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chr5:95,168,155-96,832,363

Best TWAS P=4.17e-16 · Best GWAS P=7.97e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	CTC-506B8.1	0.17	0.06	lasso	8	0.11	1.3e-06	3.4	5.6	2.1e-08	-0.46	0.30	0.57	FALSE
2	GTEx	Brain Caudate basal ganglia	ERAP1	0.28	0.22	enet	21	0.30	1.9e-09	-6.6	6.7	2.3e-11	-0.59	0.35	0.60	FALSE
3	GTEx	Brain Cerebellum	ERAP1	0.31	0.21	lasso	5	0.14	7.9e-05	-6.5	6.1	8.6e-10	-0.69	0.70	0.05	FALSE
4	GTEx	Brain Hypothalamus	ERAP1	0.27	0.10	enet	23	0.10	2.5e-03	5.3	5.7	1.5e-08	-0.42	0.14	0.15	FALSE
5	GTEx	Brain Nucleus accumbens basal ganglia	ERAP1	0.26	0.03	lasso	8	0.10	1.5e-03	-5.4	6.7	2.0e-11	-0.60	0.09	0.47	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	ERAP1	0.66	0.35	lasso	14	0.53	3.5e-20	5.3	6.5	8.8e-11	-0.56	1.00	0.00	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	CTD-2260A17.1	0.61	0.34	lasso	9	0.34	4.7e-12	-5.4	5.7	1.2e-08	-0.54	0.99	0.00	FALSE
8	GTEx	Colon Transverse	ERAP1	0.44	0.28	lasso	11	0.31	2.2e-15	4.4	5.2	1.8e-07	-0.30	1.00	0.00	FALSE
9	GTEx	Colon Transverse	CTC-506B8.1	0.14	0.07	lasso	2	0.06	5.9e-04	4.4	5.2	2.6e-07	-0.13	0.55	0.03	TRUE
10	GTEx	Esophagus Mucosa	ERAP1	0.23	0.19	lasso	15	0.22	1.1e-14	5.3	5.8	7.7e-09	-0.43	1.00	0.00	FALSE
11	GTEx	Esophagus Muscularis	CAST	0.31	0.09	enet	23	0.18	6.0e-11	3.4	5.1	2.8e-07	-0.35	0.99	0.00	FALSE
12	GTEx	Lung	ERAP1	0.41	0.27	enet	37	0.37	3.2e-29	4.4	5.6	2.0e-08	-0.31	1.00	0.00	FALSE
13	GTEx	Lung	CTC-506B8.1	0.16	0.16	enet	16	0.16	5.7e-12	3.4	5.7	1.5e-08	-0.32	1.00	0.00	FALSE
14	GTEx	Muscle Skeletal	ERAP1	0.24	0.09	lasso	14	0.24	8.0e-23	3.5	7.6	3.3e-14	-0.65	0.62	0.38	FALSE
15	GTEx	Muscle Skeletal	CTD-2260A17.1	0.17	0.09	enet	27	0.13	1.1e-12	3.5	5.6	2.7e-08	-0.54	0.96	0.04	FALSE
16	GTEx	Ovary	CTD-2260A17.1	0.40	0.28	lasso	11	0.29	8.6e-08	-8.1	-8.1	4.2e-16	0.97	0.01	0.99	TRUE
17	GTEx	Pancreas	ERAP1	0.38	0.36	lasso	12	0.43	1.0e-19	5.3	5.4	6.9e-08	-0.35	1.00	0.00	FALSE
18	GTEx	Skin Sun Exposed Lower leg	ERAP1	0.26	0.23	lasso	5	0.26	3.0e-21	4.3	5.1	2.8e-07	-0.35	1.00	0.00	FALSE
19	GTEx	Stomach	ERAP1	0.29	0.13	lasso	10	0.18	7.5e-09	5.3	5.7	1.2e-08	-0.36	1.00	0.00	FALSE
20	GTEx	Thyroid	CTC-506B8.1	0.09	0.03	enet	28	0.03	3.6e-03	3.4	6.0	2.1e-09	-0.39	0.44	0.10	FALSE
21	GTEx	Whole Blood	ERAP1	0.24	0.18	lasso	14	0.22	4.5e-20	5.3	5.7	1.6e-08	-0.42	1.00	0.00	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	ERAP1	0.38	0.32	lasso	13	0.46	5.3e-67	3.6	6.3	3.2e-10	-0.59	1.00	0.00	FALSE
23	YFS	Blood	ERAP1	0.03	0.03	lasso	8	0.02	3.2e-07	-6.7	-7.4	1.1e-13	0.76	0.26	0.74	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ERAP1	0.19	0.16	blup	130	0.23	1.0e-19	4.3	5.9	4.3e-09	-0.40	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERAP1	0.24	0.24	lasso	10	0.29	1.8e-59	4.4	5.2	1.8e-07	-0.33	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	ERAP1	0.32	0.29	blup	130	0.36	6.4e-22	4.4	6.3	3.0e-10	-0.44	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Esophageal Carcinoma	ERAP1	0.24	0.09	blup	130	0.14	4.6e-05	4.3	7.1	1.5e-12	-0.57	0.25	0.46	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	CAST	0.16	0.04	blup	168	0.03	4.4e-02	2.4	5.8	5.2e-09	-0.35	0.13	0.10	FALSE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	ERAP1	0.57	0.41	lasso	10	0.42	3.0e-14	4.4	5.8	8.2e-09	-0.46	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ERAP1	0.29	0.24	enet	17	0.29	7.7e-17	5.4	6.8	8.3e-12	-0.58	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	ERAP1	0.31	0.21	lasso	17	0.38	2.1e-45	3.6	6.7	2.5e-11	-0.57	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ERAP1	0.47	0.33	blup	130	0.36	7.0e-18	4.4	6.0	2.8e-09	-0.46	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	ERAP1	0.30	0.36	lasso	7	0.40	4.0e-49	4.4	5.4	7.9e-08	-0.35	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ERAP1	0.19	0.20	blup	131	0.21	3.0e-23	5.3	6.6	4.1e-11	-0.54	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERAP1	0.15	0.08	lasso	13	0.10	1.2e-04	5.3	5.2	2.5e-07	-0.39	0.52	0.03	FALSE
36	The Cancer Genome Atlas	Rectum Adenocarcinoma	ERAP1	0.28	0.06	blup	131	0.12	8.1e-04	-5.4	7.0	3.0e-12	-0.62	0.11	0.31	FALSE
37	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ERAP1	0.20	0.00	blup	131	0.09	2.3e-03	-5.4	6.3	3.2e-10	-0.52	0.07	0.19	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	ERAP1	0.26	0.31	lasso	9	0.35	4.1e-26	4.4	5.3	1.4e-07	-0.32	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ERAP1	0.40	0.17	enet	18	0.29	1.1e-10	3.8	6.1	1.2e-09	-0.59	0.28	0.71	FALSE
40	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ERAP1	0.26	0.22	lasso	11	0.22	6.1e-07	3.1	5.4	8.2e-08	-0.45	0.59	0.23	FALSE