Hub : Genes

KCTD9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2319	0.0882	3.0e-03	-0.008	NA	-0.004	NA	-0.002	8.4e-01	NA	4.9e-01	NA	3.8e-01
2	GTEx	Brain Cerebellar Hemisphere	0.2930	0.1040	5.5e-03	0.003	NA	-0.010	NA	0.009	2.7e-01	NA	7.3e-01	NA	1.8e-01
3	GTEx	Muscle Skeletal	0.1074	0.0315	4.2e-06	0.067	NA	0.056	NA	0.063	3.5e-07	NA	3.3e-06	NA	7.9e-07
4	YFS	Blood	0.0410	0.0120	2.0e-08	0.038	0.025	0.031	0.034	0.036	2.0e-12	9.7e-09	1.9e-10	2.1e-11	7.8e-12
5	TCGA	Lung Adenocarcinoma	0.0271	0.0189	5.6e-03	0.011	0.013	0.011	NA	0.003	1.5e-02	1.1e-02	1.8e-02	NA	1.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	3.5	5.6	10.1	3.2	0.3	2.4	-1.7	3.0
Bipolar Disorder or Schizophrenia	0.6	1.4	3.0	1.6	-0.0	1.2	-0.4	1.7
Depressed Affect (Nagel 2018)	0.9	2.0	3.6	-1.7	-1.9	-1.2	1.0	-0.8
Depression (Nagel 2018)	0.5	0.8	2.4	-0.4	-1.6	-0.9	0.4	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.4	5.3	-0.1	-0.6	-0.6	0.9	-2.3
Neuroticism (Nagel 2018)	0.3	0.8	2.5	-0.4	-1.6	-0.6	0.6	-0.7
Schizophrenia (2018)	0.1	0.3	0.9	-0.5	-0.3	-0.4	0.9	-0.2
Schizophrenia vs Biploar Disorder	3.4	4.5	7.0	-2.4	-1.6	-2.0	1.8	-2.6
Worry (Nagel 2018)	0.2	0.4	1.4	0.5	-1.2	-0.3	0.2	-0.2
Alzheimer’s Disease (in mother)	1.0	1.2	2.1	1.4	1.0	1.2	-1.2	0.2
Alzheimer’s Disease (in father)	0.4	0.4	1.1	0.9	-0.3	0.0	-1.0	0.1
Alzheimer’s Disease (including proxy)	1.1	1.6	3.3	1.8	-0.0	1.2	-1.6	0.6
Crohns Disease (2017)	1.7	3.8	7.4	2.7	-0.4	1.4	-2.6	1.8
Irritable Bowel Disease (IBD)	3.8	9.1	16.5	4.1	0.3	2.8	-3.9	2.5
Ulcerative Colitis (UC)	3.2	5.9	10.2	3.2	0.3	2.6	-3.0	2.0
Major Depression (MDD)	0.6	0.8	2.0	-0.9	-0.9	-0.3	0.5	-1.4
Reaction Time	0.1	0.3	0.6	-0.8	0.0	-0.3	-0.4	-0.7
Verbal and Numeric Reasoning (VNR)	1.3	3.1	7.9	-1.2	-1.0	-1.7	1.4	-2.8
Breast Cancer	0.3	0.8	1.3	-1.2	0.2	-1.0	1.1	-0.6
Ovarian Cancer	1.2	1.6	2.6	0.6	1.5	1.3	-1.0	1.6
Prostate Cancer	3.8	5.4	9.5	-3.1	1.2	-2.5	1.9	-2.4
Age at First Birth	0.1	0.1	0.2	-0.5	0.2	-0.2	0.3	0.1
Bipolar Disorder (2011)	0.8	0.8	3.2	0.4	0.1	0.7	0.3	1.8
Body Mass Index (BMI) (2010)	3.5	4.7	7.8	-2.8	-0.7	-2.7	2.1	-1.9
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.2	-0.5	-0.5	-0.3	0.1
Crohns Disease (2012)	1.5	2.5	4.7	2.2	0.1	1.0	-2.2	1.4
Mean Putamen Volume	0.2	0.3	0.4	-0.5	0.6	-0.3	-0.5	0.6
Fasting Glucose	0.5	0.6	1.7	0.1	0.8	0.3	-0.7	1.3
HbA1C	1.1	1.2	2.8	1.1	-0.8	1.7	-0.8	0.9
HDL Cholesterol	0.1	0.2	0.5	0.6	0.1	0.4	-0.7	0.4
LDL Cholesterol	1.7	2.6	4.1	1.8	0.8	1.9	-2.0	1.3
Lupus	0.9	1.4	2.9	-1.7	-0.4	-1.3	0.8	-1.2
Neuroticism (2016)	0.4	0.5	1.8	0.7	0.4	1.3	0.1	0.5
Primary Biliary Cirrhosis	0.2	0.3	0.9	-0.9	0.2	-0.4	0.6	-0.4
Rheumatoid Arthritis	0.6	0.9	3.9	0.1	2.0	0.2	-0.0	0.6
Schizophrenia (2014)	0.1	0.1	0.4	0.5	-0.0	0.1	0.6	0.2
Triglycerides	0.2	0.3	0.7	-0.5	0.4	-0.5	-0.1	0.9
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.4	-0.5	-0.3	0.2	-0.4
Ulcerative Colitis	4.3	6.3	10.2	3.2	0.9	2.6	-3.0	2.1
Blood Eosinophil Count	0.1	0.6	1.8	-0.6	-1.3	-0.5	0.6	-0.5
Blood Platelet Count	0.4	5.1	10.0	2.1	-1.0	3.2	-2.6	1.8
Blood Red Count	0.0	0.4	0.7	-0.2	-0.1	0.8	-0.8	0.7
Blood White Count	0.2	1.6	4.4	1.1	0.8	1.1	-2.1	0.7
Heel T-Score	4.8	37.8	57.0	5.9	4.1	6.3	-6.3	7.5
BMI	0.2	1.2	3.2	-0.9	1.8	0.6	0.4	1.1
Height	5.2	99.3	163.8	-9.5	-4.4	-11.6	9.4	-12.8
Waist Hip Ratio (WHR)	0.8	3.8	11.4	-0.3	2.3	3.4	-1.5	-0.1
Systolic Blood Pressure	0.2	1.1	3.6	-1.9	-0.6	-0.6	0.7	-0.9
Smoking Status	0.9	2.3	4.1	-1.9	-0.7	-2.0	0.9	-1.6
Allergy or Eczema	0.1	0.3	0.9	0.9	-0.1	0.5	0.4	0.3
Cardiovascular Disease	0.6	2.1	5.9	-1.9	-2.4	-0.7	-0.2	-0.8
Hypothyroidism (self reported)	2.0	4.7	8.8	2.8	0.8	1.7	-3.0	1.9
Respiratory disease	0.5	1.1	2.0	-1.1	1.0	-0.9	1.4	-0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	-0.2	-0.6	0.2	0.3	0.4
Lung FEV1/FVC ratio	1.3	6.4	11.8	-2.9	-1.0	-2.6	2.0	-3.4
Lung FVC	0.3	1.8	5.9	2.4	-1.1	1.0	-0.4	0.8
Neuroticism	0.5	1.3	4.0	-0.9	-2.0	-0.8	0.9	-0.6
Chronotype (morning person)	0.3	0.6	1.7	-0.4	-0.9	-0.3	0.3	-1.3
Hair Pigment	0.1	2.1	3.3	-1.7	-0.2	-1.8	1.6	-1.3
Tanning	0.0	0.3	1.2	0.1	0.3	0.0	-1.1	-0.6
Hand grip strength (left)	0.2	0.6	1.9	0.8	0.5	-0.2	-0.1	1.4
Number of treatments/medications taken	0.3	0.5	2.2	-1.5	0.4	-0.1	0.0	-0.1
Average weekly spirits intake	0.7	0.9	2.1	-1.4	-0.5	-1.1	1.0	-0.4
Sensitivity / hurt feelings	0.1	0.2	0.6	0.4	-0.8	0.4	-0.3	0.2
Frequency of depressed mood in last 2 weeks	2.6	3.6	5.8	-2.4	-1.6	-2.0	2.0	-1.2
Hearing difficulty/problems: Yes	1.4	2.1	3.9	-1.3	-1.8	-0.8	2.0	-1.0
Relative age of first facial hair	1.8	3.7	8.4	-1.4	-1.1	-2.1	1.6	-2.9
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	4.9	0.8	0.9	1.8	-0.7	2.2
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.3	0.3	-1.5	-1.3	0.2	-1.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.5	-0.6	0.2	0.2	0.5
Systolic blood pressure, automated reading	0.8	2.2	4.6	-2.1	-0.6	-1.3	2.1	-0.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.8	-0.6	-1.3	-0.8	0.2	-1.3
Angina	0.6	0.8	2.3	-1.5	-0.8	0.3	0.7	0.7
Medication for hormone replacement therapy	0.1	0.1	0.2	0.1	-0.2	-0.3	-0.2	0.5
Vitamin and mineral supplements	0.9	1.3	2.1	1.4	-1.1	0.9	-1.4	0.6
Supplements: Zinc	0.5	0.6	1.3	-0.7	-0.2	-0.6	0.8	-1.2
Medication: Co-codamol	0.2	0.2	0.6	-0.1	0.3	0.7	-0.2	0.8
Medication: Metformin	0.1	0.1	0.3	0.1	-0.6	-0.0	0.3	0.4
Diabetes (father)	1.2	1.4	3.3	1.2	0.9	0.7	-1.8	0.9
Diabetes (mother)	0.5	0.7	2.4	0.3	-0.5	0.1	-1.6	0.7
Severe depression (siblings)	0.3	0.3	0.8	0.7	-0.2	0.2	-0.9	0.5
Pack years adult smoking proportion	0.2	0.4	1.5	-1.2	-0.2	-0.4	-0.2	0.1
Impedance of leg (right)	0.5	2.5	6.2	-2.5	-1.3	-1.0	1.1	-1.5
Leg fat-free mass (left)	2.1	11.2	18.6	-3.2	-0.7	-3.8	3.5	-4.3
Trunk fat percentage	0.6	2.4	4.7	-2.2	1.5	-1.2	1.4	-1.2
Hand grip strength (right)	0.3	0.9	2.0	1.4	0.7	0.6	-0.3	1.4
Townsend deprivation index at recruitment	2.4	3.4	5.2	-2.2	-0.9	-1.9	1.5	-2.3
Current tobacco smoking	1.2	1.9	7.1	-2.7	-0.5	-1.2	0.5	-0.8
Average weekly fortified wine intake	1.6	1.8	3.7	1.9	-0.8	1.9	-0.9	0.7
Maternal smoking around birth	1.6	2.3	3.8	-1.4	-1.5	-1.7	0.9	-1.9
Fed-up feelings	1.2	2.3	4.7	-2.2	-1.0	-1.6	1.3	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.8	0.6	-0.9	0.6	-1.3	0.5
Relative age voice broke	0.1	0.2	0.5	-0.0	0.4	-0.2	0.6	-0.7
Taking other prescription medications	0.2	0.4	0.9	-0.2	1.0	0.5	-0.2	0.7
Age when periods started (menarche)	0.3	0.8	1.5	-0.6	1.2	-0.9	0.7	-0.9
Bilateral oophorectomy (both ovaries removed)	1.9	2.3	2.5	-1.5	-1.4	-1.5	1.6	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.4	13.5	2.4	1.3	2.3	-2.3	3.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.3	-0.2	1.5	0.5	0.1	0.7
Qualifications: CSEs or equivalent	0.6	0.8	2.1	0.7	1.4	1.1	0.2	0.2
Serious illness, injury or assault to yourself	1.5	1.8	3.0	-1.7	0.8	-1.5	1.6	-0.9
High blood pressure	0.5	1.3	3.5	-1.4	-1.9	-0.4	-0.2	-1.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.8	0.0	-1.0	-0.2	1.4	0.0
Multivitamins +/- minerals	0.8	1.0	4.6	-0.5	2.2	0.5	0.1	0.2
Stomach or abdominal pain in last month	2.0	2.5	6.2	-2.1	-0.1	-1.3	2.5	-0.3
Supplements: Glucosamine	0.8	1.1	2.1	0.4	1.3	1.1	0.6	1.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.4	-1.5	-0.4	-0.6	0.5	-0.9
Medication: Atenolol	0.3	0.4	1.5	-1.2	-0.6	0.0	0.4	0.2
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.6	-0.1	-0.4	-0.4	-0.5
Sitting height	3.5	25.1	37.9	-4.5	-2.7	-5.9	5.0	-6.2
Chronic bronchitis/emphysema (father)	2.6	3.0	5.9	2.1	-0.1	2.4	-0.8	2.0
High blood pressure (mother)	0.8	1.2	2.9	1.5	-0.2	1.7	-0.7	0.5
Body mass index (BMI)	0.2	1.0	2.5	-1.4	1.6	-0.4	0.8	-0.0
Impedance of leg (left)	0.3	1.4	4.0	-2.0	-1.0	-0.6	0.8	-0.9
Leg predicted mass (left)	2.2	11.4	19.0	-3.2	-0.7	-3.9	3.5	-4.4
Trunk fat mass	1.7	7.1	11.7	-3.4	0.7	-2.8	2.8	-2.8
Waist circumference	0.7	2.5	6.6	-2.6	1.3	-0.6	1.5	-1.3
Number of incorrect matches in round	0.2	0.3	0.7	0.6	0.0	0.4	-0.8	0.7
Past tobacco smoking	1.3	2.4	3.6	1.3	1.1	1.9	-1.6	1.8
Alcohol usually taken with meals	0.3	0.5	1.2	0.4	0.1	1.1	0.9	-0.6
Nervous feelings	0.6	1.1	1.6	-1.0	-0.8	-1.0	1.3	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	3.1	-1.8	-1.7	-1.3	1.7	-1.0
Hearing difficulty/problems with background noise	0.5	0.7	1.5	-0.6	-1.2	0.1	1.2	-0.6
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	0.2	-0.0	-0.7	0.2	-0.7
Had menopause	0.7	0.9	1.6	0.9	-1.3	1.1	-0.7	0.7
Had other major operations	0.2	0.3	0.7	-0.5	-0.8	-0.4	0.2	-0.3
Forced vital capacity (FVC)	0.5	1.8	3.8	-0.3	-0.8	-1.6	1.4	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	4.2	9.6	16.1	3.0	2.1	3.1	-3.0	4.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.8	0.7	-0.9	0.6	-0.4	0.6
Qualifications: None of the above	0.2	0.5	2.3	0.3	-0.3	0.1	-1.5	-0.0
Financial difficulties in last 2 years	0.3	0.3	1.0	-1.0	-0.3	-0.4	0.5	-0.5
Mouth/teeth dental problems	0.3	0.4	0.8	-0.7	0.8	0.2	0.9	-0.1
Heart attack	2.8	3.5	5.4	-2.3	-1.7	-1.0	1.8	-2.3
Allergy	0.3	0.6	2.2	0.4	0.0	-0.2	-1.5	-0.8
Pain all over the body in last month	1.1	1.2	2.3	-0.1	-1.1	-1.4	0.5	-1.5
Diabetes (self-reported)	0.2	0.3	0.8	0.3	-0.9	0.6	-0.4	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	0.2	0.3	0.8	0.5	-0.3
Medication: Ramipril	0.5	0.7	2.0	-0.8	0.4	-0.7	0.5	-1.4
Medication: Simvastatin	1.1	1.6	7.4	-0.5	-2.7	0.0	-0.5	0.1
Fluid intelligence score	0.3	0.6	1.2	-0.7	0.1	-0.9	0.9	-1.1
Illnesses of siblings	0.2	0.3	0.7	0.8	0.2	0.8	0.1	0.2
Neuroticism score	0.6	1.2	2.0	-1.0	-1.1	-1.4	0.9	-1.0
Weight	2.3	11.3	15.6	-3.9	-0.2	-3.7	3.4	-4.0
Impedance of arm (right)	0.8	3.6	6.8	2.3	0.1	2.6	-2.2	1.1
Arm fat percentage (right)	0.2	0.9	3.7	-0.5	1.9	0.4	-0.2	0.5
Trunk fat-free mass	4.4	25.2	36.8	-4.9	-2.2	-6.0	5.0	-6.1
Hip circumference	1.6	6.9	10.6	-3.1	0.1	-3.3	2.9	-2.3
Time employed in main current job	0.3	0.4	1.2	0.5	-0.3	0.6	0.1	1.1
Alcohol intake versus 10 years previously	0.3	0.5	1.5	-0.9	-1.2	-0.3	0.1	-0.2
Father’s age at death	2.6	3.4	7.2	1.6	1.8	1.5	-1.4	2.7
Worrier / anxious feelings	0.2	0.3	1.3	0.1	0.1	0.3	0.0	1.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.5	-2.1	0.2	-1.5	0.8	-0.6
Falls in the last year	0.6	0.8	2.3	-0.8	1.5	0.8	0.5	0.1
Hair/balding pattern: Pattern 3	0.7	1.1	2.9	0.7	-0.1	1.2	-0.8	1.7
Number of live births	2.3	3.2	3.8	1.6	2.0	1.9	-1.8	1.7
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	8.6	-1.4	-1.4	-2.1	2.3	-2.9
Pulse rate	1.1	1.9	5.6	0.0	2.4	1.1	-0.4	1.6
Happiness	1.0	1.2	3.5	0.1	-1.9	-0.5	-0.5	-1.4
Noisy workplace	0.3	0.4	1.2	-1.1	-0.1	0.1	-0.3	0.7
Qualifications: A levels/AS levels or equivalent	1.9	4.3	8.2	2.1	1.6	2.2	-1.1	2.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.9	0.1	-0.9	-0.0	-0.0	-0.4
Mouth/teeth dental problems: Dentures	0.9	1.5	4.4	0.5	-2.1	-0.1	-1.7	-0.2
Asthma	1.1	2.1	4.1	-1.8	0.8	-1.2	2.0	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.5	1.1	0.6	0.8	-1.2	0.2
Medication: Cholesterol lowering	0.3	0.5	1.9	-0.7	-1.4	-0.2	-0.4	-0.1
Depression (self-reported)	1.0	1.2	4.6	0.7	2.1	0.2	-0.8	0.4
Medication: Lansoprazole	2.6	2.9	5.0	-2.2	-0.8	-1.6	2.2	-1.2
Prospective memory result	0.3	0.4	0.9	-1.0	0.2	-0.4	0.3	0.8
Lung cancer (father)	0.7	0.8	2.0	-1.4	-0.5	-1.0	0.7	-0.6
Illnesses of mother	1.4	1.7	3.6	-1.4	-0.1	-1.9	1.1	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.9	7.3	-1.9	-1.1	-2.3	2.7	-2.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.6	0.4	0.4	-0.5	-0.3
Impedance of arm (left)	0.7	3.3	5.9	2.2	0.5	2.4	-2.0	1.2
Arm fat mass (right)	0.6	2.6	4.4	-2.1	1.0	-1.5	1.7	-1.5
Trunk predicted mass	4.7	26.8	38.8	-5.0	-2.3	-6.1	5.2	-6.2
Standing height	4.6	45.3	77.2	-6.0	-3.6	-7.7	6.4	-8.8
Length of working week for main job	0.4	0.5	1.8	-0.0	-1.4	0.2	0.4	0.6
Exposure to tobacco smoke at home	1.8	2.0	8.7	-0.5	3.0	0.1	0.1	0.9
Breastfed as a baby	0.1	0.2	0.3	-0.6	0.3	-0.3	0.5	-0.4
Tense / ‘highly strung’	0.4	0.7	2.1	0.5	0.4	0.7	0.7	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.5	-0.8	0.6	-0.5	1.2	-0.6
Hair/balding pattern: Pattern 4	0.2	0.6	1.5	-1.2	-0.1	-1.0	0.5	-0.0
Birth weight of first child	0.4	0.8	2.3	0.1	-0.1	-1.3	0.0	-1.5
Peak expiratory flow (PEF)	2.6	6.1	11.1	-2.1	-1.9	-2.1	2.7	-3.3
Pulse wave reflection index	1.3	1.6	3.7	-0.4	-1.7	-1.0	-0.4	-1.9
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	0.3	0.1	-0.4	-0.8	0.7
Loud music exposure frequency	0.3	0.4	0.8	0.1	0.5	-0.9	0.7	-0.5
Qualifications: O levels/GCSEs or equivalent	1.7	2.6	5.1	1.2	1.9	1.8	-0.1	2.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.7	-0.5	0.4	0.2	0.6
Blood clot in the leg (DVT)	1.5	1.9	3.6	0.8	-0.7	1.9	-1.2	1.9
Medication: Paracetamol	0.4	0.6	1.6	-0.3	1.0	1.2	-0.6	0.4
Headache pain in last month	0.7	1.1	3.8	-0.8	2.0	0.1	0.3	1.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	2.7	1.5	1.6	1.6	-0.5	1.2
Glaucoma (self-reported)	0.1	0.2	0.7	0.1	0.1	-0.0	0.3	0.9
Gout (self-reported)	0.4	0.5	1.2	-1.1	-0.3	-0.3	0.9	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.7	0.8	-0.1	-0.3	-0.8	0.5
Medication: Amlodipine	0.8	1.1	1.6	-0.9	-1.3	-1.3	0.2	-1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.2	0.9	0.1	-0.7	0.6
Birth weight	1.5	3.3	6.0	-1.6	-1.0	-2.3	1.3	-2.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.4	-0.8	-0.6	-1.0	1.2	-0.9
High blood pressure (siblings)	0.4	0.6	1.4	-1.2	-0.9	-0.8	0.4	-0.1
Forced vital capacity (FVC), Best measure	0.7	2.5	4.3	-1.0	-1.0	-1.7	2.1	-1.8
Body fat percentage	0.5	2.1	4.9	-2.2	1.4	-1.1	1.2	-1.0
Leg fat percentage (right)	1.0	3.7	11.1	-3.3	0.9	-1.6	1.6	-1.2
Arm fat-free mass (right)	4.8	24.7	34.1	-5.2	-1.8	-5.6	5.2	-5.8
Exposure to tobacco smoke outside home	0.4	0.6	2.1	-1.4	0.6	-0.4	0.3	0.3
Comparative body size at age 10	0.5	1.5	2.3	-1.3	1.5	-1.4	-0.5	-1.1
Number of full brothers	0.3	0.4	0.7	0.0	0.9	0.7	-0.9	0.2
Worry too long after embarrassment	1.8	3.0	8.3	-1.1	-1.3	-1.6	1.2	-2.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	3.3	1.8	0.3	1.3	-1.1	0.7
Wheeze or whistling in the chest in last year	1.3	2.3	3.9	-2.0	1.9	-1.3	1.4	-0.0
Number of children fathered	1.9	2.1	2.7	1.5	1.7	1.2	-1.2	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.3	1.2	0.1	1.1	-0.8	0.9
Age at first live birth	0.3	0.5	1.0	-1.0	0.8	-0.4	0.9	-0.1
Pulse wave peak to peak time	0.4	0.4	1.1	0.1	-0.3	-0.9	1.1	-0.2
Health satisfaction	1.4	1.8	3.0	-1.7	-0.4	-1.7	1.0	-1.4
Shortness of breath walking on level ground	1.7	2.1	4.8	0.4	1.3	1.7	-0.8	2.2
Qualifications: College or University degree	0.2	0.5	1.9	1.4	-0.2	0.4	0.6	0.5
Eye problems/disorders: None of the above	3.2	3.7	6.0	1.7	1.1	2.4	-2.5	1.6
Mouth/teeth dental problems: Loose teeth	2.7	3.2	5.5	-2.1	-0.8	-2.3	1.3	-1.9
Emphysema/chronic bronchitis	1.1	1.2	2.9	-0.0	1.7	0.5	-0.8	1.5
Medication for pain relief, constipation, heartburn	0.3	0.5	0.8	0.8	-0.4	-0.9	0.7	-0.7
Neck or shoulder pain in last month	0.5	0.8	1.9	-0.5	0.9	0.4	0.9	1.4
Medication: Blood pressure	1.2	2.2	3.2	-1.6	-1.7	-1.8	0.6	-1.4
Angina (self-reported)	0.5	0.7	1.7	-1.3	-0.7	0.5	0.6	0.8
Migraine (self-reported)	1.4	1.7	4.4	1.5	1.0	1.0	-2.1	-0.2
Medication: Ibuprofen	0.5	0.6	1.6	1.2	0.6	0.5	-0.9	0.0
Medication: Allopurinol	0.2	0.2	0.4	-0.5	0.0	0.6	0.5	-0.5
Medication: Omeprazole	2.5	3.0	6.6	-2.6	-0.4	-1.5	2.3	-0.9
Medication: Seretide 50 evohaler	0.2	0.3	0.8	0.1	-0.3	0.9	-0.6	0.0
Mean time to correctly identify matches	0.1	0.1	0.5	-0.1	0.0	-0.0	-0.7	-0.4
Heart disease (mother)	0.8	1.0	3.0	-0.5	-1.7	0.0	0.7	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	4.7	2.2	1.2	1.3	-1.8	1.4
Whole body fat mass	1.5	6.3	11.2	-3.3	0.6	-2.6	2.5	-2.6
Leg fat mass (right)	1.9	7.2	14.9	-3.9	0.3	-2.6	2.7	-2.6
Arm predicted mass (right)	5.1	26.1	34.9	-5.4	-1.9	-5.9	5.4	-5.9
Pulse rate, automated reading	0.2	0.5	1.1	-0.8	0.9	-1.0	0.4	0.1
Alcohol intake frequency.	0.0	0.1	0.3	0.0	-0.5	-0.0	-0.1	-0.5
Comparative height size at age 10	3.3	18.3	28.5	-5.0	-0.9	-5.3	3.7	-4.9
Number of full sisters	0.3	0.4	1.3	0.2	1.2	0.2	-0.6	0.4
Suffer from ‘nerves’	0.9	1.4	3.3	-0.7	-1.4	-0.9	0.9	-1.8
Overall health rating	0.6	1.2	4.4	-2.1	-1.0	-0.2	0.5	-0.6
Chest pain or discomfort	1.4	2.0	4.4	-2.1	1.9	-0.9	1.1	0.1
Had major operations	3.0	3.5	5.7	2.2	1.2	2.4	-2.4	0.1
Age at last live birth	0.9	1.3	3.0	1.0	1.7	1.2	-0.4	0.8
Family relationship satisfaction	1.2	1.5	3.5	1.8	0.1	0.8	-1.9	0.0
Leg pain on walking	0.4	0.5	1.0	-1.0	0.6	0.0	-0.1	1.0
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.7	6.3	-2.5	0.6	-1.2	2.3	-0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.5	0.6	-0.5	1.0	-0.9	1.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.2	1.8	-0.5	1.4	-1.5	0.0
Medication: Aspirin	0.3	0.4	1.1	-1.1	-0.4	0.3	-0.8	0.3
Supplements: Vitamin C	0.1	0.1	0.4	-0.5	0.0	0.1	0.7	-0.1
Knee pain experienced in last month	0.6	0.9	1.9	0.8	1.4	1.1	-0.8	-0.2
Hypertension (Self-reported)	0.6	1.8	3.8	-1.8	-1.9	-0.8	0.2	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-0.8	0.5	-0.5	1.0	-0.2
Illnesses of father: Heart disease	0.6	0.8	1.3	-0.9	-1.1	-0.9	0.6	-0.9
Illnesses of siblings: Diabetes	0.7	0.8	3.3	0.3	0.5	0.6	-1.8	0.6
Smoking status: Previous	1.0	1.4	2.4	-0.4	-0.9	-1.5	1.4	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	5.4	11.2	20.4	-3.0	-2.3	-3.7	2.9	-4.5
Whole body fat-free mass	3.5	19.9	30.1	-4.3	-1.6	-5.3	4.5	-5.5
Leg fat-free mass (right)	1.8	9.5	15.7	-2.7	-0.7	-3.6	3.3	-4.0
Arm fat percentage (left)	0.3	1.0	4.4	-0.5	2.1	0.3	-0.1	0.6
Average weekly red wine intake	0.7	1.1	2.4	-1.0	-0.5	-0.5	1.6	-1.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	0.5	0.0	0.4	-0.0	0.8
Mood swings	1.3	2.4	4.0	-2.0	-1.6	-1.8	1.5	-0.4
Loneliness, isolation	0.7	0.9	1.8	-1.0	-0.5	-1.2	0.4	-1.4
Long-standing illness, disability or infirmity	0.6	0.9	1.6	-0.6	0.9	1.3	-0.0	1.3
Ever had bowel cancer screening	0.1	0.1	0.3	0.6	-0.2	0.3	0.3	-0.4
Diabetes diagnosed by doctor	0.3	0.5	1.4	-0.6	-1.2	-0.5	0.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.6	5.2	-1.8	-2.3	-1.7	1.2	-2.3
Friendships satisfaction	0.2	0.2	1.0	-0.2	-0.1	0.0	0.0	-1.0
Qualifications: nursing, teaching	1.1	1.8	3.5	1.1	0.7	1.9	-0.7	1.8
Commuting to job workplace: Walk	0.9	1.0	2.9	0.0	-0.0	-1.2	0.7	-1.7
Eye problems/disorders: Cataract	0.5	0.5	1.2	-0.5	-0.1	-1.1	0.9	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.4	0.0	0.9	-0.4	1.2	0.0
Medication for cholesterol	0.9	1.3	3.5	1.6	1.9	0.3	-0.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.6	-0.5	0.4	-0.4	-0.2
Back pain experienced in last month	0.2	0.3	0.8	0.6	0.9	0.5	-0.6	0.2
Mineral and other dietary supplements	0.4	0.6	1.5	-0.5	-0.4	-0.9	-0.3	-1.2
Breast cancer (self-reported)	2.4	2.8	5.5	-2.1	-1.1	-1.7	2.4	-0.4
Asthma (self-reported)	0.9	1.9	3.5	-1.7	0.5	-1.4	1.9	-1.0
Osteoporosis (self-reported)	1.7	2.1	6.3	0.1	0.7	1.0	-1.6	2.5
Osteoarthritis (self-reported)	2.5	3.3	5.1	1.4	2.3	1.8	-1.6	1.9
Medication: Aspirin	0.3	0.4	1.3	-1.2	-0.3	0.1	-0.5	0.3
Medication: Gliclazide	0.6	0.6	2.8	-0.5	1.7	0.0	0.2	-0.3
Illnesses of father: None of the above (group 1)	1.3	1.6	2.8	-1.5	-0.3	-1.1	1.3	-1.7
Smoking status: Current	1.0	1.6	6.4	-2.5	-0.3	-1.0	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	1.9	-1.2	0.4	-1.2	1.4	-0.9
Whole body water mass	3.6	20.4	30.9	-4.3	-1.8	-5.3	4.6	-5.6
Leg predicted mass (right)	1.8	9.5	16.3	-2.8	-0.8	-3.5	3.3	-4.0
Arm fat mass (left)	0.8	3.1	5.3	-2.3	1.1	-1.7	1.9	-1.6
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	-0.1	0.2	0.8	-0.3	0.9
Average weekly champagne plus white wine intake	1.9	2.6	4.3	-1.2	-0.9	-1.8	1.9	-2.1
Miserableness	0.9	1.6	3.2	-1.8	-0.8	-1.2	1.3	-1.0
Guilty feelings	0.1	0.2	0.3	-0.5	0.3	-0.2	-0.1	-0.6
Wears glasses or contact lenses	1.1	1.2	2.4	-1.2	-0.0	-0.6	1.6	-1.4
Ever taken oral contraceptive pill	0.4	0.4	1.4	1.2	-0.1	0.6	-0.5	-0.1
Hearing aid user	0.1	0.1	0.2	-0.5	-0.0	-0.2	0.2	0.1
Mother’s age at death	1.1	1.4	3.5	1.3	-0.1	1.1	-1.9	0.8
Financial situation satisfaction	0.2	0.2	0.5	-0.5	0.4	-0.7	0.1	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.2	-0.7	0.3	0.5	0.1
Commuting to job workplace: Public transport	0.9	1.1	2.8	0.4	1.2	1.7	-0.7	0.7
Eye problems/disorders: Glaucoma	0.6	0.7	1.1	-0.8	0.6	-0.4	1.1	1.0
Medication: Blood pressure	0.3	0.6	2.7	-1.6	-0.3	0.6	0.1	-0.0
Pain type(s) experienced in last month: Hip pain	2.9	3.7	11.6	-1.2	3.4	0.8	0.7	2.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	0.7	0.0	0.8	0.3	0.8
High cholesterol (Self-reported)	0.9	1.6	5.8	-1.3	-2.4	0.1	-0.3	0.5
Medication: Bendroflumethiazide	0.5	0.7	2.6	-1.6	0.0	-0.4	-0.3	-0.9
Medication: Paracetamol	0.3	0.4	1.0	-0.5	1.0	0.8	-0.2	0.1
Medication: Lisinopril	0.3	0.4	1.7	-0.3	-1.3	-0.3	0.1	-0.3
Medication: Atorvastatin	0.1	0.1	0.3	-0.5	0.1	0.2	-0.1	0.5
Illnesses of father: High blood pressure	1.8	2.3	2.7	1.6	1.6	1.5	-1.6	1.1
Alcohol drinker status: Never	0.5	0.6	2.0	0.8	-1.4	0.6	-0.3	-0.2
Ever smoked	0.4	0.6	1.3	-0.7	0.0	-1.1	0.4	-1.1
Basal metabolic rate	3.3	18.1	26.9	-4.3	-1.2	-5.0	4.3	-5.2
Leg fat percentage (left)	0.9	3.1	9.4	-3.1	1.0	-1.4	1.5	-0.9
Arm fat-free mass (left)	4.4	22.5	30.2	-4.9	-1.8	-5.5	4.9	-5.5
Number of operations (self-reported)	1.9	2.7	6.0	2.5	0.2	1.9	-2.1	0.1
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.8	-0.3	-0.5	0.4	-0.8
Irritability	0.2	0.3	0.8	0.1	-0.7	0.1	0.9	0.1
Risk taking	0.6	0.8	2.8	-0.3	1.7	0.4	0.8	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	-0.1	0.3	-0.5	0.8	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	2.0	0.3	-0.8	-0.1	1.4	-0.2
Age started oral contraceptive pill	0.1	0.2	0.7	-0.0	-0.8	-0.0	0.3	0.0
Diastolic blood pressure, automated reading	0.4	1.2	3.3	-1.8	1.4	-0.4	0.8	0.1
Ever depressed for a whole week	0.3	0.4	1.6	-0.3	1.3	-0.5	0.3	-0.3
Unable to work because of sickness or disability	0.2	0.2	0.8	0.1	-0.1	0.9	-0.5	0.2
Commuting to job workplace: Cycle	2.0	2.4	4.8	-1.0	0.7	-1.9	2.2	-1.5
Myopia	0.3	0.5	0.9	-0.1	0.7	-0.1	1.0	0.9
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.5	1.6	2.1	0.5	-0.1	1.0
Cholesterol lowering medication	0.8	1.2	3.9	-0.5	-2.0	0.9	-0.6	0.8
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	4.8	-2.2	-0.4	-1.3	1.8	-0.7
Pain experienced in last month	0.5	0.8	3.3	0.1	-1.8	-0.3	-0.1	-0.6
Supplements: Calcium	0.6	0.7	1.7	0.0	1.1	0.8	-0.3	1.3
Basal cell carcinoma (self-reported)	1.2	1.4	4.0	-0.4	-2.0	-0.5	1.0	-1.2
Heart attack/myocardial infarction (self-reported)	3.4	4.5	6.5	-2.6	-1.8	-1.2	2.1	-2.6
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.8	0.9	-0.5	1.7	-1.4	1.9
Heart disease (siblings)	1.1	1.4	3.2	-1.8	0.2	-0.4	1.7	-0.8
Alcohol drinker status: Previous	0.1	0.1	0.4	-0.3	0.6	0.2	-0.0	0.5
Pack years of smoking	0.3	0.5	1.4	-1.2	-0.8	-0.5	-0.3	-0.4
Impedance of whole body	0.1	0.4	1.3	0.5	0.2	1.1	-0.8	0.2
Leg fat mass (left)	1.7	6.6	13.7	-3.7	0.4	-2.5	2.6	-2.4
Arm predicted mass (left)	4.5	22.9	31.0	-5.1	-1.7	-5.6	5.0	-5.5