[Hub]/) : Traits : Heel T-Score :

chr16:9,930,580-12,767,048

Best TWAS P=4.56e-27 · Best GWAS P=1.3e-26 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous LITAF 0.36 0.30 lasso 4 0.30 1.2e-24 -10.68 10.8 4.6e-27 -0.99 0.00 1.00 TRUE
2 GTEx Adipose Subcutaneous RP11-166B2.1 0.49 0.38 enet 9 0.38 4.6e-33 -4.96 -5.6 1.7e-08 0.14 1.00 0.00 FALSE
3 GTEx Artery Coronary RP11-166B2.1 0.42 0.20 lasso 5 0.18 1.3e-06 -4.96 -5.8 6.4e-09 0.13 0.86 0.01 FALSE
4 GTEx Artery Tibial EMP2 0.26 0.12 enet 5 0.21 3.8e-16 6.37 -6.5 6.3e-11 0.05 0.01 0.99 FALSE
5 GTEx Brain Caudate basal ganglia RP11-166B2.1 0.78 0.59 lasso 9 0.61 8.9e-22 -4.96 -5.2 1.5e-07 0.14 1.00 0.00 FALSE
6 GTEx Brain Cortex RP11-166B2.1 0.64 0.46 enet 19 0.44 1.1e-13 -4.96 -6.3 3.7e-10 0.15 1.00 0.00 FALSE
7 GTEx Brain Frontal Cortex BA9 RP11-166B2.1 0.52 0.32 enet 19 0.30 1.1e-08 -4.96 -5.6 2.2e-08 0.12 0.96 0.00 FALSE
8 GTEx Brain Hippocampus RP11-166B2.1 0.59 0.31 lasso 7 0.39 2.8e-10 -4.96 -5.7 1.5e-08 0.14 0.98 0.00 FALSE
9 GTEx Breast Mammary Tissue (Male) EMP2 0.01 0.02 lasso 1 0.12 8.1e-04 6.61 -6.6 3.8e-11 0.00 0.01 0.76 TRUE
10 GTEx Breast Mammary Tissue (Male) RP11-166B2.1 0.39 0.28 lasso 3 0.27 5.5e-07 -4.96 -5.2 2.5e-07 0.13 0.14 0.05 FALSE
11 GTEx Breast Mammary Tissue (Female) RP11-166B2.1 0.39 0.40 lasso 2 0.38 1.9e-12 -4.96 -5.6 2.4e-08 0.13 0.99 0.00 FALSE
12 GTEx Esophagus Gastroesophageal Junction RP11-166B2.1 0.67 0.42 lasso 13 0.39 2.2e-15 -4.96 -5.9 2.9e-09 0.14 1.00 0.00 FALSE
13 GTEx Esophagus Mucosa LITAF 0.19 0.19 lasso 2 0.18 6.9e-12 -10.02 10.2 2.9e-24 -0.91 0.02 0.98 FALSE
14 GTEx Esophagus Mucosa EMP2 0.31 0.11 lasso 4 0.19 9.3e-13 3.44 -5.9 4.6e-09 0.06 0.01 0.99 FALSE
15 GTEx Esophagus Mucosa RP11-27M24.1 0.23 0.11 lasso 3 0.11 1.2e-07 6.37 -6.5 7.9e-11 -0.01 0.01 0.99 FALSE
16 GTEx Esophagus Muscularis RP11-27M24.1 0.28 0.15 enet 5 0.10 1.3e-06 6.37 -6.5 7.3e-11 0.02 0.00 1.00 FALSE
17 GTEx Lung EMP2 0.12 0.01 enet 23 0.06 1.8e-05 6.28 -5.6 1.9e-08 0.08 0.01 0.98 FALSE
18 GTEx Lung RP11-166B2.1 0.25 0.17 lasso 3 0.18 9.7e-14 -4.96 -5.4 7.4e-08 0.14 1.00 0.00 FALSE
19 GTEx Lung RP11-27M24.1 0.10 0.00 enet 14 0.02 1.2e-02 6.28 -5.6 2.7e-08 0.04 0.01 0.95 FALSE
20 GTEx Nerve Tibial LITAF 0.16 0.00 enet 7 0.00 3.1e-01 -10.68 7.6 3.2e-14 -0.73 0.01 0.85 FALSE
21 GTEx Nerve Tibial EMP2 0.41 0.25 enet 34 0.28 5.8e-20 6.28 -6.6 4.6e-11 0.04 0.01 0.99 FALSE
22 GTEx Nerve Tibial RP11-27M24.1 0.34 0.20 enet 27 0.21 7.1e-15 6.28 -5.6 1.7e-08 0.03 0.01 0.99 FALSE
23 GTEx Pancreas EMP2 0.31 0.18 enet 22 0.19 2.1e-08 6.37 -5.9 4.0e-09 -0.03 0.00 1.00 FALSE
24 GTEx Pancreas RP11-166B2.1 0.46 0.37 lasso 4 0.35 1.2e-15 -4.96 -5.2 1.9e-07 0.14 1.00 0.00 FALSE
25 GTEx Pancreas RP11-27M24.1 0.24 0.06 enet 10 0.05 5.4e-03 6.37 -5.8 5.3e-09 0.02 0.01 0.98 FALSE
26 GTEx Skin Not Sun Exposed Suprapubic EMP2 0.29 0.20 enet 27 0.20 1.9e-11 3.44 -6.1 1.2e-09 0.05 0.39 0.61 FALSE
27 GTEx Skin Sun Exposed Lower leg LITAF 0.18 0.13 lasso 1 0.12 5.4e-10 -10.68 10.7 1.3e-26 -1.00 0.00 1.00 FALSE
28 GTEx Stomach RP11-166B2.1 0.46 0.29 lasso 9 0.27 1.7e-13 -4.96 -6.5 8.4e-11 0.12 1.00 0.00 FALSE
29 GTEx Testis RP11-166B2.1 0.39 0.30 lasso 3 0.29 1.7e-13 -4.96 -5.2 1.9e-07 0.13 1.00 0.00 FALSE
30 GTEx Thyroid EMP2 0.20 0.11 enet 16 0.19 1.0e-14 6.37 -6.0 2.5e-09 0.05 0.01 0.99 FALSE
31 METSIM Adipose LITAF 0.22 0.18 lasso 6 0.19 3.7e-27 -10.01 10.1 5.9e-24 -0.92 0.00 1.00 FALSE
32 NTR Blood C16orf75 0.03 0.01 enet 10 0.02 6.4e-08 0.11 5.3 1.3e-07 -0.46 0.23 0.76 FALSE
33 ROSMAP Brain Pre-frontal Cortex RP11-166B2.1 0.17 0.16 bslmm 462 0.16 5.5e-20 -4.96 -5.8 5.1e-09 0.17 1.00 0.00 FALSE
34 The Cancer Genome Atlas Brain Lower Grade Glioma TNFRSF17 0.04 0.03 blup 41 0.04 5.7e-05 -4.96 -6.5 6.7e-11 0.10 0.01 0.99 TRUE
35 The Cancer Genome Atlas Liver Hepatocellular Carcinoma LITAF 0.16 0.04 lasso 3 0.05 2.0e-03 -9.97 9.1 7.3e-20 -0.76 0.01 0.38 FALSE
36 The Cancer Genome Atlas Prostate Adenocarcinoma LITAF 0.07 0.02 enet 10 0.05 1.1e-05 -8.39 5.7 1.6e-08 -0.59 0.04 0.29 FALSE