[Hub]/) : Traits : HDL Cholesterol :

chr6:33,856,903-35,549,670

Best TWAS P=3.75e-10 · Best GWAS P=3.81e-09 conditioned to 0.829

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C6orf106 0.29 0.21 bslmm 382 0.23 6.9e-28 -5.6 -5.3 1.1e-07 0.79 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex SNRPC 0.10 0.16 lasso 4 0.15 3.6e-18 -5.1 5.2 2.2e-07 -0.67 0.20 0.80 FALSE
3 CommonMind Brain Pre-frontal Cortex UHRF1BP1 0.17 0.23 lasso 19 0.22 5.8e-27 -5.3 -5.3 1.4e-07 0.60 0.20 0.80 FALSE
4 GTEx Adipose Subcutaneous UHRF1BP1 0.30 0.35 enet 28 0.36 1.6e-30 -5.2 -5.1 2.8e-07 0.59 0.19 0.81 FALSE
5 GTEx Adipose Visceral Omentum UHRF1BP1 0.30 0.34 lasso 3 0.34 3.0e-18 -5.1 -5.1 2.9e-07 0.60 0.17 0.82 FALSE
6 GTEx Artery Aorta UHRF1BP1 0.35 0.32 lasso 10 0.30 7.7e-17 -5.0 -5.1 2.9e-07 0.61 0.17 0.83 FALSE
7 GTEx Artery Coronary UHRF1BP1 0.33 0.36 lasso 2 0.35 1.6e-12 -5.2 -5.2 2.3e-07 0.59 0.20 0.80 FALSE
8 GTEx Artery Tibial SNRPC 0.06 0.06 lasso 4 0.05 1.3e-04 -5.1 5.3 1.4e-07 -0.63 0.13 0.86 FALSE
9 GTEx Brain Caudate basal ganglia SNRPC 0.19 0.15 lasso 3 0.06 7.7e-03 -5.1 5.4 7.7e-08 -0.65 0.14 0.70 FALSE
10 GTEx Brain Cerebellar Hemisphere UHRF1BP1 0.22 0.16 lasso 12 0.15 1.0e-04 -5.1 -5.3 1.1e-07 0.64 0.09 0.81 FALSE
11 GTEx Brain Putamen basal ganglia UHRF1BP1 0.20 0.17 lasso 2 0.16 1.5e-04 -5.4 -5.3 9.7e-08 0.61 0.11 0.61 FALSE
12 GTEx Breast Mammary Tissue (Male) UHRF1BP1 0.19 0.16 enet 24 0.08 5.6e-03 -5.4 -5.4 8.2e-08 0.61 0.12 0.75 FALSE
13 GTEx Cells Transformed fibroblasts UHRF1BP1 0.34 0.32 enet 44 0.31 2.4e-23 -5.2 -5.2 2.3e-07 0.64 0.19 0.81 FALSE
14 GTEx Colon Transverse UHRF1BP1 0.42 0.28 lasso 4 0.28 1.6e-13 -5.1 -5.9 4.7e-09 0.64 0.14 0.86 FALSE
15 GTEx Esophagus Mucosa UHRF1BP1 0.14 0.15 enet 28 0.17 1.3e-11 -5.3 -5.5 2.9e-08 0.66 0.14 0.86 FALSE
16 GTEx Esophagus Mucosa SNRPC 0.12 0.10 lasso 2 0.08 4.8e-06 -5.2 5.2 2.2e-07 -0.60 0.18 0.82 FALSE
17 GTEx Esophagus Muscularis SNRPC 0.09 0.11 lasso 3 0.07 3.8e-05 -5.2 5.2 2.3e-07 -0.60 0.15 0.85 FALSE
18 GTEx Muscle Skeletal SNRPC 0.03 0.02 lasso 3 0.02 8.3e-03 -5.1 5.6 2.1e-08 -0.71 0.07 0.81 FALSE
19 GTEx Nerve Tibial UHRF1BP1 0.31 0.31 lasso 6 0.31 3.9e-22 -5.2 -5.2 2.5e-07 0.59 0.17 0.83 FALSE
20 GTEx Nerve Tibial SNRPC 0.12 0.10 lasso 4 0.08 1.5e-06 -5.2 5.2 2.3e-07 -0.60 0.16 0.84 FALSE
21 GTEx Nerve Tibial C6orf106 0.11 0.07 enet 17 0.07 1.3e-05 -5.9 -5.5 3.9e-08 0.87 0.01 0.98 FALSE
22 GTEx Skin Sun Exposed Lower leg SNRPC 0.03 0.04 lasso 2 0.03 1.9e-03 -5.2 5.1 2.8e-07 -0.59 0.13 0.78 FALSE
23 GTEx Small Intestine Terminal Ileum UHRF1BP1 0.20 0.03 lasso 5 0.00 3.4e-01 -5.2 -5.3 1.0e-07 0.60 0.08 0.45 FALSE
24 GTEx Thyroid C6orf106 0.09 0.01 enet 29 0.01 1.1e-01 -5.6 -5.7 9.6e-09 0.72 0.02 0.77 FALSE
25 GTEx Uterus UHRF1BP1 0.20 0.03 lasso 4 0.07 1.8e-02 -5.2 -5.7 1.0e-08 0.72 0.07 0.41 FALSE
26 GTEx Vagina UHRF1BP1 0.31 0.05 lasso 8 0.04 5.0e-02 -5.2 -5.4 6.7e-08 0.58 0.07 0.60 FALSE
27 METSIM Adipose C6orf106 0.04 0.02 blup 381 0.02 7.7e-04 -4.8 -6.0 1.7e-09 0.59 0.06 0.87 FALSE
28 NTR Blood C6orf106 0.03 0.02 lasso 6 0.02 7.2e-07 -5.7 -6.3 3.7e-10 0.93 0.01 0.99 TRUE
29 YFS Blood SNRPC 0.02 0.03 lasso 5 0.02 3.0e-08 -5.1 5.3 1.1e-07 -0.63 0.09 0.91 FALSE
30 YFS Blood UHRF1BP1 0.18 0.34 enet 36 0.34 2.5e-117 -4.9 -5.4 7.4e-08 0.65 0.21 0.79 FALSE
31 The Cancer Genome Atlas Bladder Urothelial Carcinoma UHRF1BP1 0.03 0.04 lasso 3 0.04 1.7e-04 -5.2 -5.2 2.4e-07 0.60 0.03 0.90 FALSE
32 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SNRPC 0.06 0.07 lasso 2 0.07 6.7e-08 -5.2 5.2 1.7e-07 -0.60 0.02 0.98 FALSE
33 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma UHRF1BP1 0.18 0.28 lasso 5 0.27 1.0e-30 -5.2 -5.2 2.0e-07 0.62 0.03 0.97 FALSE
34 The Cancer Genome Atlas Brain Lower Grade Glioma C6orf106 0.04 0.05 lasso 4 0.03 8.1e-05 -5.6 -5.7 1.4e-08 0.95 0.02 0.98 FALSE
35 The Cancer Genome Atlas Lung Adenocarcinoma C6orf106 0.03 0.03 lasso 3 0.01 7.6e-03 -4.8 -5.8 7.7e-09 0.77 0.02 0.82 FALSE