[Hub]/) : Traits : Type 2 Diabetes (T2D) :

chr1:39,182,130-40,737,589

Best TWAS P=1.65e-11 · Best GWAS P=3.35e-10 conditioned to 0.00788

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex BMP8A 0.05 0.03 lasso 3 0.02 8.8e-04 6.1 6.2 7.4e-10 0.98 0.01 0.98 FALSE
2 GTEx Adipose Subcutaneous PABPC4 0.15 0.04 lasso 8 0.04 3.3e-04 5.3 -5.6 2.2e-08 -0.86 0.03 0.97 FALSE
3 GTEx Adipose Subcutaneous RP11-69E11.4 0.14 0.08 enet 22 0.10 1.4e-08 6.3 5.8 5.2e-09 0.86 0.00 1.00 FALSE
4 GTEx Adipose Subcutaneous BMP8A 0.06 0.05 lasso 1 0.04 3.5e-04 5.6 5.6 2.5e-08 0.70 0.04 0.76 FALSE
5 GTEx Adipose Visceral Omentum RP11-69E11.4 0.10 0.07 lasso 2 0.07 1.3e-04 5.4 5.1 2.7e-07 0.67 0.18 0.77 FALSE
6 GTEx Adrenal Gland PABPC4 0.20 0.09 lasso 8 0.06 3.0e-03 6.3 -6.2 5.5e-10 -0.95 0.01 0.94 FALSE
7 GTEx Adrenal Gland RP11-69E11.4 0.11 0.05 lasso 3 0.00 2.4e-01 5.6 5.7 1.2e-08 0.76 0.03 0.74 FALSE
8 GTEx Artery Aorta RP11-69E11.4 0.13 0.10 enet 14 0.14 2.5e-08 6.1 6.2 7.2e-10 0.86 0.00 0.99 FALSE
9 GTEx Artery Tibial PABPC4 0.10 0.10 lasso 4 0.10 3.4e-08 6.3 -6.4 1.3e-10 -0.99 0.00 1.00 FALSE
10 GTEx Artery Tibial RP11-69E11.4 0.15 0.16 lasso 6 0.16 8.3e-13 5.4 5.6 1.7e-08 0.76 0.22 0.78 FALSE
11 GTEx Brain Cerebellar Hemisphere RP11-69E11.4 0.22 0.08 enet 16 0.08 4.5e-03 5.4 5.3 1.4e-07 0.71 0.15 0.64 FALSE
12 GTEx Brain Frontal Cortex BA9 RP11-69E11.4 0.23 0.10 lasso 6 0.11 7.2e-04 5.3 5.7 1.4e-08 0.71 0.04 0.74 FALSE
13 GTEx Brain Hypothalamus RP11-69E11.4 0.23 0.12 lasso 6 0.20 1.5e-05 5.0 5.5 3.9e-08 0.65 0.11 0.64 FALSE
14 GTEx Breast Mammary Tissue PABPC4 0.13 0.02 enet 14 0.04 3.4e-03 6.1 -5.7 1.0e-08 -0.93 0.01 0.98 FALSE
15 GTEx Breast Mammary Tissue RP11-69E11.4 0.15 0.05 enet 32 0.05 8.8e-04 5.1 6.7 1.7e-11 0.63 0.33 0.61 TRUE
16 GTEx Cells Transformed fibroblasts PABPC4 0.07 0.09 lasso 1 0.06 2.7e-05 6.3 -6.3 3.3e-10 -1.00 0.00 1.00 FALSE
17 GTEx Cells Transformed fibroblasts RP11-69E11.4 0.15 0.08 enet 17 0.11 9.9e-09 4.1 5.2 1.5e-07 0.71 0.42 0.58 FALSE
18 GTEx Colon Sigmoid RP11-69E11.4 0.20 0.16 lasso 5 0.20 1.1e-07 5.2 5.8 5.4e-09 0.78 0.12 0.86 FALSE
19 GTEx Colon Transverse RP11-69E11.4 0.23 0.12 lasso 4 0.15 1.8e-07 6.1 5.8 7.8e-09 0.89 0.01 0.99 FALSE
20 GTEx Esophagus Gastroesophageal Junction BMP8A 0.11 0.04 lasso 4 0.01 1.1e-01 5.1 5.2 2.0e-07 0.69 0.19 0.40 FALSE
21 GTEx Esophagus Mucosa PABPC4 0.06 0.06 lasso 3 0.08 7.3e-06 6.1 -6.4 1.7e-10 -0.98 0.00 1.00 FALSE
22 GTEx Esophagus Mucosa RP11-69E11.4 0.18 0.06 lasso 9 0.07 2.2e-05 5.4 6.0 2.0e-09 0.77 0.24 0.75 FALSE
23 GTEx Esophagus Muscularis RP11-69E11.4 0.11 0.14 enet 16 0.15 2.6e-09 4.2 5.5 4.8e-08 0.71 0.68 0.32 FALSE
24 GTEx Esophagus Muscularis BMP8A 0.08 0.05 enet 10 0.05 3.5e-04 4.2 5.4 8.3e-08 0.77 0.10 0.87 FALSE
25 GTEx Heart Left Ventricle RP11-69E11.4 0.10 0.10 lasso 4 0.08 3.8e-05 5.4 5.3 1.2e-07 0.69 0.05 0.92 FALSE
26 GTEx Lung PABPC4 0.05 0.03 lasso 3 0.02 1.3e-02 6.3 -6.2 5.3e-10 -0.96 0.01 0.98 FALSE
27 GTEx Nerve Tibial PABPC4 0.17 0.08 enet 12 0.05 2.7e-04 6.3 -5.9 2.9e-09 -0.85 0.00 1.00 FALSE
28 GTEx Nerve Tibial RP11-69E11.4 0.18 0.08 lasso 5 0.18 1.3e-12 4.8 6.2 5.7e-10 0.88 0.01 0.99 FALSE
29 GTEx Nerve Tibial RP11-69E11.8 0.05 0.00 lasso 3 0.01 6.9e-02 6.3 -6.4 1.5e-10 -0.99 0.01 0.95 FALSE
30 GTEx Skin Not Sun Exposed Suprapubic PABPC4 0.12 0.10 lasso 3 0.05 1.0e-03 6.1 -6.2 7.4e-10 -0.97 0.00 0.99 FALSE
31 GTEx Skin Not Sun Exposed Suprapubic RP11-69E11.4 0.16 0.18 lasso 3 0.15 1.0e-08 5.2 5.2 2.0e-07 0.67 0.45 0.55 FALSE
32 GTEx Skin Sun Exposed Lower leg PABPC4 0.11 0.09 lasso 7 0.08 2.7e-07 6.1 -6.2 4.6e-10 -0.96 0.00 1.00 FALSE
33 GTEx Skin Sun Exposed Lower leg RP11-69E11.4 0.13 0.12 lasso 6 0.15 1.3e-12 5.3 6.0 1.5e-09 0.75 0.34 0.66 FALSE
34 GTEx Spleen RP11-69E11.4 0.25 0.12 lasso 4 0.15 9.3e-05 5.4 6.0 2.7e-09 0.73 0.10 0.78 FALSE
35 GTEx Stomach RP11-69E11.4 0.31 0.20 lasso 4 0.20 4.0e-10 5.4 5.5 3.4e-08 0.74 0.16 0.84 FALSE
36 GTEx Testis BMP8A 0.27 0.28 lasso 6 0.27 2.0e-12 4.2 5.1 3.7e-07 0.67 0.78 0.22 FALSE
37 GTEx Thyroid RP11-69E11.4 0.17 0.04 lasso 9 0.06 4.4e-05 5.4 5.8 8.2e-09 0.81 0.01 0.98 FALSE
38 METSIM Adipose PABPC4 0.05 0.02 lasso 6 0.03 6.0e-05 6.1 -5.9 3.5e-09 -0.89 0.01 0.99 FALSE
39 NTR Blood KIAA0754 0.03 0.00 bslmm 366 0.01 1.6e-03 -2.1 5.4 5.9e-08 0.52 0.15 0.60 FALSE
40 YFS Blood PABPC4 0.04 0.03 enet 44 0.03 3.2e-11 6.1 -5.4 6.4e-08 -0.83 0.00 1.00 FALSE
41 TCGA Breast Normal PPIEL 0.06 0.00 enet 21 0.03 1.5e-08 4.2 5.4 6.9e-08 0.56 0.38 0.40 FALSE
42 TCGA Prostate Tumor BMP8A 0.04 0.02 blup 379 0.02 3.6e-04 5.2 5.2 2.1e-07 0.52 0.51 0.46 FALSE