TWAS
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About
Usage
Models
Genes
Traits
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Traits
:
Lung FEV1/FVC ratio
:
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→
chr10:3,123,433-4,526,111
Best TWAS P=6.19e-09 · Best GWAS P=2.33e-10 conditioned to 0.00178
3.2M
3.4M
3.6M
3.8M
4M
4.2M
4.4M
4.6M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Gastroesophageal Junction
KLF6
0.4
0
lasso
9
0
0.27
6.2
5.8
6.2e-09
0.71
0.02
0.74
TRUE