Best TWAS P=8.23e-12 · Best GWAS P=1.14e-16 conditioned to 1.94e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | PPARA | 0.21 | 0.04 | lasso | 4 | 0.02 | 7.5e-03 | -7.0 | 6.8 | 8.2e-12 | -0.76 | 0.74 | 0.10 | TRUE |
| 2 | GTEx | Colon Sigmoid | TRMU | 0.22 | 0.00 | lasso | 5 | -0.01 | 7.7e-01 | -5.8 | -6.7 | 1.8e-11 | 0.85 | 0.07 | 0.30 | FALSE |
| 3 | GTEx | Thyroid | TRMU | 0.21 | 0.04 | lasso | 4 | 0.03 | 3.9e-03 | -5.8 | -5.5 | 3.5e-08 | 0.77 | 0.10 | 0.62 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | PPARA | 0.04 | 0.02 | lasso | 4 | 0.01 | 5.9e-03 | -7.1 | 6.1 | 9.8e-10 | -0.77 | 0.31 | 0.61 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | PKDREJ | 0.10 | 0.09 | enet | 13 | 0.09 | 5.5e-06 | -4.0 | 5.6 | 2.3e-08 | -0.73 | 0.42 | 0.52 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PKDREJ | 0.09 | 0.09 | blup | 53 | 0.11 | 1.3e-12 | -3.8 | 5.3 | 9.7e-08 | -0.67 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TRMU | 0.05 | 0.03 | blup | 45 | 0.04 | 3.0e-05 | -6.0 | -5.8 | 5.5e-09 | 0.63 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PKDREJ | 0.06 | 0.01 | enet | 10 | 0.03 | 5.8e-03 | -3.7 | 5.7 | 9.3e-09 | -0.68 | 0.14 | 0.24 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PKDREJ | 0.27 | 0.00 | blup | 53 | 0.02 | 4.5e-02 | -7.1 | 5.8 | 5.4e-09 | -0.74 | 0.14 | 0.40 | FALSE |