[Hub]/) : Traits : HDL Cholesterol : ← →

chr6:33,856,903-35,549,670

Best TWAS P=3.75e-10 · Best GWAS P=3.81e-09 conditioned to 0.829

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C6orf106	0.29	0.21	bslmm	382	0.23	6.9e-28	-5.6	-5.3	1.1e-07	0.79	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SNRPC	0.10	0.16	lasso	4	0.15	3.6e-18	-5.1	5.2	2.2e-07	-0.67	0.20	0.80	FALSE
3	CommonMind	Brain Pre-frontal Cortex	UHRF1BP1	0.17	0.23	lasso	19	0.22	5.8e-27	-5.3	-5.3	1.4e-07	0.60	0.20	0.80	FALSE
4	GTEx	Adipose Subcutaneous	UHRF1BP1	0.30	0.35	enet	28	0.36	1.6e-30	-5.2	-5.1	2.8e-07	0.59	0.19	0.81	FALSE
5	GTEx	Adipose Visceral Omentum	UHRF1BP1	0.30	0.34	lasso	3	0.34	3.0e-18	-5.1	-5.1	2.9e-07	0.60	0.17	0.82	FALSE
6	GTEx	Artery Aorta	UHRF1BP1	0.35	0.32	lasso	10	0.30	7.7e-17	-5.0	-5.1	2.9e-07	0.61	0.17	0.83	FALSE
7	GTEx	Artery Coronary	UHRF1BP1	0.33	0.36	lasso	2	0.35	1.6e-12	-5.2	-5.2	2.3e-07	0.59	0.20	0.80	FALSE
8	GTEx	Artery Tibial	SNRPC	0.06	0.06	lasso	4	0.05	1.3e-04	-5.1	5.3	1.4e-07	-0.63	0.13	0.86	FALSE
9	GTEx	Brain Caudate basal ganglia	SNRPC	0.19	0.15	lasso	3	0.06	7.7e-03	-5.1	5.4	7.7e-08	-0.65	0.14	0.70	FALSE
10	GTEx	Brain Cerebellar Hemisphere	UHRF1BP1	0.22	0.16	lasso	12	0.15	1.0e-04	-5.1	-5.3	1.1e-07	0.64	0.09	0.81	FALSE
11	GTEx	Brain Putamen basal ganglia	UHRF1BP1	0.20	0.17	lasso	2	0.16	1.5e-04	-5.4	-5.3	9.7e-08	0.61	0.11	0.61	FALSE
12	GTEx	Breast Mammary Tissue (Male)	UHRF1BP1	0.19	0.16	enet	24	0.08	5.6e-03	-5.4	-5.4	8.2e-08	0.61	0.12	0.75	FALSE
13	GTEx	Cells Transformed fibroblasts	UHRF1BP1	0.34	0.32	enet	44	0.31	2.4e-23	-5.2	-5.2	2.3e-07	0.64	0.19	0.81	FALSE
14	GTEx	Colon Transverse	UHRF1BP1	0.42	0.28	lasso	4	0.28	1.6e-13	-5.1	-5.9	4.7e-09	0.64	0.14	0.86	FALSE
15	GTEx	Esophagus Mucosa	UHRF1BP1	0.14	0.15	enet	28	0.17	1.3e-11	-5.3	-5.5	2.9e-08	0.66	0.14	0.86	FALSE
16	GTEx	Esophagus Mucosa	SNRPC	0.12	0.10	lasso	2	0.08	4.8e-06	-5.2	5.2	2.2e-07	-0.60	0.18	0.82	FALSE
17	GTEx	Esophagus Muscularis	SNRPC	0.09	0.11	lasso	3	0.07	3.8e-05	-5.2	5.2	2.3e-07	-0.60	0.15	0.85	FALSE
18	GTEx	Muscle Skeletal	SNRPC	0.03	0.02	lasso	3	0.02	8.3e-03	-5.1	5.6	2.1e-08	-0.71	0.07	0.81	FALSE
19	GTEx	Nerve Tibial	UHRF1BP1	0.31	0.31	lasso	6	0.31	3.9e-22	-5.2	-5.2	2.5e-07	0.59	0.17	0.83	FALSE
20	GTEx	Nerve Tibial	SNRPC	0.12	0.10	lasso	4	0.08	1.5e-06	-5.2	5.2	2.3e-07	-0.60	0.16	0.84	FALSE
21	GTEx	Nerve Tibial	C6orf106	0.11	0.07	enet	17	0.07	1.3e-05	-5.9	-5.5	3.9e-08	0.87	0.01	0.98	FALSE
22	GTEx	Skin Sun Exposed Lower leg	SNRPC	0.03	0.04	lasso	2	0.03	1.9e-03	-5.2	5.1	2.8e-07	-0.59	0.13	0.78	FALSE
23	GTEx	Small Intestine Terminal Ileum	UHRF1BP1	0.20	0.03	lasso	5	0.00	3.4e-01	-5.2	-5.3	1.0e-07	0.60	0.08	0.45	FALSE
24	GTEx	Thyroid	C6orf106	0.09	0.01	enet	29	0.01	1.1e-01	-5.6	-5.7	9.6e-09	0.72	0.02	0.77	FALSE
25	GTEx	Uterus	UHRF1BP1	0.20	0.03	lasso	4	0.07	1.8e-02	-5.2	-5.7	1.0e-08	0.72	0.07	0.41	FALSE
26	GTEx	Vagina	UHRF1BP1	0.31	0.05	lasso	8	0.04	5.0e-02	-5.2	-5.4	6.7e-08	0.58	0.07	0.60	FALSE
27	METSIM	Adipose	C6orf106	0.04	0.02	blup	381	0.02	7.7e-04	-4.8	-6.0	1.7e-09	0.59	0.06	0.87	FALSE
28	NTR	Blood	C6orf106	0.03	0.02	lasso	6	0.02	7.2e-07	-5.7	-6.3	3.7e-10	0.93	0.01	0.99	TRUE
29	YFS	Blood	SNRPC	0.02	0.03	lasso	5	0.02	3.0e-08	-5.1	5.3	1.1e-07	-0.63	0.09	0.91	FALSE
30	YFS	Blood	UHRF1BP1	0.18	0.34	enet	36	0.34	2.5e-117	-4.9	-5.4	7.4e-08	0.65	0.21	0.79	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UHRF1BP1	0.03	0.04	lasso	3	0.04	1.7e-04	-5.2	-5.2	2.4e-07	0.60	0.03	0.90	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SNRPC	0.06	0.07	lasso	2	0.07	6.7e-08	-5.2	5.2	1.7e-07	-0.60	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UHRF1BP1	0.18	0.28	lasso	5	0.27	1.0e-30	-5.2	-5.2	2.0e-07	0.62	0.03	0.97	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	C6orf106	0.04	0.05	lasso	4	0.03	8.1e-05	-5.6	-5.7	1.4e-08	0.95	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	C6orf106	0.03	0.03	lasso	3	0.01	7.6e-03	-4.8	-5.8	7.7e-09	0.77	0.02	0.82	FALSE