Best TWAS P=2.11e-27 · Best GWAS P=2.18e-27 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ZBTB38 | 0.08 | 0.04 | lasso | 4 | 0.03 | 8.1e-04 | -10.5 | -10.8 | 2.1e-27 | 0.97 | 0.01 | 0.98 | TRUE |
| 2 | GTEx | Esophagus Muscularis | XRN1 | 0.09 | 0.02 | enet | 9 | 0.03 | 7.0e-03 | -6.7 | -6.0 | 1.4e-09 | -0.05 | 0.01 | 0.98 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | TRPC1 | 0.09 | 0.04 | lasso | 2 | 0.04 | 4.8e-04 | -5.2 | 5.7 | 1.2e-08 | 0.03 | 0.16 | 0.71 | FALSE |
| 4 | GTEx | Testis | ZBTB38 | 0.14 | 0.06 | lasso | 8 | 0.05 | 2.8e-03 | -6.1 | -7.4 | 1.2e-13 | 0.59 | 0.16 | 0.73 | FALSE |
| 5 | GTEx | Thyroid | ZBTB38 | 0.11 | 0.03 | enet | 32 | 0.04 | 2.9e-04 | -6.9 | -7.5 | 4.5e-14 | 0.61 | 0.06 | 0.94 | FALSE |
| 6 | NTR | Blood | ZBTB38 | 0.03 | 0.01 | lasso | 3 | 0.01 | 2.2e-05 | -10.5 | -9.9 | 3.8e-23 | 0.87 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ZBTB38 | 0.04 | 0.03 | lasso | 3 | 0.04 | 3.0e-03 | -5.8 | -7.2 | 8.2e-13 | 0.59 | 0.06 | 0.26 | FALSE |