Best TWAS P=4.31e-14 · Best GWAS P=1.33e-15 conditioned to 0.00775
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | KCTD9 | 0.23 | -0.01 | lasso | 6 | 0.00 | 3.8e-01 | 6.4 | 5.9 | 3.5e-09 | 0.70 | 0.08 | 0.24 | FALSE |
| 2 | GTEx | Muscle Skeletal | KCTD9 | 0.11 | 0.07 | lasso | 5 | 0.06 | 7.9e-07 | 6.7 | 6.3 | 2.2e-10 | 0.85 | 0.17 | 0.82 | FALSE |
| 3 | YFS | Blood | KCTD9 | 0.04 | 0.04 | lasso | 8 | 0.04 | 7.8e-12 | 6.4 | -6.3 | 2.3e-10 | -0.66 | 1.00 | 0.00 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | KCTD9 | 0.03 | 0.01 | blup | 75 | 0.01 | 1.1e-02 | 7.7 | 7.5 | 4.3e-14 | 0.92 | 0.02 | 0.71 | TRUE |
| 5 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GNRH1 | 0.09 | 0.05 | enet | 10 | 0.04 | 3.5e-03 | 6.2 | 5.7 | 1.5e-08 | 0.52 | 0.03 | 0.22 | FALSE |