Best TWAS P=1.56e-69 · Best GWAS P=5.82e-97 conditioned to 9e-25
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Pituitary | SGIP1 | 0.24 | 0.15 | enet | 18 | 0.19 | 1.3e-05 | 1.2 | 6.4 | 1.7e-10 | -0.29 | 0.27 | 0.07 | FALSE |
| 2 | NTR | Blood | MIER1 | 0.03 | 0.01 | bslmm | 573 | 0.01 | 2.7e-05 | -3.4 | -8.1 | 6.6e-16 | 0.12 | 0.88 | 0.00 | TRUE |
| 3 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IL23R | 0.06 | 0.03 | blup | 107 | 0.03 | 7.0e-03 | 13.0 | 17.6 | 1.6e-69 | -0.58 | 0.06 | 0.61 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | C1orf141 | 0.12 | 0.08 | enet | 37 | 0.10 | 1.2e-11 | -14.9 | 8.0 | 1.6e-15 | -0.46 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Rectum Adenocarcinoma | IL23R | 0.17 | 0.03 | blup | 108 | 0.15 | 2.3e-04 | -9.3 | 16.3 | 1.4e-59 | -0.56 | 0.04 | 0.52 | TRUE |
| 6 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | IL23R | 0.25 | 0.07 | lasso | 8 | 0.05 | 1.0e-02 | 6.5 | 5.6 | 1.7e-08 | -0.15 | 0.05 | 0.04 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | MIER1 | 0.19 | 0.05 | blup | 58 | 0.06 | 1.7e-06 | 1.9 | 6.1 | 9.2e-10 | -0.19 | 0.79 | 0.08 | TRUE |