Best TWAS P=2.85e-09 · Best GWAS P=2.08e-07 conditioned to 0.224
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-135L13.4 | 0.38 | 0.15 | enet | 32 | 0.21 | 1.6e-16 | -4.8 | -5.3 | 1.0e-07 | 0.70 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | EPN2 | 0.14 | 0.08 | lasso | 7 | 0.09 | 3.6e-05 | -5.1 | -5.5 | 4.3e-08 | 0.77 | 0.01 | 0.96 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | EPN2 | 0.06 | -0.01 | lasso | 4 | 0.03 | 7.5e-02 | -5.1 | -5.7 | 1.3e-08 | 0.73 | 0.02 | 0.23 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | EPN2 | 0.19 | 0.00 | lasso | 5 | 0.00 | 3.9e-01 | -5.1 | -5.5 | 3.2e-08 | 0.70 | 0.02 | 0.44 | FALSE |
| 5 | GTEx | Testis | RNF112 | 0.13 | 0.16 | lasso | 2 | 0.13 | 3.4e-06 | -5.0 | -5.3 | 1.3e-07 | 0.75 | 0.01 | 0.98 | FALSE |
| 6 | NTR | Blood | GRAP | 0.05 | 0.03 | blup | 177 | 0.05 | 1.7e-14 | -3.7 | 5.9 | 2.8e-09 | -0.65 | 0.10 | 0.89 | TRUE |
| 7 | YFS | Blood | PRPSAP2 | 0.05 | 0.04 | blup | 154 | 0.05 | 6.6e-17 | 3.3 | 5.8 | 6.2e-09 | -0.49 | 0.85 | 0.05 | TRUE |
| 8 | YFS | Blood | RNF112 | 0.05 | 0.05 | lasso | 3 | 0.05 | 3.5e-16 | -5.1 | -5.2 | 2.5e-07 | 0.71 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | RNF112 | 0.04 | 0.04 | lasso | 2 | 0.03 | 5.8e-05 | -5.1 | -5.4 | 7.7e-08 | 0.86 | 0.00 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | GRAPL | 0.04 | 0.02 | enet | 2 | 0.02 | 1.3e-02 | -5.0 | 5.1 | 3.1e-07 | -1.00 | 0.00 | 0.58 | FALSE |