Best TWAS P=2.53e-10 · Best GWAS P=7.88e-17 conditioned to 4.94e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | LRRK2 | 0.33 | -0.01 | enet | 48 | 0.12 | 1.0e-04 | 2.7 | 5.2 | 2.0e-07 | 0.56 | 0.03 | 0.94 | FALSE |
| 2 | GTEx | Nerve Tibial | LRRK2 | 0.20 | 0.11 | lasso | 6 | 0.19 | 1.2e-13 | 2.4 | 5.6 | 2.1e-08 | 0.55 | 0.76 | 0.24 | FALSE |
| 3 | GTEx | Stomach | LRRK2 | 0.14 | 0.00 | lasso | 3 | 0.03 | 1.8e-02 | 7.5 | 6.3 | 2.5e-10 | 0.71 | 0.50 | 0.49 | TRUE |