Best TWAS P=9.48e-12 · Best GWAS P=6.83e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CPE | 0.19 | 0.04 | enet | 31 | 0.06 | 5.2e-06 | -4.3 | 5.1 | 2.7e-07 | 0.68 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Artery Coronary | CPE | 0.26 | 0.01 | lasso | 11 | 0.03 | 2.7e-02 | 6.7 | 5.7 | 9.6e-09 | 0.86 | 0.02 | 0.91 | FALSE |
| 3 | GTEx | Esophagus Muscularis | CPE | 0.12 | 0.09 | lasso | 2 | 0.06 | 9.3e-05 | 6.8 | 6.7 | 2.5e-11 | 1.00 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Lung | CPE | 0.12 | 0.05 | lasso | 10 | 0.06 | 1.7e-05 | -2.7 | 5.3 | 1.0e-07 | 0.76 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Nerve Tibial | CPE | 0.21 | 0.21 | lasso | 8 | 0.19 | 1.6e-13 | 6.7 | 6.7 | 2.3e-11 | 0.94 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | CPE | 0.09 | 0.06 | lasso | 8 | 0.04 | 1.4e-04 | 6.7 | 6.8 | 1.1e-11 | 0.95 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Testis | CPE | 0.39 | 0.38 | lasso | 10 | 0.34 | 4.7e-16 | 6.7 | -6.8 | 9.5e-12 | -0.96 | 0.01 | 0.99 | TRUE |
| 8 | METSIM | Adipose | CPE | 0.04 | 0.01 | lasso | 9 | 0.01 | 5.9e-03 | 6.7 | 6.6 | 5.1e-11 | 0.88 | 0.02 | 0.97 | FALSE |