[Hub]/) : Traits : Type 2 Diabetes (T2D) (2018) : ← →

chr4:5,575,751-7,002,344

Best TWAS P=5.32e-17 · Best GWAS P=9.56e-19 conditioned to 6.25e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex WFS1 0.10 0.03 lasso 2 0.02 4.8e-04 -8.2 8.1 7.9e-16 -0.73 0.14 0.79 FALSE
2 GTEx Brain Cerebellar Hemisphere WFS1 0.72 0.49 lasso 13 0.47 1.3e-13 -7.9 8.0 1.1e-15 -0.73 0.09 0.91 FALSE
3 GTEx Brain Cerebellum WFS1 0.44 0.26 lasso 10 0.27 9.8e-09 -7.9 7.9 2.8e-15 -0.73 0.10 0.90 FALSE
4 GTEx Cells Transformed fibroblasts WFS1 0.22 0.04 enet 25 0.08 2.6e-06 -7.7 8.0 1.0e-15 -0.77 0.08 0.92 FALSE
5 GTEx Muscle Skeletal WFS1 0.13 0.11 lasso 5 0.09 3.9e-09 -7.7 7.5 5.9e-14 -0.67 0.67 0.33 FALSE
6 GTEx Skin Not Sun Exposed Suprapubic WFS1 0.35 0.25 lasso 7 0.28 7.6e-16 -7.7 7.5 6.8e-14 -0.62 0.09 0.91 FALSE
7 GTEx Skin Sun Exposed Lower leg WFS1 0.29 0.29 lasso 3 0.29 2.6e-24 -7.9 7.9 2.0e-15 -0.73 0.38 0.62 FALSE
8 GTEx Testis WFS1 0.38 0.05 lasso 7 0.01 7.0e-02 -7.7 5.4 6.4e-08 -0.29 0.30 0.19 FALSE
9 GTEx Thyroid WFS1 0.19 0.12 lasso 4 0.10 2.9e-08 -7.9 7.9 2.4e-15 -0.73 0.36 0.64 FALSE
10 METSIM Adipose WFS1 0.06 0.01 enet 14 0.02 1.5e-04 -8.3 7.3 2.3e-13 -0.72 0.02 0.97 FALSE
11 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma WFS1 0.07 0.10 lasso 3 0.10 2.6e-11 -8.2 8.4 5.3e-17 -0.73 0.08 0.92 TRUE
12 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WFS1 0.04 0.00 blup 76 0.01 4.0e-02 -3.0 7.3 3.8e-13 -0.67 0.04 0.37 FALSE
13 The Cancer Genome Atlas Thyroid Carcinoma WFS1 0.04 0.01 blup 76 0.01 1.6e-02 -7.8 8.3 7.5e-17 -0.78 0.06 0.89 FALSE