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chr22:40,472,399-43,615,241

Best TWAS P=4.84e-34 · Best GWAS P=4.72e-26 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CSDC2	0.20	0.30	lasso	5	0.32	2.1e-40	8.1	9.1	9.3e-20	-0.04	0.20	0.80	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MEI1	0.09	0.10	blup	343	0.10	3.1e-12	8.1	8.1	6.0e-16	-0.01	0.78	0.22	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NHP2L1	0.08	0.09	bslmm	299	0.10	9.9e-12	8.1	-7.4	1.1e-13	0.11	0.92	0.08	FALSE
4	CommonMind	Brain Pre-frontal Cortex	POLR3H	0.24	0.31	enet	24	0.35	1.3e-44	10.0	9.7	2.0e-22	-0.09	0.03	0.97	FALSE
5	CommonMind	Brain Pre-frontal Cortex	SLC25A17	0.03	0.01	blup	301	0.01	9.6e-03	2.5	-7.1	1.4e-12	0.05	0.20	0.03	FALSE
6	CommonMind	Brain Pre-frontal Cortex	TOB2	0.02	0.01	bslmm	278	0.01	3.5e-02	9.7	8.0	8.7e-16	-0.03	0.40	0.29	FALSE
7	GTEx	Adipose Subcutaneous	ST13	0.06	0.02	lasso	5	0.03	7.4e-04	3.2	5.6	1.9e-08	-0.18	0.26	0.03	FALSE
8	GTEx	Adrenal Gland	CCDC134	0.15	0.06	lasso	4	0.07	1.6e-03	4.2	5.3	1.3e-07	0.01	0.10	0.05	FALSE
9	GTEx	Artery Aorta	L3MBTL2	0.14	0.01	lasso	6	0.04	1.8e-03	-8.3	7.2	7.9e-13	-0.17	0.26	0.10	FALSE
10	GTEx	Artery Aorta	ACO2	0.08	0.08	lasso	5	0.06	2.8e-04	9.9	9.7	2.5e-22	-0.03	0.04	0.91	FALSE
11	GTEx	Artery Aorta	RP4-756G23.5	0.10	0.06	lasso	5	0.02	1.5e-02	7.5	8.9	6.4e-19	-0.13	0.12	0.06	FALSE
12	GTEx	Artery Coronary	CYP2D8P1	0.13	0.01	lasso	3	0.04	1.3e-02	-4.1	5.2	1.8e-07	-0.03	0.14	0.04	FALSE
13	GTEx	Artery Tibial	L3MBTL2	0.05	0.06	lasso	3	0.05	1.0e-04	-7.0	6.7	2.7e-11	-0.12	0.48	0.02	TRUE
14	GTEx	Artery Tibial	ACO2	0.06	0.02	enet	15	0.06	1.2e-05	10.0	5.9	4.5e-09	0.05	0.03	0.97	FALSE
15	GTEx	Artery Tibial	PMM1	0.04	0.04	lasso	4	0.02	1.8e-02	8.1	-7.5	4.2e-14	0.01	0.07	0.83	FALSE
16	GTEx	Artery Tibial	RP4-669P10.16	0.08	0.08	lasso	6	0.06	2.3e-05	-5.8	5.8	6.7e-09	-0.06	0.75	0.01	FALSE
17	GTEx	Brain Caudate basal ganglia	CSDC2	0.13	0.03	enet	9	0.08	2.0e-03	1.8	7.2	5.9e-13	-0.02	0.09	0.58	FALSE
18	GTEx	Brain Caudate basal ganglia	CYP2D8P1	0.14	0.00	lasso	6	-0.01	7.8e-01	-3.9	5.4	5.9e-08	0.00	0.07	0.10	FALSE
19	GTEx	Brain Cerebellar Hemisphere	POLR3H	0.10	0.08	lasso	7	0.08	4.9e-03	9.7	9.7	3.7e-22	-0.06	0.11	0.52	FALSE
20	GTEx	Brain Cerebellum	SMDT1	0.50	0.43	enet	21	0.47	9.8e-16	-4.2	5.6	2.3e-08	-0.07	1.00	0.00	FALSE
21	GTEx	Brain Cortex	POLR3H	0.27	0.21	lasso	8	0.18	8.5e-06	9.7	9.7	3.0e-22	-0.05	0.06	0.94	FALSE
22	GTEx	Brain Cortex	CSDC2	0.31	0.32	lasso	5	0.28	1.8e-08	7.5	8.9	6.7e-19	-0.04	0.47	0.53	FALSE
23	GTEx	Brain Cortex	SMDT1	0.15	0.07	enet	16	0.06	8.8e-03	-5.0	7.1	1.4e-12	-0.06	0.11	0.11	TRUE
24	GTEx	Brain Frontal Cortex BA9	POLR3H	0.13	0.09	lasso	7	0.04	3.4e-02	9.8	9.7	2.2e-22	-0.07	0.06	0.72	FALSE
25	GTEx	Brain Frontal Cortex BA9	CSDC2	0.25	0.23	lasso	8	0.24	3.8e-07	10.0	10.0	1.7e-23	-0.07	0.06	0.94	FALSE
26	GTEx	Brain Hippocampus	POLR3H	0.16	0.11	lasso	14	0.05	2.4e-02	9.8	9.9	3.8e-23	-0.06	0.06	0.74	FALSE
27	GTEx	Brain Nucleus accumbens basal ganglia	CSDC2	0.25	0.28	lasso	2	0.29	1.8e-08	9.7	9.2	6.0e-20	-0.06	0.18	0.82	FALSE
28	GTEx	Brain Putamen basal ganglia	POLR3H	0.23	0.06	enet	20	0.04	4.5e-02	9.7	7.5	6.1e-14	0.04	0.05	0.56	FALSE
29	GTEx	Brain Putamen basal ganglia	CSDC2	0.19	0.06	lasso	4	0.13	5.3e-04	8.0	8.5	1.8e-17	-0.01	0.11	0.49	FALSE
30	GTEx	Breast Mammary Tissue	DESI1	0.29	0.05	enet	18	0.11	3.1e-06	-3.1	5.2	2.4e-07	0.03	0.82	0.03	TRUE
31	GTEx	Breast Mammary Tissue	NDUFA6-AS1	0.13	0.06	lasso	5	0.05	9.6e-04	-5.8	6.0	1.9e-09	-0.05	0.69	0.01	FALSE
32	GTEx	Breast Mammary Tissue (Female)	CYP2D8P1	0.24	0.03	enet	11	0.06	5.6e-03	-4.1	5.6	1.7e-08	-0.05	0.18	0.06	FALSE
33	GTEx	Cells EBV-transformed lymphocytes	L3MBTL2	0.12	0.08	lasso	6	0.05	1.0e-02	-6.9	-8.3	1.3e-16	0.11	0.16	0.05	FALSE
34	GTEx	Cells EBV-transformed lymphocytes	PMM1	0.20	0.16	lasso	7	0.14	1.9e-05	9.9	-10.0	1.5e-23	0.05	0.14	0.84	FALSE
35	GTEx	Cells EBV-transformed lymphocytes	TEF	0.23	0.13	lasso	7	0.16	6.9e-06	9.9	10.0	1.5e-23	-0.05	0.34	0.64	FALSE
36	GTEx	Cells Transformed fibroblasts	SLC25A17	0.09	0.03	enet	10	0.06	4.2e-05	7.8	6.6	3.4e-11	-0.06	0.92	0.00	FALSE
37	GTEx	Cells Transformed fibroblasts	PMM1	0.12	0.07	enet	15	0.11	1.0e-08	8.2	-7.5	7.9e-14	0.02	0.57	0.42	FALSE
38	GTEx	Cells Transformed fibroblasts	CSDC2	0.09	0.02	enet	18	0.06	3.6e-05	10.0	8.2	2.7e-16	-0.05	0.02	0.96	FALSE
39	GTEx	Esophagus Gastroesophageal Junction	TOB2	0.16	0.01	enet	14	0.03	3.5e-02	-7.3	-8.8	1.2e-18	0.09	0.06	0.08	FALSE
40	GTEx	Esophagus Mucosa	RANGAP1	0.07	0.02	lasso	4	0.02	8.6e-03	7.6	-7.5	5.0e-14	-0.02	0.26	0.08	FALSE
41	GTEx	Esophagus Mucosa	PMM1	0.05	0.00	enet	14	0.01	7.1e-02	9.5	-7.3	2.5e-13	-0.01	0.10	0.73	FALSE
42	GTEx	Esophagus Mucosa	NDUFA6-AS1	0.06	0.01	lasso	7	0.00	3.0e-01	-6.0	5.6	1.8e-08	-0.05	0.21	0.03	FALSE
43	GTEx	Esophagus Muscularis	PMM1	0.07	0.05	lasso	5	0.05	6.8e-04	9.7	-9.4	5.2e-21	0.04	0.29	0.66	FALSE
44	GTEx	Muscle Skeletal	PMM1	0.04	0.03	lasso	3	0.02	1.8e-03	8.1	-8.3	1.0e-16	0.03	0.35	0.56	FALSE
45	GTEx	Nerve Tibial	ACO2	0.06	0.05	lasso	5	0.04	8.5e-04	9.9	7.8	7.7e-15	-0.01	0.02	0.98	FALSE
46	GTEx	Ovary	ACO2	0.14	0.12	lasso	3	0.13	4.5e-04	9.7	10.6	5.0e-26	-0.06	0.05	0.84	FALSE
47	GTEx	Pancreas	POLR3H	0.14	0.00	enet	13	0.03	1.7e-02	-3.3	-6.0	1.9e-09	0.01	0.09	0.47	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	NDUFA6-AS1	0.11	0.02	lasso	5	0.02	1.7e-02	-6.0	5.5	3.0e-08	-0.12	0.18	0.04	TRUE
49	GTEx	Skin Sun Exposed Lower leg	SLC25A17	0.06	0.04	lasso	3	0.02	5.0e-03	7.2	6.3	3.2e-10	-0.21	0.30	0.11	FALSE
50	GTEx	Skin Sun Exposed Lower leg	PMM1	0.04	0.00	lasso	4	0.02	1.4e-02	1.5	-5.7	1.2e-08	0.02	0.11	0.46	FALSE
51	GTEx	Skin Sun Exposed Lower leg	XPNPEP3	0.06	0.00	enet	16	0.00	1.5e-01	3.2	5.5	3.7e-08	-0.24	0.12	0.04	FALSE
52	GTEx	Spleen	SLC25A17	0.25	0.04	lasso	4	0.12	4.3e-04	7.3	6.7	2.1e-11	-0.15	0.17	0.09	TRUE
53	GTEx	Stomach	DESI1	0.12	0.07	enet	14	0.06	4.9e-04	9.8	8.8	1.2e-18	-0.01	0.10	0.88	FALSE
54	GTEx	Testis	CCDC134	0.20	0.29	lasso	20	0.26	4.9e-12	8.1	-8.2	1.7e-16	0.03	0.56	0.44	FALSE
55	GTEx	Testis	CYP2D6	0.17	0.12	lasso	5	0.09	6.0e-05	-4.0	5.2	1.8e-07	-0.05	0.82	0.01	FALSE
56	GTEx	Testis	POLR3H	0.32	0.51	enet	9	0.51	5.6e-26	9.7	9.6	7.1e-22	-0.04	0.45	0.55	FALSE
57	GTEx	Testis	PMM1	0.09	0.10	lasso	4	0.11	1.0e-05	4.6	-6.4	1.4e-10	0.03	0.31	0.57	FALSE
58	GTEx	Testis	TEF	0.06	0.05	lasso	5	0.04	5.5e-03	9.4	9.6	7.1e-22	0.01	0.30	0.30	FALSE
59	GTEx	Testis	RP5-821D11.7	0.15	0.16	lasso	8	0.12	9.0e-06	8.1	-7.6	4.1e-14	0.01	0.27	0.72	FALSE
60	GTEx	Thyroid	ZC3H7B	0.11	0.07	enet	7	0.07	3.9e-06	-7.3	-6.7	1.7e-11	0.15	0.43	0.04	FALSE
61	GTEx	Thyroid	ACO2	0.08	0.09	lasso	6	0.10	9.6e-08	9.7	9.9	3.6e-23	-0.05	0.02	0.98	FALSE
62	GTEx	Thyroid	RP1-257I20.14	0.09	0.03	enet	18	0.06	3.3e-05	-5.8	5.9	3.4e-09	-0.06	0.34	0.03	FALSE
63	GTEx	Uterus	ACO2	0.13	0.06	enet	31	0.08	9.5e-03	10.0	9.3	2.1e-20	-0.04	0.08	0.69	FALSE
64	GTEx	Uterus	RRP7A	0.44	0.07	enet	16	0.19	1.0e-04	-3.8	-5.2	1.9e-07	-0.01	0.05	0.08	FALSE
65	GTEx	Vagina	PMM1	0.25	0.13	lasso	4	0.14	5.3e-04	10.3	-9.5	3.1e-21	0.03	0.04	0.78	FALSE
66	GTEx	Whole Blood	PMM1	0.04	0.01	enet	26	0.01	4.5e-02	10.0	-6.3	2.8e-10	0.02	0.06	0.60	TRUE
67	NTR	Blood	EP300	0.04	0.00	bslmm	275	0.02	2.9e-06	-6.9	5.7	1.2e-08	-0.02	0.49	0.01	FALSE
68	NTR	Blood	TEF	0.01	0.02	lasso	2	0.02	3.8e-06	9.7	9.5	2.4e-21	-0.01	0.39	0.60	FALSE
69	YFS	Blood	EP300	0.05	0.04	blup	284	0.05	5.2e-15	-7.1	12.2	4.8e-34	-0.30	1.00	0.00	TRUE
70	YFS	Blood	MEI1	0.09	0.18	lasso	21	0.19	2.7e-59	8.1	9.4	4.1e-21	-0.04	0.21	0.79	FALSE
71	YFS	Blood	NHP2L1	0.02	0.00	bslmm	300	0.01	1.6e-05	7.3	9.1	6.0e-20	-0.07	0.27	0.66	FALSE
72	YFS	Blood	TEF	0.09	0.17	lasso	2	0.17	9.0e-53	9.6	9.6	5.7e-22	0.00	0.60	0.40	FALSE
73	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PMM1	0.04	0.03	lasso	6	0.02	6.1e-03	9.7	-9.7	3.7e-22	0.06	0.01	0.79	FALSE
74	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	XPNPEP3	0.07	0.05	enet	6	0.07	1.2e-06	7.4	5.2	1.5e-07	-0.01	0.91	0.00	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	MEI1	0.01	0.01	blup	62	0.01	1.1e-02	8.1	7.8	6.6e-15	-0.07	0.02	0.94	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	PMM1	0.16	0.03	blup	20	0.05	7.2e-10	7.9	-6.3	3.2e-10	0.00	0.05	0.95	FALSE
77	The Cancer Genome Atlas	Colon Adenocarcinoma	MEI1	0.05	0.00	blup	64	0.03	1.1e-02	8.1	6.9	3.9e-12	-0.05	0.02	0.55	FALSE
78	The Cancer Genome Atlas	Colon Adenocarcinoma	PMM1	0.20	0.06	lasso	1	0.05	6.6e-04	8.0	-8.1	8.6e-16	0.04	0.03	0.20	FALSE
79	The Cancer Genome Atlas	Colon Adenocarcinoma	TEF	0.04	0.03	blup	36	0.03	9.5e-03	10.0	9.8	7.0e-23	-0.02	0.03	0.71	FALSE
80	The Cancer Genome Atlas	Glioblastoma Multiforme	MEI1	0.26	0.22	lasso	4	0.21	5.3e-07	8.1	7.5	6.6e-14	0.00	0.02	0.98	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MEI1	0.03	0.01	blup	64	0.02	3.8e-03	8.1	7.6	2.3e-14	-0.01	0.02	0.86	FALSE
82	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PMM1	0.02	0.02	blup	18	0.02	3.9e-03	7.5	-8.9	4.0e-19	0.05	0.02	0.71	FALSE
83	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLR3H	0.04	0.04	blup	22	0.04	6.8e-05	9.8	-8.9	8.1e-19	0.06	0.01	0.99	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MEI1	0.04	0.05	blup	61	0.05	5.5e-06	8.0	8.0	1.4e-15	-0.03	0.03	0.97	FALSE
85	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ACO2	0.03	0.01	blup	41	0.04	3.9e-03	-4.4	9.2	5.3e-20	-0.02	0.02	0.56	FALSE
86	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MEI1	0.06	0.04	blup	64	0.04	3.5e-03	8.1	7.8	5.2e-15	-0.06	0.02	0.92	FALSE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	MEI1	0.08	0.08	blup	60	0.08	6.9e-10	8.1	7.9	3.3e-15	-0.13	0.02	0.98	FALSE
88	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MEI1	0.06	0.05	blup	62	0.08	2.0e-04	7.4	6.7	2.0e-11	0.05	0.04	0.84	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	MEI1	0.03	0.04	enet	8	0.03	1.0e-04	8.1	7.9	3.7e-15	-0.03	0.03	0.96	FALSE
90	The Cancer Genome Atlas	Lung Adenocarcinoma	PMM1	0.02	0.03	lasso	5	0.02	1.1e-03	9.7	-9.7	3.4e-22	0.06	0.01	0.91	FALSE
91	The Cancer Genome Atlas	Lung Adenocarcinoma	POLR3H	0.03	0.01	blup	26	0.01	6.4e-02	10.0	-9.3	1.3e-20	0.04	0.01	0.93	FALSE
92	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PHF5A	0.03	0.00	blup	30	0.01	2.9e-02	9.9	9.0	1.9e-19	-0.02	0.01	0.56	FALSE
93	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PMM1	0.02	0.01	blup	19	0.02	4.0e-03	8.1	-8.5	1.9e-17	0.03	0.02	0.71	FALSE
94	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TOB2	0.03	0.00	blup	28	0.02	3.4e-03	10.1	9.5	2.5e-21	-0.03	0.01	0.59	FALSE
95	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PMM1	0.05	0.06	blup	18	0.06	4.1e-05	7.9	-9.0	2.1e-19	0.05	0.02	0.98	FALSE
96	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	XPNPEP3	0.12	0.02	blup	39	0.04	1.0e-03	-2.2	-6.7	2.1e-11	0.76	0.01	0.38	TRUE
97	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PMM1	0.08	0.08	blup	23	0.09	1.1e-04	8.0	-8.7	4.1e-18	0.04	0.04	0.91	FALSE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	CENPM	0.04	0.01	lasso	2	0.02	2.7e-03	-5.5	-5.2	2.6e-07	0.17	0.02	0.43	TRUE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	MEI1	0.02	0.02	blup	69	0.01	1.5e-02	8.1	8.4	6.5e-17	-0.04	0.02	0.85	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	NHP2L1	0.04	0.01	blup	28	0.02	2.3e-03	7.4	-7.3	2.1e-13	-0.02	0.01	0.87	FALSE
101	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLR3H	0.04	0.05	blup	27	0.05	3.4e-06	9.8	-9.9	3.7e-23	0.07	0.01	0.99	FALSE
102	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TEF	0.30	0.06	blup	36	0.09	1.8e-03	9.4	9.3	9.8e-21	0.01	0.02	0.57	FALSE
103	The Cancer Genome Atlas	Stomach Adenocarcinoma	C22orf46	0.02	0.03	blup	25	0.03	5.5e-03	8.1	-8.2	1.8e-16	0.05	0.01	0.82	FALSE
104	The Cancer Genome Atlas	Stomach Adenocarcinoma	MEI1	0.04	0.04	enet	4	0.03	2.5e-03	8.1	8.2	3.4e-16	-0.03	0.03	0.92	FALSE
105	The Cancer Genome Atlas	Stomach Adenocarcinoma	POLR3H	0.04	0.06	lasso	1	0.04	4.8e-04	7.9	-7.9	3.4e-15	0.03	0.02	0.90	FALSE
106	The Cancer Genome Atlas	Stomach Adenocarcinoma	RANGAP1	0.19	0.04	enet	10	0.05	2.8e-04	8.0	6.7	1.8e-11	-0.12	0.05	0.06	FALSE
107	The Cancer Genome Atlas	Testicular Germ Cell Tumors	POLR3H	0.10	0.02	blup	23	0.06	3.4e-03	10.0	-8.9	4.7e-19	0.02	0.01	0.82	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	L3MBTL2	0.05	0.03	enet	9	0.04	1.8e-04	8.0	7.6	2.4e-14	-0.01	0.01	0.98	TRUE
109	The Cancer Genome Atlas	Thyroid Carcinoma	MEI1	0.02	0.03	enet	2	0.02	2.3e-03	8.1	8.1	3.9e-16	-0.04	0.02	0.85	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	PMM1	0.09	0.11	blup	22	0.10	4.6e-10	8.1	-8.8	2.2e-18	0.03	0.09	0.91	FALSE
111	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PMM1	0.08	0.07	blup	24	0.05	1.8e-02	7.5	-8.4	3.8e-17	0.03	0.02	0.44	FALSE