Best TWAS P=6.1e-19 · Best GWAS P=2.75e-28 conditioned to 0.926
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | HTR7P1 | 0.39 | 0.24 | enet | 44 | 0.35 | 4.2e-44 | 2.6 | -5.3 | 1.4e-07 | -0.24 | 1.00 | 0.00 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | KIAA1467 | 0.08 | 0.09 | lasso | 2 | 0.08 | 2.6e-10 | 6.3 | -6.4 | 2.0e-10 | -0.09 | 1.00 | 0.00 | FALSE |
3 | GTEx | Breast Mammary Tissue (Female) | KIAA1467 | 0.48 | -0.01 | lasso | 23 | 0.00 | 3.6e-01 | 1.2 | 6.4 | 1.2e-10 | 0.12 | 0.07 | 0.05 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | LRP6 | 0.27 | 0.15 | enet | 16 | 0.20 | 5.5e-15 | 9.6 | 6.7 | 2.2e-11 | 0.10 | 0.08 | 0.92 | TRUE |
5 | GTEx | Cells Transformed fibroblasts | HTR7P1 | 0.45 | 0.33 | enet | 29 | 0.40 | 2.2e-31 | 2.7 | -5.9 | 3.5e-09 | -0.25 | 1.00 | 0.00 | FALSE |
6 | GTEx | Colon Sigmoid | GPRC5A | 0.27 | 0.00 | enet | 2 | 0.00 | 2.1e-01 | 8.9 | 8.9 | 6.1e-19 | 0.14 | 0.75 | 0.01 | TRUE |
7 | GTEx | Esophagus Muscularis | HEBP1 | 0.26 | 0.16 | enet | 32 | 0.20 | 1.7e-12 | 2.9 | 6.3 | 3.3e-10 | 0.29 | 1.00 | 0.00 | FALSE |
8 | GTEx | Uterus | CREBL2 | 0.61 | 0.01 | lasso | 14 | 0.00 | 3.3e-01 | 2.6 | 5.2 | 2.3e-07 | 0.46 | 0.04 | 0.28 | TRUE |
9 | METSIM | Adipose | LRP6 | 0.13 | 0.05 | blup | 626 | 0.05 | 2.8e-08 | 9.7 | 6.4 | 1.2e-10 | 0.01 | 0.09 | 0.91 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | KIAA1467 | 0.17 | 0.05 | enet | 9 | 0.06 | 5.4e-08 | 6.3 | -6.8 | 1.0e-11 | -0.10 | 1.00 | 0.00 | TRUE |
11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | HTR7P1 | 0.10 | 0.03 | blup | 62 | 0.05 | 3.2e-05 | 2.7 | -6.1 | 1.3e-09 | -0.66 | 0.02 | 0.96 | FALSE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIAA1467 | 0.02 | 0.01 | blup | 51 | 0.01 | 2.3e-02 | -3.5 | 5.2 | 1.9e-07 | 0.05 | 0.36 | 0.02 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | HTR7P1 | 0.30 | 0.04 | blup | 65 | 0.09 | 8.1e-06 | 1.6 | -6.9 | 6.3e-12 | -0.56 | 0.08 | 0.49 | TRUE |
14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LRP6 | 0.05 | 0.00 | enet | 16 | 0.01 | 3.0e-02 | 4.0 | 6.2 | 4.3e-10 | 0.04 | 0.02 | 0.36 | FALSE |
15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HEBP1 | 0.07 | 0.01 | blup | 68 | 0.03 | 4.9e-03 | 1.7 | 5.4 | 6.5e-08 | 0.24 | 0.02 | 0.04 | FALSE |