Best TWAS P=2.05e-10 · Best GWAS P=4.4e-10 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CTC-228N24.3 | 0.24 | 0.15 | enet | 16 | 0.20 | 3.4e-16 | -5.5 | 6.1 | 1.1e-09 | -0.96 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adrenal Gland | CTC-228N24.3 | 0.34 | 0.10 | lasso | 9 | 0.09 | 4.2e-04 | -4.6 | 5.3 | 1.0e-07 | -0.90 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Aorta | CTC-228N24.3 | 0.20 | 0.04 | lasso | 8 | 0.07 | 7.4e-05 | -1.5 | 5.4 | 8.5e-08 | -0.94 | 0.04 | 0.95 | FALSE |
4 | GTEx | Artery Coronary | CTC-228N24.3 | 0.31 | 0.10 | lasso | 3 | 0.10 | 2.9e-04 | -6.1 | 5.3 | 9.8e-08 | -0.90 | 0.01 | 0.92 | FALSE |
5 | GTEx | Artery Tibial | CTC-228N24.3 | 0.20 | 0.16 | lasso | 7 | 0.14 | 3.0e-11 | -5.5 | 5.4 | 5.7e-08 | -0.96 | 0.01 | 0.99 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | CTC-228N24.3 | 0.24 | -0.01 | enet | 26 | 0.04 | 2.2e-02 | -5.7 | 5.3 | 1.0e-07 | -0.59 | 0.03 | 0.73 | FALSE |
7 | GTEx | Colon Sigmoid | CTC-228N24.3 | 0.20 | 0.22 | enet | 11 | 0.23 | 1.1e-08 | -6.1 | 6.4 | 2.0e-10 | -0.95 | 0.00 | 1.00 | TRUE |
8 | GTEx | Esophagus Mucosa | CTC-228N24.3 | 0.18 | 0.14 | enet | 11 | 0.14 | 9.8e-10 | -5.5 | 5.5 | 4.5e-08 | -0.92 | 0.01 | 0.99 | FALSE |
9 | GTEx | Heart Atrial Appendage | CTC-228N24.3 | 0.22 | 0.07 | lasso | 5 | 0.07 | 4.1e-04 | -6.2 | 5.4 | 5.5e-08 | -0.90 | 0.00 | 0.99 | FALSE |
10 | GTEx | Lung | CTC-228N24.3 | 0.18 | 0.14 | enet | 16 | 0.14 | 3.2e-11 | -5.5 | 6.0 | 1.5e-09 | -0.93 | 0.01 | 0.99 | FALSE |
11 | GTEx | Nerve Tibial | CTC-228N24.3 | 0.32 | 0.18 | lasso | 10 | 0.16 | 1.6e-11 | -6.1 | 6.0 | 2.2e-09 | -0.99 | 0.00 | 1.00 | FALSE |
12 | GTEx | Pancreas | CTC-228N24.3 | 0.14 | 0.19 | lasso | 2 | 0.17 | 1.1e-07 | -5.5 | 5.5 | 3.1e-08 | -0.96 | 0.01 | 0.99 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | CTC-228N24.3 | 0.29 | 0.21 | lasso | 7 | 0.22 | 1.7e-12 | -5.5 | 5.8 | 5.2e-09 | -0.96 | 0.00 | 1.00 | FALSE |
14 | GTEx | Skin Sun Exposed Lower leg | CTC-228N24.3 | 0.29 | 0.17 | enet | 12 | 0.22 | 4.3e-18 | -6.2 | 5.8 | 6.2e-09 | -0.91 | 0.00 | 1.00 | FALSE |
15 | GTEx | Stomach | CTC-228N24.3 | 0.17 | 0.04 | lasso | 6 | 0.08 | 1.5e-04 | -5.9 | 5.3 | 1.1e-07 | -0.83 | 0.01 | 0.97 | FALSE |
16 | METSIM | Adipose | CTC-228N24.3 | 0.17 | 0.19 | lasso | 6 | 0.18 | 1.9e-26 | -5.5 | 5.7 | 1.0e-08 | -0.98 | 0.02 | 0.98 | FALSE |
17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ33630 | 0.05 | 0.04 | enet | 14 | 0.03 | 2.1e-07 | -5.5 | 5.4 | 7.4e-08 | -0.84 | 0.03 | 0.97 | FALSE |
18 | The Cancer Genome Atlas | Glioblastoma Multiforme | FLJ33630 | 0.38 | 0.20 | lasso | 5 | 0.17 | 6.5e-06 | -5.5 | 5.7 | 9.2e-09 | -0.98 | 0.00 | 0.99 | FALSE |
19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FLJ33630 | 0.10 | 0.07 | lasso | 3 | 0.08 | 7.0e-09 | -6.1 | 6.3 | 3.3e-10 | -0.96 | 0.00 | 1.00 | FALSE |
20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FLJ33630 | 0.19 | 0.16 | enet | 4 | 0.16 | 1.2e-17 | -5.5 | 5.8 | 8.9e-09 | -0.98 | 0.01 | 0.99 | FALSE |
21 | The Cancer Genome Atlas | Lung Adenocarcinoma | FLJ33630 | 0.07 | 0.05 | lasso | 1 | 0.04 | 1.3e-05 | -6.1 | 6.1 | 8.2e-10 | -1.00 | 0.00 | 1.00 | FALSE |
22 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FLJ33630 | 0.09 | 0.08 | lasso | 4 | 0.09 | 4.9e-10 | -5.5 | 5.8 | 8.4e-09 | -0.97 | 0.00 | 1.00 | FALSE |
23 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FLJ33630 | 0.08 | 0.03 | lasso | 2 | 0.04 | 5.7e-03 | -6.1 | 5.7 | 1.0e-08 | -0.93 | 0.00 | 0.93 | FALSE |
24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FLJ33630 | 0.08 | 0.05 | blup | 70 | 0.04 | 4.4e-05 | -6.1 | 6.1 | 9.4e-10 | -0.87 | 0.00 | 1.00 | FALSE |
25 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FLJ33630 | 0.26 | 0.14 | lasso | 3 | 0.13 | 2.2e-05 | -5.5 | 5.7 | 1.2e-08 | -0.95 | 0.00 | 0.99 | FALSE |
26 | The Cancer Genome Atlas | Thyroid Carcinoma | FLJ33630 | 0.10 | 0.10 | lasso | 2 | 0.09 | 5.3e-09 | -5.5 | 5.5 | 3.2e-08 | -0.96 | 0.03 | 0.97 | FALSE |