Best TWAS P=6.12e-11 · Best GWAS P=2.42e-13 conditioned to 0.000924
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TMEM170B | 0.22 | 0.22 | lasso | 4 | 0.20 | 1.8e-16 | 6.1 | -6.1 | 1.2e-09 | -0.89 | 0.92 | 0.08 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | TMEM170B | 0.20 | 0.10 | lasso | 3 | 0.09 | 2.8e-05 | 6.0 | -6.0 | 1.6e-09 | -0.91 | 0.10 | 0.90 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | TMEM170B | 0.21 | 0.14 | lasso | 10 | 0.12 | 1.4e-09 | 5.5 | -6.0 | 1.9e-09 | -0.77 | 0.59 | 0.41 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | TMEM170B | 0.16 | 0.10 | lasso | 4 | 0.10 | 2.4e-06 | 5.8 | -6.1 | 8.8e-10 | -0.86 | 0.86 | 0.11 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | TMEM170B | 0.19 | 0.19 | lasso | 6 | 0.20 | 2.1e-16 | 6.0 | -5.6 | 2.1e-08 | -0.90 | 0.94 | 0.06 | FALSE |
| 6 | GTEx | Whole Blood | TMEM170B | 0.11 | 0.01 | lasso | 3 | 0.00 | 2.7e-01 | 6.1 | -6.5 | 6.1e-11 | -0.87 | 0.08 | 0.49 | TRUE |
| 7 | METSIM | Adipose | TMEM170B | 0.21 | 0.30 | lasso | 2 | 0.30 | 6.8e-45 | 6.0 | -6.0 | 1.8e-09 | -0.91 | 0.93 | 0.07 | FALSE |