Best TWAS P=1.87e-08 · Best GWAS P=3.17e-07 conditioned to 0.223
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | YFS | Blood | PPP1R14B | 0.02 | 0.01 | blup | 333 | 0.01 | 1.8e-03 | -4.4 | 5.6 | 1.9e-08 | -0.77 | 0.01 | 0.96 | TRUE |
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC88B | 0.22 | 0.24 | bslmm | 358 | 0.25 | 5.8e-30 | -5.1 | 5.5 | 3.0e-08 | -0.98 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC88B | 0.02 | 0.02 | enet | 9 | 0.02 | 2.4e-05 | -5.0 | 5.5 | 4.5e-08 | -0.95 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | CCDC88B | 0.45 | 0.39 | lasso | 3 | 0.41 | 1.2e-11 | -5.1 | 5.3 | 1.4e-07 | -0.98 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Tibial | PPP1R14B | 0.21 | 0.13 | lasso | 4 | 0.13 | 4.0e-10 | -5.1 | 5.2 | 2.5e-07 | -0.99 | 0.00 | 1.00 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CCDC88B | 0.33 | 0.39 | lasso | 9 | 0.40 | 1.1e-54 | -5.0 | 5.1 | 2.8e-07 | -0.97 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Brain Cerebellum | CCDC88B | 0.48 | 0.55 | lasso | 4 | 0.54 | 1.6e-18 | -5.1 | 5.1 | 3.0e-07 | -1.00 | 0.00 | 1.00 | FALSE |