Best TWAS P=3.53e-08 · Best GWAS P=1.09e-07 conditioned to 0.682
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HSF2 | 0.13 | 0.14 | lasso | 3 | 0.13 | 5.5e-11 | -5.2 | 5.3 | 1.4e-07 | -1.00 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Aorta | HSF2 | 0.19 | 0.14 | lasso | 3 | 0.10 | 3.4e-06 | -5.2 | 5.3 | 1.2e-07 | -1.00 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | HSF2 | 0.32 | 0.27 | lasso | 5 | 0.25 | 1.4e-08 | -5.3 | 5.3 | 1.0e-07 | -1.00 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Lung | HSF2 | 0.14 | 0.09 | lasso | 6 | 0.08 | 5.6e-07 | -5.2 | 5.5 | 4.5e-08 | -0.88 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Nerve Tibial | HSF2 | 0.12 | 0.07 | lasso | 3 | 0.06 | 6.0e-05 | -5.2 | 5.2 | 2.1e-07 | -0.94 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Spleen | HSF2 | 0.43 | 0.24 | enet | 19 | 0.24 | 6.8e-07 | -5.2 | 5.1 | 2.7e-07 | -0.92 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Thyroid | HSF2 | 0.13 | 0.01 | lasso | 5 | 0.06 | 4.7e-05 | -3.7 | 5.5 | 4.5e-08 | -0.65 | 0.03 | 0.94 | FALSE |
| 8 | GTEx | Whole Blood | HSF2 | 0.06 | 0.05 | lasso | 3 | 0.03 | 3.3e-04 | -5.2 | 5.5 | 3.5e-08 | -0.94 | 0.01 | 0.99 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HSF2 | 0.15 | 0.04 | blup | 68 | 0.05 | 1.6e-06 | -5.2 | 5.2 | 2.0e-07 | -0.89 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | HSF2 | 0.05 | 0.03 | lasso | 1 | 0.02 | 1.5e-03 | -5.3 | 5.3 | 1.1e-07 | -1.00 | 0.00 | 0.96 | FALSE |