Best TWAS P=4.82e-09 · Best GWAS P=1.81e-09 conditioned to 0.000303
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | TSPAN3 | 0.26 | 0.14 | lasso | 6 | 0.12 | 8.2e-05 | 3.5 | 5.8 | 4.8e-09 | -0.49 | 0.08 | 0.57 | TRUE |
| 2 | GTEx | Colon Transverse | RCN2 | 0.20 | 0.04 | enet | 21 | 0.08 | 1.8e-04 | -5.8 | 5.2 | 2.1e-07 | -0.73 | 0.02 | 0.92 | FALSE |
| 3 | GTEx | Heart Left Ventricle | RP11-797A18.4 | 0.16 | 0.09 | enet | 12 | 0.08 | 3.3e-05 | -4.2 | 5.3 | 1.0e-07 | -0.71 | 0.66 | 0.21 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | TSPAN3 | 0.11 | 0.03 | enet | 8 | 0.10 | 2.5e-08 | 3.5 | 5.5 | 4.5e-08 | -0.56 | 0.20 | 0.63 | FALSE |
| 5 | GTEx | Testis | TSPAN3 | 0.19 | 0.05 | lasso | 7 | 0.06 | 1.6e-03 | -4.3 | 5.2 | 2.4e-07 | -0.56 | 0.25 | 0.13 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SCAPER | 0.05 | 0.02 | lasso | 3 | 0.02 | 7.5e-05 | -5.1 | 5.2 | 2.2e-07 | -0.46 | 0.01 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SCAPER | 0.05 | 0.02 | blup | 151 | 0.02 | 2.3e-03 | -3.1 | 5.7 | 9.6e-09 | -0.37 | 0.02 | 0.79 | FALSE |
| 8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | SCAPER | 0.37 | 0.00 | blup | 151 | 0.07 | 1.0e-02 | 4.6 | 5.7 | 1.2e-08 | -0.31 | 0.03 | 0.54 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SCAPER | 0.18 | 0.01 | blup | 151 | 0.02 | 2.2e-02 | -4.9 | 5.5 | 3.0e-08 | -0.40 | 0.04 | 0.72 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | SCAPER | 0.04 | 0.00 | blup | 151 | 0.02 | 5.9e-03 | 4.6 | 5.2 | 1.9e-07 | -0.24 | 0.03 | 0.42 | FALSE |