[Hub]/) : Traits : Heel T-Score : ← →

chr16:9,930,580-12,767,048

Best TWAS P=4.56e-27 · Best GWAS P=1.3e-26 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	LITAF	0.36	0.30	lasso	4	0.30	1.2e-24	-10.68	10.8	4.6e-27	-0.99	0.00	1.00	TRUE
2	GTEx	Adipose Subcutaneous	RP11-166B2.1	0.49	0.38	enet	9	0.38	4.6e-33	-4.96	-5.6	1.7e-08	0.14	1.00	0.00	FALSE
3	GTEx	Artery Coronary	RP11-166B2.1	0.42	0.20	lasso	5	0.18	1.3e-06	-4.96	-5.8	6.4e-09	0.13	0.86	0.01	FALSE
4	GTEx	Artery Tibial	EMP2	0.26	0.12	enet	5	0.21	3.8e-16	6.37	-6.5	6.3e-11	0.05	0.01	0.99	FALSE
5	GTEx	Brain Caudate basal ganglia	RP11-166B2.1	0.78	0.59	lasso	9	0.61	8.9e-22	-4.96	-5.2	1.5e-07	0.14	1.00	0.00	FALSE
6	GTEx	Brain Cortex	RP11-166B2.1	0.64	0.46	enet	19	0.44	1.1e-13	-4.96	-6.3	3.7e-10	0.15	1.00	0.00	FALSE
7	GTEx	Brain Frontal Cortex BA9	RP11-166B2.1	0.52	0.32	enet	19	0.30	1.1e-08	-4.96	-5.6	2.2e-08	0.12	0.96	0.00	FALSE
8	GTEx	Brain Hippocampus	RP11-166B2.1	0.59	0.31	lasso	7	0.39	2.8e-10	-4.96	-5.7	1.5e-08	0.14	0.98	0.00	FALSE
9	GTEx	Breast Mammary Tissue (Male)	EMP2	0.01	0.02	lasso	1	0.12	8.1e-04	6.61	-6.6	3.8e-11	0.00	0.01	0.76	TRUE
10	GTEx	Breast Mammary Tissue (Male)	RP11-166B2.1	0.39	0.28	lasso	3	0.27	5.5e-07	-4.96	-5.2	2.5e-07	0.13	0.14	0.05	FALSE
11	GTEx	Breast Mammary Tissue (Female)	RP11-166B2.1	0.39	0.40	lasso	2	0.38	1.9e-12	-4.96	-5.6	2.4e-08	0.13	0.99	0.00	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	RP11-166B2.1	0.67	0.42	lasso	13	0.39	2.2e-15	-4.96	-5.9	2.9e-09	0.14	1.00	0.00	FALSE
13	GTEx	Esophagus Mucosa	LITAF	0.19	0.19	lasso	2	0.18	6.9e-12	-10.02	10.2	2.9e-24	-0.91	0.02	0.98	FALSE
14	GTEx	Esophagus Mucosa	EMP2	0.31	0.11	lasso	4	0.19	9.3e-13	3.44	-5.9	4.6e-09	0.06	0.01	0.99	FALSE
15	GTEx	Esophagus Mucosa	RP11-27M24.1	0.23	0.11	lasso	3	0.11	1.2e-07	6.37	-6.5	7.9e-11	-0.01	0.01	0.99	FALSE
16	GTEx	Esophagus Muscularis	RP11-27M24.1	0.28	0.15	enet	5	0.10	1.3e-06	6.37	-6.5	7.3e-11	0.02	0.00	1.00	FALSE
17	GTEx	Lung	EMP2	0.12	0.01	enet	23	0.06	1.8e-05	6.28	-5.6	1.9e-08	0.08	0.01	0.98	FALSE
18	GTEx	Lung	RP11-166B2.1	0.25	0.17	lasso	3	0.18	9.7e-14	-4.96	-5.4	7.4e-08	0.14	1.00	0.00	FALSE
19	GTEx	Lung	RP11-27M24.1	0.10	0.00	enet	14	0.02	1.2e-02	6.28	-5.6	2.7e-08	0.04	0.01	0.95	FALSE
20	GTEx	Nerve Tibial	LITAF	0.16	0.00	enet	7	0.00	3.1e-01	-10.68	7.6	3.2e-14	-0.73	0.01	0.85	FALSE
21	GTEx	Nerve Tibial	EMP2	0.41	0.25	enet	34	0.28	5.8e-20	6.28	-6.6	4.6e-11	0.04	0.01	0.99	FALSE
22	GTEx	Nerve Tibial	RP11-27M24.1	0.34	0.20	enet	27	0.21	7.1e-15	6.28	-5.6	1.7e-08	0.03	0.01	0.99	FALSE
23	GTEx	Pancreas	EMP2	0.31	0.18	enet	22	0.19	2.1e-08	6.37	-5.9	4.0e-09	-0.03	0.00	1.00	FALSE
24	GTEx	Pancreas	RP11-166B2.1	0.46	0.37	lasso	4	0.35	1.2e-15	-4.96	-5.2	1.9e-07	0.14	1.00	0.00	FALSE
25	GTEx	Pancreas	RP11-27M24.1	0.24	0.06	enet	10	0.05	5.4e-03	6.37	-5.8	5.3e-09	0.02	0.01	0.98	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	EMP2	0.29	0.20	enet	27	0.20	1.9e-11	3.44	-6.1	1.2e-09	0.05	0.39	0.61	FALSE
27	GTEx	Skin Sun Exposed Lower leg	LITAF	0.18	0.13	lasso	1	0.12	5.4e-10	-10.68	10.7	1.3e-26	-1.00	0.00	1.00	FALSE
28	GTEx	Stomach	RP11-166B2.1	0.46	0.29	lasso	9	0.27	1.7e-13	-4.96	-6.5	8.4e-11	0.12	1.00	0.00	FALSE
29	GTEx	Testis	RP11-166B2.1	0.39	0.30	lasso	3	0.29	1.7e-13	-4.96	-5.2	1.9e-07	0.13	1.00	0.00	FALSE
30	GTEx	Thyroid	EMP2	0.20	0.11	enet	16	0.19	1.0e-14	6.37	-6.0	2.5e-09	0.05	0.01	0.99	FALSE
31	METSIM	Adipose	LITAF	0.22	0.18	lasso	6	0.19	3.7e-27	-10.01	10.1	5.9e-24	-0.92	0.00	1.00	FALSE
32	NTR	Blood	C16orf75	0.03	0.01	enet	10	0.02	6.4e-08	0.11	5.3	1.3e-07	-0.46	0.23	0.76	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	RP11-166B2.1	0.17	0.16	bslmm	462	0.16	5.5e-20	-4.96	-5.8	5.1e-09	0.17	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNFRSF17	0.04	0.03	blup	41	0.04	5.7e-05	-4.96	-6.5	6.7e-11	0.10	0.01	0.99	TRUE
35	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	LITAF	0.16	0.04	lasso	3	0.05	2.0e-03	-9.97	9.1	7.3e-20	-0.76	0.01	0.38	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	LITAF	0.07	0.02	enet	10	0.05	1.1e-05	-8.39	5.7	1.6e-08	-0.59	0.04	0.29	FALSE