TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Crohns Disease (2017)
:
→
chr1:7,314,655-8,738,937
Best TWAS P=2.29e-08 · Best GWAS P=7.45e-08 conditioned to 3.79e-06
7.4M
7.6M
7.8M
8M
8.2M
8.4M
8.6M
8.8M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Skin Sun Exposed Lower leg
PARK7
0.13
0.06
lasso
8
0.09
3.1e-08
4.0
-5.6
2.3e-08
-0.14
0.11
0.88
TRUE
4
The Cancer Genome Atlas
Prostate Adenocarcinoma
PARK7
0.09
0.05
lasso
4
0.07
3.4e-08
4.0
-5.2
1.7e-07
-0.16
0.05
0.93
FALSE
3
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
PARK7
0.04
0.03
blup
36
0.03
4.9e-04
-4.9
-5.2
2.2e-07
-0.15
0.01
0.95
FALSE
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
ERRFI1
0.01
0.01
blup
27
0.00
4.3e-02
-4.7
5.2
2.3e-07
0.19
0.01
0.81
FALSE