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chr15:79,427,450-80,913,123

Best TWAS P=5.48e-50 · Best GWAS P=3.54e-49 conditioned to 0.0169

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ST20	0.57	0.30	enet	24	0.42	1.7e-36	10.6	-9.0	2.5e-19	0.51	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	MTHFS	0.27	0.02	lasso	12	0.09	2.3e-05	-1.3	-8.4	3.5e-17	0.79	0.02	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	ST20	0.19	0.16	lasso	3	0.15	2.3e-08	10.6	-11.2	6.7e-29	0.60	0.51	0.46	FALSE
4	GTEx	Adrenal Gland	MTHFS	0.26	0.05	enet	32	0.06	3.4e-03	2.7	-5.7	1.5e-08	0.59	0.15	0.57	FALSE
5	GTEx	Artery Aorta	MTHFS	0.25	0.15	enet	22	0.20	2.8e-11	2.7	-6.0	2.4e-09	0.67	0.82	0.18	FALSE
6	GTEx	Artery Aorta	ST20	0.51	0.26	enet	21	0.39	4.9e-23	10.6	-10.1	8.7e-24	0.66	0.92	0.08	FALSE
7	GTEx	Artery Coronary	MTHFS	0.44	0.07	enet	13	0.21	1.4e-07	-1.4	-5.7	1.5e-08	0.64	0.13	0.41	FALSE
8	GTEx	Artery Coronary	ST20	0.39	0.03	lasso	9	0.23	2.3e-08	4.9	-6.6	3.8e-11	0.46	0.20	0.18	FALSE
9	GTEx	Artery Tibial	MTHFS	0.31	0.20	enet	28	0.28	9.4e-22	3.5	-5.5	5.0e-08	0.68	0.91	0.09	FALSE
10	GTEx	Artery Tibial	ST20	0.32	0.21	lasso	4	0.29	4.4e-23	10.6	-11.6	5.3e-31	0.70	1.00	0.00	FALSE
11	GTEx	Brain Caudate basal ganglia	MTHFS	0.24	0.18	lasso	2	0.07	3.8e-03	6.1	-6.2	6.2e-10	0.62	0.21	0.38	FALSE
12	GTEx	Brain Cerebellar Hemisphere	ST20	0.70	0.36	lasso	8	0.52	2.0e-15	10.6	-11.3	1.1e-29	0.73	0.06	0.93	FALSE
13	GTEx	Brain Cerebellum	ST20	0.44	0.33	lasso	5	0.41	3.0e-13	10.6	-11.3	1.5e-29	0.62	0.67	0.31	FALSE
14	GTEx	Brain Frontal Cortex BA9	ST20	0.54	0.17	lasso	11	0.14	1.9e-04	-14.7	-14.9	5.5e-50	0.93	0.00	0.98	TRUE
15	GTEx	Brain Hippocampus	ST20	0.44	0.06	lasso	8	0.22	6.4e-06	-14.7	-11.1	7.4e-29	0.77	0.01	0.94	FALSE
16	GTEx	Breast Mammary Tissue	ST20	0.53	0.32	lasso	11	0.42	2.8e-23	10.6	-8.3	7.9e-17	0.47	1.00	0.00	FALSE
17	GTEx	Breast Mammary Tissue (Male)	ST20	0.54	0.33	lasso	4	0.43	3.4e-11	10.6	-11.3	1.7e-29	0.63	0.27	0.62	FALSE
18	GTEx	Cells Transformed fibroblasts	MTHFS	0.36	0.27	lasso	12	0.39	4.4e-31	2.6	-5.7	1.0e-08	0.66	1.00	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	ST20	0.44	0.27	lasso	8	0.34	1.8e-26	10.6	-10.4	3.7e-25	0.59	1.00	0.00	FALSE
20	GTEx	Colon Sigmoid	MTHFS	0.19	0.11	enet	25	0.16	1.9e-06	-6.6	-7.2	9.0e-13	0.63	0.33	0.34	FALSE
21	GTEx	Colon Sigmoid	ST20	0.65	0.30	lasso	12	0.49	1.1e-19	10.6	-9.5	1.6e-21	0.57	0.29	0.71	FALSE
22	GTEx	Colon Transverse	ST20	0.56	0.22	lasso	7	0.49	3.4e-26	10.6	-7.5	4.9e-14	0.42	1.00	0.00	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	MTHFS	0.38	0.21	lasso	7	0.23	6.7e-09	2.7	-5.7	1.5e-08	0.64	0.78	0.21	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	ST20	0.47	0.34	lasso	4	0.38	1.1e-14	10.6	-11.6	3.6e-31	0.65	0.93	0.07	FALSE
25	GTEx	Esophagus Mucosa	MTHFS	0.21	0.03	enet	27	0.04	5.6e-04	-14.7	-8.5	2.2e-17	0.74	0.01	0.99	FALSE
26	GTEx	Esophagus Mucosa	ST20	0.51	0.27	enet	22	0.42	2.3e-30	10.6	-9.0	1.8e-19	0.53	1.00	0.00	FALSE
27	GTEx	Esophagus Muscularis	ST20	0.55	0.25	lasso	12	0.45	8.8e-30	10.6	-9.7	4.9e-22	0.60	0.99	0.01	FALSE
28	GTEx	Heart Left Ventricle	MTHFS	0.23	0.09	enet	18	0.22	9.1e-12	3.3	-8.4	3.5e-17	0.73	0.06	0.94	FALSE
29	GTEx	Heart Left Ventricle	ST20	0.20	0.16	lasso	5	0.17	1.6e-09	10.6	-7.6	2.9e-14	0.38	0.98	0.00	FALSE
30	GTEx	Lung	MTHFS	0.25	0.15	lasso	5	0.17	9.5e-13	10.7	-11.6	2.8e-31	0.91	0.01	0.99	FALSE
31	GTEx	Lung	ST20	0.38	0.23	enet	40	0.26	5.3e-20	10.6	-8.5	2.5e-17	0.45	1.00	0.00	FALSE
32	GTEx	Muscle Skeletal	MTHFS	0.22	0.17	enet	24	0.26	6.6e-25	3.3	-7.3	3.3e-13	0.73	1.00	0.00	FALSE
33	GTEx	Muscle Skeletal	ST20	0.29	0.12	enet	41	0.18	5.7e-17	10.6	-9.9	3.2e-23	0.58	0.99	0.01	FALSE
34	GTEx	Nerve Tibial	MTHFS	0.34	0.12	lasso	11	0.29	1.1e-20	10.7	-10.6	4.2e-26	0.79	0.00	1.00	FALSE
35	GTEx	Nerve Tibial	ST20	0.60	0.35	lasso	7	0.49	4.2e-39	10.6	-10.4	1.5e-25	0.63	1.00	0.00	FALSE
36	GTEx	Ovary	ST20	0.74	0.44	enet	19	0.53	2.6e-15	10.6	-13.5	1.4e-41	0.81	0.04	0.96	FALSE
37	GTEx	Pancreas	ST20	0.42	0.32	lasso	6	0.36	8.3e-16	10.6	-9.1	8.9e-20	0.45	1.00	0.00	FALSE
38	GTEx	Pituitary	ST20	0.57	0.34	enet	24	0.52	3.7e-15	10.6	-6.7	1.8e-11	0.33	0.75	0.06	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	MTHFS	0.22	0.07	lasso	7	0.11	1.3e-06	-14.7	-11.7	1.5e-31	0.86	0.00	0.99	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	ST20	0.59	0.30	lasso	11	0.44	4.3e-26	10.6	-8.9	3.8e-19	0.52	1.00	0.00	FALSE
41	GTEx	Skin Sun Exposed Lower leg	MTHFS	0.14	0.10	enet	15	0.10	9.8e-09	-14.7	-10.9	1.1e-27	0.88	0.00	1.00	FALSE
42	GTEx	Skin Sun Exposed Lower leg	ST20	0.51	0.26	lasso	13	0.45	1.0e-40	10.6	-10.0	1.6e-23	0.61	1.00	0.00	FALSE
43	GTEx	Stomach	ST20	0.47	0.24	enet	22	0.34	9.1e-17	10.6	-8.9	4.8e-19	0.52	0.96	0.03	FALSE
44	GTEx	Testis	ST20	0.50	0.32	lasso	9	0.43	1.1e-20	10.6	-10.3	7.8e-25	0.56	0.99	0.01	FALSE
45	GTEx	Thyroid	ST20	0.60	0.33	enet	33	0.51	8.8e-45	10.6	-9.8	1.1e-22	0.61	1.00	0.00	FALSE
46	GTEx	Uterus	ST20	0.61	0.02	lasso	4	0.34	8.6e-08	10.6	-8.4	3.9e-17	0.45	0.11	0.21	FALSE
47	GTEx	Whole Blood	ST20	0.24	0.16	lasso	6	0.20	2.3e-18	10.6	-6.0	1.7e-09	0.25	1.00	0.00	FALSE
48	METSIM	Adipose	ST20	0.34	0.18	lasso	12	0.26	1.4e-38	10.6	-9.3	9.5e-21	0.49	1.00	0.00	FALSE
49	NTR	Blood	MTHFS	0.03	0.00	enet	10	0.01	1.0e-03	-14.7	-10.1	7.1e-24	0.79	0.00	1.00	FALSE
50	NTR	Blood	ST20	0.03	0.03	lasso	6	0.02	6.0e-08	12.8	12.7	4.6e-37	-0.80	0.02	0.98	FALSE
51	YFS	Blood	MTHFS	0.14	0.11	enet	36	0.15	4.7e-48	6.1	-10.5	9.9e-26	0.82	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MTHFS	0.12	0.14	enet	13	0.18	2.0e-15	2.3	-5.5	2.9e-08	0.60	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	MTHFS	0.10	0.05	enet	13	0.10	5.0e-20	-1.3	-6.3	2.7e-10	0.63	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	ST20	0.09	0.04	enet	14	0.05	4.8e-10	10.6	-8.0	9.9e-16	0.52	0.96	0.03	FALSE
55	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MTHFS	0.09	0.09	blup	83	0.08	1.0e-04	2.3	-5.9	4.5e-09	0.59	0.29	0.30	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	MTHFS	0.17	0.07	blup	82	0.14	1.1e-08	2.5	-5.7	1.2e-08	0.63	0.89	0.10	FALSE
57	The Cancer Genome Atlas	Glioblastoma Multiforme	MTHFS	0.19	0.14	enet	13	0.20	1.2e-06	2.5	-5.7	1.4e-08	0.64	0.21	0.69	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MTHFS	0.10	0.09	lasso	8	0.16	1.3e-17	2.5	-8.3	8.2e-17	0.76	0.13	0.87	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ST20	0.06	0.02	blup	52	0.03	1.9e-04	2.5	-9.2	4.0e-20	0.67	0.04	0.93	FALSE
60	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ST20	0.13	0.13	lasso	4	0.10	1.5e-05	-14.7	13.5	1.7e-41	-0.96	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MTHFS	0.12	0.08	blup	82	0.19	1.1e-20	3.3	-7.1	1.1e-12	0.71	0.96	0.04	FALSE
62	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ST20	0.12	0.01	blup	51	0.03	1.9e-02	10.6	-9.7	2.7e-22	0.64	0.01	0.61	FALSE
63	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ST20	0.30	0.04	enet	17	0.26	5.5e-11	10.6	-9.2	3.3e-20	0.58	0.08	0.86	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	MTHFS	0.12	0.06	lasso	6	0.14	1.7e-14	6.2	-8.2	1.6e-16	0.75	0.04	0.96	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	ST20	0.09	0.08	enet	5	0.09	1.7e-09	10.6	-13.4	3.2e-41	0.76	0.21	0.79	FALSE
66	The Cancer Genome Atlas	Rectum Adenocarcinoma	MTHFS	0.33	0.13	blup	82	0.10	2.5e-03	2.7	-5.7	1.3e-08	0.54	0.07	0.22	FALSE
67	The Cancer Genome Atlas	Soft Tissue Sarcoma	ST20	0.07	0.03	blup	52	0.05	6.3e-04	3.3	-9.6	1.0e-21	0.77	0.02	0.92	FALSE
68	The Cancer Genome Atlas	Skin Cutaneous Melanoma	MTHFS	0.14	0.01	enet	17	0.12	4.2e-04	-14.7	-8.3	1.4e-16	0.74	0.01	0.73	FALSE
69	The Cancer Genome Atlas	Stomach Adenocarcinoma	ST20	0.11	0.03	blup	53	0.06	2.6e-05	10.6	-10.9	1.1e-27	0.73	0.02	0.84	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	ST20	0.19	0.08	blup	52	0.19	5.8e-18	-14.7	-10.8	3.4e-27	0.74	0.00	1.00	FALSE