Best TWAS P=4.35e-27 · Best GWAS P=4.85e-57 conditioned to 4.55e-22
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | EXOC2 | 0.22 | 0.17 | lasso | 3 | 0.19 | 2.7e-13 | -4.49 | -5.7 | 1.3e-08 | -0.03 | 1.00 | 0.00 | TRUE |
| 2 | NTR | Blood | EXOC2 | 0.03 | 0.00 | bslmm | 624 | 0.01 | 3.4e-04 | 8.42 | 6.2 | 4.1e-10 | -0.53 | 0.39 | 0.22 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | EXOC2 | 0.07 | 0.02 | lasso | 5 | 0.05 | 1.8e-07 | 12.29 | 5.6 | 1.8e-08 | -0.44 | 0.72 | 0.02 | FALSE |
| 4 | YFS | Blood | EXOC2 | 0.05 | 0.02 | lasso | 5 | 0.02 | 9.7e-09 | 10.66 | 9.2 | 4.1e-20 | -0.49 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | EXOC2 | 0.05 | 0.02 | blup | 204 | 0.03 | 3.9e-04 | 12.14 | 5.6 | 1.9e-08 | -0.47 | 0.40 | 0.06 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EXOC2 | 0.18 | 0.03 | blup | 203 | 0.10 | 1.4e-11 | -0.87 | 6.0 | 1.9e-09 | -0.23 | 0.93 | 0.01 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EXOC2 | 0.07 | 0.06 | lasso | 5 | 0.06 | 2.6e-07 | 12.29 | 10.8 | 4.3e-27 | -0.52 | 0.91 | 0.00 | TRUE |