[Hub]/) : Traits : Heel T-Score :

chr12:11,585,380-13,990,434

Best TWAS P=6.1e-19 · Best GWAS P=2.75e-28 conditioned to 0.926

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HTR7P1 0.39 0.24 enet 44 0.35 4.2e-44 2.6 -5.3 1.4e-07 -0.24 1.00 0.00 TRUE
2 CommonMind Brain Pre-frontal Cortex KIAA1467 0.08 0.09 lasso 2 0.08 2.6e-10 6.3 -6.4 2.0e-10 -0.09 1.00 0.00 FALSE
3 GTEx Breast Mammary Tissue (Female) KIAA1467 0.48 -0.01 lasso 23 0.00 3.6e-01 1.2 6.4 1.2e-10 0.12 0.07 0.05 FALSE
4 GTEx Cells Transformed fibroblasts LRP6 0.27 0.15 enet 16 0.20 5.5e-15 9.6 6.7 2.2e-11 0.10 0.08 0.92 TRUE
5 GTEx Cells Transformed fibroblasts HTR7P1 0.45 0.33 enet 29 0.40 2.2e-31 2.7 -5.9 3.5e-09 -0.25 1.00 0.00 FALSE
6 GTEx Colon Sigmoid GPRC5A 0.27 0.00 enet 2 0.00 2.1e-01 8.9 8.9 6.1e-19 0.14 0.75 0.01 TRUE
7 GTEx Esophagus Muscularis HEBP1 0.26 0.16 enet 32 0.20 1.7e-12 2.9 6.3 3.3e-10 0.29 1.00 0.00 FALSE
8 GTEx Uterus CREBL2 0.61 0.01 lasso 14 0.00 3.3e-01 2.6 5.2 2.3e-07 0.46 0.04 0.28 TRUE
9 METSIM Adipose LRP6 0.13 0.05 blup 626 0.05 2.8e-08 9.7 6.4 1.2e-10 0.01 0.09 0.91 FALSE
10 ROSMAP Brain Pre-frontal Cortex KIAA1467 0.17 0.05 enet 9 0.06 5.4e-08 6.3 -6.8 1.0e-11 -0.10 1.00 0.00 TRUE
11 The Cancer Genome Atlas Bladder Urothelial Carcinoma HTR7P1 0.10 0.03 blup 62 0.05 3.2e-05 2.7 -6.1 1.3e-09 -0.66 0.02 0.96 FALSE
12 The Cancer Genome Atlas Breast Invasive Carcinoma KIAA1467 0.02 0.01 blup 51 0.01 2.3e-02 -3.5 5.2 1.9e-07 0.05 0.36 0.02 FALSE
13 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma HTR7P1 0.30 0.04 blup 65 0.09 8.1e-06 1.6 -6.9 6.3e-12 -0.56 0.08 0.49 TRUE
14 The Cancer Genome Atlas Lung Squamous Cell Carcinoma LRP6 0.05 0.00 enet 16 0.01 3.0e-02 4.0 6.2 4.3e-10 0.04 0.02 0.36 FALSE
15 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma HEBP1 0.07 0.01 blup 68 0.03 4.9e-03 1.7 5.4 6.5e-08 0.24 0.02 0.04 FALSE