[Hub]/) : Traits : Heel T-Score : ← →

chr16:17,891,776-20,596,558

Best TWAS P=1.03e-09 · Best GWAS P=1.68e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ABCC6P1	0.05	0.03	lasso	3	0.05	3.0e-06	6.0	5.2	1.8e-07	0.84	0.01	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IQCK	0.06	0.04	lasso	5	0.06	2.3e-07	-5.2	5.8	7.4e-09	-0.02	0.05	0.94	FALSE
3	GTEx	Adipose Subcutaneous	KNOP1	0.26	0.38	lasso	6	0.40	9.0e-35	-5.2	-5.2	1.7e-07	0.03	0.05	0.95	FALSE
4	GTEx	Adipose Subcutaneous	GPRC5B	0.07	0.04	lasso	4	0.03	1.3e-03	-4.9	5.2	1.5e-07	0.02	0.08	0.80	FALSE
5	GTEx	Adipose Subcutaneous	AC002550.5	0.41	0.50	enet	17	0.52	7.9e-49	-5.2	-5.5	3.2e-08	0.02	0.05	0.95	FALSE
6	GTEx	Adipose Visceral Omentum	KNOP1	0.39	0.52	lasso	3	0.53	9.1e-32	-5.1	-5.4	7.4e-08	0.02	0.10	0.90	FALSE
7	GTEx	Adrenal Gland	KNOP1	0.40	0.34	lasso	4	0.40	1.1e-15	-5.5	-5.6	2.5e-08	0.02	0.03	0.97	FALSE
8	GTEx	Adrenal Gland	AC002550.5	0.37	0.39	enet	28	0.40	1.6e-15	-5.1	-5.2	2.2e-07	0.00	0.08	0.92	FALSE
9	GTEx	Artery Aorta	KNOP1	0.50	0.48	lasso	8	0.49	4.0e-30	-5.1	-5.3	1.0e-07	0.01	0.10	0.90	FALSE
10	GTEx	Artery Aorta	AC002550.5	0.52	0.52	lasso	7	0.49	1.9e-30	-5.1	-5.4	6.4e-08	0.02	0.10	0.90	FALSE
11	GTEx	Artery Coronary	KNOP1	0.28	0.25	lasso	7	0.32	2.5e-11	-5.0	-5.7	1.5e-08	0.02	0.03	0.97	FALSE
12	GTEx	Artery Coronary	AC002550.5	0.30	0.34	enet	11	0.37	1.5e-13	-5.1	-5.5	4.5e-08	0.02	0.06	0.94	FALSE
13	GTEx	Artery Tibial	AC002550.5	0.31	0.36	lasso	8	0.39	6.8e-32	-5.1	-5.3	1.1e-07	0.02	0.08	0.91	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-1035H13.2	0.29	0.02	lasso	2	0.04	3.0e-02	6.0	6.1	1.0e-09	0.98	0.01	0.88	TRUE
15	GTEx	Brain Frontal Cortex BA9	KNOP1	0.43	0.33	lasso	14	0.30	1.0e-08	-5.0	-5.3	1.1e-07	0.02	0.07	0.93	FALSE
16	GTEx	Brain Frontal Cortex BA9	AC002550.5	0.53	0.40	enet	15	0.43	9.0e-13	-5.1	-5.4	7.9e-08	0.02	0.07	0.92	FALSE
17	GTEx	Brain Hypothalamus	AC002550.5	0.37	0.47	lasso	2	0.46	3.1e-12	-5.1	-5.3	1.3e-07	0.02	0.05	0.95	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	KNOP1	0.34	0.38	lasso	5	0.37	1.0e-10	-5.1	-5.4	6.4e-08	0.02	0.06	0.94	FALSE
19	GTEx	Breast Mammary Tissue	AC002550.5	0.37	0.49	enet	13	0.50	3.3e-29	-5.1	-5.3	1.0e-07	0.01	0.03	0.97	FALSE
20	GTEx	Breast Mammary Tissue (Male)	AC002550.5	0.37	0.29	lasso	3	0.35	4.8e-09	-5.7	-5.9	4.2e-09	0.01	0.01	0.99	TRUE
21	GTEx	Breast Mammary Tissue (Female)	AC002550.5	0.36	0.26	enet	19	0.33	1.3e-10	-5.5	-5.2	2.0e-07	0.01	0.02	0.98	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	KNOP1	0.70	0.58	lasso	7	0.59	2.1e-23	-5.2	-5.2	2.0e-07	0.03	0.06	0.94	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	AC002550.5	0.81	0.65	lasso	15	0.64	2.9e-26	-5.1	-5.2	2.4e-07	0.03	0.07	0.93	FALSE
24	GTEx	Cells Transformed fibroblasts	KNOP1	0.07	0.08	lasso	5	0.08	2.5e-06	-5.1	-5.1	3.0e-07	0.02	0.06	0.94	FALSE
25	GTEx	Colon Sigmoid	KNOP1	0.32	0.35	lasso	6	0.32	4.9e-12	-5.1	-5.4	7.5e-08	0.01	0.06	0.94	FALSE
26	GTEx	Colon Transverse	KNOP1	0.22	0.23	enet	19	0.24	9.8e-12	-5.1	-5.2	2.1e-07	0.01	0.04	0.96	FALSE
27	GTEx	Colon Transverse	AC002550.5	0.35	0.36	enet	15	0.41	5.0e-21	-5.1	-5.6	2.6e-08	0.01	0.06	0.93	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	KNOP1	0.51	0.44	enet	22	0.56	5.3e-24	-5.5	-5.6	2.0e-08	0.00	0.02	0.98	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	AC002550.5	0.62	0.54	enet	35	0.63	4.4e-29	-5.2	-5.9	4.3e-09	0.01	0.06	0.94	FALSE
30	GTEx	Esophagus Mucosa	KNOP1	0.31	0.43	lasso	5	0.43	5.6e-31	-5.1	-5.3	1.2e-07	0.02	0.09	0.91	FALSE
31	GTEx	Esophagus Mucosa	AC002550.5	0.38	0.52	lasso	3	0.51	2.6e-39	-5.1	-5.2	2.1e-07	0.01	0.10	0.90	FALSE
32	GTEx	Esophagus Muscularis	KNOP1	0.47	0.51	lasso	10	0.56	1.9e-40	-5.1	-5.3	1.3e-07	0.02	0.06	0.94	FALSE
33	GTEx	Esophagus Muscularis	AC002550.5	0.40	0.49	lasso	7	0.47	1.4e-31	-5.1	-5.2	2.2e-07	0.02	0.07	0.93	FALSE
34	GTEx	Heart Left Ventricle	KNOP1	0.34	0.48	lasso	2	0.44	2.3e-25	-5.1	-5.3	1.4e-07	0.02	0.10	0.90	FALSE
35	GTEx	Liver	KNOP1	0.23	0.21	lasso	7	0.25	1.4e-07	-5.2	-5.5	4.6e-08	0.03	0.02	0.97	FALSE
36	GTEx	Liver	AC002550.5	0.43	0.42	enet	13	0.47	1.1e-14	-5.2	-5.4	8.3e-08	0.02	0.02	0.98	FALSE
37	GTEx	Lung	KNOP1	0.34	0.48	lasso	8	0.49	4.0e-42	-5.1	-5.3	1.4e-07	0.02	0.10	0.90	FALSE
38	GTEx	Lung	GPRC5B	0.08	0.05	lasso	4	0.06	2.4e-05	-5.2	5.1	3.0e-07	-0.03	0.08	0.91	FALSE
39	GTEx	Lung	AC002550.5	0.43	0.55	lasso	9	0.54	6.4e-48	-5.1	-5.3	1.3e-07	0.02	0.09	0.91	FALSE
40	GTEx	Muscle Skeletal	KNOP1	0.29	0.45	lasso	6	0.44	7.0e-48	-5.1	-5.1	2.8e-07	0.02	0.09	0.91	FALSE
41	GTEx	Muscle Skeletal	AC002550.5	0.35	0.53	lasso	6	0.52	3.2e-59	-5.1	-5.3	1.3e-07	0.02	0.09	0.91	FALSE
42	GTEx	Ovary	KNOP1	0.61	0.64	lasso	7	0.57	4.4e-17	-5.1	-5.3	1.4e-07	0.01	0.07	0.92	FALSE
43	GTEx	Pancreas	KNOP1	0.42	0.37	lasso	11	0.40	4.2e-18	-5.2	-5.3	9.8e-08	0.01	0.05	0.94	FALSE
44	GTEx	Pancreas	AC002550.5	0.37	0.36	lasso	12	0.36	3.2e-16	-5.1	-5.4	6.9e-08	0.03	0.06	0.94	FALSE
45	GTEx	Pituitary	KNOP1	0.40	0.36	lasso	3	0.30	3.1e-08	-5.1	-5.5	4.8e-08	0.01	0.05	0.94	FALSE
46	GTEx	Pituitary	AC002550.5	0.52	0.53	lasso	3	0.52	3.8e-15	-5.1	-5.2	2.7e-07	0.02	0.08	0.92	FALSE
47	GTEx	Prostate	KNOP1	0.54	0.32	lasso	11	0.24	9.4e-07	-5.0	-5.2	2.2e-07	0.02	0.08	0.91	FALSE
48	GTEx	Prostate	AC002550.5	0.49	0.25	lasso	8	0.33	5.7e-09	-5.1	-5.2	2.1e-07	0.02	0.07	0.92	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	KNOP1	0.37	0.43	lasso	3	0.41	5.0e-24	-5.2	-5.3	9.5e-08	0.02	0.06	0.93	FALSE
50	GTEx	Skin Sun Exposed Lower leg	KNOP1	0.33	0.47	lasso	9	0.48	5.4e-44	-5.1	-5.3	9.5e-08	0.02	0.09	0.91	FALSE
51	GTEx	Skin Sun Exposed Lower leg	AC002550.5	0.38	0.56	lasso	6	0.57	8.6e-58	-5.1	-5.3	1.4e-07	0.02	0.10	0.90	FALSE
52	GTEx	Spleen	KNOP1	0.45	0.36	lasso	7	0.41	1.2e-11	-5.1	-5.2	2.5e-07	0.02	0.05	0.95	FALSE
53	GTEx	Testis	RP11-1035H13.2	0.16	0.07	enet	25	0.06	1.6e-03	3.9	5.2	1.7e-07	0.75	0.02	0.93	FALSE
54	GTEx	Testis	AC002550.5	0.49	0.57	lasso	5	0.56	7.7e-30	-5.1	-5.5	4.8e-08	0.01	0.08	0.92	FALSE
55	GTEx	Uterus	KNOP1	0.29	0.22	enet	10	0.18	1.7e-04	-5.1	-5.2	2.0e-07	0.02	0.05	0.84	FALSE
56	GTEx	Uterus	AC002550.5	0.51	0.40	lasso	12	0.36	2.3e-08	-5.1	-5.2	2.5e-07	0.02	0.05	0.94	FALSE
57	GTEx	Vagina	KNOP1	0.43	0.35	lasso	5	0.36	4.2e-09	-5.1	-5.2	1.7e-07	0.02	0.06	0.94	FALSE
58	GTEx	Whole Blood	KNOP1	0.08	0.04	lasso	3	0.04	1.7e-04	-5.1	-5.8	6.6e-09	0.01	0.02	0.98	FALSE
59	GTEx	Whole Blood	AC002550.5	0.15	0.10	lasso	4	0.10	6.3e-10	-5.1	-5.2	2.5e-07	0.02	0.09	0.91	FALSE
60	METSIM	Adipose	KNOP1	0.15	0.23	bslmm	442	0.24	9.4e-35	-5.1	-5.2	1.6e-07	0.01	0.08	0.92	FALSE
61	NTR	Blood	C16orf88	0.03	0.03	bslmm	453	0.03	2.2e-09	-5.3	-5.5	4.4e-08	0.04	0.07	0.93	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	CTD-2380F24.1	0.20	0.29	lasso	1	0.29	2.4e-37	-5.2	5.2	1.5e-07	-0.03	0.05	0.94	FALSE
63	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ARL6IP1	0.05	0.03	lasso	1	0.04	5.5e-04	6.0	-6.0	1.8e-09	-0.99	0.01	0.90	FALSE
64	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C16orf88	0.08	0.08	lasso	2	0.08	4.9e-07	-5.1	-5.2	1.6e-07	0.03	0.03	0.97	FALSE
65	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCK	0.05	0.02	blup	73	0.03	1.0e-03	-5.4	-5.2	1.5e-07	0.01	0.01	0.95	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf88	0.10	0.08	lasso	3	0.08	7.1e-17	-5.1	-5.4	6.6e-08	0.02	0.02	0.97	FALSE
67	The Cancer Genome Atlas	Colon Adenocarcinoma	C16orf88	0.10	0.04	blup	37	0.04	1.6e-03	-5.0	-5.3	1.5e-07	0.03	0.02	0.94	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C16orf88	0.22	0.08	lasso	3	0.08	2.0e-09	-5.5	-5.3	1.3e-07	0.00	0.00	1.00	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf88	0.15	0.10	lasso	4	0.10	8.2e-12	-5.1	-5.5	4.0e-08	0.04	0.02	0.97	FALSE
70	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf88	0.07	0.05	lasso	2	0.05	7.7e-04	-5.5	-5.6	2.5e-08	0.01	0.01	0.89	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf88	0.22	0.30	lasso	8	0.30	1.2e-34	-5.0	-5.1	2.7e-07	0.03	0.03	0.97	FALSE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C16orf88	0.10	0.10	lasso	3	0.13	3.7e-14	-5.5	-5.1	2.9e-07	0.01	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCK	0.03	0.03	lasso	3	0.02	7.2e-04	-5.7	-5.7	1.3e-08	-0.01	0.01	0.98	FALSE
74	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IQCK	0.07	0.02	blup	73	0.04	1.7e-03	-5.0	-5.7	1.3e-08	0.03	0.03	0.61	FALSE
75	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C16orf88	0.34	0.21	lasso	4	0.17	3.1e-07	-5.5	-5.5	3.1e-08	0.01	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	IQCK	0.04	0.01	blup	73	0.01	1.8e-02	-4.9	-5.3	8.7e-08	0.03	0.04	0.64	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf88	0.20	0.18	blup	37	0.19	6.3e-18	-5.1	-5.5	4.3e-08	0.02	0.03	0.97	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	IQCK	0.05	0.04	lasso	3	0.03	4.3e-04	-5.1	-5.1	2.7e-07	0.03	0.08	0.87	FALSE