TWAS
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Genes
Traits
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Traits
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Crohns Disease (2017)
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chr10:80,130,592-82,984,432
Best TWAS P=5.33e-15 · Best GWAS P=8.9e-15 conditioned to 3.05e-05
80M
80.5M
81M
81.5M
82M
82.5M
83M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
YFS
Blood
ZMIZ1
0.02
0.02
lasso
2
0.02
4.8e-06
-7.7
-7.8
5.3e-15
0.61
0.01
0.99
TRUE
3
YFS
Blood
TSPAN14
0.31
0.34
lasso
7
0.38
8.3e-132
-6.3
-6.3
2.4e-10
-0.05
0.00
1.00
TRUE
1
CommonMind
Brain Pre-frontal Cortex
TSPAN14
0.15
0.13
enet
17
0.15
3.2e-18
-6.2
6.2
4.7e-10
0.04
0.00
1.00
FALSE
2
GTEx
Skin Sun Exposed Lower leg
TSPAN14
0.13
0.04
lasso
4
0.06
1.9e-05
-6.3
-6.0
2.4e-09
-0.05
0.00
1.00
FALSE