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chr5:176,040,488-177,426,530

Best TWAS P=3.3e-22 · Best GWAS P=4.92e-22 conditioned to 0.0144

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RGS14	0.29	0.16	lasso	7	0.20	2.2e-23	9.2	-9.5	2.0e-21	-0.92	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	RGS14	0.31	0.10	lasso	3	0.10	2.8e-08	8.6	-8.9	4.7e-19	-0.89	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	MXD3	0.16	0.05	enet	13	0.06	1.7e-05	-2.1	-5.1	2.8e-07	-0.40	0.84	0.08	FALSE
4	GTEx	Adrenal Gland	RGS14	0.28	0.24	lasso	4	0.24	3.7e-09	8.6	-8.9	3.6e-19	-0.86	0.02	0.98	FALSE
5	GTEx	Artery Aorta	RGS14	0.35	0.31	lasso	6	0.29	1.5e-16	9.2	-9.4	5.2e-21	-0.96	0.00	1.00	FALSE
6	GTEx	Artery Aorta	LMAN2	0.13	0.10	lasso	6	0.06	1.9e-04	8.6	8.5	2.5e-17	0.70	0.26	0.55	FALSE
7	GTEx	Artery Aorta	MXD3	0.36	0.22	enet	45	0.29	2.4e-16	-2.1	-5.6	1.7e-08	-0.40	1.00	0.00	FALSE
8	GTEx	Artery Tibial	RGS14	0.49	0.12	enet	10	0.14	6.2e-11	9.2	-9.6	8.1e-22	-0.93	0.00	1.00	FALSE
9	GTEx	Brain Cerebellum	RGS14	0.25	0.11	enet	10	0.18	4.8e-06	8.6	-7.9	2.2e-15	-0.78	0.01	0.98	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	MXD3	0.24	0.14	enet	10	0.25	2.9e-07	-2.1	-6.1	1.3e-09	-0.53	0.14	0.53	FALSE
11	GTEx	Breast Mammary Tissue	RGS14	0.13	0.14	lasso	1	0.11	2.0e-06	9.2	-9.2	4.5e-20	-0.96	0.00	1.00	FALSE
12	GTEx	Breast Mammary Tissue	MXD3	0.26	0.08	lasso	5	0.10	1.3e-05	-2.1	-6.1	1.3e-09	-0.47	0.43	0.19	FALSE
13	GTEx	Breast Mammary Tissue (Female)	RGS14	0.12	0.04	lasso	4	0.09	1.2e-03	9.2	-7.6	2.6e-14	-0.69	0.01	0.66	FALSE
14	GTEx	Breast Mammary Tissue (Female)	MXD3	0.23	0.08	lasso	3	0.09	1.1e-03	-3.9	-7.3	2.0e-13	-0.56	0.06	0.22	FALSE
15	GTEx	Cells Transformed fibroblasts	RGS14	0.52	0.39	lasso	6	0.47	4.9e-39	9.2	-9.6	1.1e-21	-0.93	0.00	1.00	FALSE
16	GTEx	Esophagus Mucosa	RGS14	0.31	0.23	enet	8	0.24	5.2e-16	8.6	-8.5	2.2e-17	-0.84	0.15	0.85	FALSE
17	GTEx	Esophagus Muscularis	RGS14	0.13	0.12	enet	3	0.15	3.7e-09	9.2	-9.3	1.1e-20	-0.92	0.00	1.00	FALSE
18	GTEx	Heart Atrial Appendage	RGS14	0.18	0.18	lasso	2	0.20	2.5e-09	9.2	-9.3	1.3e-20	-0.94	0.00	1.00	FALSE
19	GTEx	Heart Left Ventricle	RGS14	0.20	0.11	lasso	2	0.08	3.6e-05	9.2	-9.1	1.3e-19	-0.95	0.00	1.00	FALSE
20	GTEx	Lung	RGS14	0.12	0.11	lasso	1	0.08	5.5e-07	9.2	-9.2	4.5e-20	-0.96	0.00	1.00	FALSE
21	GTEx	Nerve Tibial	RGS14	0.22	0.10	lasso	6	0.08	1.8e-06	8.6	-9.2	2.2e-20	-0.91	0.00	0.99	FALSE
22	GTEx	Pancreas	RGS14	0.25	0.12	lasso	13	0.12	1.5e-05	8.6	-9.4	5.9e-21	-0.88	0.03	0.97	FALSE
23	GTEx	Pituitary	RGS14	0.48	0.34	lasso	6	0.35	1.4e-09	9.2	-9.0	3.1e-19	-0.94	0.00	1.00	FALSE
24	GTEx	Prostate	RGS14	0.59	0.11	enet	39	0.17	4.4e-05	8.6	-6.7	2.8e-11	-0.57	0.01	0.86	FALSE
25	GTEx	Skin Sun Exposed Lower leg	RGS14	0.15	0.16	lasso	3	0.15	9.1e-13	9.2	-9.3	1.3e-20	-0.95	0.00	1.00	FALSE
26	GTEx	Skin Sun Exposed Lower leg	MXD3	0.19	0.14	lasso	6	0.12	4.2e-10	-3.9	-6.0	2.0e-09	-0.44	1.00	0.00	FALSE
27	GTEx	Stomach	RGS14	0.11	0.17	enet	6	0.17	1.1e-08	8.6	-9.1	1.4e-19	-0.85	0.01	0.99	FALSE
28	GTEx	Testis	RGS14	0.63	0.47	enet	9	0.47	4.8e-23	9.2	-9.3	1.2e-20	-0.92	0.00	1.00	FALSE
29	GTEx	Thyroid	RGS14	0.15	0.14	enet	9	0.13	2.2e-10	8.6	-8.7	5.3e-18	-0.86	0.02	0.98	FALSE
30	GTEx	Thyroid	MXD3	0.31	0.17	lasso	8	0.24	1.1e-18	-2.1	-5.5	4.0e-08	-0.42	1.00	0.00	FALSE
31	GTEx	Uterus	MXD3	0.51	0.10	enet	30	0.24	1.1e-05	8.6	-5.7	1.5e-08	-0.52	0.06	0.30	FALSE
32	METSIM	Adipose	MXD3	0.18	0.18	lasso	3	0.21	1.3e-30	-2.1	-5.2	2.2e-07	-0.43	1.00	0.00	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	RGS14	0.32	0.35	enet	12	0.38	1.1e-51	8.7	-9.1	9.4e-20	-0.91	0.29	0.71	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	MXD3	0.41	0.20	bslmm	300	0.30	1.2e-39	-2.0	-5.1	2.9e-07	-0.48	1.00	0.00	FALSE
35	YFS	Blood	MXD3	0.04	0.03	lasso	4	0.04	5.8e-13	8.8	-8.2	2.6e-16	-0.52	0.89	0.11	FALSE
36	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RGS14	0.09	0.08	enet	7	0.10	1.2e-08	9.2	-9.5	1.6e-21	-0.92	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	RGS14	0.08	0.10	lasso	2	0.12	1.5e-23	8.6	-9.2	5.0e-20	-0.91	0.86	0.14	FALSE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	RAB24	0.08	0.04	enet	7	0.06	3.4e-04	8.5	-8.2	2.9e-16	-0.55	0.01	0.80	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	RGS14	0.08	0.11	lasso	2	0.11	9.4e-07	8.4	-8.5	2.1e-17	-0.73	0.21	0.75	FALSE
40	The Cancer Genome Atlas	Glioblastoma Multiforme	RGS14	0.22	0.24	blup	39	0.27	6.9e-09	8.2	-9.7	3.3e-22	-0.87	0.01	0.99	TRUE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LMAN2	0.04	0.00	blup	46	0.00	1.6e-01	-3.9	5.3	1.1e-07	0.31	0.02	0.04	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MXD3	0.05	0.00	lasso	6	0.00	6.9e-01	4.4	5.4	5.4e-08	0.33	0.02	0.06	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RGS14	0.10	0.07	lasso	2	0.09	3.9e-10	8.2	-8.9	4.7e-19	-0.90	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RGS14	0.05	0.03	enet	5	0.05	7.2e-06	9.2	-9.0	3.1e-19	-0.87	0.00	0.99	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RGS14	0.19	0.05	enet	16	0.05	6.6e-04	8.7	-6.0	1.6e-09	-0.68	0.05	0.75	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	RGS14	0.03	0.02	blup	39	0.03	8.1e-05	8.7	-9.6	5.7e-22	-0.84	0.11	0.86	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RGS14	0.14	0.12	lasso	3	0.13	2.1e-14	8.6	-8.9	3.4e-19	-0.85	0.49	0.51	FALSE
48	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RGS14	0.13	0.13	lasso	2	0.14	1.1e-09	9.2	-9.3	1.8e-20	-0.92	0.02	0.98	FALSE
49	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RGS14	0.07	0.11	lasso	3	0.10	8.2e-05	9.2	-9.1	1.5e-19	-0.90	0.02	0.92	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	FGFR4	0.11	0.04	enet	19	0.06	8.7e-07	3.4	-5.5	4.3e-08	-0.34	0.62	0.34	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRELID1	0.05	0.00	blup	37	0.03	2.3e-04	-3.7	7.3	3.4e-13	0.60	0.01	0.44	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	RGS14	0.30	0.18	blup	39	0.25	1.6e-25	8.6	-8.3	1.3e-16	-0.81	0.15	0.85	FALSE
53	The Cancer Genome Atlas	Skin Cutaneous Melanoma	F12	0.15	0.19	lasso	1	0.18	1.1e-05	8.2	-8.2	2.5e-16	-0.63	0.07	0.25	FALSE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	RGS14	0.03	0.03	lasso	2	0.04	1.3e-03	9.2	-9.3	2.0e-20	-0.95	0.00	0.94	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RGS14	0.19	0.03	blup	39	0.03	3.6e-02	8.6	-7.8	6.8e-15	-0.75	0.02	0.57	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	RGS14	0.26	0.18	lasso	5	0.19	4.5e-18	8.6	-9.4	5.8e-21	-0.92	0.02	0.98	FALSE