[Hub]/) : Traits : Heel T-Score : ← →

chr10:130,566,749-132,459,060

Best TWAS P=9.65e-19 · Best GWAS P=1.33e-23 conditioned to 0.000109

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EBF3	0.12	0.05	bslmm	650	0.07	2.1e-09	-4.8	6.7	1.5e-11	-0.47	0.59	0.40	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MGMT	0.29	0.27	lasso	14	0.31	6.0e-38	-4.6	7.1	1.4e-12	-0.76	0.74	0.26	FALSE
3	GTEx	Adipose Subcutaneous	MGMT	0.39	0.27	enet	30	0.48	1.2e-44	-6.3	6.1	1.3e-09	-0.76	0.97	0.03	FALSE
4	GTEx	Adipose Visceral Omentum	MGMT	0.39	0.16	enet	11	0.24	9.1e-13	-4.8	6.4	1.3e-10	-0.77	0.91	0.09	FALSE
5	GTEx	Adrenal Gland	MGMT	0.39	0.25	lasso	6	0.30	1.5e-11	-4.6	6.3	2.1e-10	-0.72	0.69	0.31	FALSE
6	GTEx	Artery Aorta	MGMT	0.50	0.28	enet	60	0.37	1.2e-21	-4.6	5.2	1.6e-07	-0.66	0.93	0.07	FALSE
7	GTEx	Artery Tibial	MGMT	0.42	0.30	enet	22	0.46	1.9e-40	-9.6	7.0	3.2e-12	-0.81	0.17	0.83	FALSE
8	GTEx	Brain Cerebellar Hemisphere	MGMT	0.53	0.15	lasso	8	0.19	1.3e-05	-4.6	5.9	4.6e-09	-0.69	0.24	0.40	FALSE
9	GTEx	Brain Cerebellum	EBF3	0.23	0.11	lasso	4	0.05	1.2e-02	-5.1	5.8	8.1e-09	-0.15	0.13	0.25	TRUE
10	GTEx	Brain Cerebellum	MGMT	0.38	0.17	enet	18	0.27	1.1e-08	-6.3	7.4	1.1e-13	-0.81	0.02	0.98	FALSE
11	GTEx	Brain Frontal Cortex BA9	MGMT	0.29	0.15	lasso	5	0.16	6.8e-05	5.0	5.3	9.3e-08	-0.68	0.13	0.60	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	MGMT	0.32	0.29	lasso	1	0.21	2.4e-06	-6.3	6.3	3.9e-10	-0.82	0.06	0.90	FALSE
13	GTEx	Breast Mammary Tissue	MGMT	0.60	0.21	enet	13	0.33	1.6e-17	-4.8	7.2	4.6e-13	-0.78	0.82	0.18	FALSE
14	GTEx	Breast Mammary Tissue (Female)	MGMT	0.46	0.31	lasso	4	0.33	1.1e-10	-4.8	6.7	2.1e-11	-0.77	0.18	0.80	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	MGMT	0.57	0.03	lasso	22	0.20	3.4e-07	-4.5	7.0	2.9e-12	-0.77	0.06	0.93	FALSE
16	GTEx	Cells Transformed fibroblasts	MGMT	0.45	0.30	enet	31	0.42	4.8e-34	-6.3	7.0	1.9e-12	-0.81	0.97	0.03	FALSE
17	GTEx	Colon Sigmoid	MGMT	0.55	0.21	enet	29	0.29	9.1e-11	-4.8	6.6	3.6e-11	-0.66	0.28	0.71	FALSE
18	GTEx	Colon Transverse	MGMT	0.47	0.24	enet	58	0.35	1.6e-17	-4.8	5.5	5.1e-08	-0.72	0.09	0.91	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	MGMT	0.34	0.31	lasso	6	0.28	9.8e-11	-9.6	8.6	1.1e-17	-0.82	0.12	0.88	FALSE
20	GTEx	Esophagus Muscularis	MGMT	0.50	0.29	enet	40	0.34	3.4e-21	-4.8	6.4	1.5e-10	-0.70	0.96	0.04	FALSE
21	GTEx	Heart Atrial Appendage	MGMT	0.41	0.17	enet	33	0.22	4.6e-10	-4.8	8.0	1.1e-15	-0.77	0.13	0.87	FALSE
22	GTEx	Heart Left Ventricle	MGMT	0.27	0.20	lasso	7	0.22	6.3e-12	-4.8	5.7	1.0e-08	-0.72	0.59	0.41	FALSE
23	GTEx	Liver	MGMT	0.46	0.39	lasso	4	0.42	8.2e-13	-4.8	6.0	2.3e-09	-0.79	0.68	0.31	FALSE
24	GTEx	Lung	MGMT	0.39	0.24	enet	28	0.33	5.5e-26	-4.8	6.5	7.4e-11	-0.75	0.78	0.22	FALSE
25	GTEx	Muscle Skeletal	MGMT	0.30	0.15	lasso	7	0.27	2.0e-26	-6.3	6.5	7.5e-11	-0.78	0.77	0.23	FALSE
26	GTEx	Nerve Tibial	MGMT	0.50	0.23	enet	46	0.42	6.9e-32	-6.3	7.4	1.6e-13	-0.80	0.14	0.86	FALSE
27	GTEx	Ovary	MGMT	0.52	0.09	enet	59	0.12	8.6e-04	-6.3	6.0	2.5e-09	-0.65	0.05	0.90	FALSE
28	GTEx	Pancreas	MGMT	0.32	0.03	lasso	7	0.17	8.0e-08	-4.8	5.4	6.1e-08	-0.59	0.32	0.55	FALSE
29	GTEx	Pituitary	MGMT	0.40	0.19	enet	9	0.23	1.9e-06	-6.3	6.8	7.3e-12	-0.87	0.01	0.98	FALSE
30	GTEx	Prostate	MGMT	0.25	0.13	lasso	4	0.20	9.4e-06	-4.6	7.5	9.5e-14	-0.81	0.02	0.94	FALSE
31	GTEx	Skin Sun Exposed Lower leg	MGMT	0.45	0.30	enet	42	0.46	1.6e-41	-9.6	7.3	2.2e-13	-0.79	0.21	0.79	FALSE
32	GTEx	Small Intestine Terminal Ileum	MGMT	0.31	0.14	enet	11	0.21	1.6e-05	-9.6	7.8	4.7e-15	-0.82	0.05	0.86	FALSE
33	GTEx	Spleen	MGMT	0.49	0.15	enet	53	0.04	4.1e-02	-9.6	5.8	6.6e-09	-0.73	0.03	0.91	FALSE
34	GTEx	Stomach	MGMT	0.33	0.20	enet	9	0.25	2.3e-12	-6.4	6.6	3.4e-11	-0.75	0.82	0.18	FALSE
35	GTEx	Thyroid	MGMT	0.44	0.35	lasso	11	0.43	1.9e-35	-4.6	6.2	4.5e-10	-0.75	1.00	0.00	FALSE
36	GTEx	Vagina	MGMT	0.33	0.23	lasso	4	0.24	3.3e-06	-6.3	7.8	4.6e-15	-0.86	0.06	0.82	FALSE
37	METSIM	Adipose	MGMT	0.18	0.11	lasso	9	0.18	1.5e-25	-9.9	8.2	2.8e-16	-0.87	0.01	0.99	FALSE
38	NTR	Blood	MGMT	0.08	0.07	lasso	8	0.08	3.7e-24	-4.8	7.4	1.3e-13	-0.82	1.00	0.00	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	MGMT	0.41	0.38	enet	46	0.48	3.6e-69	-4.8	6.0	1.5e-09	-0.76	1.00	0.00	FALSE
40	YFS	Blood	MGMT	0.50	0.40	enet	94	0.55	1.6e-218	-4.8	6.7	1.6e-11	-0.70	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	MGMT	0.16	0.17	enet	22	0.21	2.4e-41	-4.8	6.4	2.0e-10	-0.75	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MGMT	0.18	0.03	blup	239	0.12	2.3e-06	-4.8	6.2	7.9e-10	-0.72	0.11	0.87	FALSE
43	The Cancer Genome Atlas	Colon Adenocarcinoma	MGMT	0.24	0.09	blup	238	0.14	2.3e-08	-9.6	7.7	1.9e-14	-0.73	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MGMT	0.10	0.09	enet	23	0.10	1.9e-11	-6.3	5.6	2.2e-08	-0.76	0.84	0.16	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MGMT	0.26	0.32	lasso	10	0.37	2.9e-43	-4.7	6.8	8.2e-12	-0.78	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MGMT	0.40	0.24	enet	29	0.37	1.9e-22	-4.7	6.7	3.0e-11	-0.72	0.92	0.08	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	MGMT	0.13	0.07	lasso	5	0.10	2.4e-11	-4.8	7.3	2.3e-13	-0.78	0.17	0.83	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	MGMT	0.11	0.07	enet	16	0.14	2.8e-16	-4.8	7.5	7.1e-14	-0.86	0.02	0.98	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MGMT	0.09	0.09	enet	9	0.09	8.4e-11	5.0	5.3	1.3e-07	-0.69	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MGMT	0.30	0.12	enet	30	0.22	2.0e-09	5.1	6.9	4.8e-12	-0.75	0.27	0.73	FALSE
51	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MGMT	0.27	0.24	lasso	7	0.19	3.3e-08	-8.5	8.5	1.8e-17	-0.79	0.13	0.87	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	MGMT	0.39	0.31	enet	60	0.35	1.8e-37	-4.8	5.7	1.5e-08	-0.71	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Rectum Adenocarcinoma	MGMT	0.39	-0.01	blup	239	0.09	4.0e-03	1.9	6.0	2.0e-09	-0.44	0.03	0.23	FALSE
54	The Cancer Genome Atlas	Soft Tissue Sarcoma	MGMT	0.14	0.05	blup	235	0.11	5.4e-07	-9.6	8.8	9.7e-19	-0.75	0.08	0.91	TRUE
55	The Cancer Genome Atlas	Stomach Adenocarcinoma	MGMT	0.15	0.08	lasso	4	0.10	7.5e-08	-4.8	6.7	2.2e-11	-0.78	0.22	0.78	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	MGMT	0.48	0.37	enet	52	0.48	2.0e-52	-4.8	6.2	6.8e-10	-0.73	1.00	0.00	FALSE