TWAS
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Genes
Traits
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Traits
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Blood White Count
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chr10:12,445,539-15,072,216
Best TWAS P=2.82e-08 · Best GWAS P=6.76e-09 conditioned to 0.000494
12.5M
13M
13.5M
14M
14.5M
15M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
YFS
Blood
OPTN
0.29
0.20
lasso
6
0.20
2.9e-63
-5.4
5.5
2.8e-08
-0.05
0.01
0.99
TRUE
2
GTEx
Brain Cerebellum
RP11-295P9.3
0.45
0.31
enet
25
0.36
2.4e-11
4.0
-5.3
1.1e-07
0.45
0.69
0.28
TRUE
3
YFS
Blood
BEND7
0.09
0.03
lasso
10
0.08
1.4e-25
4.7
-5.2
2.0e-07
0.59
0.40
0.59
FALSE
1
CommonMind
Brain Pre-frontal Cortex
FRMD4A
0.11
0.04
lasso
6
0.02
1.7e-03
-5.1
5.2
2.5e-07
-0.40
0.05
0.95
FALSE