Best TWAS P=1.78e-10 · Best GWAS P=1.74e-26 conditioned to 6.68e-17
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | NPC2 | 0.17 | 0.14 | lasso | 2 | 0.14 | 4.1e-11 | -6.0 | -6.0 | 2.3e-09 | -0.03 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-293M10.6 | 0.35 | 0.09 | enet | 32 | 0.05 | 2.1e-02 | -1.6 | 5.2 | 2.4e-07 | 0.05 | 0.00 | 0.01 | TRUE |
| 3 | GTEx | Nerve Tibial | NPC2 | 0.11 | 0.09 | lasso | 2 | 0.07 | 1.6e-05 | -6.0 | -6.1 | 1.3e-09 | -0.04 | 0.71 | 0.01 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | ALDH6A1 | 0.12 | 0.00 | enet | 36 | 0.01 | 3.4e-02 | 1.5 | -6.4 | 1.8e-10 | -0.25 | 0.11 | 0.04 | TRUE |
| 5 | GTEx | Spleen | RP5-1021I20.4 | 0.33 | 0.01 | enet | 50 | 0.02 | 8.7e-02 | -2.0 | -5.8 | 7.8e-09 | -0.18 | 0.05 | 0.12 | TRUE |
| 6 | GTEx | Thyroid | NPC2 | 0.13 | 0.05 | lasso | 4 | 0.02 | 4.9e-03 | -5.4 | -5.5 | 2.9e-08 | -0.03 | 0.29 | 0.03 | FALSE |
| 7 | METSIM | Adipose | NPC2 | 0.03 | 0.01 | lasso | 2 | 0.01 | 1.4e-02 | -6.0 | -6.1 | 9.6e-10 | -0.02 | 0.46 | 0.02 | FALSE |
| 8 | NTR | Blood | ISCA2 | 0.10 | 0.07 | lasso | 6 | 0.07 | 1.6e-21 | -5.4 | -5.5 | 4.3e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 9 | YFS | Blood | ISCA2 | 0.22 | 0.19 | enet | 11 | 0.21 | 7.1e-66 | -6.0 | -5.6 | 1.8e-08 | -0.01 | 1.00 | 0.00 | FALSE |
| 10 | YFS | Blood | NPC2 | 0.09 | 0.06 | enet | 10 | 0.07 | 1.6e-22 | 3.9 | -5.8 | 8.7e-09 | -0.04 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | VSX2 | 0.05 | 0.03 | blup | 48 | 0.04 | 4.5e-05 | -4.5 | 5.9 | 4.8e-09 | 0.23 | 0.05 | 0.91 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | ISCA2 | 0.03 | 0.02 | lasso | 3 | 0.00 | 2.3e-01 | -6.0 | -6.1 | 8.6e-10 | -0.06 | 0.00 | 0.90 | TRUE |