[Hub]/) : Traits : Heel T-Score : ← →

chr2:28,235,763-29,966,380

Best TWAS P=2.09e-26 · Best GWAS P=5.32e-26 conditioned to 0.0514

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PPP1CB	0.12	0.08	blup	574	0.10	3.3e-12	10.5	-9.4	6.4e-21	-0.72	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TRMT61B	0.26	0.35	lasso	4	0.35	1.2e-43	8.3	8.4	6.5e-17	0.74	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	TRMT61B	0.21	0.24	lasso	5	0.22	2.7e-18	8.4	8.3	8.3e-17	0.74	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	TRMT61B	0.31	0.33	lasso	13	0.31	1.1e-16	8.2	8.6	8.6e-18	0.79	0.57	0.43	FALSE
5	GTEx	Adipose Visceral Omentum	PPP1CB	0.15	0.01	lasso	3	0.03	6.5e-03	7.5	-6.6	4.8e-11	-0.60	0.18	0.51	FALSE
6	GTEx	Adrenal Gland	TRMT61B	0.30	0.27	enet	17	0.23	9.6e-09	8.2	8.1	5.3e-16	0.72	0.62	0.38	FALSE
7	GTEx	Adrenal Gland	PPP1CB	0.16	0.07	lasso	6	0.07	1.6e-03	8.4	-9.7	2.2e-22	-0.84	0.04	0.89	FALSE
8	GTEx	Artery Aorta	TRMT61B	0.26	0.29	enet	16	0.29	4.0e-16	8.2	8.3	7.1e-17	0.75	1.00	0.00	FALSE
9	GTEx	Artery Coronary	TRMT61B	0.21	0.16	lasso	3	0.17	2.8e-06	8.1	9.5	2.7e-21	0.83	0.08	0.91	FALSE
10	GTEx	Artery Tibial	TRMT61B	0.29	0.27	lasso	4	0.28	1.1e-21	8.4	8.3	1.3e-16	0.74	1.00	0.00	FALSE
11	GTEx	Brain Caudate basal ganglia	TRMT61B	0.22	0.01	enet	5	0.04	2.5e-02	8.1	9.1	1.0e-19	0.84	0.06	0.82	FALSE
12	GTEx	Brain Cerebellum	TRMT61B	0.26	0.00	lasso	6	0.00	4.1e-01	7.3	6.6	4.3e-11	0.59	0.07	0.06	FALSE
13	GTEx	Brain Cortex	FAM179A	0.65	0.36	lasso	10	0.42	4.8e-13	4.7	5.2	1.6e-07	0.35	1.00	0.00	FALSE
14	GTEx	Brain Frontal Cortex BA9	TRMT61B	0.39	0.24	lasso	8	0.17	3.5e-05	8.2	8.2	2.8e-16	0.73	0.14	0.79	FALSE
15	GTEx	Brain Frontal Cortex BA9	PPP1CB	0.27	0.14	lasso	5	0.12	4.3e-04	7.5	-8.2	1.9e-16	-0.68	0.22	0.24	FALSE
16	GTEx	Brain Putamen basal ganglia	TRMT61B	0.27	0.12	enet	11	0.20	1.3e-05	8.2	9.8	1.5e-22	0.93	0.02	0.96	FALSE
17	GTEx	Breast Mammary Tissue	TRMT61B	0.32	0.17	lasso	7	0.20	8.2e-11	8.4	8.7	5.1e-18	0.76	0.90	0.10	FALSE
18	GTEx	Breast Mammary Tissue (Male)	FAM179A	0.31	0.21	lasso	6	0.17	1.1e-04	4.7	5.2	1.5e-07	0.45	0.08	0.26	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	TRMT61B	0.40	0.28	enet	34	0.18	1.3e-06	8.4	7.7	1.8e-14	0.63	0.93	0.07	FALSE
20	GTEx	Cells Transformed fibroblasts	TRMT61B	0.36	0.46	lasso	6	0.46	2.8e-38	8.2	8.2	2.8e-16	0.75	1.00	0.00	FALSE
21	GTEx	Colon Sigmoid	TRMT61B	0.31	0.14	lasso	6	0.16	1.8e-06	7.3	7.4	1.7e-13	0.72	0.06	0.92	FALSE
22	GTEx	Colon Transverse	TRMT61B	0.15	0.12	lasso	5	0.10	1.1e-05	8.4	8.3	8.2e-17	0.74	0.26	0.72	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	TRMT61B	0.41	0.33	lasso	10	0.31	8.2e-12	7.5	7.7	1.2e-14	0.70	0.96	0.04	FALSE
24	GTEx	Esophagus Mucosa	TRMT61B	0.18	0.22	lasso	3	0.22	1.7e-14	8.2	8.1	4.1e-16	0.74	0.99	0.01	FALSE
25	GTEx	Esophagus Muscularis	TRMT61B	0.27	0.34	lasso	3	0.33	1.0e-20	8.2	8.3	8.6e-17	0.75	1.00	0.00	FALSE
26	GTEx	Heart Atrial Appendage	TRMT61B	0.38	0.27	lasso	4	0.24	5.5e-11	8.2	8.3	7.6e-17	0.75	0.59	0.41	FALSE
27	GTEx	Heart Left Ventricle	TRMT61B	0.21	0.17	lasso	3	0.15	1.9e-08	8.2	8.2	1.7e-16	0.75	0.70	0.30	FALSE
28	GTEx	Lung	TRMT61B	0.20	0.24	lasso	9	0.24	4.2e-18	8.3	8.6	5.8e-18	0.73	1.00	0.00	FALSE
29	GTEx	Muscle Skeletal	TRMT61B	0.16	0.14	enet	17	0.14	1.1e-13	8.4	8.4	3.5e-17	0.75	1.00	0.00	FALSE
30	GTEx	Nerve Tibial	TRMT61B	0.15	0.16	lasso	5	0.13	1.4e-09	7.5	7.5	7.8e-14	0.70	0.86	0.14	FALSE
31	GTEx	Pancreas	TRMT61B	0.17	0.14	lasso	2	0.12	7.5e-06	-8.6	8.7	3.2e-18	0.61	0.57	0.35	FALSE
32	GTEx	Pituitary	TRMT61B	0.28	0.11	enet	28	0.10	1.9e-03	8.4	6.0	1.7e-09	0.58	0.19	0.54	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	TRMT61B	0.20	0.13	lasso	5	0.12	7.3e-07	8.4	8.4	4.5e-17	0.74	0.87	0.09	FALSE
34	GTEx	Skin Sun Exposed Lower leg	TRMT61B	0.12	0.17	lasso	4	0.16	8.4e-13	8.4	8.6	8.8e-18	0.74	1.00	0.00	FALSE
35	GTEx	Spleen	TRMT61B	0.48	0.39	lasso	6	0.36	3.0e-10	7.5	8.0	1.5e-15	0.71	0.80	0.16	FALSE
36	GTEx	Stomach	TRMT61B	0.32	0.24	lasso	5	0.26	9.7e-13	8.4	7.8	4.5e-15	0.72	0.83	0.17	FALSE
37	GTEx	Testis	TRMT61B	0.32	0.28	lasso	3	0.27	2.7e-12	8.4	8.3	8.6e-17	0.74	1.00	0.00	FALSE
38	GTEx	Thyroid	TRMT61B	0.18	0.23	lasso	6	0.22	1.0e-16	8.2	8.3	9.7e-17	0.75	1.00	0.00	FALSE
39	GTEx	Thyroid	PPP1CB	0.07	0.00	enet	7	0.00	3.4e-01	8.1	-8.7	4.2e-18	-0.71	0.14	0.60	FALSE
40	GTEx	Thyroid	AC097724.3	0.07	0.03	lasso	4	0.03	4.1e-03	-8.5	-8.5	2.2e-17	-0.59	0.31	0.38	FALSE
41	METSIM	Adipose	PPP1CB	0.07	0.08	lasso	3	0.08	1.1e-11	-8.6	-8.6	5.9e-18	-0.58	0.98	0.02	FALSE
42	METSIM	Adipose	TRMT61B	0.06	0.08	enet	12	0.09	8.5e-13	8.1	5.7	9.7e-09	0.67	1.00	0.00	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	TRMT61B	0.15	0.11	lasso	8	0.10	3.7e-13	8.2	8.5	1.4e-17	0.77	0.79	0.21	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	PPP1CB	0.13	0.04	lasso	5	0.08	1.4e-10	10.5	-9.7	2.0e-22	-0.63	0.02	0.98	FALSE
45	YFS	Blood	PPP1CB	0.07	0.10	enet	17	0.12	9.2e-36	-8.6	-8.6	9.3e-18	-0.58	0.96	0.04	FALSE
46	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRMT61B	0.14	0.17	lasso	2	0.16	1.9e-13	8.2	8.2	2.3e-16	0.75	0.08	0.92	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPP1CB	0.04	0.02	blup	39	0.02	1.6e-04	10.5	-10.2	1.6e-24	-0.70	0.00	0.98	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRMT61B	0.10	0.17	lasso	2	0.17	1.2e-33	8.2	8.2	1.8e-16	0.75	0.15	0.85	FALSE
49	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRMT61B	0.14	0.16	blup	43	0.16	2.4e-08	8.3	7.1	1.5e-12	0.71	0.08	0.92	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	PPP1CB	0.05	0.02	blup	39	0.03	4.7e-03	10.0	-10.6	2.1e-26	-0.89	0.02	0.90	TRUE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	TRMT61B	0.20	0.23	lasso	7	0.22	6.1e-13	8.1	7.8	4.0e-15	0.74	0.09	0.91	FALSE
52	The Cancer Genome Atlas	Glioblastoma Multiforme	TRMT61B	0.35	0.22	lasso	3	0.22	2.1e-07	8.1	8.4	2.9e-17	0.73	0.04	0.96	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TRMT61B	0.12	0.15	lasso	4	0.16	1.7e-17	8.4	8.8	1.7e-18	0.72	0.04	0.96	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPP1CB	0.04	0.04	lasso	1	0.03	9.8e-05	-8.5	-8.5	1.3e-17	-0.60	0.22	0.60	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRMT61B	0.17	0.29	enet	17	0.32	9.9e-37	8.1	8.0	1.1e-15	0.72	0.08	0.92	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TRMT61B	0.12	0.18	lasso	4	0.18	1.8e-10	8.2	8.6	1.2e-17	0.74	0.06	0.94	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	PLB1	0.11	0.07	lasso	3	0.09	1.9e-10	4.3	-7.0	2.5e-12	0.03	0.71	0.29	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPP1CB	0.03	0.03	lasso	4	0.03	5.6e-04	8.4	-8.4	6.5e-17	-0.74	0.10	0.13	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRMT61B	0.24	0.38	enet	16	0.38	8.3e-46	8.2	7.8	4.2e-15	0.74	0.09	0.91	FALSE
60	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TRMT61B	0.08	0.09	lasso	1	0.07	3.4e-04	8.2	8.2	2.7e-16	0.75	0.05	0.82	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	TRMT61B	0.09	0.11	blup	43	0.11	1.5e-12	8.3	7.4	1.8e-13	0.73	0.07	0.93	FALSE
62	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRMT61B	0.10	0.17	lasso	3	0.16	1.6e-17	8.3	8.3	6.9e-17	0.75	0.06	0.94	FALSE
63	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRMT61B	0.14	0.14	lasso	6	0.13	3.7e-09	8.3	8.3	8.7e-17	0.75	0.07	0.93	FALSE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TRMT61B	0.20	0.12	enet	12	0.18	3.2e-08	8.1	7.4	1.3e-13	0.67	0.03	0.97	FALSE
65	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PLB1	0.24	0.12	lasso	5	0.14	2.5e-06	9.0	9.6	1.0e-21	0.24	0.01	0.99	TRUE
66	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SPDYA	0.05	0.03	blup	49	0.05	6.0e-03	7.5	9.2	3.2e-20	0.78	0.02	0.56	FALSE
67	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TRMT61B	0.30	0.30	enet	18	0.30	2.6e-12	8.2	8.4	5.3e-17	0.73	0.05	0.95	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPP1CB	0.09	0.13	lasso	4	0.12	9.7e-13	8.2	-8.2	2.0e-16	-0.73	0.98	0.02	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRMT61B	0.20	0.31	lasso	4	0.31	4.8e-33	8.4	8.4	3.3e-17	0.75	0.05	0.95	FALSE
70	The Cancer Genome Atlas	Rectum Adenocarcinoma	PPP1CB	0.14	0.05	lasso	2	0.05	2.8e-02	7.5	-8.5	1.9e-17	-0.84	0.01	0.38	FALSE
71	The Cancer Genome Atlas	Soft Tissue Sarcoma	TRMT61B	0.13	0.12	enet	14	0.13	2.7e-08	8.3	8.6	9.0e-18	0.68	0.03	0.97	FALSE
72	The Cancer Genome Atlas	Stomach Adenocarcinoma	TRMT61B	0.13	0.14	enet	11	0.15	5.5e-11	8.4	7.7	9.8e-15	0.72	0.07	0.93	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	PPP1CB	0.11	0.06	lasso	7	0.10	2.4e-10	-8.5	-9.8	1.7e-22	-0.61	0.08	0.92	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	TRMT61B	0.29	0.37	lasso	4	0.38	1.5e-38	8.2	8.1	4.8e-16	0.73	0.07	0.93	FALSE
75	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRMT61B	0.26	0.15	lasso	7	0.14	1.0e-04	8.1	8.1	6.4e-16	0.74	0.03	0.80	FALSE