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chr19:18,408,222-20,451,172

Best TWAS P=2.59e-11 · Best GWAS P=7.09e-10 conditioned to 0.678

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Spleen	LPAR2	0.27	0.06	lasso	6	0.04	2.7e-02	5.3	-6.7	2.6e-11	-0.85	0.03	0.74	TRUE
4	GTEx	Brain Cerebellum	SUGP2	0.15	-0.01	enet	27	0.00	2.3e-01	5.6	6.6	4.8e-11	0.55	0.05	0.45	TRUE
15	GTEx	Whole Blood	LPAR2	0.10	0.07	lasso	5	0.07	8.0e-07	6.2	-6.4	1.4e-10	-0.90	0.01	0.99	FALSE
9	GTEx	Lung	LPAR2	0.07	0.09	lasso	3	0.05	9.9e-05	6.2	-6.4	2.0e-10	-0.98	0.00	1.00	FALSE
6	GTEx	Cells Transformed fibroblasts	LPAR2	0.04	0.05	lasso	2	0.04	5.5e-04	6.2	-6.2	4.8e-10	-0.97	0.01	0.96	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSSK6	0.02	0.02	blup	33	0.02	1.8e-03	5.1	6.2	7.7e-10	0.72	0.03	0.64	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	YJEFN3	0.04	0.05	lasso	7	0.04	1.6e-04	5.5	-6.0	1.6e-09	-0.82	0.01	0.96	FALSE
29	The Cancer Genome Atlas	Soft Tissue Sarcoma	HAPLN4	0.11	0.01	blup	38	0.02	2.7e-02	5.9	6.0	1.9e-09	0.75	0.01	0.88	FALSE
11	GTEx	Nerve Tibial	LPAR2	0.14	0.05	lasso	5	0.06	2.3e-05	6.2	-6.0	2.1e-09	-0.97	0.01	0.99	FALSE
18	YFS	Blood	LPAR2	0.14	0.15	lasso	5	0.16	3.6e-48	6.1	-6.0	2.2e-09	-0.96	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HAPLN4	0.07	0.10	lasso	6	0.10	5.3e-12	5.8	5.9	3.0e-09	0.73	0.04	0.96	FALSE
13	GTEx	Thyroid	YJEFN3	0.05	0.02	lasso	3	0.02	1.2e-02	6.1	-5.9	3.0e-09	-0.72	0.04	0.86	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GMIP	0.03	0.02	lasso	4	0.02	3.2e-03	6.2	5.9	3.3e-09	0.94	0.00	0.94	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAPLN4	0.07	0.05	lasso	7	0.07	2.9e-08	5.9	5.9	4.2e-09	0.70	0.00	1.00	FALSE
10	GTEx	Muscle Skeletal	SUGP1	0.11	0.06	lasso	7	0.07	9.5e-08	5.8	-5.8	6.4e-09	-0.73	0.06	0.94	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	GATAD2A	0.04	0.03	blup	61	0.05	1.3e-03	5.2	5.7	9.5e-09	0.70	0.05	0.73	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	HAPLN4	0.08	0.06	blup	37	0.09	1.8e-09	4.8	5.7	1.2e-08	0.63	0.02	0.98	FALSE
5	GTEx	Brain Cerebellum	PBX4	0.20	0.09	lasso	6	0.13	9.9e-05	5.6	5.7	1.3e-08	0.82	0.07	0.75	FALSE
7	GTEx	Colon Transverse	YJEFN3	0.09	0.09	lasso	3	0.07	4.3e-04	5.4	-5.6	1.9e-08	-0.72	0.04	0.91	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAPLN4	0.04	0.07	lasso	4	0.06	1.3e-12	5.3	5.6	2.1e-08	0.72	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	CILP2	0.02	0.02	blup	30	0.02	1.6e-04	5.5	5.6	2.3e-08	0.73	0.01	0.95	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	YJEFN3	0.04	0.05	lasso	2	0.05	4.3e-06	5.5	-5.5	3.9e-08	-0.73	0.01	0.99	FALSE
16	NTR	Blood	LPAR2	0.04	0.03	lasso	3	0.03	3.6e-11	6.2	-5.4	8.6e-08	-0.90	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	HAPLN4	0.10	0.08	blup	38	0.11	8.5e-07	4.5	5.3	1.3e-07	0.66	0.04	0.96	FALSE
14	GTEx	Whole Blood	TMEM161A	0.06	0.00	enet	2	0.00	1.4e-01	5.2	-5.2	1.8e-07	-0.57	0.15	0.28	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	TSSK6	0.04	0.00	blup	346	0.01	1.1e-02	5.2	5.2	2.0e-07	0.67	0.06	0.85	FALSE
3	GTEx	Brain Cerebellar Hemisphere	ATP13A1	0.19	0.15	lasso	2	0.07	7.3e-03	5.2	5.2	2.1e-07	0.66	0.07	0.43	FALSE
8	GTEx	Esophagus Mucosa	LPAR2	0.08	0.03	lasso	2	0.01	1.1e-01	5.1	-5.2	2.1e-07	-0.67	0.07	0.79	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GATAD2A	0.13	0.30	lasso	7	0.29	2.4e-35	5.1	-5.2	2.2e-07	-0.60	0.58	0.42	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	YJEFN3	0.08	0.06	blup	33	0.08	7.1e-08	5.5	-5.1	2.8e-07	-0.79	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GATAD2A	0.02	0.02	lasso	1	0.02	2.1e-03	5.1	5.1	2.9e-07	0.57	0.07	0.22	FALSE