.06 lasso 6 0.10 1.7e-03 -5.8 -5.5 4.9e-08 0.94 0.03 0.89 FALSE
10 GTEx Brain Cerebellum STX1B 0.24 0.16 lasso 11 0.18 4.8e-06 -5.7 -5.5 2.9e-08 0.95 0.03 0.96 FALSE
11 GTEx Brain Cerebellum STX4 0.14 0.25 lasso 1 0.24 8.3e-08 -5.8 -5.8 6.0e-09 0.97 0.02 0.97 FALSE
12 GTEx Brain Cerebellum RP11-196G11.2 0.31 0.30 lasso 4 0.36 1.3e-11 -5.8 -5.9 4.7e-09 0.98 0.03 0.97 FALSE
13 GTEx Breast Mammary Tissue RP11-196G11.2 0.13 0.16 lasso 4 0.17 5.0e-09 -5.7 -5.3 1.1e-07 0.98 0.04 0.96 FALSE
14 GTEx Breast Mammary Tissue (Male) RP11-196G11.2 0.15 0.16 lasso 4 0.09 3.9e-03 -5.7 -5.7 1.3e-08 0.99 0.03 0.92 FALSE
15 GTEx Cells Transformed fibroblasts STX1B 0.12 0.10 lasso 5 0.10 6.8e-08 -5.6 -5.2 2.3e-07 0.94 0.03 0.97 FALSE
16 GTEx Cells Transformed fibroblasts RP11-196G11.2 0.14 0.14 lasso 6 0.13 2.9e-10 -5.8 -5.8 5.2e-09 0.98 0.02 0.98 FALSE
17 GTEx Colon Transverse HSD3B7 0.16 0.15 enet 20 0.19 2.1e-09 -5.6 -5.2 2.3e-07 0.91 0.04 0.96 FALSE
18 GTEx Colon Transverse STX4 0.10 0.09 lasso 3 0.06 6.6e-04 -5.7 -5.7 1.4e-08 0.99 0.03 0.93 FALSE
19 GTEx Colon Transverse RP11-196G11.2 0.24 0.11 lasso 5 0.15 1.9e-07 -5.6 -5.7 9.9e-09 0.96 0.03 0.97 FALSE
20 GTEx Esophagus Gastroesophageal Junction KAT8 0.18 0.11 lasso 4 0.24 4.9e-09 -4.0 -5.3 1.5e-07 0.86 0.05 0.94 FALSE
21 GTEx Esophagus Mucosa STX1B 0.12 0.03 lasso 5 0.05 1.7e-04 -5.9 -6.1 1.1e-09 0.88 0.02 0.97 TRUE
22 GTEx Esophagus Mucosa HSD3B7 0.38 0.32 lasso 5 0.36 1.2e-24 -5.8 -5.4 6.8e-08 0.96 0.03 0.97 FALSE
23 GTEx Esophagus Mucosa STX4 0.08 0.00 enet 21 0.02 1.0e-02 -5.4 -5.5 4.0e-08 0.81 0.06 0.89 FALSE
24 GTEx Esophagus Mucosa RP11-196G11.2 0.09 0.03 enet 13 0.05 1.5e-04 -5.7 -5.8 5.0e-09 0.91 0.04 0.95 FALSE
25 GTEx Esophagus Muscularis STX4 0.05 0.05 lasso 3 0.03 6.7e-03 -5.6 -5.8 8.9e-09 0.97 0.02 0.95 FALSE
26 GTEx Esophagus Muscularis RP11-196G11.2 0.14 0.14 lasso 6 0.13 3.7e-08 -5.7 -5.5 3.9e-08 0.96 0.02 0.98 FALSE
27 GTEx Heart Left Ventricle HSD3B7 0.12 0.08 lasso 3 0.07 2.0e-04 -5.6 -5.7 1.1e-08 0.97 0.05 0.94 FALSE
28 GTEx Lung RP11-196G11.2 0.21 0.12 enet 22 0.14 1.6e-10 -5.9 -5.9 2.8e-09 0.90 0.02 0.98 FALSE
29 GTEx Muscle Skeletal STX4 0.04 0.04 lasso 3 0.03 2.9e-04 -5.8 -5.7 1.4e-08 0.95 0.03 0.97 FALSE
30 GTEx Muscle Skeletal RP11-196G11.2 0.15 0.10 enet 10 0.12 1.0e-11 -5.8 -5.7 1.4e-08 0.95 0.03 0.97 FALSE
31 GTEx Nerve Tibial STX1B 0.21 0.14 enet 17 0.18 1.6e-12 -5.7 -5.4 6.0e-08 0.97 0.04 0.96 FALSE
32 GTEx Nerve Tibial HSD3B7 0.09 0.05 lasso 3 0.03 2.4e-03 -5.9 -5.9 2.9e-09 0.99 0.03 0.89 FALSE
33 GTEx Nerve Tibial RP11-196G11.2 0.17 0.22 lasso 6 0.22 2.3e-15 -5.6 -5.9 4.0e-09 0.97 0.03 0.97 FALSE
34 GTEx Ovary RP11-196G11.2 0.41 0.22 lasso 10 0.25 6.0e-07 -5.8 -5.7 1.2e-08 0.96 0.04 0.96 FALSE
35 GTEx Pancreas STX1B 0.23 0.18 lasso 3 0.16 2.8e-07 -5.7 -5.7 1.4e-08 0.99 0.04 0.96 FALSE
36 GTEx Pancreas RP11-196G11.2 0.13 0.11 lasso 1 0.11 2.5e-05 -5.6 -5.6 2.0e-08 0.97 0.03 0.96 FALSE
37 GTEx Pituitary HSD3B7 0.13 0.07 lasso 7 0.05 2.1e-02 -5.6 -5.8 8.7e-09 0.94 0.05 0.86 FALSE
38 GTEx Pituitary RP11-196G11.2 0.21 0.28 lasso 6 0.23 1.4e-06 -5.7 -5.6 2.2e-08 0.97 0.03 0.95 FALSE
39 GTEx Skin Not Sun Exposed Suprapubic HSD3B7 0.11 0.12 enet 6 0.10 5.9e-06 -5.8 -5.4 5.9e-08 0.96 0.03 0.97 FALSE
40 GTEx Skin Not Sun Exposed Suprapubic RP11-196G11.2 0.22 0.21 lasso 9 0.26 3.2e-14 -5.7 -5.7 9.9e-09 0.97 0.03 0.97 FALSE
41 GTEx Skin Sun Exposed Lower leg STX1B 0.05 0.04 enet 4 0.05 7.2e-05 -5.7 -5.8 7.8e-09 0.99 0.03 0.96 FALSE
42 GTEx Skin Sun Exposed Lower leg HSD3B7 0.12 0.17 lasso 5 0.16 2.7e-13 -5.4 -5.7 1.5e-08 0.95 0.06 0.94 FALSE
43 GTEx Skin Sun Exposed Lower leg RP11-196G11.2 0.16 0.15 lasso 7 0.15 4.0e-12 -5.8 -6.0 2.3e-09 0.98 0.03 0.97 FALSE
44 GTEx Small Intestine Terminal Ileum RP11-196G11.2 0.18 0.07 enet 15 0.06 1.5e-02 -5.6 -6.0 2.5e-09 0.82 0.03 0.78 FALSE
45 GTEx Stomach RP11-196G11.2 0.25 0.16 enet 21 0.14 4.6e-07 -3.9 -5.3 1.3e-07 0.78 0.20 0.79 FALSE
46 GTEx Testis STX1B 0.26 0.23 lasso 5 0.25 1.2e-11 -5.8 -5.7 1.1e-08 0.96 0.02 0.98 FALSE
47 GTEx Testis STX4 0.15 0.02 lasso 6 0.01 8.2e-02 -5.8 -5.2 2.0e-07 0.95 0.03 0.84 FALSE
48 GTEx Testis RP11-196G11.2 0.14 0.11 lasso 4 0.13 3.1e-06 -5.6 -5.8 7.4e-09 0.98 0.03 0.97 FALSE
49 GTEx Thyroid RP11-196G11.2 0.11 0.14 lasso 2 0.14 3.5e-11 -5.9 -5.9 3.8e-09 1.00 0.02 0.98 FALSE
50 GTEx Uterus RP11-196G11.2 0.18 0.16 lasso 20 0.15 5.4e-04 -5.7 -5.8 7.4e-09 0.98 0.04 0.92 FALSE
51 GTEx Whole Blood RP11-196G11.2 0.07 0.05 lasso 3 0.06 1.4e-06 -5.6 -5.4 6.2e-08 0.91 0.05 0.95 FALSE
52 METSIM Adipose RP11-196G11.2 0.13 0.17 lasso 9 0.16 2.2e-23 -5.8 -5.8 5.1e-09 0.97 0.02 0.98 FALSE
53 ROSMAP Brain Pre-frontal Cortex STX1B 0.08 0.10 lasso 7 0.10 3.0e-12 -5.7 -5.6 1.8e-08 0.93 0.04 0.96 FALSE
54 ROSMAP Brain Pre-frontal Cortex HSD3B7 0.03 0.05 lasso 6 0.02 3.0e-04 -5.8 -5.7 1.0e-08 0.96 0.02 0.98 FALSE
55 ROSMAP Brain Pre-frontal Cortex SETD1A 0.02 0.01 blup 232 0.02 4.3e-04 -3.9 -5.1 4.1e-07 0.86 0.08 0.80 FALSE
56 ROSMAP Brain Pre-frontal Cortex STX4 0.06 0.11 lasso 10 0.11 1.4e-13 -5.8 5.8 6.0e-09 -0.97 0.03 0.97 FALSE
57 ROSMAP Brain Pre-frontal Cortex RP11-196G11.2 0.12 0.12 lasso 4 0.12 1.1e-14 -5.8 -5.8 5.2e-09 0.97 0.02 0.98 FALSE
58 YFS Blood STX4 0.03 0.06 lasso 2 0.05 4.3e-17 -5.8 -5.8 7.2e-09 0.95 0.02 0.98 FALSE
59 TCGA Breast Tumor HSD3B7 0.13 0.14 lasso 10 0.12 8.9e-04 -4.5 -5.1 3.8e-07 0.89 0.06 0.88 FALSE
60 TCGA Breast Normal FUS 0.01 0.00 blup 245 0.01 1.1e-02 -5.8 -5.3 1.3e-07 0.84 0.04 0.79 FALSE
61 TCGA Prostate Tumor HSD3B7 0.26 0.28 enet 25 0.30 1.1e-38 -5.8 -5.4 8.8e-08 0.87 0.04 0.96 FALSE