[Hub]/) : Traits : Heel T-Score :

chr20:56,265,764-58,262,841

Best TWAS P=3.65e-08 · Best GWAS P=6.75e-10 conditioned to 1.31e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous NELFCD 0.43 0.31 enet 36 0.38 3.3e-33 4.8 -5.4 7.2e-08 0.01 0.00 0.98 TRUE
2 GTEx Adipose Subcutaneous VAPB 0.45 0.33 enet 19 0.39 5.4e-34 -5.3 -5.1 2.8e-07 0.08 0.14 0.86 FALSE
3 GTEx Adipose Visceral Omentum VAPB 0.34 0.30 lasso 5 0.29 2.3e-15 -5.3 -5.4 8.1e-08 0.08 0.08 0.92 FALSE
4 GTEx Artery Aorta VAPB 0.39 0.30 lasso 8 0.31 8.8e-18 -5.3 -5.2 1.7e-07 0.08 0.13 0.87 FALSE
5 GTEx Artery Coronary VAPB 0.28 0.26 lasso 4 0.24 1.5e-08 -5.3 -5.3 1.4e-07 0.08 0.10 0.89 FALSE
6 GTEx Artery Tibial VAPB 0.44 0.37 lasso 6 0.37 1.1e-30 -5.3 -5.2 1.5e-07 0.07 0.15 0.85 FALSE
7 GTEx Breast Mammary Tissue VAPB 0.48 0.22 lasso 9 0.28 1.1e-14 -5.3 -5.2 2.6e-07 0.08 0.12 0.88 FALSE
8 GTEx Cells EBV-transformed lymphocytes VAPB 0.65 0.37 enet 13 0.47 3.2e-17 -5.3 -5.2 1.7e-07 0.08 0.15 0.85 FALSE
9 GTEx Cells Transformed fibroblasts VAPB 0.32 0.29 lasso 4 0.34 1.2e-26 -5.3 -5.2 2.4e-07 0.08 0.13 0.87 FALSE
10 GTEx Esophagus Gastroesophageal Junction VAPB 0.29 0.18 enet 13 0.19 2.2e-07 -5.3 -5.5 3.7e-08 0.16 0.11 0.89 TRUE
11 GTEx Esophagus Muscularis VAPB 0.38 0.34 enet 17 0.34 4.0e-21 -5.6 -5.4 7.7e-08 0.09 0.06 0.94 FALSE
12 GTEx Heart Atrial Appendage VAPB 0.24 0.21 lasso 2 0.17 5.0e-08 -5.3 -5.3 1.1e-07 0.07 0.11 0.89 FALSE
13 GTEx Heart Left Ventricle VAPB 0.21 0.06 lasso 2 0.07 1.1e-04 -5.3 -5.2 1.7e-07 0.07 0.16 0.77 FALSE
14 GTEx Lung VAPB 0.24 0.16 lasso 8 0.20 4.4e-15 -5.3 -5.2 2.3e-07 0.08 0.20 0.79 FALSE
15 GTEx Muscle Skeletal NELFCD 0.30 0.22 enet 17 0.26 3.5e-25 4.8 -5.2 2.0e-07 -0.01 0.00 0.98 FALSE
16 GTEx Muscle Skeletal VAPB 0.17 0.15 enet 10 0.17 1.9e-16 -5.3 -5.2 2.1e-07 0.09 0.09 0.91 FALSE
17 GTEx Nerve Tibial NELFCD 0.30 0.17 enet 25 0.23 2.8e-16 4.8 -5.2 1.8e-07 0.01 0.01 0.98 FALSE
18 GTEx Pancreas VAPB 0.21 0.11 lasso 4 0.06 1.4e-03 -5.3 -5.2 2.3e-07 0.08 0.18 0.76 FALSE
19 GTEx Skin Not Sun Exposed Suprapubic VAPB 0.18 0.16 lasso 2 0.14 3.9e-08 -5.3 -5.3 1.3e-07 0.07 0.15 0.85 FALSE
20 GTEx Stomach VAPB 0.29 0.22 enet 7 0.20 1.2e-09 -5.3 -5.1 2.7e-07 0.08 0.17 0.83 FALSE
21 GTEx Testis VAPB 0.41 0.18 lasso 6 0.21 1.7e-09 -5.3 -5.3 1.0e-07 0.05 0.16 0.84 FALSE
22 The Cancer Genome Atlas Esophageal Carcinoma TH1L 0.19 0.16 blup 46 0.19 8.9e-07 3.6 -5.2 2.1e-07 -0.03 0.04 0.86 FALSE