Hub : Traits :

Lung FEV1/FVC ratio

5061 significantly associated models · 1137 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	1781220	4040155	3	2	1.1e-11	7.8e-34	1.9e-24	29	ARHGEF16 RP3-395M20.9
2	1	5611729	7460433	7	1	1.1e-22	4.9e-22	1.0e+00	100	THAP3
3	1	8467353	11222393	4	2	5.7e-09	1.1e-16	5.1e-16	4	GPR157 PGD
4	1	15752716	18461490	25	9	3.9e-75	3.9e-75	1.0e+00	100	ATP13A2 CROCC EPHA2 MFAP2 MST1L PADI2 RP11-108M9.4 RP11-108M9.5
5	1	18940380	20503710	2	1	2.9e-11	1.8e-17	1.1e-07	61	CAPZB
6	1	21902950	22511922	1	1	9.0e-09	5.6e-10	7.2e-08	25	HSPG2
7	1	31402148	32762733	1	1	1.9e-10	1.5e-10	1.0e+00	100	PEF1
8	1	36079508	41065744	21	5	3.9e-22	5.7e-19	9.1e-03	91	DNALI1 PABPC4 SH3D21 TRIT1 YRDC
9	1	44779991	48392033	19	3	6.4e-18	2.9e-18	1.7e-02	92	ATPAF1 MUTYH RP1-18D14.7
10	1	71163715	73435171	1	1	3.6e-09	3.4e-08	7.4e-03	76	NEGR1
11	1	77464831	79300939	5	1	8.5e-22	2.3e-15	2.3e-01	98	GIPC2
12	1	91800946	94294492	6	8	2.9e-25	5.3e-75	NaN	NaN	BTBD8 EPHX4 EVI5 FAM69A
13	1	109098737	110517617	2	1	9.5e-09	1.4e-07	1.5e-01	92	CELSR2
14	1	110716511	113310418	9	5	2.1e-28	3.0e-30	NaN	NaN	CEPT1 DENND2D WNT2B
15	1	149672809	150847647	4	2	3.7e-11	4.2e-11	1.0e+00	100	C1orf54 MTMR11
16	1	154956662	155445842	1	1	3.6e-16	5.0e-20	1.4e-05	78	GBA
17	1	160851894	162347618	2	1	8.2e-09	2.4e-06	3.3e-05	23	FCGR2B
18	1	180672792	181235009	1	1	3.9e-08	3.5e-08	1.0e+00	100	STX6
19	1	195927451	197414097	1	1	9.1e-08	3.2e-07	1.8e-01	93	CFH
20	1	200740278	202607593	3	2	1.5e-10	1.5e-13	1.3e-07	49	LMOD1 RP11-134G8.8
21	1	203890813	207334619	13	5	2.7e-17	7.3e-18	2.4e-07	64	CNTN2 LRRN2 NUCKS1 SRGAP2
22	1	217760821	219208920	2	2	1.2e-22	1.2e-29	5.9e-18	42	RRP15 TGFB2
23	1	222096959	223537385	2	1	5.0e-09	8.0e-08	4.3e-05	42	RP11-378J18.8
24	2	8649517	10229911	1	1	8.5e-20	4.2e-30	3.7e-12	63	ASAP2
25	2	14610061	16399845	1	1	2.9e-07	4.2e-28	2.0e-24	14	NBAS
26	2	17368202	19236850	1	1	2.1e-25	9.1e-47	9.1e-26	47	KCNS3
27	2	24021231	25889403	5	1	9.7e-14	1.8e-12	6.2e-01	100	ADCY3
28	2	28235763	29792216	4	1	1.6e-08	3.7e-08	2.3e-01	95	TRMT61B
29	2	32964253	34480075	1	1	2.3e-07	3.2e-13	3.0e-11	17	RASGRP3
30	2	35883253	37472804	2	1	9.1e-23	5.6e-28	9.1e-07	80	CRIM1
31	2	41701800	44521246	10	11	1.4e-23	3.1e-28	NaN	NaN	AC010883.5 COX7A2L EML4 FTOP1 HAAO KCNG3 MTA3 OXER1
32	2	55401562	56843605	1	1	4.0e-16	3.6e-25	1.3e-10	62	EFEMP1
33	2	60546132	62460013	7	1	9.9e-16	1.7e-12	1.1e-01	95	AHSA2
34	2	64168232	65670908	1	2	5.6e-13	4.2e-16	6.0e-01	100	SERTAD2
35	2	73005579	74383630	1	1	2.1e-07	7.3e-07	5.2e-01	98	ALMS1-IT1
36	2	85678425	87126250	4	1	4.0e-09	9.3e-09	1.0e+00	100	IMMT
37	2	98714445	101629737	12	2	2.5e-13	3.2e-12	1.0e+00	100	C2orf15 LONRF2
38	2	102274098	103686111	2	1	1.0e-19	4.9e-21	9.1e-05	83	IL1RL1
39	2	119497419	121675485	5	2	1.7e-09	2.1e-08	2.1e-01	95	TMEM185B TMEM37
40	2	151570279	153056846	1	1	1.1e-09	7.7e-10	2.1e-01	96	RIF1
41	2	159775621	161318004	2	1	9.7e-10	3.3e-08	3.3e-01	97	MARCH7
42	3	3574205	5232074	2	2	4.6e-09	5.2e-15	6.4e-07	60	ITPR1-AS1 SUMF1
43	3	10904692	12457119	1	1	9.8e-10	4.8e-19	3.9e-14	28	VGLL4
44	3	13527134	14942024	1	1	2.6e-07	9.5e-18	6.5e-13	30	LSM3
45	3	24520283	26396178	2	2	2.7e-26	6.4e-67	3.9e-48	29	RARB TOP2B
46	3	40594264	42967174	2	1	1.8e-12	5.7e-11	1.0e+00	100	ULK4
47	3	44079200	45500950	1	1	3.1e-08	4.7e-08	1.2e-01	92	KIAA1143
48	3	48702606	50580658	9	2	8.8e-10	1.3e-09	1.0e+00	100	GMPPB NAT6
49	3	51860817	54093832	4	2	6.0e-10	7.6e-16	8.4e-08	56	CACNA1D GNL3
50	3	54802351	56217454	1	1	2.9e-12	1.7e-33	4.0e-36	-8	WNT5A
51	3	56341514	58613378	10	2	2.1e-25	5.8e-26	1.0e+00	100	CCDC66 SLMAP
52	3	72238172	74372906	2	2	2.4e-16	1.6e-15	6.2e-13	18	GXYLT2 PDZRN3
53	3	126695780	129224131	7	3	2.6e-53	1.7e-45	1.5e-06	88	ABTB1 EEFSEC TPRA1
54	3	141992282	143476411	2	1	1.7e-07	1.7e-07	3.0e-01	96	U2SURP
55	3	153142317	154733231	3	1	1.5e-13	2.0e-12	1.2e-01	95	ARHGEF26
56	3	155070465	157226796	5	2	4.5e-14	2.1e-13	2.4e-01	98	RP11-305K5.1 SSR3
57	3	182655858	184099956	1	1	1.3e-09	6.9e-10	5.1e-02	90	KLHL24
58	3	185112300	185786406	1	1	4.8e-09	1.0e-11	1.6e-04	69	IGF2BP2
59	3	194754763	196158773	1	1	2.8e-07	3.3e-06	1.9e-05	16	MUC20
60	4	703813	1215100	1	1	2.9e-09	5.6e-06	1.9e-01	92	DGKQ
61	4	7060959	8621167	3	3	2.3e-12	3.2e-15	2.0e-04	78	AFAP1 AFAP1-AS1 LOC84740
62	4	9370814	10812968	3	1	3.9e-08	7.3e-09	4.1e-02	88	SLC2A9
63	4	53038557	54427925	1	1	6.3e-10	3.0e-10	1.1e-03	73	RASL11B
64	4	55582068	56988744	1	1	1.2e-08	9.6e-07	2.2e-05	25	TMEM165
65	4	76342004	77927345	2	1	1.2e-08	1.1e-07	6.6e-03	74	NUP54
66	4	78734563	79701528	1	1	2.1e-11	4.1e-16	4.8e-08	55	FRAS1
67	4	88924176	90916437	4	7	2.4e-36	5.1e-96	1.0e-16	84	FAM13A GPRIN3 NAP1L5 TIGD2
68	4	105598022	107931444	6	17	1.0e-42	5.5e-55	NaN	NaN	ARHGEF38 INTS12 NPNT PPA2 TBCK
69	4	112366943	113899790	3	1	5.5e-09	3.9e-08	6.7e-02	89	AP1AR
70	4	139253139	141220335	6	1	1.0e-15	2.3e-15	1.0e+00	100	RAB33B
71	4	144104906	146788825	6	6	1.1e-99	3.9e-255	NaN	NaN	HHIP-AS1 OTUD4 RP11-673E1.1
72	4	152543783	155397517	7	2	3.1e-13	5.9e-16	1.5e-05	71	ARFIP1 SFRP2
73	5	12225	1390349	6	1	2.3e-19	2.2e-21	1.0e+00	100	AC026740.1
74	5	12998006	14640921	1	1	1.7e-10	4.0e-11	4.4e-02	91	DNAH5
75	5	33958959	35523639	1	1	5.0e-11	1.3e-10	2.8e-01	97	RAI14
76	5	35608310	36124514	1	1	2.4e-07	6.8e-08	9.4e-02	90	IL7R
77	5	42831514	44249820	1	1	4.7e-08	4.1e-11	2.9e-05	60	PAIP1
78	5	49462228	50432178	1	1	5.6e-09	1.2e-08	1.0e+00	100	EMB
79	5	51425511	53094674	4	10	8.5e-16	6.3e-58	NaN	NaN	CTD-2366F13.2 ITGA1 ITGA2 MOCS2
80	5	53116123	54538913	1	1	2.4e-07	1.5e-08	7.2e-03	78	SNX18
81	5	71557313	73083183	1	1	4.8e-08	3.7e-06	3.6e-04	40	FCHO2
82	5	75812681	78353059	4	2	9.5e-10	2.4e-12	3.8e-04	74	LHFPL2 PDE8B
83	5	80873851	82264985	1	1	2.1e-07	5.6e-07	1.4e-06	7	RPS23
84	5	93348659	95856679	5	1	2.7e-42	4.6e-49	6.3e-12	78	SPATA9
85	5	97434545	99024399	4	1	1.1e-16	6.8e-15	9.8e-01	100	CTD-2007H13.3
86	5	111667502	113515807	1	1	5.9e-08	7.4e-08	2.7e-02	83	MCC
87	5	120708748	122110593	2	3	1.9e-32	7.3e-29	9.2e-03	95	LOX SNCAIP
88	5	125506061	128116643	5	2	1.9e-15	3.9e-15	1.0e+00	100	C5orf63 CTC-228N24.3
89	5	130451873	133140038	16	10	6.2e-30	1.0e-37	NaN	NaN	AC004041.2 HSPA4 PDLIM4 SLC22A5 UQCRQ
90	5	147012186	149420698	6	10	8.6e-98	1.7e-147	2.3e-05	97	AFAP1L1 FBXO38 SH3TC2 SPINK5 SPINK9
91	5	149787068	151886485	4	3	4.5e-22	4.5e-23	6.8e-03	92	CCDC69 G3BP1 GM2A
92	5	155758384	157862392	8	10	8.2e-116	9.1e-97	1.0e+00	100	ADAM19 HAVCR1 NIPAL4
93	6	202452	1392108	1	1	1.8e-09	5.0e-09	1.4e-03	70	EXOC2
94	6	6701209	8352004	3	3	1.5e-27	1.7e-49	6.8e-50	-1	DSP EEF1E1 RIOK1
95	6	17060849	18686970	1	2	5.0e-10	3.2e-11	3.3e-01	98	KIF13A
96	6	20966438	22913739	1	1	1.5e-08	1.1e-55	1.9e-49	12	CASC15
97	6	33856903	36158878	8	11	4.0e-22	1.0e-18	NaN	NaN	C6orf106 DEF6 RPL10A TCP11 ZNF76
98	6	55625041	58206146	5	2	5.2e-09	1.8e-15	1.0e-08	48	KIAA1586 PRIM2
99	6	73090786	74157617	1	1	2.6e-07	1.3e-44	2.0e-39	12	KCNQ5
100	6	89941356	91704536	1	1	2.4e-10	5.4e-16	4.5e-07	61	BACH2
101	6	108183628	110710018	7	6	2.1e-16	2.8e-82	6.9e-56	33	ARMC2 FOXO3 RP11-425D10.10 SMPD2
102	6	115569351	120041948	6	4	1.1e-10	8.2e-16	2.5e-08	52	DCBLD1 FRK RP11-351A11.1 ZUFSP
103	6	121058929	122457698	1	1	3.3e-10	2.2e-15	6.4e-08	54	GJA1
104	6	125970401	127355237	1	1	1.2e-11	5.1e-12	1.0e+00	100	CENPW
105	7	2032803	3581391	2	1	1.0e-17	2.8e-16	1.6e-02	91	GNA12
106	7	6502367	7988091	1	1	1.5e-17	2.6e-15	9.7e-03	89	C1GALT1
107	7	13938159	15187921	1	1	1.8e-13	4.5e-13	2.7e-07	50	DGKB
108	7	19674247	21151172	2	1	9.9e-10	2.6e-12	6.0e-04	76	CTA-293F17.1
109	7	73425238	74494207	2	1	2.5e-08	3.3e-13	3.8e-12	9	GTF2IRD2
110	7	89179487	90714682	4	1	2.1e-10	6.4e-10	5.5e-01	99	DPY19L2P4
111	7	98356158	100865847	26	5	2.1e-28	2.0e-25	NaN	NaN	AP4M1 CNPY4 OR2AE1 TRIM4
112	7	115619298	117135212	1	1	5.5e-12	1.7e-12	1.0e+00	100	MET
113	7	120294932	121729795	1	1	2.2e-08	1.8e-10	2.1e-05	55	FAM3C
114	7	129342404	130839735	2	1	2.6e-08	1.7e-08	3.4e-02	86	CEP41
115	7	134081554	135590031	2	1	4.1e-08	8.7e-18	2.0e-12	33	WDR91
116	7	139088401	140572110	1	1	5.7e-13	4.7e-09	1.7e-01	95	JHDM1D
117	7	150529449	151024986	1	1	4.2e-08	6.2e-08	3.8e-01	97	TMUB1
118	8	8295058	9692925	1	1	3.5e-11	1.2e-14	5.7e-06	65	PPP1R3B
119	8	16188310	18638660	8	10	1.9e-22	3.2e-22	NaN	NaN	ASAH1 MICU3 PCM1 RP11-806O11.1
120	8	21758119	23240950	5	1	3.8e-09	5.0e-09	1.0e+00	100	BIN3
121	8	29223230	30694153	3	1	5.3e-08	5.9e-08	3.5e-01	97	MBOAT4
122	8	38025175	38574366	1	1	2.1e-08	1.7e-11	1.9e-04	69	FGFR1
123	8	70854206	72277458	1	1	2.9e-08	1.6e-08	1.0e+00	100	LACTB2
124	8	73280829	74727081	2	1	3.9e-10	5.3e-09	7.6e-01	100	SBSPON
125	8	100277018	101937374	2	1	1.3e-07	5.5e-07	3.0e-01	96	SPAG1
126	8	102002608	103832256	2	1	8.8e-11	4.8e-16	1.6e-12	24	KB-1107E3.1
127	8	108515373	110190556	3	1	3.0e-16	1.6e-15	1.7e-03	84	EIF3E
128	8	120254953	121763223	3	1	3.9e-11	1.1e-10	1.8e-04	66	DEPDC6
129	8	125745994	127150370	1	1	1.3e-07	3.6e-08	7.8e-08	5	TRIB1
130	8	130160834	131728731	1	1	5.3e-08	5.7e-09	3.0e-04	61	FAM49B
131	8	140969818	142706843	2	2	9.0e-08	1.1e-07	4.6e-02	86	DENND3 PTK2
132	9	14857740	16758776	1	1	1.5e-11	2.8e-12	4.8e-02	92	CCDC171
133	9	33130640	35043291	2	2	4.9e-08	5.4e-08	1.9e-02	81	NUDT2 UBE2R2
134	9	35641859	37183628	1	1	2.2e-07	1.8e-07	1.0e+00	100	RNF38
135	9	37222681	38765310	1	1	2.1e-09	3.1e-11	3.4e-04	71	SHB
136	9	88200133	89668506	3	1	1.4e-18	2.4e-17	1.0e+00	100	ISCA1
137	9	95502571	96898436	1	1	2.5e-07	1.9e-10	1.4e-04	64	RP11-165J3.6
138	9	97520168	98975128	2	5	1.7e-37	8.5e-46	1.0e+00	100	PTCH1 RP11-435O5.5
139	9	99707397	102521881	5	6	4.6e-18	2.9e-14	5.3e-01	99	C9orf156 COL15A1 NCBP1 TSTD2 XPA
140	9	131169528	132569553	1	1	1.2e-07	9.7e-07	2.8e-01	95	CRAT
141	10	3123433	4526111	1	1	6.2e-09	2.3e-10	1.8e-03	76	KLF6
142	10	5432213	5953148	1	1	1.7e-15	1.5e-15	1.3e-02	90	ASB13
143	10	11477584	13569805	4	6	1.6e-74	5.1e-97	NaN	NaN	CAMK1D CDC123 NUDT5 SEC61A2
144	10	21123825	22724472	1	1	1.3e-10	5.7e-15	1.0e-13	9	MLLT10
145	10	30411253	32016090	1	2	1.5e-13	4.1e-14	3.3e-01	98	ZNF438
146	10	32035353	33875979	2	1	7.8e-09	4.4e-11	5.4e-04	72	CCDC7
147	10	51801913	53080509	1	1	1.2e-07	3.1e-08	1.4e-02	80	SGMS1
148	10	63856856	66034105	6	1	9.4e-20	6.5e-16	1.1e-04	77	NRBF2
149	10	74173864	79018276	18	15	2.7e-16	3.2e-21	0.0e+00	-2270	ADK C10orf11 CAMK2G FAM149B1 NUDT13 SEC24C TTC18 VCL
150	10	80723467	82984432	17	8	5.6e-24	2.4e-22	NaN	NaN	BEND3P3 FAM213A MBL1P PLAC9 RP11-119F19.2 SFTPD TSPAN14
151	10	95606207	97070115	2	1	1.4e-08	8.3e-09	3.1e-02	86	HELLS
152	10	103527782	104956035	2	2	2.4e-08	1.5e-11	3.0e-04	71	ACTR1A TMEM180
153	10	110937872	112588355	2	1	7.3e-10	2.7e-10	1.0e+00	100	ADD3
154	10	120269685	121907055	1	1	3.7e-08	2.6e-08	6.8e-08	6	GRK5
155	10	123257402	124889817	3	3	8.8e-10	1.8e-14	7.7e-04	81	ATE1 PLEKHA1
156	11	198510	1479601	4	2	1.4e-10	2.0e-08	8.5e-01	100	IFITM3 TSPAN4
157	11	3177939	4855124	2	1	2.3e-10	2.4e-10	1.0e+00	100	STIM1
158	11	8233876	11227175	10	6	1.4e-12	3.5e-15	3.0e-08	50	ADM AMPD3 DENND5A SBF2 TMEM41B TMEM9B
159	11	29646947	31048683	2	1	1.1e-09	6.9e-10	1.0e+00	100	C11orf46
160	11	34189564	35732073	2	11	1.9e-15	5.8e-13	NaN	NaN	APIP PDHX
161	11	56666189	58284951	7	1	6.9e-14	9.0e-12	6.5e-01	100	SERPING1
162	11	61697904	63110149	3	1	9.4e-10	4.2e-09	7.1e-03	79	EML3
163	11	65060427	65571855	1	1	3.2e-10	2.7e-12	3.9e-04	74	LTBP3
164	11	69606128	70966113	2	1	3.0e-10	5.4e-11	9.3e-14	-29	CTTN
165	11	71339667	74335121	17	14	7.5e-33	4.5e-29	1.0e+00	100	ARAP1-AS1 ARHGEF17 ATG16L2 CLPB FAM168A PDE2A PLEKHB1 RELT RP11-707G14.1 RP11-800A3.7 STARD10
166	11	77027574	78979645	7	1	4.0e-16	3.6e-16	1.3e-01	96	GAB2
167	11	99859184	101559718	2	2	1.6e-14	1.4e-13	3.4e-02	92	ARHGAP42
168	11	110202535	110833266	1	1	1.1e-08	1.5e-12	3.8e-07	48	ARHGAP20
169	11	116384511	117800682	1	1	8.8e-08	2.0e-06	2.9e-01	95	PCSK7
170	11	120623637	122199441	1	1	6.9e-10	9.9e-14	2.4e-07	52	SORL1
171	11	124617939	127007433	6	3	1.4e-09	3.1e-17	2.5e-09	50	CDON RP11-680F20.12 ST3GAL4
172	11	130542882	132906064	1	1	1.9e-11	2.7e-27	1.8e-17	38	NTM
173	12	403545	2299048	1	2	2.0e-17	2.7e-16	9.2e-03	90	ERC1
174	12	14575459	16190627	1	1	3.3e-16	2.8e-19	7.8e-05	81	RERG
175	12	27172878	28607631	3	1	2.5e-12	3.6e-11	5.0e-02	91	LOC100133893
176	12	51650192	53088525	1	1	1.7e-08	9.0e-20	6.0e-13	37	ACVR1B
177	12	53136542	55276396	10	3	1.6e-19	3.3e-21	7.1e-01	100	HOXC8 LOC400043 PCBP2
178	12	55601472	58303535	10	2	3.0e-30	8.9e-30	1.0e+00	100	LRP1 SUOX
179	12	69791807	70342778	1	1	1.3e-10	6.3e-08	2.3e-06	24	BEST3
180	12	89286081	90799212	1	1	8.6e-09	3.9e-09	8.9e-03	80	ATP2B1
181	12	94772262	97056904	7	7	1.4e-28	1.0e-60	NaN	NaN	AMDHD1 CCDC38 FGD6 LTA4H NTN4 SNRPF
182	12	101441467	103101412	2	2	1.2e-08	5.3e-06	6.6e-01	99	DRAM1 GNPTAB
183	12	123387922	125118479	5	1	2.5e-10	7.3e-10	2.7e-01	97	TCTN2
184	13	28011686	29410882	1	1	2.8e-07	2.3e-08	8.5e-07	22	PAN3-AS1
185	13	39533590	41928314	2	2	7.7e-09	5.1e-11	4.9e-05	62	COG6 FOXO1
186	13	47958937	49351645	1	2	4.0e-08	6.8e-07	5.8e-01	99	MED4-AS1
187	13	49583846	51061044	1	1	4.8e-13	1.6e-15	2.6e-04	79	KPNA3
188	14	22600863	24464590	8	5	1.7e-15	7.7e-15	1.0e+00	100	HAUS4 MRPL52 PPP1R3E RBM23 RP11-298I3.1
189	14	51775331	53232305	2	1	4.6e-09	4.9e-11	7.9e-04	74	NID2
190	14	53731553	55118795	1	1	1.4e-36	1.9e-30	7.5e-04	91	BMP4
191	14	73488591	77414761	10	5	1.1e-12	4.7e-16	2.0e-05	72	C14orf179 ELMSAN1 GPATCH2L LIN52 RPS6KL1
192	14	99421061	100845457	2	1	2.6e-11	8.0e-11	1.0e+00	100	HHIPL1
193	15	39530508	43299687	24	12	1.5e-36	6.8e-33	NaN	NaN	BMF EIF2AK4 MAPKBP1 MGA PLA2G4B RPAP1 SPTBN5
194	15	48584083	51750846	11	9	1.4e-19	1.4e-34	NaN	NaN	DTWD1 FAM227B RP11-295H24.3 SECISBP2L SPPL2A
195	15	62636766	66097711	12	6	2.6e-15	3.0e-28	7.2e-09	72	HERC1 PIF1 RASL12 TPM1 USP3
196	15	66662107	68492262	2	2	1.8e-11	2.3e-14	8.2e-05	73	IQCH SMAD3
197	15	70426659	73087366	5	5	1.1e-229	9.2e-206	6.4e-56	74	CTD-2524L6.3 LARP6 THSD4
198	15	73524629	74915888	1	1	1.0e-10	3.3e-12	3.5e-10	19	LOXL1-AS1
199	15	75253414	79537269	18	11	3.7e-35	4.7e-32	NaN	NaN	CHRNA5 PEAK1 PSTPIP1 RP11-797A18.4 SCAPER SNX33 TSPAN3 UBE2Q2
200	15	83167559	86489699	18	9	2.6e-29	1.5e-47	NaN	NaN	AC103965.1 GOLGA6L4 RP11-182J1.14 RP11-182J1.16 RP11-382A20.2 UBE2Q2P1 ZSCAN2
201	15	98944630	100972747	5	2	1.8e-22	1.2e-20	2.8e-02	94	LYSMD4 SYNM
202	16	3608256	5251131	2	2	1.3e-14	3.3e-14	1.0e+00	100	HMOX2 RP11-95P2.1
203	16	29214126	31695263	14	2	4.8e-13	2.2e-11	7.9e-01	100	C16orf93 TBX6
204	16	57311211	59241430	8	3	8.1e-56	7.0e-58	1.5e-08	88	MMP15 TEPP
205	16	65813302	69084178	39	3	1.0e-29	1.2e-27	6.7e-01	100	ATP6V0D1 CTCF DYNC1LI2
206	16	72122463	73789190	1	1	1.2e-07	2.7e-07	6.7e-01	99	ZFHX3
207	16	74270536	76281066	7	10	1.2e-76	3.5e-77	1.0e+00	100	BCAR1 CFDP1 TMEM170A
208	17	1717695	2453908	1	1	2.5e-21	4.9e-19	3.5e-03	89	SMG6
209	17	3011213	4966954	8	2	1.6e-26	5.1e-27	5.1e-01	100	ATP2A3
210	17	5782945	8484683	2	2	2.6e-08	6.8e-07	1.0e+00	100	KIAA0753 LSMD1
211	17	17017584	18923818	16	3	3.5e-14	1.9e-12	2.5e-01	97	ALKBH5 CCDC144B TOM1L2
212	17	26706946	31275580	21	2	1.5e-52	4.6e-53	1.0e+00	100	LRRC37B SSH2
213	17	36211659	39048774	14	14	2.2e-37	3.1e-31	1.0e+00	100	CWC25 GSDMB IKZF3 MSL1 ORMDL3 PCGF2 PIP4K2B THRA
214	17	45337417	49307326	14	9	6.2e-15	2.8e-16	1.5e-02	91	CDK5RAP3 HOXB2 HOXB-AS1 MYCBPAP NFE2L1 PRR15L SNX11 ZNF652
215	17	60013554	61464730	2	1	2.8e-19	2.9e-18	2.3e-04	82	MRC2
216	17	61765524	63531331	5	3	2.6e-18	2.4e-17	1.8e-06	68	DDX5 PLEKHM1P SMURF2
217	17	65123352	66885526	8	1	1.4e-17	9.8e-16	6.1e-01	100	LINC00674
218	17	72829885	74267010	1	1	1.0e-11	1.1e-09	5.7e-01	99	LLGL2
219	17	76320835	77734689	1	1	1.0e-07	3.1e-08	1.7e-08	-4	C1QTNF1
220	17	79280925	80680449	1	1	8.7e-10	2.6e-08	2.9e-01	96	STRA13
221	18	7329035	11250447	5	5	5.0e-18	1.1e-29	6.9e-31	-4	KIAA0802 NAPG PTPRM RP11-21J18.1 SOGA2
222	18	19692435	21303692	1	1	2.4e-08	2.1e-19	7.2e-15	25	RBBP8
223	19	1086043	2560423	3	1	4.9e-09	8.7e-11	5.0e-03	81	KLF16
224	19	3268722	3783070	1	1	2.0e-07	4.4e-08	8.1e-02	90	FZR1
225	19	7211841	8619461	2	1	8.1e-10	1.1e-10	1.0e+00	100	ARHGEF18
226	19	13445144	14854034	1	1	2.6e-07	1.0e-11	1.2e-09	20	IL27RA
227	19	17672385	19081701	2	1	2.5e-08	2.1e-07	2.8e-02	82	JUND
228	19	31077263	32530559	1	1	5.3e-18	6.2e-36	3.7e-22	40	TSHZ3
229	19	36181046	37950253	7	1	2.8e-09	8.4e-09	6.4e-01	99	ZNF260
230	19	40259342	42504505	8	5	1.5e-15	6.5e-13	8.4e-02	94	CYP2B7P1 HNRNPUL1 ITPKC RAB4B SHKBP1
231	19	45286263	50460914	17	8	1.7e-37	9.6e-36	1.0e+00	100	CCDC9 CPT1C DMPK DMWD FUT2 PNMAL1 SYMPK
232	19	51598669	53017693	1	1	5.0e-15	5.0e-15	1.0e+00	100	FPR3
233	20	2961408	4359816	1	1	8.3e-10	3.7e-12	1.0e-03	78	ADAM33
234	20	18506005	20398583	1	1	1.6e-10	6.1e-12	1.1e-02	86	SLC24A3
235	20	24532613	26307797	3	1	6.2e-09	9.4e-09	1.7e-01	94	CTD-2514C3.1
236	20	30060562	35916342	23	19	4.1e-17	1.4e-14	NaN	NaN	ACSS2 C20orf112 C20orf203 C20orf24 EIF6 ITCH MAP1LC3A PROCR RALY RP5-1085F17.3 RSL24D1P6 TGIF2 TSPY26P
237	20	43293270	44801026	4	1	7.2e-16	3.1e-11	1.2e-01	94	SYS1-DBNDD2
238	20	47554392	49028687	1	1	2.0e-10	1.6e-10	2.2e-04	67	B4GALT5
239	20	60064969	61679007	4	2	5.1e-17	3.3e-15	2.7e-07	57	CABLES2 RP11-157P1.5
240	21	18271223	19680363	1	1	3.8e-10	2.5e-10	1.7e-07	32	BTG3
241	21	27593540	29033093	1	2	6.2e-09	2.3e-10	1.6e-01	95	ADAMTS5
242	21	34589270	36786042	4	4	1.6e-21	7.6e-37	1.9e-34	7	CLIC6 LINC00310 LINC00649 MRPS6
243	21	39849553	41512399	5	1	1.5e-11	3.6e-09	6.6e-01	99	HMGN1
244	22	17581838	19203078	1	1	1.2e-26	3.7e-27	9.2e-04	91	MICAL3
245	22	19262852	20330744	2	2	1.6e-16	2.7e-15	3.2e-03	86	ARVCF ZDHHC8
246	22	20732809	21465050	3	1	8.6e-23	7.3e-28	1.0e-06	80	SCARF2
247	22	29015590	31171274	10	8	1.3e-29	5.5e-29	NaN	NaN	ASCC2 NF2 NIPSNAP1 ZMAT5
248	22	37835576	38415721	1	1	4.0e-08	9.5e-07	9.2e-01	100	TRIOBP
249	22	40472399	43615241	9	3	1.6e-13	1.5e-12	5.5e-02	93	EP300 MKL1 RRP7A

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder (2018)	1.18	4	1	2.2	-0.63	3.7e-01	ADD3 C2orf15 GNL3 UBE2Q2P1
Bipolar Disorder or Schizophrenia	1.20	9	6	13.3	-0.41	2.4e-01	AC103965.1 ACTR1A CHRNA5 CTCF FBXO38 GNL3 RP11-182J1.16 UBE2Q2P1 ZSCAN2
Depressed Affect (Nagel 2018)	1.01	4	2	4.4	-0.37	6.3e-01	GMPPB PTCH1 RP1-18D14.7 RPS6KL1
Intelligence (Savage-Jansen 2018)	1.15	19	10	22.2	0.22	3.1e-01	ACTR1A BTG3 CENPW CRAT FOXO3 GMPPB GNL3 HERC1 JUND LMOD1 NEGR1 PEF1 PPA2 PTCH1 RP11-165J3.6 RP11-435O5.5 SERPING1 SUOX TRIOBP
Neuroticism (Nagel 2018)	1.08	8	4	8.9	-0.17	6.1e-01	ADM BTG3 CENPW FBXO38 PTCH1 RPS6KL1 SBF2 SERPING1
Schizophrenia (2018)	1.10	6	5	11.1	-0.95	1.2e-03	AC103965.1 ACTR1A CHRNA5 GNL3 RP11-182J1.16 UBE2Q2P1
Schizophrenia vs Biploar Disorder	1.10	1	0	0.0	0.00	1.0e+00	C2orf15
Worry (Nagel 2018)	1.16	7	3	6.7	0.09	8.4e-01	ACTR1A ADK CENPW GNL3 PTCH1 RPS6KL1 VCL
Alzheimer’s Disease (including proxy)	0.94	1	0	0.0	0.00	1.0e+00	SPPL2A
Crohns Disease (2017)	1.48	15	12	26.7	0.63	2.1e-03	AC010883.5 ADCY3 CAMK2G FUT2 GSDMB IKZF3 ITPKC ORMDL3 PDLIM4 SH3D21 SLC22A5 SMAD3 STARD10 TSPAN14 UQCRQ
Irritable Bowel Disease (IBD)	1.59	15	11	24.4	0.69	7.3e-04	AC010883.5 ADCY3 AHSA2 BACH2 FUT2 GSDMB IKZF3 ITPKC ORMDL3 PDLIM4 SLC22A5 SMAD3 STARD10 TSPAN14 UQCRQ
Ulcerative Colitis (UC)	1.44	9	5	11.1	0.85	9.8e-04	AC026740.1 AHSA2 EIF6 GMPPB GSDMB IKZF3 ORMDL3 PDLIM4 RP3-395M20.9
Major Depression (MDD)	1.33	1	1	2.2	0.00	1.0e+00	NEGR1
Reaction Time	1.11	1	1	2.2	0.00	1.0e+00	FOXO3
Verbal and Numeric Reasoning (VNR)	1.21	9	6	13.3	0.30	3.4e-01	ALKBH5 BTG3 FOXO3 GMPPB GNL3 NEGR1 PEF1 PPA2 SUOX
Breast Cancer	1.17	9	6	13.3	-0.35	3.3e-01	ADCY3 ATE1 HSPA4 MKL1 MLLT10 PCM1 RPS23 SLC22A5 UQCRQ
Ovarian Cancer	1.00	2	0	0.0	0.00	1.0e+00	DNALI1 HOXB2
Prostate Cancer	1.21	4	1	2.2	0.71	1.8e-01	EEFSEC NUCKS1 PPA2 RIF1
Age at First Birth	1.01	1	0	0.0	0.00	1.0e+00	GMPPB
Bipolar Disorder (2011)	1.59	1	0	0.0	0.00	1.0e+00	GNL3
Body Mass Index (BMI) (2010)	1.20	2	2	4.4	0.00	1.0e+00	ADCY3 NEGR1
Coronary Artery Disease (CAD)	1.45	1	1	2.2	0.00	1.0e+00	CELSR2
Crohns Disease (2012)	1.26	8	8	17.8	0.52	1.0e-01	FUT2 GSDMB IKZF3 ORMDL3 PDLIM4 SLC22A5 SMAD3 UQCRQ
HDL Cholesterol	1.48	7	5	11.1	0.41	3.1e-01	C6orf106 CTCF GSDMB IKZF3 ORMDL3 PABPC4 RPAP1
LDL Cholesterol	1.61	5	4	8.9	0.22	6.4e-01	C6orf106 CELSR2 EVI5 FUT2 RP11-680F20.12
Lupus	1.29	3	1	2.2	0.00	1.0e+00	APIP TCP11 ZNF76
Neuroticism (2016)	1.20	2	2	4.4	0.00	1.0e+00	ADM SBF2
Primary Biliary Cirrhosis	1.35	4	4	8.9	0.73	9.7e-02	GSDMB IKZF3 IL7R ORMDL3
Schizophrenia (2014)	0.99	6	5	11.1	-0.46	3.0e-01	AC103965.1 ACTR1A GNL3 RP11-182J1.16 SMG6 UBE2Q2P1
Triglycerides	1.11	2	1	2.2	0.00	1.0e+00	NRBF2 PCSK7
Type 2 Diabetes (T2D) (2012)	1.50	2	1	2.2	0.00	1.0e+00	IGF2BP2 STARD10
Ulcerative Colitis	1.50	4	4	8.9	0.72	1.0e-01	GSDMB IKZF3 ORMDL3 RP3-395M20.9
Blood Eosinophil Count	1.80	58	43	95.6	-0.41	4.0e-04	AC010883.5 AC103965.1 ADD3 AHSA2 ARMC2 BACH2 C16orf93 C20orf112 CCDC9 COG6 CTA-293F17.1 CTD-2007H13.3 DEF6 DMPK DMWD EXOC2 FBXO38 FCHO2 FOXO1 GNA12 HAUS4 HMOX2 HSPA4 IL1RL1 IL7R IQCH ITPKC LINC00674 LRP1 MSL1 PCBP2 PDLIM4 PSTPIP1 RBBP8 RP11-182J1.16 RP11-298I3.1 RP11-425D10.10 RP11-680F20.12 RP3-395M20.9 SCAPER SEC24C SLC22A5 SMAD3 SMPD2 SUOX SYMPK TBX6 TCP11 TEPP THRA TOM1L2 TPRA1 TSPY26P UQCRQ ZNF652 ZNF76 ZSCAN2 ZUFSP
Blood Platelet Count	1.26	94	72	160.0	-0.19	5.4e-02	AC010883.5 AC103965.1 ADD3 ADK AP4M1 ATG16L2 ATP2A3 BCAR1 BIN3 C10orf11 C16orf93 C1orf54 C20orf203 C6orf106 C9orf156 CAPZB CCDC66 CEPT1 CFDP1 CNPY4 CNTN2 DENND2D DEPDC6 DMPK DMWD EEFSEC EVI5 FAM69A FCGR2B FCHO2 FGD6 FOXO1 FUT2 GIPC2 GNA12 GNL3 HELLS HHIP-AS1 HMGN1 HMOX2 IGF2BP2 IMMT JHDM1D LHFPL2 LSMD1 MARCH7 MUTYH NIPSNAP1 NRBF2 OR2AE1 OTUD4 PCSK7 PDE8B PDLIM4 PGD PIF1 PLAC9 PPA2 RAI14 RALY RARB RP11-157P1.5 RP11-165J3.6 RP11-182J1.16 RP11-425D10.10 RP11-673E1.1 RP11-797A18.4 RP11-800A3.7 RP1-18D14.7 RP11-95P2.1 RPS6KL1 SERPING1 SERTAD2 SH3D21 SLC22A5 SMG6 SMPD2 SNX33 SSH2 SYMPK TIGD2 TMEM170A TMEM180 TMEM185B TOP2B TPM1 TRIM4 TRIT1 UQCRQ VCL WNT2B ZMAT5 ZNF260 ZSCAN2
Blood Red Count	1.01	75	54	120.0	0.03	7.6e-01	ACSS2 ADM ALKBH5 AP4M1 ARMC2 ATP13A2 ATPAF1 BACH2 C16orf93 C20orf203 C9orf156 CENPW CNPY4 CNTN2 CROCC CTCF CTD-2514C3.1 CTD-2524L6.3 DCBLD1 DYNC1LI2 EIF2AK4 EPHA2 FAM69A FCGR2B FOXO1 GJA1 GNL3 GPATCH2L GPRIN3 HELLS HOXB2 HOXB-AS1 IGF2BP2 LIN52 LINC00649 LSMD1 MAP1LC3A MAPKBP1 MRC2 MST1L MUTYH ORMDL3 PABPC4 PRIM2 PRR15L PSTPIP1 RAI14 RP11-425D10.10 RP11-435O5.5 RP11-673E1.1 RP11-797A18.4 RP1-18D14.7 RPAP1 RSL24D1P6 SBF2 SERPING1 SERTAD2 SHKBP1 SMG6 SMPD2 SNX33 SSH2 STRA13 SUOX SYMPK TBX6 TMEM165 TMEM9B TRIOBP TRMT61B TSPAN3 UBE2Q2 UBE2Q2P1 ULK4 WDR91
Blood White Count	2.45	72	50	111.1	-0.19	7.8e-02	ACTR1A ADAM33 AHSA2 ALKBH5 ARHGAP42 ASCC2 BACH2 C16orf93 C1orf54 CCDC9 CDK5RAP3 CENPW CEPT1 DEF6 EVI5 FAM213A FAM69A FBXO38 FCGR2B GM2A GMPPB GNA12 GSDMB HELLS HMOX2 HOXC8 IFITM3 IKZF3 IL1RL1 ITCH ITGA2 ITPKC KB-1107E3.1 KLF6 MAP1LC3A MARCH7 MSL1 NF2 NFE2L1 NIPSNAP1 NRBF2 ORMDL3 PDLIM4 PEAK1 PPA2 PRR15L PSTPIP1 PTCH1 RAI14 RALY RIOK1 RP11-435O5.5 RP11-797A18.4 RPL10A SCAPER SLC22A5 SMG6 SMPD2 SNRPF SPINK9 SPPL2A SSH2 TBX6 THRA TIGD2 TOM1L2 TSPAN14 TSPAN3 UQCRQ ZMAT5 ZNF652 ZNF76
Heel T-Score	1.94	77	57	126.7	0.13	2.0e-01	AC010883.5 AC103965.1 ACSS2 ASCC2 ATE1 BMP4 C11orf46 C16orf93 C2orf15 CAMK2G CAPZB CDK5RAP3 CTC-228N24.3 DDX5 DEF6 DGKQ DYNC1LI2 EIF3E EP300 EVI5 FAM213A FAM3C FCHO2 GAB2 GJA1 GNA12 GRK5 HHIP-AS1 HSPA4 HSPG2 IGF2BP2 IQCH ITCH ITPR1-AS1 LACTB2 LSMD1 LTBP3 MAP1LC3A MKL1 MRC2 NEGR1 NFE2L1 NIPSNAP1 OTUD4 PCGF2 PEAK1 PIP4K2B PLAC9 PRR15L PTCH1 PTPRM RALY RP11-165J3.6 RP11-435O5.5 RP11-95P2.1 RPL10A SERPING1 SERTAD2 SMG6 SPPL2A SSH2 SSR3 STRA13 TCP11 THAP3 THSD4 TMEM9B TRIOBP TRMT61B TSPAN14 TSPAN3 UBE2Q2P1 USP3 VGLL4 WNT2B ZNF438 ZNF76
BMI	1.29	56	37	82.2	0.45	3.1e-04	ACTR1A ADCY3 ARHGEF26 ATP13A2 C16orf93 C6orf106 CCDC171 CDK5RAP3 CEP41 CTD-2524L6.3 EP300 EVI5 FAM69A FGFR1 FOXO3 GAB2 GIPC2 GMPPB GNL3 GTF2IRD2 HOXB-AS1 IQCH ITCH KB-1107E3.1 KLF16 KLHL24 LINC00674 LMOD1 LOXL1-AS1 LRP1 MKL1 MLLT10 MTA3 MUTYH NEGR1 NFE2L1 NRBF2 OTUD4 PABPC4 PEF1 PSTPIP1 PTPRM RAB4B RALY RP11-797A18.4 RP1-18D14.7 RP3-395M20.9 SMG6 SNX11 SSH2 SUOX TBX6 THAP3 TRMT61B TSPAN4 UBE2R2
Height	2.41	169	144	320.0	0.02	8.2e-01	AC010883.5 AC103965.1 ACSS2 ADAMTS5 ADCY3 ADM AFAP1 AFAP1-AS1 ALKBH5 ARHGEF26 ARHGEF38 ARMC2 ASAH1 ASB13 ATP13A2 BCAR1 BMF BTBD8 C10orf11 C11orf46 C1orf54 C20orf24 C6orf106 C9orf156 CCDC144B CCDC66 CCDC9 CELSR2 CENPW CFDP1 COG6 CRIM1 CROCC CTA-293F17.1 CTCF CTD-2524L6.3 CWC25 DDX5 DEF6 DEPDC6 DMWD DRAM1 DYNC1LI2 EFEMP1 EIF2AK4 EIF6 ERC1 EVI5 EXOC2 FAM69A FOXO3 FRK FUT2 FZR1 GAB2 GBA GIPC2 GNA12 GNL3 GNPTAB GOLGA6L4 GRK5 GTF2IRD2 HHIP-AS1 HMGN1 HOXB2 HOXB-AS1 HSPG2 IKZF3 ISCA1 ITCH ITPKC KIAA0753 KLHL24 LINC00674 LLGL2 LOX LOXL1-AS1 LRP1 LRRC37B LSM3 LTBP3 LYSMD4 MAP1LC3A MET MFAP2 MRC2 MRPS6 MSL1 MST1L MTMR11 MUTYH NCBP1 NFE2L1 NUCKS1 NUDT2 NUDT5 ORMDL3 OTUD4 PABPC4 PADI2 PDE2A PDHX PDLIM4 PEAK1 PEF1 PGD PIP4K2B PLA2G4B PLEKHA1 PLEKHM1P PPA2 PROCR PRR15L PSTPIP1 PTCH1 PTPRM RALY RBBP8 RP11-108M9.4 RP11-108M9.5 RP11-157P1.5 RP11-165J3.6 RP11-182J1.14 RP11-182J1.16 RP11-382A20.2 RP11-425D10.10 RP11-435O5.5 RP11-797A18.4 RP11-95P2.1 RPL10A RPS6KL1 RRP15 SBF2 SCAPER SEC61A2 SGMS1 SH3D21 SHKBP1 SLC22A5 SLC2A9 SMPD2 SMURF2 SNX11 SPPL2A SSH2 ST3GAL4 STRA13 TBX6 TCP11 TCTN2 TGFB2 TMEM165 TMEM170A TMEM180 TMEM185B TMUB1 TRIB1 TRIOBP TSPAN3 UBE2Q2 UBE2Q2P1 UBE2R2 UQCRQ ZMAT5 ZNF438 ZNF652 ZNF76 ZSCAN2
Waist Hip Ratio (WHR)	1.49	49	30	66.7	0.22	1.1e-01	ABTB1 AC103965.1 ADM ALKBH5 AMPD3 ARHGEF26 ATP13A2 C10orf11 CCDC144B CENPW CEP41 CFH COL15A1 CTC-228N24.3 CTCF DGKQ DMWD EML3 FOXO3 FUT2 GNL3 HERC1 HHIP-AS1 HMOX2 HOXC8 HSPA4 IGF2BP2 IQCH JUND LYSMD4 MAPKBP1 MFAP2 MST1L NID2 OTUD4 PIP4K2B PLA2G4B RP11-182J1.14 RP11-182J1.16 RP11-95P2.1 RPAP1 RPL10A SBF2 TCTN2 TOM1L2 TSPAN4 U2SURP UBE2Q2P1 VGLL4
Systolic Blood Pressure	1.70	64	42	93.3	-0.38	4.8e-04	ACTR1A ADCY3 ADK ADM AFAP1 AFAP1-AS1 ARHGAP42 ARHGEF26 ATP2B1 BCAR1 BMP4 CAMK1D CDC123 CFDP1 CTC-228N24.3 CTD-2514C3.1 DCBLD1 DDX5 DEF6 DMPK DMWD EIF2AK4 ELMSAN1 EPHA2 FAM149B1 FAM213A FBXO38 FUT2 GIPC2 HAUS4 HELLS HHIPL1 HOXC8 HSPA4 KB-1107E3.1 KIAA0753 MAPKBP1 MET MRC2 NRBF2 PLA2G4B RP11-298I3.1 RP11-800A3.7 RPL10A RPS6KL1 SBF2 SEC24C SERPING1 SH3TC2 SLC24A3 SMAD3 SNX11 SPINK9 TCP11 THAP3 TMEM170A TRIOBP TSHZ3 TSPAN14 TTC18 ULK4 VCL VGLL4 ZNF652
Smoking Status	1.31	8	2	4.4	-0.16	7.1e-01	ACTR1A GMPPB IQCH MET RARB SUOX ZFHX3 ZNF652
Allergy or Eczema	1.99	24	14	31.1	-0.49	7.6e-03	AC010883.5 AMPD3 BACH2 BCAR1 C6orf106 EVI5 FAM69A FOXO1 GRK5 GSDMB IKZF3 IL1RL1 IL7R IQCH MSL1 NEGR1 ORMDL3 SMAD3 SUOX THRA TMEM170A TOM1L2 UQCRQ ZNF652
Cardiovascular Disease	1.48	26	14	31.1	-0.07	7.0e-01	ADK ARHGAP42 ATP2B1 BCAR1 C1GALT1 CACNA1D CELSR2 CEP41 CFDP1 FUT2 HOXC8 HSPA4 KB-1107E3.1 KLF16 LMOD1 MET NEGR1 NPNT NRBF2 RPAP1 SSH2 SUOX THAP3 TMEM170A TSPAN3 ZNF652
Hypothyroidism (self reported)	1.26	10	7	15.6	-0.36	3.1e-01	BACH2 C9orf156 CTCF FUT2 IL7R JUND NCBP1 PLEKHA1 SUOX XPA
Respiratory disease	3.42	30	22	48.9	-0.68	6.0e-07	ADAM19 BACH2 C16orf93 C1orf54 DDX5 DEF6 DMWD EEFSEC FOXO1 GSDMB HOXB2 IKZF3 IL1RL1 IL7R IQCH LRP1 LTBP3 MSL1 ORMDL3 PDLIM4 RP11-425D10.10 SLC22A5 SMAD3 SUOX TCP11 THRA TSPAN14 UQCRQ ZNF652 ZNF76
Type 2 Diabetes (T2D) (2018)	1.69	11	7	15.6	-0.71	1.0e-02	AC010883.5 C1GALT1 CAMK1D CDC123 CENPW CFDP1 CLPB IGF2BP2 LOC100133893 PLA2G4B STARD10
Lung FVC	2.10	84	63	140.0	-0.18	6.5e-02	AFAP1L1 ARAP1-AS1 ATP13A2 ATP6V0D1 BIN3 BMF BMP4 C10orf11 C6orf106 CAMK1D CAMK2G CCDC171 CDC123 CDK5RAP3 CENPW CFH CHRNA5 CROCC CTC-228N24.3 CTD-2514C3.1 DSP EFEMP1 EIF2AK4 EIF6 EML3 EPHA2 EPHX4 ERC1 FBXO38 FOXO3 GM2A GMPPB HMOX2 HOXC8 HSPA4 IGF2BP2 INTS12 IQCH ITCH JUND KCNQ5 LLGL2 LONRF2 LOX LOXL1-AS1 MAP1LC3A MFAP2 MICAL3 MRPS6 MST1L NFE2L1 NUCKS1 NUDT5 PAIP1 PCSK7 PLEKHM1P PROCR PTCH1 RALY RBBP8 RP11-108M9.5 RP11-382A20.2 RP11-435O5.5 RPL10A RRP15 SEC24C SHKBP1 SLC22A5 SLMAP SMPD2 SMURF2 SOGA2 SPTBN5 STARD10 STRA13 SUOX TCP11 THSD4 TIGD2 TMUB1 TRIOBP ZFHX3 ZMAT5 ZNF76
Neuroticism	1.11	10	2	4.4	-0.04	9.0e-01	ADM BTG3 CENPW FBXO38 GAB2 IQCH PTCH1 RPS6KL1 SBF2 SERPING1
Chronotype (morning person)	1.08	5	1	2.2	0.05	9.4e-01	C1orf54 CTD-2524L6.3 EVI5 SHB TMEM180
Hair Pigment	0.51	42	31	68.9	-0.21	1.3e-01	AC010883.5 ACSS2 ADAMTS5 ADCY3 ADD3 ADM ARHGAP42 ATP2B1 C20orf112 C20orf24 C6orf106 C9orf156 CNTN2 DEF6 EIF3E EIF6 EMB EML4 EXOC2 FOXO3 FRAS1 GAB2 GBA HMOX2 HOXB-AS1 ITCH LRRN2 MAP1LC3A MSL1 NFE2L1 NUCKS1 PPP1R3B PROCR PRR15L RALY RP5-1085F17.3 RSL24D1P6 SBF2 SH3D21 SNX11 SUOX ZNF76
Tanning	0.77	20	15	33.3	0.48	1.7e-02	ACSS2 ADCY3 C20orf24 CNTN2 CTD-2514C3.1 DTWD1 EIF6 GAB2 GBA GNL3 HMOX2 ITCH MAP1LC3A NRBF2 PROCR RALY RP11-305K5.1 RP5-1085F17.3 SNX11 SSR3
Hand grip strength (left)	1.57	24	12	26.7	0.49	4.3e-03	ACSS2 ACTR1A ADCY3 AFAP1 AFAP1-AS1 DEF6 EIF6 GBA HOXB2 ITCH LOXL1-AS1 MAP1LC3A NUCKS1 PDLIM4 PEF1 PIP4K2B PROCR RPS6KL1 SLC22A5 SNX11 TCP11 TGFB2 TRIOBP ZNF76
Number of treatments/medications taken	1.32	6	2	4.4	-0.60	2.1e-01	GMPPB LINC00674 LRP1 RNF38 RPS6KL1 ZNF652
Sensitivity / hurt feelings	1.11	2	1	2.2	-0.94	6.5e-02	PPP1R3B PTCH1
Frequency of depressed mood in last 2 weeks	1.13	1	0	0.0	0.00	1.0e+00	SERPING1
Hearing difficulty/problems: Yes	1.17	1	0	0.0	0.00	1.0e+00	ADK
Relative age of first facial hair	1.12	4	1	2.2	-0.97	5.0e-03	AC004041.2 FOXO3 HSPA4 VGLL4
Ever had hysterectomy (womb removed)	1.01	1	0	0.0	0.00	1.0e+00	C11orf46
Systolic blood pressure, automated reading	1.73	28	15	33.3	-0.55	7.7e-04	ADK ARHGAP42 ATP2B1 BCAR1 CAMK1D CFDP1 DEF6 DMPK DMWD EIF2AK4 FBXO38 HAUS4 HHIPL1 HOXC8 NFE2L1 NRBF2 PPA2 PPP1R3B RP11-298I3.1 SBF2 SEC24C SNX11 SPINK9 TCP11 THAP3 TMEM170A ULK4 VGLL4
Eye problems/disorders: Diabetes related eye disease	1.11	1	0	0.0	0.00	1.0e+00	IGF2BP2
Angina	1.26	2	2	4.4	0.00	1.0e+00	CELSR2 ZNF652
Vitamin and mineral supplements	1.29	1	1	2.2	0.00	1.0e+00	LRP1
Medication: Metformin	1.62	4	2	4.4	-0.85	1.5e-01	AC010883.5 CAMK1D CDC123 IGF2BP2
Diabetes (father)	1.18	2	2	4.4	0.00	1.0e+00	AC010883.5 IGF2BP2
Diabetes (mother)	1.61	4	4	8.9	-0.93	7.1e-02	CAMK1D CDC123 IGF2BP2 STARD10
Pack years adult smoking proportion	1.53	2	2	4.4	0.00	1.0e+00	CHRNA5 RAB4B
Impedance of leg (right)	1.67	64	46	102.2	0.02	8.5e-01	AC010883.5 AC103965.1 ACTR1A ADCY3 ADM ALKBH5 AMPD3 ARVCF ATP13A2 BCAR1 BTBD8 C10orf11 C16orf93 C6orf106 CAMK2G CFDP1 CROCC CTC-228N24.3 EP300 EPHA2 EVI5 GMPPB GNL3 GOLGA6L4 GTF2IRD2 HELLS HOXC8 ITCH JUND KLF16 LMOD1 LOC400043 LSM3 MFAP2 MKL1 MST1L MTMR11 NEGR1 NUCKS1 OTUD4 PABPC4 PEAK1 PLA2G4B PSTPIP1 PTCH1 RALY RP11-108M9.5 RP11-165J3.6 RP11-182J1.14 RP11-182J1.16 RP11-382A20.2 RP11-797A18.4 SBF2 SCAPER SCARF2 SH3D21 SMG6 SUOX TBX6 TSPAN3 TSPAN4 UBE2Q2P1 ZNF652 ZSCAN2
Leg fat-free mass (left)	1.72	57	43	95.6	0.36	1.1e-03	ACSS2 ACTR1A ADM ARHGEF26 BTBD8 C10orf11 C16orf93 C1orf54 C20orf24 C6orf106 CENPW CTC-228N24.3 DEF6 EIF6 EPHA2 FOXO3 FZR1 GIPC2 GMPPB GNA12 HHIP-AS1 ITCH KLF16 KLHL24 LMOD1 LOXL1-AS1 MAP1LC3A MKL1 MSL1 NEGR1 NUCKS1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RP11-435O5.5 RPL10A SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SUOX TBX6 TCP11 TGFB2 TSPAN4 UQCRQ ZMAT5 ZNF76
Trunk fat percentage	1.26	34	22	48.9	0.30	7.2e-02	AC103965.1 ADCY3 ADM C16orf93 C6orf106 CCDC171 CENPW EML3 FOXO3 GBA GNA12 GOLGA6L4 HOXC8 IQCH JUND KCNG3 KLHL24 LINC00674 LMOD1 NEGR1 NTM OTUD4 PABPC4 RARB RP11-182J1.14 RP11-182J1.16 RP11-95P2.1 RPS6KL1 SBF2 SNX11 SYNM THAP3 UBE2Q2P1 ZSCAN2
Hand grip strength (right)	1.64	18	13	28.9	0.62	4.9e-04	ACSS2 ACTR1A ADCY3 AFAP1 ATP2A3 EIF6 HOXB2 ITCH LOXL1-AS1 MAP1LC3A NUCKS1 PDLIM4 PEF1 PIP4K2B PROCR SLC22A5 TCP11 TGFB2
Current tobacco smoking	1.19	1	1	2.2	0.00	1.0e+00	ACTR1A
Maternal smoking around birth	1.15	2	1	2.2	0.00	1.0e+00	ACTR1A TSPAN14
Fed-up feelings	1.09	3	1	2.2	0.00	1.0e+00	GMPPB PPP1R3B RPS6KL1
Relative age voice broke	0.97	2	0	0.0	0.00	1.0e+00	FOXO3 RP11-95P2.1
Taking other prescription medications	1.34	8	3	6.7	-0.87	5.1e-03	ADAM19 GMPPB GSDMB IKZF3 IL1RL1 ORMDL3 RPS6KL1 ZNF652
Age when periods started (menarche)	1.26	14	9	20.0	-0.12	6.8e-01	ADCY3 AP4M1 CENPW COG6 FOXO3 GAB2 GMPPB GNL3 HMGN1 KLF16 NEGR1 NUCKS1 PAN3-AS1 SUOX
Bilateral oophorectomy (both ovaries removed)	1.00	1	1	2.2	0.00	1.0e+00	C11orf46
Heel bone mineral density (BMD) T-score, automated (left)	1.46	18	9	20.0	-0.19	4.2e-01	BMP4 DGKQ DYNC1LI2 EP300 FAM213A FAM3C HHIP-AS1 LACTB2 MRC2 OTUD4 PPP1R3B PTCH1 RP11-165J3.6 RP11-435O5.5 SERTAD2 SMG6 THAP3 WNT2B
High blood pressure	1.49	17	9	20.0	-0.38	1.0e-01	ARHGAP42 ATP2B1 C1GALT1 CEP41 CFDP1 EEFSEC FUT2 HOXC8 KB-1107E3.1 MET NEGR1 NRBF2 PDLIM4 SLC22A5 SUOX TSPAN3 ZNF652
Hayfever, allergic rhinitis or eczema	1.91	15	13	28.9	-0.84	8.2e-06	BACH2 C6orf106 FOXO1 GSDMB IKZF3 IL1RL1 IL7R MSL1 ORMDL3 SMAD3 SUOX THRA TOM1L2 UQCRQ ZNF652
Multivitamins +/- minerals	1.35	2	1	2.2	0.00	1.0e+00	NUCKS1 PGD
Supplements: Glucosamine	1.26	1	1	2.2	0.00	1.0e+00	NRBF2
Medication: Atenolol	1.20	1	0	0.0	0.00	1.0e+00	MET
Medication: Levothyroxine sodium	1.24	4	4	8.9	-0.47	5.3e-01	BACH2 C9orf156 NCBP1 SUOX
Sitting height	2.22	84	56	124.4	0.12	1.9e-01	AC103965.1 ACSS2 ADCY3 ADM AFAP1 AFAP1-AS1 ATP13A2 BEND3P3 BTBD8 C10orf11 C20orf24 C6orf106 C9orf156 CCDC171 CDON CENPW COX7A2L CRIM1 DEPDC6 DMWD DRAM1 DYNC1LI2 EFEMP1 EIF2AK4 EIF6 EML4 ERC1 EVI5 FAM69A FOXO3 FRK FUT2 FZR1 GNA12 GNPTAB GOLGA6L4 HELLS HERC1 HHIP-AS1 HOXB-AS1 HSPG2 ISCA1 ITCH LOXL1-AS1 LRP1 LRRC37B MAP1LC3A MFAP2 MRC2 MST1L MTA3 MTMR11 MUTYH NUCKS1 OTUD4 PDLIM4 PIP4K2B PLEKHA1 PPA2 PPP1R3B PROCR PTCH1 RALY RP11-182J1.14 RP11-182J1.16 RP11-425D10.10 RP11-435O5.5 RP11-95P2.1 RPL10A RRP15 SBF2 SLC22A5 SMPD2 ST3GAL4 STRA13 TGFB2 TMEM165 TRIOBP UBE2Q2P1 UQCRQ VGLL4 ZNF652 ZNF76 ZSCAN2
Chronic bronchitis/emphysema (father)	1.50	1	1	2.2	0.00	1.0e+00	CHRNA5
High blood pressure (mother)	1.34	2	1	2.2	0.00	1.0e+00	HOXC8 TMEM170A
Body mass index (BMI)	1.19	32	17	37.8	0.41	1.5e-02	ACTR1A ADCY3 ATP13A2 C16orf93 C6orf106 CCDC171 CDK5RAP3 EP300 EVI5 FOXO3 GMPPB GNL3 ITCH KLF16 LINC00674 LMOD1 MKL1 MUTYH NEGR1 NFE2L1 OTUD4 PABPC4 PPP1R3B PTPRM RP11-797A18.4 RP1-18D14.7 RP3-395M20.9 SCAPER SMG6 SUOX TBX6 TSPAN4
Impedance of leg (left)	1.66	66	45	100.0	-0.01	9.0e-01	AC010883.5 AC103965.1 ACTR1A ADCY3 ADM ALKBH5 AMPD3 ARVCF ATP13A2 BCAR1 BTBD8 C10orf11 C16orf93 C6orf106 CAMK2G CEP41 CFDP1 CROCC CTC-228N24.3 EP300 EPHA2 EVI5 GMPPB GNL3 GOLGA6L4 GTF2IRD2 HELLS ITCH JUND KLF16 LMOD1 LSM3 MFAP2 MKL1 MST1L MTMR11 NEGR1 NUCKS1 OTUD4 PABPC4 PEAK1 PPA2 PSTPIP1 PTCH1 RALY RP11-108M9.5 RP11-165J3.6 RP11-182J1.14 RP11-182J1.16 RP11-382A20.2 RP11-797A18.4 RPS6KL1 SBF2 SCAPER SCARF2 SH3D21 SMG6 SMPD2 SUOX TBX6 TSPAN3 TSPAN4 UBE2Q2P1 ULK4 ZNF652 ZSCAN2
Leg predicted mass (left)	1.72	56	43	95.6	0.37	7.9e-04	ACSS2 ACTR1A ADM ARHGEF26 BTBD8 C10orf11 C16orf93 C1orf54 C20orf24 C6orf106 CENPW CTC-228N24.3 DEF6 EIF6 EPHA2 FOXO3 FZR1 GIPC2 GMPPB GNA12 HHIP-AS1 ITCH KLF16 KLHL24 LMOD1 LOXL1-AS1 MAP1LC3A MSL1 NEGR1 NUCKS1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RP11-435O5.5 RPL10A SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SUOX TBX6 TCP11 TGFB2 TSPAN4 UQCRQ ZMAT5 ZNF76
Trunk fat mass	1.30	33	24	53.3	0.41	1.3e-02	AC103965.1 ADCY3 ARHGEF26 C16orf93 C6orf106 CCDC171 FOXO3 GNA12 GOLGA6L4 IQCH ITCH JUND KB-1107E3.1 KLF16 KLHL24 LINC00674 LMOD1 MAP1LC3A NEGR1 OTUD4 PABPC4 PLEKHA1 RARB RP11-182J1.14 RP11-182J1.16 RP1-18D14.7 RP11-95P2.1 RPL10A SNX11 TBX6 THAP3 UBE2Q2P1 ZSCAN2
Waist circumference	1.28	25	17	37.8	0.20	3.4e-01	ADCY3 C16orf93 C6orf106 CCDC171 FOXO3 GOLGA6L4 HOXC8 IQCH JUND KB-1107E3.1 KLF16 LINC00674 LMOD1 MICU3 MLLT10 NEGR1 OTUD4 PABPC4 RP11-182J1.16 RP3-395M20.9 RPL10A SMG6 SNX11 SUOX TBX6
Number of incorrect matches in round	1.14	1	0	0.0	0.00	1.0e+00	TSPAN14
Past tobacco smoking	1.29	3	3	6.7	0.00	1.0e+00	ACTR1A IQCH TMEM180
Alcohol usually taken with meals	1.16	2	1	2.2	0.00	1.0e+00	ACTR1A SERPING1
Nervous feelings	1.13	7	3	6.7	-0.09	8.3e-01	ACTR1A CENPW FBXO38 GNL3 PPP1R3B RPS6KL1 SBF2
Frequency of tenseness / restlessness in last 2 weeks	0.94	1	0	0.0	0.00	1.0e+00	GMPPB
Hearing difficulty/problems with background noise	1.12	2	1	2.2	0.00	1.0e+00	NUCKS1 VGLL4
Hair/balding pattern: Pattern 2	1.13	1	1	2.2	0.00	1.0e+00	C10orf11
Had other major operations	1.07	1	0	0.0	0.00	1.0e+00	PPA2
Forced vital capacity (FVC)	2.39	61	41	91.1	-0.07	5.2e-01	ADCY3 ATP13A2 BMF C10orf11 C11orf46 CAMK1D CCDC171 CDC123 CDK5RAP3 CENPW CHRNA5 CRIM1 CROCC CTC-228N24.3 CTCF DEF6 EFEMP1 EIF2AK4 EML3 ERC1 GNA12 GNPTAB HHIP-AS1 INTS12 IQCH LONRF2 LOXL1-AS1 MFAP2 MST1L NFE2L1 NUDT5 OTUD4 PADI2 PCSK7 PIP4K2B PLEKHA1 PLEKHM1P PPA2 PSTPIP1 PTCH1 RP11-108M9.4 RP11-108M9.5 RP11-182J1.14 RP11-182J1.16 RP11-382A20.2 RP11-435O5.5 RP11-797A18.4 RPL10A RRP15 SCAPER SEC24C SH3D21 SHKBP1 SLMAP SMPD2 SMURF2 SSH2 TCP11 TGFB2 UBE2Q2P1 ZNF76
Heel bone mineral density (BMD) T-score, automated (right)	1.52	14	7	15.6	-0.11	7.0e-01	BMP4 EPHA2 FAM213A FAM3C HHIP-AS1 OTUD4 PPP1R3B PTCH1 RP11-165J3.6 SERTAD2 SMG6 SNCAIP THAP3 WNT2B
Ever unenthusiastic/disinterested for a whole week	0.87	1	0	0.0	0.00	1.0e+00	GMPPB
Qualifications: None of the above	1.21	6	4	8.9	-0.21	6.1e-01	ACTR1A FOXO3 GMPPB NEGR1 PPA2 SUOX
Mouth/teeth dental problems	1.05	1	0	0.0	0.00	1.0e+00	FUT2
Heart attack	1.14	2	0	0.0	0.00	1.0e+00	CELSR2 ZNF652
Allergy	2.49	25	17	37.8	0.82	1.0e-08	BACH2 C6orf106 CAMK2G DEF6 EEFSEC FOXO1 GSDMB IKZF3 IL1RL1 IL7R IQCH LRP1 MSL1 NUDT13 ORMDL3 PDLIM4 RBBP8 RP5-1085F17.3 SEC24C SLC22A5 SMAD3 SUOX THRA UQCRQ ZNF652
Diabetes (self-reported)	1.57	4	1	2.2	-0.91	3.4e-02	AC010883.5 FBXO38 IGF2BP2 LOC100133893
Hayfever/allergic rhinitis (self-reported)	1.64	7	2	4.4	-0.95	9.9e-04	BACH2 GSDMB IKZF3 IL1RL1 IL7R SMAD3 SUOX
Medication: Simvastatin	1.31	3	2	4.4	0.00	1.0e+00	CELSR2 DMWD FUT2
Fluid intelligence score	1.20	9	4	8.9	0.36	2.3e-01	ALKBH5 BTG3 FOXO3 GMPPB NEGR1 PEF1 PPA2 PTCH1 RARB
Illnesses of siblings	1.35	1	0	0.0	0.00	1.0e+00	SSH2
Neuroticism score	1.19	7	3	6.7	0.04	9.2e-01	ADM FBXO38 PPP1R3B PTCH1 RPS6KL1 SBF2 SERPING1
Weight	1.47	55	39	86.7	0.53	2.0e-06	AC103965.1 ACSS2 ACTR1A ADCY3 ARHGEF26 C16orf93 C6orf106 CCDC171 CENPW EIF6 FOXO1 FOXO3 FZR1 GIPC2 GMPPB GNA12 GOLGA6L4 HHIP-AS1 ITCH KB-1107E3.1 KLF16 KLHL24 LINC00674 LMOD1 MAP1LC3A NEGR1 NUCKS1 OTUD4 PABPC4 PEF1 PLEKHA1 PPA2 PROCR RALY RP11-182J1.14 RP11-182J1.16 RP11-435O5.5 RP1-18D14.7 RP11-95P2.1 RP3-395M20.9 RPL10A SLC22A5 SMG6 SMPD2 SNX11 SUOX TBX6 TCP11 TGFB2 TRMT61B TSPAN4 UBE2Q2P1 ZMAT5 ZNF76 ZSCAN2
Impedance of arm (right)	1.57	55	41	91.1	-0.22	9.0e-02	AC103965.1 ACTR1A ADM AMPD3 ARVCF ATP13A2 C10orf11 C6orf106 CENPW EFEMP1 EML3 EP300 EVI5 FOXO3 GAB2 GBA GMPPB GNL3 GOLGA6L4 GTF2IRD2 HOXC8 ITCH JUND LMOD1 LOC400043 LOXL1-AS1 MFAP2 MKL1 MST1L MTMR11 NEGR1 NFE2L1 NRBF2 NUCKS1 PEF1 PPP1R3B PSTPIP1 RALY RIF1 RP11-108M9.4 RP11-108M9.5 RP11-182J1.14 RP11-182J1.16 RP11-797A18.4 RP3-395M20.9 SBF2 SCARF2 SMAD3 SMG6 SUOX TBX6 TSPAN3 TSPAN4 UBE2Q2P1 ZNF652
Arm fat percentage (right)	1.18	27	13	28.9	0.12	5.5e-01	ADCY3 ADM AFAP1-AS1 C16orf93 C6orf106 CCDC171 CENPW GBA IQCH JUND KCNG3 KLF16 KLHL24 LINC00674 LMOD1 NEGR1 PABPC4 RARB RP1-18D14.7 SBF2 SSH2 SSR3 SYNM TBX6 THAP3 UBE2Q2P1 ZNF76
Trunk fat-free mass	2.00	59	48	106.7	0.34	1.9e-03	ACSS2 ACTR1A ADM AMPD3 ATP13A2 BTBD8 C10orf11 C1orf54 C20orf24 C6orf106 CCDC66 CENPW CTC-228N24.3 DEF6 EIF6 FOXO3 GBA GIPC2 GMPPB GNA12 HHIP-AS1 ITCH LMOD1 LOXL1-AS1 MAP1LC3A MKL1 MSL1 NUCKS1 OR2AE1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RBBP8 RP11-435O5.5 RPL10A RPS6KL1 SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SNX33 SUOX TBX6 TCP11 TGFB2 TRIM4 UQCRQ ZMAT5 ZNF76
Hip circumference	1.31	39	28	62.2	0.37	1.5e-02	AC103965.1 ACTR1A ADCY3 ARHGEF26 C16orf93 C6orf106 CCDC171 FOXO3 GIPC2 GMPPB GNA12 GOLGA6L4 HHIP-AS1 ITCH KB-1107E3.1 KLF16 KLHL24 LINC00674 LMOD1 MAP1LC3A NEGR1 OTUD4 PABPC4 PEF1 PTCH1 RALY RP11-182J1.14 RP11-182J1.16 RP11-435O5.5 RP1-18D14.7 RP11-95P2.1 RPL10A SMPD2 SNX11 TBX6 TRMT61B TSPAN4 UBE2Q2P1 ZSCAN2
Alcohol intake versus 10 years previously	1.04	3	0	0.0	0.00	1.0e+00	FUT2 NEGR1 PABPC4
Father's age at death	1.07	1	1	2.2	0.00	1.0e+00	CHRNA5
Worrier / anxious feelings	1.18	5	4	8.9	0.05	9.2e-01	ACTR1A PPP1R3B PTCH1 RPS6KL1 SERPING1
Frequency of tiredness / lethargy in last 2 weeks	1.05	2	0	0.0	0.00	1.0e+00	GMPPB SERPING1
Hair/balding pattern: Pattern 3	1.18	2	1	2.2	0.00	1.0e+00	CENPW MAP1LC3A
Forced expiratory volume in 1-second (FEV1)	3.38	73	49	108.9	0.75	2.7e-20	AC103965.1 ADAM19 ADAMTS5 ADCY3 AFAP1 AFAP1L1 ARHGEF17 ASCC2 ATP13A2 BCAR1 C10orf11 C1GALT1 C20orf112 CAMK1D CAMK2G CCDC171 CDC123 CENPW CHRNA5 CTD-2524L6.3 DEF6 DENND2D EFEMP1 EML3 FAM149B1 FAM168A FBXO38 GIPC2 GM2A GMPPB GOLGA6L4 HHIP-AS1 IGF2BP2 INTS12 KPNA3 LLGL2 LONRF2 LOXL1-AS1 LRRC37B MICAL3 NIPAL4 NRBF2 NUDT5 OTUD4 PCGF2 PLEKHM1P PPA2 PTCH1 RELT RP11-182J1.14 RP11-182J1.16 RP11-382A20.2 RP11-425D10.10 RP11-435O5.5 RP11-680F20.12 RP11-800A3.7 RPL10A RSL24D1P6 SEC24C SLMAP SMPD2 SOGA2 SPINK9 SUOX SYNM TCP11 TGFB2 THSD4 TTC18 UBE2Q2P1 ZNF438 ZNF76 ZSCAN2
Pulse rate	1.22	3	2	4.4	0.00	1.0e+00	GJA1 GNL3 PPP1R3E
Qualifications: A levels/AS levels or equivalent	0.99	5	2	4.4	-0.14	7.9e-01	ACTR1A GMPPB NEGR1 PPA2 SUOX
Mouth/teeth dental problems: Dentures	1.12	4	0	0.0	0.38	6.2e-01	CHRNA5 EIF2AK4 FUT2 HERC1
Asthma	3.21	24	20	44.4	-0.71	4.1e-06	ADAM19 BACH2 C16orf93 DEF6 DMWD EEFSEC GSDMB IKZF3 IL1RL1 IL7R IQCH LRP1 LTBP3 MSL1 ORMDL3 PDLIM4 SLC22A5 SMAD3 SRGAP2 SUOX THRA UQCRQ ZNF652 ZNF76
Medication: Ibuprofen (e.g. Nurofen)	1.15	1	1	2.2	0.00	1.0e+00	LRP1
Medication: Cholesterol lowering	1.38	3	2	4.4	0.00	1.0e+00	CELSR2 FUT2 IGF2BP2
Prospective memory result	1.16	1	0	0.0	0.00	1.0e+00	PEF1
Lung cancer (father)	1.05	1	1	2.2	0.00	1.0e+00	CHRNA5
Forced expiratory volume in 1-second (FEV1), Best measure	3.46	70	51	113.3	0.78	5.8e-22	AC103965.1 ADAM19 ADCY3 AFAP1 AFAP1L1 ARHGEF17 ASCC2 ATP13A2 BCAR1 C10orf11 C1GALT1 C20orf112 CAMK1D CAMK2G CDC123 CENPW CEPT1 CHRNA5 CTD-2524L6.3 DEF6 DENND2D DNALI1 EFEMP1 EIF6 EML3 FAM168A FBXO38 FRK GIPC2 GM2A GMPPB GOLGA6L4 HHIP-AS1 INTS12 KPNA3 LLGL2 LONRF2 LOXL1-AS1 LRRC37B MICAL3 MST1L NIPAL4 NRBF2 NUDT5 OTUD4 PAIP1 PCGF2 PDLIM4 PLEKHM1P PPA2 RELT RP11-182J1.14 RP11-182J1.16 RP11-382A20.2 RPL10A RSL24D1P6 SEC24C SLMAP SMPD2 SOGA2 SPINK9 SUOX SYNM TCP11 TGFB2 THSD4 UBE2Q2P1 ZNF438 ZNF76 ZSCAN2
Impedance of arm (left)	1.60	59	40	88.9	-0.20	1.1e-01	AC103965.1 ACTR1A ADM AMPD3 ATP13A2 C10orf11 CENPW CROCC EEFSEC EFEMP1 EML3 EP300 EVI5 FOXO3 GAB2 GBA GMPPB GNA12 GNL3 GOLGA6L4 GTF2IRD2 HOXC8 ITCH JUND LMOD1 LOC400043 LOXL1-AS1 LSM3 MFAP2 MKL1 MST1L MTMR11 NEGR1 NFE2L1 NRBF2 OR2AE1 PEF1 PPP1R3B PRR15L PSTPIP1 RALY RIF1 RP11-108M9.4 RP11-108M9.5 RP11-182J1.14 RP11-182J1.16 RP11-797A18.4 RP3-395M20.9 SBF2 SCAPER SCARF2 SMG6 SUOX TBX6 TRIM4 TSPAN3 TSPAN4 UBE2Q2P1 ZNF652
Arm fat mass (right)	1.17	25	19	42.2	0.38	5.4e-02	ADCY3 ARHGEF26 C16orf93 C6orf106 CCDC171 FOXO3 GMPPB IQCH ITCH JUND KLF16 KLHL24 LINC00674 LMOD1 NEGR1 OTUD4 PABPC4 RALY RP1-18D14.7 RP3-395M20.9 RPL10A SUOX TBX6 TSPAN4 UBE2Q2P1
Trunk predicted mass	1.99	58	48	106.7	0.34	2.1e-03	ACSS2 ACTR1A ADM AMPD3 ATP13A2 BTBD8 C10orf11 C1orf54 C20orf24 C6orf106 CCDC66 CENPW CTC-228N24.3 DEF6 EIF6 FOXO3 GBA GIPC2 GMPPB GNA12 HHIP-AS1 ITCH LMOD1 LOXL1-AS1 MAP1LC3A MKL1 MSL1 NUCKS1 OR2AE1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RBBP8 RP11-435O5.5 RPL10A RPS6KL1 SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SNX33 SUOX TBX6 TCP11 TGFB2 TRIM4 ZMAT5 ZNF76
Standing height	2.40	113	98	217.8	0.06	4.8e-01	AC103965.1 ACSS2 ADCY3 ADM AFAP1 AFAP1-AS1 ALKBH5 ASB13 ATP13A2 BTBD8 C11orf46 C20orf24 C6orf106 C9orf156 CCDC144B CCDC66 CENPW CFDP1 COG6 CRIM1 CROCC CTCF DEF6 DEPDC6 DMWD DRAM1 EFEMP1 EIF6 ERC1 EVI5 FAM69A FOXO3 FRK FUT2 FZR1 GNA12 GNL3 GNPTAB GOLGA6L4 GRK5 HHIP-AS1 HMGN1 HOXB-AS1 ISCA1 ITCH KIAA0753 LLGL2 LOX LOXL1-AS1 LRP1 LRRC37B LSM3 MAP1LC3A MFAP2 MRC2 MRPS6 MSL1 MST1L MTMR11 MUTYH NFE2L1 NUCKS1 OTUD4 PABPC4 PADI2 PDLIM4 PEAK1 PGD PIP4K2B PLEKHA1 PLEKHM1P PPA2 PROCR PRR15L PSTPIP1 PTCH1 RALY RBBP8 RP11-108M9.4 RP11-108M9.5 RP11-165J3.6 RP11-182J1.14 RP11-182J1.16 RP11-382A20.2 RP11-425D10.10 RP11-435O5.5 RP11-797A18.4 RP11-95P2.1 RPL10A RPS6KL1 RRP15 SBF2 SCAPER SH3D21 SLC22A5 SLC2A9 SMPD2 SNX11 SSH2 ST3GAL4 STRA13 TBX6 TCP11 TGFB2 TMEM170A TSPAN3 UBE2Q2 UBE2Q2P1 UQCRQ ZNF438 ZNF652 ZNF76 ZSCAN2
Exposure to tobacco smoke at home	0.95	1	0	0.0	0.00	1.0e+00	GMPPB
Tense / 'highly strung'	1.06	2	0	0.0	0.00	1.0e+00	NUCKS1 PTCH1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.10	2	1	2.2	0.00	1.0e+00	NEGR1 RPS6KL1
Hair/balding pattern: Pattern 4	1.10	8	3	6.7	0.03	9.4e-01	C10orf11 CENPW CTCF HSPA4 ITCH MAP1LC3A RIOK1 VGLL4
Birth weight of first child	1.78	7	3	6.7	0.57	4.4e-02	ARMC2 CRIM1 OTUD4 PPA2 SUOX TMEM170A ZNF76
Peak expiratory flow (PEF)	3.05	40	19	42.2	0.92	2.1e-26	AC010883.5 ACSS2 ADAM19 ADAMTS5 ARHGEF17 BCAR1 BMP4 C10orf11 C1GALT1 CAMK1D CDC123 DEF6 EIF6 FAM168A FBXO38 FUT2 FZR1 GIPC2 HHIP-AS1 HOXB2 HOXB-AS1 IGF2BP2 MAP1LC3A NUCKS1 NUDT5 OTUD4 PPA2 RARB RELT RP11-800A3.7 SBSPON SMPD2 SPINK9 SSH2 TCP11 TCTN2 TGFB2 THSD4 TMEM170A ZNF76
Pulse wave reflection index	1.17	1	0	0.0	0.00	1.0e+00	PPP1R3E
Blood clot in the leg (DVT)	1.17	2	2	4.4	0.00	1.0e+00	EIF6 PROCR
Medication: Paracetamol	1.18	2	1	2.2	0.00	1.0e+00	GMPPB LRP1
Headache pain in last month	1.45	6	3	6.7	0.11	8.3e-01	BCAR1 LRP1 PPP1R3B SLC24A3 SUOX TMEM170A
Medication for cholesterol, blood pressure or diabetes	1.40	6	3	6.7	0.71	1.2e-01	ARHGAP42 ATP2B1 CAMK1D CELSR2 FUT2 ZNF652
Glaucoma (self-reported)	1.11	2	2	4.4	0.00	1.0e+00	AFAP1 AFAP1-AS1
Hypothyroidism/myxoedema (self-reported)	1.23	8	6	13.3	0.02	9.7e-01	ARMC2 BACH2 C9orf156 CTCF NCBP1 PLEKHA1 SUOX ZNF76
Medication: Ventolin 100micrograms inhaler	2.03	7	5	11.1	-0.98	2.6e-06	FOXO1 GSDMB IKZF3 IL1RL1 ORMDL3 SMAD3 ZNF652
Birth weight	1.68	12	5	11.1	0.25	3.8e-01	ARMC2 CENPW DTWD1 FCGR2B GNA12 NUCKS1 PPA2 PTCH1 RP11-425D10.10 RP11-435O5.5 SHB ZNF76
Chronic bronchitis/emphysema (mother)	1.28	3	1	2.2	0.00	1.0e+00	CHRNA5 HHIP-AS1 RARB
High blood pressure (siblings)	1.21	1	1	2.2	0.00	1.0e+00	NRBF2
Forced vital capacity (FVC), Best measure	2.33	59	37	82.2	-0.08	4.9e-01	AC103965.1 ADCY3 ATP13A2 BMF BTBD8 C10orf11 C5orf63 CCDC171 CDC123 CDK5RAP3 CENPW CHRNA5 CRIM1 CROCC DEF6 DRAM1 EFEMP1 EML3 ERC1 GNA12 GNPTAB HHIP-AS1 INTS12 IQCH LONRF2 LOXL1-AS1 MFAP2 MSL1 MST1L NFE2L1 NUDT5 OTUD4 PADI2 PCSK7 PIP4K2B PLEKHM1P PPA2 PSTPIP1 PTCH1 RP11-108M9.4 RP11-108M9.5 RP11-182J1.14 RP11-182J1.16 RP11-382A20.2 RP11-435O5.5 RPL10A RRP15 SCAPER SEC24C SH3D21 SHKBP1 SMPD2 SMURF2 SSH2 TCP11 TGFB2 UBE2Q2P1 ZNF438 ZNF76
Body fat percentage	1.27	34	20	44.4	0.41	1.2e-02	AC103965.1 ADCY3 ADM C16orf93 C6orf106 CCDC171 CENPW CTC-228N24.3 FOXO3 GBA GOLGA6L4 HOXC8 IQCH JUND KCNG3 KLF16 KLHL24 LINC00674 LMOD1 NEGR1 NTM RARB RP11-165J3.6 RP11-182J1.14 RP11-182J1.16 RP1-18D14.7 RP11-95P2.1 RPS6KL1 SBF2 SSH2 SYNM THAP3 UBE2Q2P1 ZSCAN2
Leg fat percentage (right)	1.39	33	17	37.8	0.54	1.2e-03	ADCY3 ADM C6orf106 CCDC171 CDK5RAP3 CENPW CTC-228N24.3 EIF6 GMPPB GOLGA6L4 IQCH JUND LINC00674 LMOD1 LRP1 MLLT10 MUTYH NBAS NEGR1 NFE2L1 PLEKHM1P PRIM2 RP11-165J3.6 RP11-182J1.14 RP11-182J1.16 RP11-95P2.1 RP3-395M20.9 RPS6KL1 SBF2 SSH2 SYNM THAP3 UBE2Q2P1
Arm fat-free mass (right)	1.87	56	44	97.8	0.42	1.7e-04	ACSS2 ACTR1A ADM ARHGEF26 BTBD8 C10orf11 C16orf93 C20orf24 C6orf106 CCDC66 CENPW DEF6 EIF6 FOXO3 GBA GIPC2 GMPPB GNA12 HHIP-AS1 ITCH LMOD1 LOXL1-AS1 MAP1LC3A MET MKL1 NEGR1 NUCKS1 OR2AE1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RBBP8 RP11-435O5.5 RP3-395M20.9 RPL10A SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SUOX TBX6 TCP11 TGFB2 TRIM4 TSPAN4 ZMAT5 ZNF76
Comparative body size at age 10	1.49	12	9	20.0	0.33	2.8e-01	ADCY3 ATP6V0D1 C16orf93 EP300 FGFR1 FUT2 GOLGA6L4 NEGR1 NUCKS1 PAN3-AS1 VGLL4 ZNF652
Worry too long after embarrassment	1.14	2	0	0.0	0.00	1.0e+00	PPA2 SERPING1
Wheeze or whistling in the chest in last year	1.89	10	6	13.3	-0.78	6.4e-04	ADAM19 BACH2 GMPPB GSDMB IKZF3 IL1RL1 MSL1 ORMDL3 SMAD3 THRA
Age at first live birth	1.03	1	0	0.0	0.00	1.0e+00	GMPPB
Qualifications: College or University degree	1.22	17	12	26.7	0.28	1.9e-01	ACTR1A CCDC144B EIF6 EML3 FOXO3 GMPPB HAUS4 JUND LMOD1 MAP1LC3A MET NEGR1 NIPSNAP1 PPA2 PROCR RP11-298I3.1 SUOX
Medication for pain relief, constipation, heartburn	1.26	2	1	2.2	0.00	1.0e+00	LRP1 RPS6KL1
Medication: Blood pressure	1.40	4	3	6.7	-0.99	1.3e-02	ARHGAP42 ATP2B1 CEP41 ZNF652
Angina (self-reported)	1.28	2	1	2.2	0.00	1.0e+00	CELSR2 ZNF652
Migraine (self-reported)	1.16	2	1	2.2	0.00	1.0e+00	LRP1 SLC24A3
Medication: Ibuprofen	1.14	1	1	2.2	0.00	1.0e+00	LRP1
Medication: Seretide 50 evohaler	1.57	2	0	0.0	0.00	1.0e+00	IL1RL1 ZNF652
Mean time to correctly identify matches	1.08	2	1	2.2	0.00	1.0e+00	FOXO3 NUCKS1
Whole body fat mass	1.26	34	24	53.3	0.41	1.2e-02	AC103965.1 ADCY3 ARHGEF26 C16orf93 C6orf106 CCDC171 FOXO3 GMPPB GNA12 GOLGA6L4 IQCH ITCH JUND KB-1107E3.1 KLF16 KLHL24 LINC00674 LMOD1 NEGR1 OTUD4 PABPC4 RP11-182J1.14 RP11-182J1.16 RP1-18D14.7 RP11-95P2.1 RP3-395M20.9 RPL10A SNX11 SUOX SYNM TBX6 THAP3 UBE2Q2P1 ZSCAN2
Leg fat mass (right)	1.26	37	22	48.9	0.52	7.2e-04	ACTR1A ADCY3 ARHGEF26 C16orf93 C6orf106 CCDC171 FOXO3 GIPC2 GMPPB GOLGA6L4 IQCH ITCH JUND KB-1107E3.1 KLF16 KLHL24 LINC00674 LMOD1 MLLT10 NBAS NEGR1 OTUD4 PABPC4 PEF1 RALY RP11-182J1.14 RP11-182J1.16 RP1-18D14.7 RP11-95P2.1 RP3-395M20.9 RPL10A SSH2 SUOX TBX6 THAP3 UBE2Q2P1 ZSCAN2
Arm predicted mass (right)	1.86	58	44	97.8	0.40	2.6e-04	ACSS2 ACTR1A ADM ARHGEF26 ARVCF BTBD8 C10orf11 C16orf93 C20orf24 C6orf106 CCDC66 CENPW DEF6 EIF6 FOXO3 GBA GIPC2 GMPPB GNA12 HHIP-AS1 ITCH LMOD1 LOXL1-AS1 MAP1LC3A MET MKL1 NEGR1 NUCKS1 OR2AE1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RBBP8 RP11-182J1.16 RP11-435O5.5 RP3-395M20.9 RPL10A SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SUOX TBX6 TCP11 TGFB2 TRIM4 TSPAN4 ZMAT5 ZNF76
Pulse rate, automated reading	1.42	24	12	26.7	-0.15	4.7e-01	ALKBH5 AP4M1 C6orf106 EIF2AK4 EML3 GAB2 GJA1 GNL3 HERC1 HMGN1 LOC100133893 MET MUTYH NEGR1 PABPC4 PCGF2 PPP1R3E RP11-351A11.1 RP11-382A20.2 RP11-95P2.1 SERPING1 SERTAD2 SUOX SYS1-DBNDD2
Alcohol intake frequency.	1.07	5	2	4.4	0.25	6.3e-01	CCDC144B FUT2 LRP1 PPA2 SUOX
Comparative height size at age 10	2.05	66	54	120.0	0.14	1.7e-01	AC010883.5 AC103965.1 ACSS2 ADCY3 ATP13A2 C10orf11 C20orf24 C6orf106 C9orf156 CENPW CRIM1 CROCC DEF6 EFEMP1 EIF6 EVI5 FAM69A FOXO3 FUT2 GNA12 GOLGA6L4 HHIP-AS1 ITCH JUND LOXL1-AS1 MAP1LC3A MFAP2 MRPS6 MSL1 MST1L MTMR11 NUCKS1 OTUD4 PADI2 PDLIM4 PIP4K2B PLEKHA1 PLEKHM1P PPA2 PROCR PSTPIP1 PTCH1 RBBP8 RP11-108M9.4 RP11-108M9.5 RP11-165J3.6 RP11-182J1.14 RP11-182J1.16 RP11-435O5.5 RP11-797A18.4 RPL10A RPS6KL1 SH3D21 SLC22A5 SMPD2 TBX6 TCP11 TGFB2 TMEM170A TMEM41B UBE2Q2 UBE2Q2P1 UQCRQ ZNF438 ZNF76 ZSCAN2
Number of full sisters	1.29	1	0	0.0	0.00	1.0e+00	NRBF2
Suffer from 'nerves'	0.97	3	0	0.0	0.00	1.0e+00	PTCH1 RPS6KL1 TBX6
Overall health rating	1.15	4	3	6.7	-0.54	4.6e-01	GMPPB LINC00674 LMOD1 ZNF652
Chest pain or discomfort	1.25	1	0	0.0	0.00	1.0e+00	IL1RL1
Had major operations	1.01	1	0	0.0	0.00	1.0e+00	ZNF652
Age at last live birth	1.02	1	1	2.2	0.00	1.0e+00	GMPPB
Medication: Aspirin	1.17	3	0	0.0	0.00	1.0e+00	CELSR2 DEPDC6 IGF2BP2
Knee pain experienced in last month	1.06	1	0	0.0	0.00	1.0e+00	PABPC4
Hypertension (Self-reported)	1.50	18	10	22.2	-0.18	4.4e-01	ARHGAP42 ATP2B1 C1GALT1 CEP41 CFDP1 FUT2 HOXC8 HSPA4 KB-1107E3.1 MET NRBF2 PDLIM4 RPAP1 SLC22A5 SUOX TPRA1 TSPAN3 ZNF652
Illnesses of father: Heart disease	1.29	4	2	4.4	0.31	6.9e-01	CELSR2 RP11-378J18.8 SMAD3 SMG6
Illnesses of siblings: Diabetes	1.10	1	1	2.2	0.00	1.0e+00	IGF2BP2
Forced expiratory volume in 1-second (FEV1), predicted	1.98	27	19	42.2	0.39	1.6e-02	AC103965.1 ADCY3 ATP13A2 C6orf106 CENPW DEF6 EIF6 GNA12 GOLGA6L4 HHIP-AS1 LOXL1-AS1 MAP1LC3A MST1L OTUD4 PDLIM4 PROCR PTCH1 RP11-182J1.14 RP11-182J1.16 RP11-435O5.5 RPL10A SLC22A5 TCP11 TGFB2 UBE2Q2P1 ZNF76 ZSCAN2
Whole body fat-free mass	1.89	64	47	104.4	0.36	5.5e-04	ACSS2 ACTR1A ADM AMPD3 ARHGEF26 BTBD8 C10orf11 C16orf93 C1orf54 C20orf24 C6orf106 CCDC66 CENPW CTC-228N24.3 DEF6 EIF6 EPHA2 FOXO3 FZR1 GBA GIPC2 GMPPB GNA12 HHIP-AS1 ITCH LMOD1 LOXL1-AS1 MAP1LC3A MET MKL1 MSL1 NEGR1 NUCKS1 OR2AE1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RBBP8 RP11-435O5.5 RPL10A SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SNX33 SUOX TBX6 TCP11 TGFB2 TRIM4 TSPAN4 UQCRQ ZMAT5 ZNF76
Leg fat-free mass (right)	1.71	56	43	95.6	0.33	3.0e-03	ACSS2 ACTR1A ADM ARHGEF26 BTBD8 C10orf11 C16orf93 C1orf54 C20orf24 C5orf63 C6orf106 CENPW CTC-228N24.3 DEF6 EIF6 EPHA2 FOXO3 FZR1 GMPPB GNA12 HHIP-AS1 ITCH LMOD1 MAP1LC3A MSL1 NEGR1 NUCKS1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PLEKHM1P PPA2 PROCR PTCH1 RALY RP11-435O5.5 RPL10A SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SNX33 SUOX TBX6 TCP11 TGFB2 TSPAN4 UQCRQ ZMAT5 ZNF76
Arm fat percentage (left)	1.19	28	14	31.1	0.07	7.1e-01	ADCY3 AFAP1 AFAP1-AS1 C16orf93 C6orf106 CCDC171 CENPW GBA HOXC8 IQCH JUND KCNG3 KLF16 KLHL24 LINC00674 LMOD1 NEGR1 OXER1 PABPC4 RP1-18D14.7 SBF2 SSH2 SSR3 SYNM TBX6 THAP3 UBE2Q2P1 ZNF76
Average weekly red wine intake	1.10	1	0	0.0	0.00	1.0e+00	SERPING1
Mood swings	1.07	4	2	4.4	-0.78	6.9e-02	FBXO38 GMPPB NUCKS1 RPS6KL1
Long-standing illness, disability or infirmity	1.28	4	0	0.0	-0.53	4.7e-01	CCDC171 EMB NEGR1 ZNF652
Diabetes diagnosed by doctor	1.69	6	3	6.7	0.13	8.1e-01	AC010883.5 CFDP1 CLPB IGF2BP2 LOC100133893 PLA2G4B
Qualifications: nursing, teaching	1.15	3	1	2.2	0.00	1.0e+00	CFH NEGR1 PPA2
Eye problems/disorders: Cataract	1.03	1	1	2.2	0.00	1.0e+00	SLC24A3
Mouth/teeth dental problems: Mouth ulcers	1.10	2	0	0.0	0.00	1.0e+00	GSDMB IKZF3
Medication for cholesterol	1.40	2	0	0.0	0.00	1.0e+00	FUT2 MTA3
Back pain experienced in last month	1.11	1	0	0.0	0.00	1.0e+00	C6orf106
Asthma (self-reported)	3.24	24	19	42.2	-0.71	3.1e-06	ADAM19 BACH2 C16orf93 DDX5 DEF6 DMWD EEFSEC GSDMB IKZF3 IL1RL1 IL7R IQCH LRP1 MSL1 ORMDL3 PDLIM4 SLC22A5 SMAD3 SRGAP2 SUOX THRA UQCRQ ZNF652 ZNF76
Osteoarthritis (self-reported)	1.16	1	0	0.0	0.00	1.0e+00	MBL1P
Medication: Aspirin	1.18	2	0	0.0	0.00	1.0e+00	CELSR2 IGF2BP2
Medication: Gliclazide	1.18	1	1	2.2	0.00	1.0e+00	IGF2BP2
Smoking status: Current	1.20	1	1	2.2	0.00	1.0e+00	ACTR1A
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.74	31	15	33.3	0.92	2.5e-21	ADAM19 ASCC2 BCAR1 C10orf11 CAMK1D CAMK2G CDC123 CHRNA5 EML3 FBXO38 GMPPB HHIP-AS1 INTS12 KPNA3 LLGL2 MICAL3 NRBF2 OTUD4 PCGF2 PPA2 RARB RP11-382A20.2 RPL10A SEC24C SLMAP SMPD2 SOGA2 SPINK9 TCP11 TMEM170A ZNF76
Whole body water mass	1.89	63	47	104.4	0.36	6.2e-04	ACSS2 ACTR1A ADM AMPD3 ARHGEF26 BTBD8 C10orf11 C16orf93 C1orf54 C20orf24 C6orf106 CCDC66 CENPW CTC-228N24.3 DEF6 EIF6 EPHA2 FOXO3 FZR1 GBA GIPC2 GMPPB GNA12 HHIP-AS1 ITCH LMOD1 LOXL1-AS1 MAP1LC3A MKL1 MSL1 NEGR1 NUCKS1 OR2AE1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RBBP8 RP11-435O5.5 RPL10A SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SNX33 SUOX TBX6 TCP11 TGFB2 TRIM4 TSPAN4 UQCRQ ZMAT5 ZNF76
Leg predicted mass (right)	1.71	57	44	97.8	0.32	4.1e-03	ACSS2 ACTR1A ADM ARHGEF26 BTBD8 C10orf11 C16orf93 C1orf54 C20orf24 C5orf63 C6orf106 CENPW CTC-228N24.3 DEF6 EIF6 EPHA2 FOXO3 FZR1 GMPPB GNA12 HHIP-AS1 ITCH LMOD1 LOXL1-AS1 MAP1LC3A MSL1 NEGR1 NUCKS1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PLEKHM1P PPA2 PROCR PTCH1 RALY RP11-435O5.5 RPL10A SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SNX33 SUOX TBX6 TCP11 TGFB2 TSPAN4 UQCRQ ZMAT5 ZNF76
Arm fat mass (left)	1.17	25	19	42.2	0.32	1.1e-01	ADCY3 ARHGEF26 C16orf93 C6orf106 CCDC171 FOXO3 GMPPB GNA12 IQCH ITCH JUND KLF16 KLHL24 LINC00674 LMOD1 NEGR1 OTUD4 PABPC4 RALY RP1-18D14.7 RP3-395M20.9 RPL10A SUOX TBX6 TSPAN4
Number of self-reported non-cancer illnesses	1.38	5	2	4.4	-0.99	1.3e-03	GSDMB IL1RL1 IQCH NEGR1 ZNF652
Miserableness	1.02	3	1	2.2	0.00	1.0e+00	GMPPB LOXL1-AS1 PPP1R3B
Guilty feelings	1.19	2	1	2.2	0.00	1.0e+00	PTCH1 RPS6KL1
Eye problems/disorders: Glaucoma	1.13	2	2	4.4	0.00	1.0e+00	AFAP1 AFAP1-AS1
Medication: Blood pressure	1.31	5	2	4.4	-0.44	3.8e-01	ARHGAP42 C1GALT1 HOXC8 NRBF2 SLC22A5
High cholesterol (Self-reported)	1.28	2	2	4.4	0.00	1.0e+00	CELSR2 FUT2
Medication: Bendroflumethiazide	1.22	1	0	0.0	0.00	1.0e+00	ATP2B1
Medication: Paracetamol	1.16	2	1	2.2	0.00	1.0e+00	GMPPB LRP1
Medication: Lisinopril	1.21	2	0	0.0	0.00	1.0e+00	NRBF2 XPA
Medication: Atorvastatin	1.25	1	1	2.2	0.00	1.0e+00	CELSR2
Ever smoked	1.20	2	1	2.2	0.00	1.0e+00	ACTR1A ZFHX3
Basal metabolic rate	1.79	66	46	102.2	0.39	1.9e-04	ACSS2 ACTR1A ADM ARHGEF26 BTBD8 C10orf11 C16orf93 C1orf54 C20orf24 C6orf106 CCDC66 CENPW CTC-228N24.3 DEF6 EIF6 EPHA2 FOXO3 FZR1 GIPC2 GMPPB GNA12 HHIP-AS1 ISCA1 ITCH LINC00674 LMOD1 LOXL1-AS1 MAP1LC3A MET MKL1 NEGR1 NUCKS1 OR2AE1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RBBP8 RP11-182J1.16 RP11-435O5.5 RP11-95P2.1 RPL10A SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SNX33 SUOX TBX6 TCP11 TGFB2 TRIM4 TRMT61B TSPAN4 UQCRQ ZMAT5 ZNF76
Leg fat percentage (left)	1.37	34	16	35.6	0.54	7.2e-04	ADCY3 ADM C6orf106 CCDC171 CDK5RAP3 CENPW CTC-228N24.3 EIF6 FOXO3 GMPPB GOLGA6L4 GRK5 IQCH JUND LINC00674 LMOD1 LRP1 MLLT10 MUTYH NBAS NEGR1 NFE2L1 PTCH1 RP11-165J3.6 RP11-182J1.14 RP11-435O5.5 RP11-95P2.1 RP3-395M20.9 RPS6KL1 SBF2 SSH2 SYNM THAP3 UBE2Q2P1
Arm fat-free mass (left)	1.79	59	45	100.0	0.41	2.0e-04	ACSS2 ACTR1A ADM ARHGEF26 BTBD8 C10orf11 C16orf93 C20orf24 C6orf106 CCDC66 CENPW DEF6 EIF6 FOXO3 GBA GIPC2 GMPPB GNA12 HHIP-AS1 ITCH LMOD1 LOXL1-AS1 MAP1LC3A MET MKL1 NEGR1 NUCKS1 OR2AE1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RBBP8 RP11-435O5.5 RP3-395M20.9 RPL10A SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SNX33 SUOX TBX6 TCP11 TGFB2 TRIM4 TRMT61B TSPAN4 ZMAT5 ZNF76
Number of operations (self-reported)	1.29	1	1	2.2	0.00	1.0e+00	PPA2
Average weekly beer plus cider intake	1.22	1	0	0.0	0.00	1.0e+00	PCM1
Irritability	1.14	2	0	0.0	0.00	1.0e+00	AC010883.5 FCHO2
Fractured/broken bones in last 5 years	1.07	1	0	0.0	0.00	1.0e+00	FAM3C
Diastolic blood pressure, automated reading	1.52	27	15	33.3	0.17	3.6e-01	ADM ARHGAP42 ATP2A3 ATP2B1 C1GALT1 DEF6 DPY19L2P4 HAUS4 KLF16 LMOD1 LSMD1 MAPKBP1 MICAL3 NRBF2 PLA2G4B PPP1R3B RP11-351A11.1 RP11-800A3.7 RPAP1 SBF2 SLC24A3 SLMAP TCP11 THSD4 TPRA1 ULK4 ZNF652
Ever depressed for a whole week	1.00	1	0	0.0	0.00	1.0e+00	GMPPB
Myopia	1.09	2	0	0.0	0.00	1.0e+00	BMP4 LRP1
Vascular/heart problems diagnosed by doctor	1.47	16	10	22.2	0.42	8.3e-02	ARHGAP42 ATP2B1 C1GALT1 CEP41 CFDP1 FUT2 HOXC8 HSPA4 KB-1107E3.1 MET NRBF2 PDLIM4 SLC22A5 SMG6 TSPY26P ZNF652
Cholesterol lowering medication	1.24	4	2	4.4	-0.09	9.1e-01	CELSR2 EPHA2 FUT2 SSH2
Pain experienced in last month	1.17	7	3	6.7	0.57	1.8e-01	CENPW GMPPB HNRNPUL1 LRP1 PABPC4 RAB4B SUOX
Basal cell carcinoma (self-reported)	1.16	1	0	0.0	0.00	1.0e+00	ITGA2
Heart attack/myocardial infarction (self-reported)	1.16	3	1	2.2	0.00	1.0e+00	CELSR2 RP11-378J18.8 ZNF652
Deep venous thrombosis (DVT) (self-reported)	1.21	2	2	4.4	0.00	1.0e+00	EIF6 PROCR
Heart disease (siblings)	1.31	1	0	0.0	0.00	1.0e+00	RP11-378J18.8
Pack years of smoking	1.52	2	2	4.4	0.00	1.0e+00	CHRNA5 RAB4B
Impedance of whole body	1.63	69	52	115.6	-0.12	3.2e-01	AC010883.5 AC103965.1 ACTR1A ADCY3 ADM AMPD3 ARVCF ATP13A2 BCAR1 BTBD8 C10orf11 C6orf106 CENPW CEP41 CROCC CTC-228N24.3 EFEMP1 EP300 EVI5 FOXO3 GAB2 GBA GMPPB GNL3 GOLGA6L4 GTF2IRD2 HELLS HOXC8 ITCH JUND KLF16 LMOD1 LOC400043 LSM3 MFAP2 MKL1 MST1L MTMR11 NEGR1 NFE2L1 NIPSNAP1 NUCKS1 OR2AE1 OTUD4 PABPC4 PEAK1 PEF1 PSTPIP1 PTCH1 RALY RIF1 RP11-108M9.5 RP11-182J1.14 RP11-182J1.16 RP11-797A18.4 RP3-395M20.9 SBF2 SCAPER SCARF2 SMG6 SNX33 SUOX TBX6 TRIM4 TSPAN3 TSPAN4 UBE2Q2P1 ZNF652 ZSCAN2
Leg fat mass (left)	1.25	35	21	46.7	0.47	3.8e-03	ACTR1A ADCY3 C16orf93 C6orf106 CCDC171 FOXO3 GIPC2 GMPPB GOLGA6L4 IQCH ITCH JUND KLF16 KLHL24 LINC00674 LMOD1 MLLT10 NBAS NEGR1 OTUD4 PABPC4 PEF1 RALY RP11-182J1.14 RP11-182J1.16 RP1-18D14.7 RP11-95P2.1 RP3-395M20.9 RPL10A SUOX TBX6 THAP3 UBE2Q2P1 ZMAT5 ZSCAN2
Arm predicted mass (left)	1.81	59	43	95.6	0.41	1.7e-04	ACSS2 ACTR1A ADM ARHGEF26 BTBD8 C10orf11 C16orf93 C20orf24 C6orf106 CCDC66 CENPW DEF6 EIF6 FOXO3 GBA GIPC2 GMPPB GNA12 HHIP-AS1 ITCH LMOD1 LOXL1-AS1 MAP1LC3A MET MKL1 NEGR1 NUCKS1 OR2AE1 OTUD4 PABPC4 PDLIM4 PEF1 PIP4K2B PLEKHA1 PPA2 PROCR PTCH1 RALY RBBP8 RP11-435O5.5 RP3-395M20.9 RPL10A SBF2 SCARF2 SH3D21 SLC22A5 SMG6 SMPD2 SNX11 SNX33 SUOX TBX6 TCP11 TGFB2 TRIM4 TRMT61B TSPAN4 ZMAT5 ZNF76

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	133	3.8	5.6
GTEx	Adipose Visceral Omentum	60	2.9	4.9
GTEx	Adrenal Gland	42	2.9	5.2
GTEx	Artery Aorta	103	3.5	5.7
GTEx	Artery Coronary	42	3.5	5.0
GTEx	Artery Tibial	149	4.0	5.6
GTEx	Brain Caudate basal ganglia	26	2.8	4.7
GTEx	Brain Cerebellar Hemisphere	47	3.2	4.8
GTEx	Brain Cerebellum	69	3.5	5.7
GTEx	Brain Cortex	34	3.3	5.5
GTEx	Brain Frontal Cortex BA9	33	3.6	5.3
GTEx	Brain Hippocampus	11	2.1	4.8
GTEx	Brain Hypothalamus	19	3.2	5.5
GTEx	Brain Nucleus accumbens basal ganglia	28	3.2	5.1
GTEx	Brain Putamen basal ganglia	22	3.5	4.9
GTEx	Breast Mammary Tissue	53	2.7	4.8
GTEx	Breast Mammary Tissue (Male)	27	2.3	4.3
GTEx	Breast Mammary Tissue (Female)	43	2.6	4.6
GTEx	Cells EBV-transformed lymphocytes	38	2.7	5.1
GTEx	Cells Transformed fibroblasts	134	3.2	5.4
GTEx	Colon Sigmoid	54	3.7	5.2
GTEx	Colon Transverse	58	2.8	4.8
GTEx	Esophagus Gastroesophageal Junction	50	3.5	5.7
GTEx	Esophagus Mucosa	105	3.2	5.2
GTEx	Esophagus Muscularis	106	3.3	5.2
GTEx	Heart Atrial Appendage	45	2.8	4.9
GTEx	Heart Left Ventricle	46	3.0	4.9
GTEx	Liver	21	2.9	4.7
GTEx	Lung	123	4.3	5.7
GTEx	Muscle Skeletal	90	3.1	5.0
GTEx	Nerve Tibial	136	3.1	5.3
GTEx	Ovary	37	4.1	6.2
GTEx	Pancreas	54	3.3	5.1
GTEx	Pituitary	43	3.9	5.4
GTEx	Prostate	26	3.1	5.2
GTEx	Skin Not Sun Exposed Suprapubic	85	3.5	5.3
GTEx	Skin Sun Exposed Lower leg	134	3.7	5.5
GTEx	Small Intestine Terminal Ileum	12	2.6	4.7
GTEx	Spleen	57	4.0	5.0
GTEx	Stomach	56	3.8	5.2
GTEx	Testis	109	3.5	5.2
GTEx	Thyroid	149	3.7	5.4
GTEx	Uterus	12	2.1	4.3
GTEx	Vagina	17	2.7	5.4
GTEx	Whole Blood	84	4.2	5.9
METSIM	Adipose	149	3.2	5.0
NTR	Blood	65	2.7	4.9
ROSMAP	Brain Pre-frontal Cortex	130	3.0	4.8
YFS	Blood	132	2.9	4.5
CommonMind	Brain Pre-frontal Cortex	160	3.0	4.8
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	60	3.6	5.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	146	3.3	4.9
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	33	3.0	5.3
The Cancer Genome Atlas	Colon Adenocarcinoma	74	3.6	5.5
The Cancer Genome Atlas	Esophageal Carcinoma	27	3.9	5.3
The Cancer Genome Atlas	Glioblastoma Multiforme	43	4.2	5.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	93	3.4	5.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	127	3.1	4.8
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	62	3.0	4.6
The Cancer Genome Atlas	Brain Lower Grade Glioma	124	2.9	4.8
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	31	2.8	4.8
The Cancer Genome Atlas	Lung Adenocarcinoma	104	3.5	5.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	75	3.0	4.9
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	40	2.5	4.6
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	53	3.2	4.9
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	45	3.4	5.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	134	2.9	4.8
The Cancer Genome Atlas	Rectum Adenocarcinoma	22	3.2	5.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	35	3.3	5.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	14	2.6	4.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	53	3.1	5.0
The Cancer Genome Atlas	Testicular Germ Cell Tumors	35	2.7	4.7
The Cancer Genome Atlas	Thyroid Carcinoma	156	3.0	4.9
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	17	3.3	4.5