Hub : Traits :

Irritable Bowel Disease (IBD)

1696 significantly associated models · 294 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	752566	2373089	4	2	3.6e-08	3.3e-08	2.1e-02	83	CPSF3L SLC35E2
2	1	7314655	8738937	2	1	7.4e-14	2.2e-15	4.1e-03	87	PARK7
3	1	19658506	21114833	1	1	3.6e-16	6.3e-20	1.3e-07	67	PLA2G5
4	1	66697368	68559650	3	6	2.5e-49	4.8e-111	7.2e-68	40	IL12RB2 IL23R MIER1
5	1	149854324	152008309	7	2	3.5e-08	7.1e-14	2.0e-11	20	HORMAD1 TDRKH
6	1	154325302	156551848	18	2	6.9e-12	1.6e-10	7.6e-01	100	ADAM15 GBAP1
7	1	160559549	162630958	5	2	3.7e-14	2.0e-20	1.2e-08	62	FCGR2A ITLN1
8	1	200014178	201528243	2	2	1.0e-12	1.0e-21	7.0e-10	59	CAMSAP1L1 CAMSAP2
9	1	209265152	210674209	2	1	2.0e-09	1.2e-08	7.7e-01	100	RP3-434O14.8
10	2	24324172	25837917	3	1	4.5e-13	7.6e-11	8.5e-01	100	ADCY3
11	2	26883355	29344127	3	2	5.3e-11	9.2e-12	3.1e-02	90	AC074117.10 RP11-373D23.3
12	2	42753863	44157441	2	1	9.1e-12	5.7e-10	3.5e-04	67	ZFP36L2
13	2	60466491	62460013	9	1	3.9e-24	2.7e-28	8.1e-06	84	PEX13
14	2	101981794	103767612	4	1	2.3e-12	1.4e-11	9.8e-03	85	IL1R1
15	2	199443880	201021954	1	1	1.5e-07	6.4e-09	3.2e-07	22	SATB2
16	2	218296003	219878756	8	1	4.8e-10	1.2e-09	3.3e-02	88	ARPC2
17	2	233227833	234904144	3	1	2.2e-28	5.4e-29	1.0e+00	100	ATG16L1
18	2	240827284	242991746	3	2	1.5e-17	2.2e-14	9.8e-02	95	AC005104.3 GPR35
19	3	46323859	50932324	40	3	1.2e-33	1.2e-35	1.0e+00	100	APEH NBEAL2 SHISA5
20	4	122377715	123976639	1	2	1.7e-11	1.4e-11	7.0e-02	93	KIAA1109
21	5	39986432	41555158	2	2	5.6e-11	3.6e-40	2.2e-27	33	CARD6 PTGER4
22	5	95519506	97065386	3	1	2.4e-12	6.8e-11	6.1e-01	99	ERAP2
23	5	129797129	132900729	15	6	5.0e-28	3.7e-27	NaN	NaN	C5orf56 IRF1 PDLIM4 SLC22A5
24	5	140789933	142230251	1	1	2.4e-10	3.5e-10	2.9e-01	97	NDFIP1
25	5	149577574	151024052	5	1	1.1e-16	5.2e-16	1.9e-02	92	DCTN4
26	5	157889391	159336686	2	1	3.6e-27	4.4e-32	1.9e-06	84	IL12B
27	5	176086479	177426530	1	1	1.6e-10	3.0e-10	1.0e+00	100	RGS14
28	6	110883139	112605814	2	1	1.9e-08	1.6e-10	1.8e-03	76	TRAF3IP2-AS1
29	6	166651581	167841508	3	1	2.8e-17	3.5e-18	6.9e-03	90	RNASET2
30	7	2032803	3510741	1	1	1.2e-07	1.6e-07	4.1e-01	98	AMZ1
31	7	73425238	74494207	2	1	7.1e-08	1.3e-06	7.8e-01	100	PMS2P5
32	7	98282214	100979310	2	2	4.0e-09	5.5e-09	5.1e-07	26	ARPC1B GIGYF1
33	7	106847492	108340749	2	1	9.5e-14	8.2e-16	5.5e-04	82	DLD
34	9	4287179	6472714	3	1	2.5e-21	3.1e-26	1.5e-06	79	IGHEP2
35	9	116849447	118266112	1	2	1.3e-24	4.1e-27	1.3e-03	91	TNFSF15
36	9	138126646	140332478	12	3	6.3e-35	3.5e-36	1.0e+00	100	CARD9 RP11-611D20.2
37	10	34607015	36198981	2	1	6.1e-13	9.1e-13	1.0e+00	100	CUL2
38	10	63253359	65264300	4	2	9.7e-17	2.3e-36	3.8e-22	41	ADO RTKN2
39	10	74740461	76150389	1	1	2.9e-07	1.9e-07	1.9e-01	94	AGAP5
40	10	80130592	82984432	2	2	4.4e-11	3.6e-12	3.9e-05	65	TSPAN14 ZMIZ1
41	10	93657148	95110026	1	1	2.0e-07	4.1e-08	6.9e-02	89	KIF11
42	11	1625363	2161858	1	1	3.0e-07	1.1e-06	1.0e+00	100	LSP1
43	11	75457950	77069746	2	2	3.1e-14	1.8e-28	1.6e-12	59	LRRC32
44	12	39904158	41454590	1	1	2.5e-10	7.9e-17	4.9e-08	57	LRRK2
45	12	67971319	69424500	1	1	7.8e-08	1.9e-25	5.8e-20	23	MDM1
46	12	111873167	113289070	1	1	1.1e-07	1.8e-11	1.2e-05	58	TRAFD1
47	14	35347512	36033703	1	1	9.9e-08	3.1e-06	6.7e-04	47	KIAA0391
48	14	88232546	88727363	1	1	8.0e-08	5.7e-12	1.6e-05	61	GPR65
49	15	66662107	68183665	1	2	4.8e-16	3.0e-21	2.5e-05	80	SMAD3
50	16	10646170	12426645	3	2	1.3e-11	1.2e-09	3.8e-01	98	LITAF RMI2
51	16	27412414	30141258	26	1	1.1e-16	4.8e-15	2.0e-01	97	SULT1A1
52	16	49403920	51535063	7	13	1.3e-33	1.8e-45	NaN	NaN	ADCY7 BRD7 CYLD HEATR3 NKD1 NOD2
53	17	32444431	32933043	1	1	1.3e-07	6.7e-13	5.6e-11	17	CCL13
54	17	36710513	39048774	17	2	3.5e-27	1.7e-29	5.3e-03	94	CASC3 PNMT
55	17	39328012	41699963	10	3	6.9e-16	1.3e-18	3.7e-01	99	HSD17B1P1 PTRF STAT5A
56	18	12538482	13133577	1	1	2.0e-18	1.0e-15	6.3e-01	100	PTPN2
57	19	389805	1802433	3	2	5.9e-13	4.2e-17	7.3e-06	72	GPX4 POLR2E
58	19	9829303	11275258	2	2	7.3e-11	1.4e-13	6.7e-06	63	PDE4A S1PR5
59	19	40534637	41938222	2	1	4.6e-08	2.2e-07	6.5e-01	99	ITPKC
60	20	57072048	58529763	1	1	1.4e-08	7.4e-10	7.0e-04	70	ZNF831
61	20	61522825	62912463	11	2	1.6e-23	1.8e-18	6.1e-02	95	RTEL1 STMN3
62	21	15634304	17135372	1	1	1.4e-09	7.5e-31	5.2e-23	27	NRIP1
63	21	44948764	46443886	2	4	6.6e-20	1.8e-24	2.7e-02	95	ICOSLG PFKL
64	22	21075537	22685340	4	1	2.2e-15	3.6e-15	1.0e+00	100	CCDC116
65	22	29304253	31118395	2	2	9.5e-10	8.4e-10	6.8e-02	91	MTMR3 NF2
66	22	38719189	40529415	3	2	2.8e-20	4.6e-24	2.0e-09	65	APOBEC3D SYNGR1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder or Schizophrenia	0.89	1	0	0.0	0.00	1.0e+00	GIGYF1
Depressed Affect (Nagel 2018)	1.00	1	1	2.2	0.00	1.0e+00	APEH
Intelligence (Savage-Jansen 2018)	1.09	2	2	4.4	0.00	1.0e+00	APEH SULT1A1
Neuroticism (Nagel 2018)	0.99	1	0	0.0	0.00	1.0e+00	RNASET2
Schizophrenia (2018)	1.00	1	0	0.0	0.00	1.0e+00	GIGYF1
Worry (Nagel 2018)	1.22	2	0	0.0	0.00	1.0e+00	MTMR3 SATB2
Crohns Disease (2017)	26.46	80	64	142.2	0.97	3.8e-64	AC074117.10 ADAM15 ADCY3 ADCY7 ADO AGAP5 APEH APOBEC3D ARPC1B ARPC2 ATG16L1 BRD7 C5orf56 CAMSAP1L1 CAMSAP2 CARD6 CARD9 CCDC116 CCL13 CPSF3L CUL2 CYLD DCTN4 ERAP2 GBAP1 GIGYF1 GPR35 GPR65 GPX4 HEATR3 ICOSLG IGHEP2 IL12B IL12RB2 IL1R1 IL23R IRF1 ITLN1 ITPKC KIAA0391 KIAA1109 KIF11 LITAF LRRC32 LRRK2 MIER1 MTMR3 NDFIP1 NKD1 NOD2 NRIP1 PARK7 PDE4A PDLIM4 PEX13 PFKL PMS2P5 PNMT POLR2E PTGER4 PTPN2 PTRF RMI2 RNASET2 RP11-373D23.3 RP11-611D20.2 RP3-434O14.8 RTEL1 S1PR5 SLC22A5 SMAD3 STAT5A STMN3 SULT1A1 SYNGR1 TNFSF15 TRAFD1 TSPAN14 ZFP36L2 ZMIZ1
Ulcerative Colitis (UC)	12.76	53	31	68.9	0.96	1.5e-33	ADO AMZ1 APEH ARPC2 BRD7 CAMSAP1L1 CAMSAP2 CARD9 CASC3 CCDC116 CPSF3L DLD FCGR2A GBAP1 GPR35 HORMAD1 HSD17B1P1 ICOSLG IGHEP2 IL12B IL12RB2 IL1R1 IL23R KIAA1109 LRRC32 LSP1 MDM1 NF2 PARK7 PEX13 PFKL PLA2G5 PNMT PTPN2 PTRF RGS14 RMI2 RP11-611D20.2 RP3-434O14.8 RTEL1 RTKN2 SATB2 SHISA5 SLC22A5 SLC35E2 SMAD3 STMN3 SULT1A1 SYNGR1 TNFSF15 TRAF3IP2-AS1 ZFP36L2 ZNF831
Reaction Time	0.94	1	0	0.0	0.00	1.0e+00	ADCY3
Verbal and Numeric Reasoning (VNR)	1.15	4	2	4.4	0.17	8.3e-01	ADCY3 APEH NBEAL2 SULT1A1
Breast Cancer	1.52	7	2	4.4	0.08	8.6e-01	ADCY3 APEH GBAP1 HSD17B1P1 IRF1 PARK7 PMS2P5
Age at First Birth	1.06	1	1	2.2	0.00	1.0e+00	APEH
Body Mass Index (BMI) (2010)	1.11	2	1	2.2	0.00	1.0e+00	ADCY3 SULT1A1
Crohns Disease (2012)	20.33	49	39	86.7	0.98	2.5e-41	ADAM15 ADCY3 ADCY7 ADO APEH ATG16L1 BRD7 C5orf56 CARD6 CARD9 CCDC116 CUL2 CYLD DCTN4 ERAP2 GBAP1 ICOSLG IGHEP2 IL12B IL12RB2 IL1R1 IL23R IRF1 LRRC32 LRRK2 MIER1 MTMR3 NDFIP1 NKD1 NOD2 PDE4A PDLIM4 PEX13 PFKL PNMT PTGER4 PTPN2 PTRF RNASET2 RTEL1 S1PR5 SLC22A5 SMAD3 STMN3 SULT1A1 SYNGR1 TNFSF15 TSPAN14 ZMIZ1
Fasting Glucose	1.67	1	1	2.2	0.00	1.0e+00	AC074117.10
HDL Cholesterol	1.26	2	2	4.4	0.00	1.0e+00	CCDC116 PNMT
Lupus	2.01	3	2	4.4	0.00	1.0e+00	CCDC116 FCGR2A IL12RB2
Primary Biliary Cirrhosis	2.74	4	4	8.9	0.54	4.6e-01	IL12RB2 PNMT RMI2 SYNGR1
Rheumatoid Arthritis	2.39	4	1	2.2	0.45	5.5e-01	FCGR2A LRRC32 PNMT PTPN2
Schizophrenia (2014)	0.94	2	0	0.0	0.00	1.0e+00	FCGR2A GIGYF1
Triglycerides	3.22	2	1	2.2	0.00	1.0e+00	AC074117.10 RP11-373D23.3
Type 2 Diabetes (T2D) (2012)	1.39	1	1	2.2	0.00	1.0e+00	KIF11
Ulcerative Colitis	10.84	33	17	37.8	0.95	2.7e-18	AMZ1 APEH ARPC2 BRD7 CAMSAP1L1 CAMSAP2 CARD9 CUL2 DLD FCGR2A GPR35 ICOSLG IGHEP2 IL12B IL1R1 IL23R KIAA1109 LRRC32 LRRK2 MDM1 PARK7 PEX13 PLA2G5 PNMT PTRF RTEL1 SATB2 SLC22A5 STMN3 SYNGR1 TNFSF15 TRAF3IP2-AS1 ZFP36L2
Blood Eosinophil Count	7.62	33	26	57.8	-0.05	7.4e-01	AC005104.3 ADCY3 ADO AMZ1 C5orf56 CAMSAP2 CARD9 CASC3 CCDC116 CUL2 ERAP2 GIGYF1 GPR35 GPR65 GPX4 HORMAD1 HSD17B1P1 ICOSLG IGHEP2 IRF1 KIAA1109 KIF11 LRRC32 NDFIP1 PDLIM4 PFKL PTPN2 RGS14 SLC22A5 SMAD3 TNFSF15 TRAFD1 ZFP36L2
Blood Platelet Count	2.59	27	22	48.9	-0.08	6.9e-01	AC074117.10 ADAM15 ADO AMZ1 ARPC2 ATG16L1 C5orf56 GBAP1 GPR35 HEATR3 HORMAD1 IGHEP2 IRF1 MTMR3 NBEAL2 NDFIP1 PDLIM4 PNMT PTGER4 RMI2 RTEL1 SLC22A5 STMN3 SULT1A1 TRAFD1 ZFP36L2 ZMIZ1
Blood Red Count	1.12	18	12	26.7	0.33	1.8e-01	AC005104.3 FCGR2A GBAP1 GIGYF1 GPX4 IGHEP2 KIF11 NDFIP1 PNMT POLR2E PTGER4 PTPN2 RGS14 RTEL1 STMN3 SULT1A1 TRAF3IP2-AS1 TRAFD1
Blood White Count	3.56	32	23	51.1	-0.15	3.8e-01	AC074117.10 ADCY3 ADO AMZ1 APEH ARPC1B ARPC2 C5orf56 CARD9 CCDC116 ERAP2 GPX4 HEATR3 IRF1 ITPKC LSP1 NBEAL2 NDFIP1 PDE4A PDLIM4 PEX13 PNMT POLR2E RGS14 RNASET2 RP11-373D23.3 RTEL1 SHISA5 SLC22A5 STMN3 TRAFD1 TSPAN14
Heel T-Score	0.77	13	7	15.6	-0.09	7.8e-01	AMZ1 APEH ARPC2 CAMSAP2 CCDC116 GBAP1 HORMAD1 NBEAL2 PMS2P5 SATB2 STAT5A TSPAN14 ZFP36L2
BMI	1.45	8	6	13.3	0.46	2.5e-01	ADCY3 APEH ARPC1B GPR65 PMS2P5 RTEL1 SULT1A1 TRAFD1
Height	1.98	27	22	48.9	0.32	8.3e-02	AC005104.3 AC074117.10 ADCY3 ADO AMZ1 APOBEC3D ARPC2 ATG16L1 C5orf56 CARD9 CCDC116 HSD17B1P1 IL1R1 IL23R IRF1 KIAA1109 KIF11 LRRC32 MIER1 MTMR3 PARK7 PDE4A PDLIM4 PTRF RGS14 RP11-373D23.3 SLC22A5
Waist Hip Ratio (WHR)	0.86	4	3	6.7	-0.09	9.1e-01	DLD HSD17B1P1 NBEAL2 STAT5A
Systolic Blood Pressure	1.33	18	6	13.3	0.12	6.3e-01	AC074117.10 ADCY3 ADO AGAP5 APEH ARPC2 CCDC116 CPSF3L CUL2 ERAP2 KIF11 LSP1 RP11-373D23.3 SLC35E2 SMAD3 STMN3 TRAFD1 TSPAN14
Smoking Status	1.21	2	1	2.2	0.00	1.0e+00	ERAP2 RTEL1
Allergy or Eczema	5.78	26	12	26.7	0.47	1.1e-02	AC074117.10 ADAM15 AMZ1 C5orf56 CASC3 CCDC116 GPR35 IGHEP2 IRF1 KIAA0391 KIAA1109 LRRC32 NBEAL2 NDFIP1 PEX13 PNMT PTGER4 RGS14 RP11-373D23.3 RTEL1 SMAD3 STAT5A STMN3 SULT1A1 TDRKH TRAFD1
Cardiovascular Disease	1.68	11	6	13.3	0.30	3.8e-01	AC074117.10 ADO ATG16L1 C5orf56 LSP1 NBEAL2 PMS2P5 RP11-373D23.3 SLC22A5 STMN3 TRAFD1
Hypothyroidism (self reported)	3.70	13	5	11.1	0.35	2.3e-01	AC005104.3 BRD7 CAMSAP1L1 GIGYF1 KIAA1109 MTMR3 NRIP1 PTPN2 PTRF RNASET2 STAT5A TRAFD1 ZMIZ1
Respiratory disease	5.72	11	10	22.2	0.02	9.6e-01	C5orf56 IRF1 KIAA1109 KIF11 LRRC32 NDFIP1 PDLIM4 PNMT RGS14 SLC22A5 SMAD3
Type 2 Diabetes (T2D) (2018)	1.97	5	3	6.7	-0.62	2.7e-01	AC074117.10 KIF11 PMS2P5 STMN3 ZFP36L2
Lung FEV1/FVC ratio	1.76	16	10	22.2	0.35	1.6e-01	AC005104.3 ADCY3 ADO AMZ1 IL1R1 IRF1 ITPKC NF2 PDLIM4 PMS2P5 PNMT RGS14 SLC22A5 SMAD3 TSPAN14 ZFP36L2
Lung FVC	1.61	15	9	20.0	-0.49	4.8e-02	AGAP5 APEH C5orf56 CARD9 GBAP1 HORMAD1 IRF1 PARK7 PNMT RTEL1 SATB2 SLC22A5 SLC35E2 STMN3 SULT1A1
Chronotype (morning person)	1.16	2	1	2.2	0.00	1.0e+00	HORMAD1 KIAA1109
Hair Pigment	0.29	9	8	17.8	0.56	1.1e-01	AC074117.10 ADAM15 ADCY3 CUL2 GBAP1 GIGYF1 RP11-373D23.3 SYNGR1 ZNF831
Tanning	0.29	6	4	8.9	-0.70	1.2e-01	AC074117.10 ADCY3 ADO GBAP1 HORMAD1 RP11-373D23.3
Hand grip strength (left)	1.59	6	4	8.9	0.54	2.7e-01	ADCY3 C5orf56 FCGR2A IRF1 PDLIM4 SLC22A5
Number of treatments/medications taken	1.77	3	0	0.0	0.00	1.0e+00	AC074117.10 PMS2P5 TRAFD1
Average weekly spirits intake	1.18	1	0	0.0	0.00	1.0e+00	APEH
Relative age of first facial hair	0.99	2	0	0.0	0.00	1.0e+00	CUL2 SATB2
Systolic blood pressure, automated reading	1.29	3	2	4.4	0.00	1.0e+00	ADO LSP1 PMS2P5
Medication: Metformin	1.86	4	0	0.0	-0.54	4.6e-01	AC074117.10 KIF11 NF2 ZFP36L2
Impedance of leg (right)	0.90	9	5	11.1	0.29	4.6e-01	AC074117.10 ADCY3 CCDC116 GBAP1 HEATR3 HORMAD1 PMS2P5 SULT1A1 ZFP36L2
Leg fat-free mass (left)	1.64	13	9	20.0	0.37	1.9e-01	AC005104.3 AC074117.10 ADO AMZ1 APEH GBAP1 IRF1 PARK7 PDE4A PDLIM4 SLC22A5 SULT1A1 TRAFD1
Trunk fat percentage	1.48	6	4	8.9	0.47	3.5e-01	ADCY3 AMZ1 APEH HORMAD1 RTEL1 SULT1A1
Hand grip strength (right)	1.70	6	4	8.9	0.63	1.3e-01	ADCY3 C5orf56 FCGR2A IRF1 PDLIM4 SLC22A5
Current tobacco smoking	1.35	2	2	4.4	0.00	1.0e+00	RTEL1 STMN3
Fed-up feelings	1.30	1	1	2.2	0.00	1.0e+00	APEH
Taking other prescription medications	1.99	1	0	0.0	0.00	1.0e+00	RNASET2
Age when periods started (menarche)	1.59	5	3	6.7	-0.50	3.9e-01	ADCY3 APEH LSP1 PMS2P5 SATB2
High blood pressure	1.54	7	5	11.1	-0.38	4.0e-01	ADO IRF1 LSP1 PDLIM4 PMS2P5 SLC22A5 TRAFD1
Hayfever, allergic rhinitis or eczema	5.66	19	12	26.7	0.36	9.2e-02	AC074117.10 C5orf56 CCDC116 IGHEP2 IRF1 KIAA0391 KIAA1109 LRRC32 NDFIP1 PEX13 PNMT PTGER4 RGS14 RP11-373D23.3 RTEL1 SLC22A5 SMAD3 STMN3 TRAFD1
Medication: Atenolol	1.46	1	1	2.2	0.00	1.0e+00	TRAFD1
Medication: Levothyroxine sodium	3.04	6	2	4.4	0.44	3.9e-01	BRD7 CPSF3L GIGYF1 PTRF RNASET2 TRAFD1
Sitting height	1.75	15	11	24.4	0.17	5.3e-01	AC074117.10 ADCY3 ADO AMZ1 ARPC2 CARD9 CCDC116 DCTN4 HSD17B1P1 IRF1 MTMR3 PARK7 PDLIM4 RGS14 SLC22A5
Body mass index (BMI)	1.41	5	3	6.7	0.66	2.2e-01	ADCY3 APEH ARPC1B PMS2P5 SULT1A1
Impedance of leg (left)	0.92	8	5	11.1	0.27	5.1e-01	AC074117.10 ADCY3 CCDC116 GBAP1 HEATR3 PMS2P5 SULT1A1 ZFP36L2
Leg predicted mass (left)	1.63	13	9	20.0	0.37	1.9e-01	AC005104.3 AC074117.10 ADO AMZ1 APEH GBAP1 IRF1 PARK7 PDE4A PDLIM4 SLC22A5 SULT1A1 TRAFD1
Trunk fat mass	1.57	5	4	8.9	0.47	4.2e-01	ADCY3 AMZ1 APEH RTEL1 SULT1A1
Waist circumference	1.48	5	3	6.7	0.36	5.5e-01	ADCY3 AMZ1 APEH SULT1A1 ZMIZ1
Past tobacco smoking	1.16	1	0	0.0	0.00	1.0e+00	ADAM15
Nervous feelings	1.08	2	0	0.0	0.00	1.0e+00	MTMR3 SATB2
Had menopause	1.31	1	1	2.2	0.00	1.0e+00	AC074117.10
Forced vital capacity (FVC)	1.28	10	6	13.3	0.11	7.7e-01	AC005104.3 ADCY3 AMZ1 ARPC2 HORMAD1 MTMR3 RTEL1 SATB2 SLC35E2 STMN3
Heel bone mineral density (BMD) T-score, automated (right)	0.81	1	0	0.0	0.00	1.0e+00	ZFP36L2
Qualifications: None of the above	0.92	2	2	4.4	0.00	1.0e+00	APEH SULT1A1
Mouth/teeth dental problems	1.47	2	0	0.0	0.00	1.0e+00	GBAP1 PMS2P5
Heart attack	1.36	1	0	0.0	0.00	1.0e+00	ZFP36L2
Allergy	6.23	20	11	24.4	-0.19	3.7e-01	AMZ1 C5orf56 CCDC116 IGHEP2 IRF1 KIAA0391 KIAA1109 KIF11 LRRC32 NBEAL2 NDFIP1 PDLIM4 PEX13 PNMT RGS14 RTEL1 SLC22A5 SMAD3 STMN3 TRAFD1
Diabetes (self-reported)	2.03	3	3	6.7	0.00	1.0e+00	AC074117.10 KIF11 PMS2P5
Hayfever/allergic rhinitis (self-reported)	3.03	4	3	6.7	0.58	1.7e-01	KIAA1109 LRRC32 PNMT SMAD3
Medication: Simvastatin	1.32	1	0	0.0	0.00	1.0e+00	AC074117.10
Fluid intelligence score	1.10	2	2	4.4	0.00	1.0e+00	APEH SULT1A1
Weight	1.61	11	6	13.3	0.48	1.1e-01	AC005104.3 AC074117.10 ADCY3 AMZ1 APEH IRF1 PDE4A RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1
Impedance of arm (right)	1.04	8	2	4.4	0.93	7.2e-04	AC074117.10 APEH HORMAD1 LRRC32 SATB2 SLC35E2 SMAD3 TRAFD1
Arm fat percentage (right)	1.59	4	3	6.7	0.63	3.7e-01	ADCY3 AMZ1 APEH SULT1A1
Trunk fat-free mass	1.50	16	11	24.4	0.36	1.6e-01	AC005104.3 AC074117.10 ADO AMZ1 ARPC2 CARD9 IRF1 MTMR3 PARK7 PDE4A PDLIM4 RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Hip circumference	1.49	7	4	8.9	0.55	2.0e-01	ADCY3 AMZ1 APEH PDE4A RTEL1 SULT1A1 TRAFD1
Alcohol intake versus 10 years previously	1.11	2	1	2.2	0.00	1.0e+00	AC074117.10 APEH
Father's age at death	1.62	1	0	0.0	0.00	1.0e+00	APEH
Worrier / anxious feelings	1.04	1	0	0.0	0.00	1.0e+00	SATB2
Forced expiratory volume in 1-second (FEV1)	1.22	7	2	4.4	0.23	6.1e-01	ADCY3 APEH HORMAD1 MTMR3 PDLIM4 SLC35E2 STMN3
Pulse rate	1.31	2	1	2.2	0.00	1.0e+00	AC074117.10 GIGYF1
Qualifications: A levels/AS levels or equivalent	1.20	2	1	2.2	0.00	1.0e+00	APEH SULT1A1
Mouth/teeth dental problems: Dentures	1.64	5	1	2.2	0.16	8.0e-01	ADCY3 C5orf56 GBAP1 PMS2P5 PNMT
Asthma	5.69	11	10	22.2	0.00	1.0e+00	C5orf56 CUL2 IRF1 KIAA1109 KIF11 LRRC32 NDFIP1 PDLIM4 PNMT SLC22A5 SMAD3
Medication: Cholesterol lowering	1.23	1	1	2.2	0.00	1.0e+00	AC074117.10
Forced expiratory volume in 1-second (FEV1), Best measure	1.23	7	0	0.0	0.35	4.5e-01	ADCY3 APEH ICOSLG MTMR3 PDLIM4 S1PR5 STMN3
Impedance of arm (left)	1.01	9	3	6.7	0.94	1.8e-04	AC074117.10 AMZ1 APEH HORMAD1 LRRC32 SATB2 SLC35E2 SMAD3 TRAFD1
Arm fat mass (right)	1.56	4	4	8.9	0.55	4.5e-01	ADCY3 AMZ1 APEH SULT1A1
Trunk predicted mass	1.50	16	11	24.4	0.36	1.6e-01	AC005104.3 AC074117.10 ADO AMZ1 ARPC2 CARD9 IRF1 MTMR3 PARK7 PDE4A PDLIM4 RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Standing height	1.97	21	14	31.1	0.39	5.5e-02	AC005104.3 AC074117.10 ADCY3 ADO AMZ1 ARPC2 C5orf56 CARD9 CCDC116 HSD17B1P1 IL1R1 IRF1 MIER1 MTMR3 PARK7 PDE4A PDLIM4 PTRF RP11-373D23.3 SLC22A5 SULT1A1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.18	1	0	0.0	0.00	1.0e+00	MIER1
Hair/balding pattern: Pattern 4	0.89	1	0	0.0	0.00	1.0e+00	RP3-434O14.8
Birth weight of first child	1.52	2	0	0.0	0.00	1.0e+00	TRAFD1 TSPAN14
Peak expiratory flow (PEF)	1.11	2	0	0.0	0.00	1.0e+00	CPSF3L ZFP36L2
Gout (self-reported)	1.60	1	1	2.2	0.00	1.0e+00	AC074117.10
Hypothyroidism/myxoedema (self-reported)	3.30	8	3	6.7	0.37	3.3e-01	BRD7 GIGYF1 KIAA1109 MTMR3 PTRF RNASET2 STAT5A TRAFD1
Medication: Ventolin 100micrograms inhaler	2.65	5	3	6.7	0.49	2.6e-01	KIAA1109 LRRC32 NDFIP1 PNMT SMAD3
Birth weight	1.51	3	2	4.4	0.00	1.0e+00	AMZ1 KIF11 TRAFD1
Forced vital capacity (FVC), Best measure	1.20	7	5	11.1	0.14	7.7e-01	AC005104.3 ADCY3 AMZ1 HORMAD1 MTMR3 SATB2 STMN3
Body fat percentage	1.54	5	4	8.9	0.47	4.2e-01	ADCY3 AMZ1 APEH RTEL1 SULT1A1
Leg fat percentage (right)	1.56	4	4	8.9	0.07	9.3e-01	ADCY3 APEH RTEL1 SULT1A1
Arm fat-free mass (right)	1.52	13	9	20.0	0.30	3.0e-01	AC005104.3 AC074117.10 AMZ1 APEH CARD9 IRF1 PARK7 PDE4A PDLIM4 RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1
Comparative body size at age 10	2.51	2	2	4.4	0.00	1.0e+00	ADCY3 SULT1A1
Wheeze or whistling in the chest in last year	2.55	6	5	11.1	0.21	6.2e-01	APEH KIAA1109 LRRC32 PNMT RTEL1 SMAD3
Age at first live birth	1.03	1	0	0.0	0.00	1.0e+00	APEH
Shortness of breath walking on level ground	1.51	1	0	0.0	0.00	1.0e+00	LRRC32
Qualifications: College or University degree	1.41	4	2	4.4	0.98	2.3e-02	APEH RTEL1 STMN3 SULT1A1
Medication: Blood pressure	1.25	1	0	0.0	0.00	1.0e+00	LSP1
Medication: Allopurinol	1.27	1	1	2.2	0.00	1.0e+00	AC074117.10
Medication: Seretide 50 evohaler	2.02	4	0	0.0	-0.56	4.4e-01	IRF1 PDLIM4 SLC22A5 SMAD3
Whole body fat mass	1.60	5	4	8.9	0.45	4.5e-01	ADCY3 AMZ1 APEH RTEL1 SULT1A1
Leg fat mass (right)	1.56	5	4	8.9	0.40	5.0e-01	ADCY3 AMZ1 APEH RTEL1 SULT1A1
Arm predicted mass (right)	1.56	14	10	22.2	0.23	4.2e-01	AC005104.3 AC074117.10 AMZ1 APEH CARD9 IRF1 PARK7 PDE4A PDLIM4 RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Pulse rate, automated reading	1.59	3	2	4.4	0.00	1.0e+00	AC074117.10 AGAP5 GIGYF1
Alcohol intake frequency.	1.31	4	2	4.4	0.34	6.6e-01	AC074117.10 APEH PMS2P5 SULT1A1
Comparative height size at age 10	1.87	16	14	31.1	0.50	2.8e-02	AC005104.3 AC074117.10 ADCY3 AMZ1 ARPC2 C5orf56 CARD9 CCDC116 IRF1 KIF11 MTMR3 PDLIM4 SLC22A5 SULT1A1 TRAFD1 ZFP36L2
Suffer from 'nerves'	1.15	2	1	2.2	0.00	1.0e+00	SATB2 SULT1A1
Overall health rating	1.26	2	1	2.2	0.00	1.0e+00	APEH PMS2P5
Age at last live birth	0.97	1	0	0.0	0.00	1.0e+00	APEH
Hypertension (Self-reported)	1.46	7	4	8.9	-0.40	3.8e-01	ADO IRF1 LSP1 PDLIM4 PMS2P5 SLC22A5 TRAFD1
Illnesses of father: Heart disease	1.40	1	0	0.0	0.00	1.0e+00	SMAD3
Forced expiratory volume in 1-second (FEV1), predicted	1.37	5	1	2.2	0.92	2.5e-02	AMZ1 IRF1 PDE4A PDLIM4 SLC22A5
Whole body fat-free mass	1.56	17	10	22.2	0.35	1.6e-01	AC005104.3 AC074117.10 ADO AMZ1 ARPC2 CARD9 GBAP1 IRF1 MTMR3 PARK7 PDE4A PDLIM4 RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Leg fat-free mass (right)	1.58	13	9	20.0	0.52	5.4e-02	AC005104.3 AC074117.10 ADO AMZ1 GBAP1 IRF1 MTMR3 PARK7 PDE4A PDLIM4 SLC22A5 SULT1A1 TRAFD1
Arm fat percentage (left)	1.59	4	4	8.9	0.63	3.7e-01	ADCY3 AMZ1 APEH SULT1A1
Mood swings	1.15	1	0	0.0	0.00	1.0e+00	APEH
Diabetes diagnosed by doctor	2.02	4	3	6.7	-0.99	6.4e-03	AC074117.10 KIF11 PMS2P5 ZFP36L2
Qualifications: nursing, teaching	0.74	1	0	0.0	0.00	1.0e+00	APEH
Mouth/teeth dental problems: Mouth ulcers	2.22	4	1	2.2	0.60	4.0e-01	BRD7 IL12B PNMT TNFSF15
Medication for cholesterol	1.26	1	0	0.0	0.00	1.0e+00	TRAFD1
Asthma (self-reported)	5.63	11	10	22.2	-0.01	9.8e-01	C5orf56 CUL2 IRF1 KIAA1109 KIF11 LRRC32 NDFIP1 PDLIM4 PNMT SLC22A5 SMAD3
Smoking status: Current	1.25	2	0	0.0	0.00	1.0e+00	RTEL1 STMN3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.09	3	0	0.0	0.00	1.0e+00	AMZ1 PNMT STMN3
Whole body water mass	1.56	17	10	22.2	0.34	1.6e-01	AC005104.3 AC074117.10 ADO AMZ1 ARPC2 CARD9 GBAP1 IRF1 MTMR3 PARK7 PDE4A PDLIM4 RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Leg predicted mass (right)	1.58	13	9	20.0	0.52	5.5e-02	AC005104.3 AC074117.10 ADO AMZ1 GBAP1 IRF1 MTMR3 PARK7 PDE4A PDLIM4 SLC22A5 SULT1A1 TRAFD1
Arm fat mass (left)	1.54	4	4	8.9	0.55	4.5e-01	ADCY3 AMZ1 APEH SULT1A1
Number of self-reported non-cancer illnesses	2.33	6	1	2.2	0.40	4.3e-01	AC074117.10 IRF1 LRRC32 PMS2P5 STMN3 TRAFD1
Miserableness	1.06	1	0	0.0	0.00	1.0e+00	APEH
Medication: Blood pressure	1.53	4	1	2.2	-0.48	5.2e-01	IRF1 LSP1 SLC22A5 TRAFD1
High cholesterol (Self-reported)	1.49	1	1	2.2	0.00	1.0e+00	AC074117.10
Medication: Bendroflumethiazide	1.55	1	1	2.2	0.00	1.0e+00	LSP1
Medication: Atorvastatin	1.48	1	1	2.2	0.00	1.0e+00	AC074117.10
Ever smoked	1.25	2	0	0.0	0.00	1.0e+00	ADAM15 ERAP2
Basal metabolic rate	1.58	17	10	22.2	0.29	2.4e-01	AC005104.3 AC074117.10 ADO AMZ1 APEH CARD9 GBAP1 IRF1 MTMR3 PARK7 PDE4A PDLIM4 RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Leg fat percentage (left)	1.60	4	4	8.9	0.13	8.7e-01	ADCY3 APEH RTEL1 SULT1A1
Arm fat-free mass (left)	1.50	15	8	17.8	0.27	3.0e-01	AC005104.3 AC074117.10 AMZ1 APEH CARD9 IRF1 MTMR3 PARK7 PDE4A PDLIM4 RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1
Number of operations (self-reported)	1.81	3	1	2.2	0.00	1.0e+00	AMZ1 MTMR3 PARK7
Irritability	0.96	1	0	0.0	0.00	1.0e+00	ZFP36L2
Diastolic blood pressure, automated reading	1.54	10	6	13.3	0.30	4.0e-01	ADAM15 ADO APEH ERAP2 GIGYF1 LSP1 PMS2P5 RTEL1 STMN3 TRAFD1
Vascular/heart problems diagnosed by doctor	1.64	7	5	11.1	0.43	2.9e-01	ADO IRF1 LSP1 PDLIM4 PMS2P5 SLC22A5 TRAFD1
Cholesterol lowering medication	1.40	1	1	2.2	0.00	1.0e+00	AC074117.10
Pain experienced in last month	1.33	1	0	0.0	0.00	1.0e+00	APEH
Heart attack/myocardial infarction (self-reported)	1.40	1	0	0.0	0.00	1.0e+00	ZFP36L2
Impedance of whole body	0.90	9	2	4.4	0.70	3.5e-02	AC074117.10 ADCY3 APEH HEATR3 HORMAD1 PMS2P5 SATB2 SLC35E2 ZFP36L2
Leg fat mass (left)	1.57	5	4	8.9	0.41	4.9e-01	ADCY3 AMZ1 APEH RTEL1 SULT1A1
Arm predicted mass (left)	1.52	16	8	17.8	0.23	3.8e-01	AC005104.3 AC074117.10 AMZ1 APEH ARPC2 CARD9 IRF1 MTMR3 PARK7 PDE4A PDLIM4 RP11-373D23.3 SLC22A5 SULT1A1 TRAFD1 ZMIZ1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	36	1.03	2.4
GTEx	Adipose Visceral Omentum	21	1.03	2.5
GTEx	Adrenal Gland	17	1.17	2.4
GTEx	Artery Aorta	31	1.04	2.3
GTEx	Artery Coronary	17	1.44	2.5
GTEx	Artery Tibial	41	1.09	2.4
GTEx	Brain Caudate basal ganglia	12	1.30	2.4
GTEx	Brain Cerebellar Hemisphere	22	1.48	2.6
GTEx	Brain Cerebellum	22	1.11	2.5
GTEx	Brain Cortex	19	1.84	2.5
GTEx	Brain Frontal Cortex BA9	12	1.30	2.5
GTEx	Brain Hippocampus	7	1.33	2.4
GTEx	Brain Hypothalamus	8	1.35	2.6
GTEx	Brain Nucleus accumbens basal ganglia	12	1.39	2.4
GTEx	Brain Putamen basal ganglia	10	1.60	2.5
GTEx	Breast Mammary Tissue	23	1.17	2.3
GTEx	Breast Mammary Tissue (Male)	11	0.92	2.3
GTEx	Breast Mammary Tissue (Female)	16	0.98	2.4
GTEx	Cells EBV-transformed lymphocytes	11	0.77	2.5
GTEx	Cells Transformed fibroblasts	41	0.98	2.4
GTEx	Colon Sigmoid	18	1.23	2.5
GTEx	Colon Transverse	26	1.26	2.4
GTEx	Esophagus Gastroesophageal Junction	23	1.59	2.5
GTEx	Esophagus Mucosa	40	1.21	2.7
GTEx	Esophagus Muscularis	32	0.99	2.4
GTEx	Heart Atrial Appendage	22	1.39	2.6
GTEx	Heart Left Ventricle	16	1.04	2.3
GTEx	Liver	7	0.98	2.3
GTEx	Lung	43	1.50	2.6
GTEx	Muscle Skeletal	24	0.83	2.3
GTEx	Nerve Tibial	49	1.13	2.4
GTEx	Ovary	17	1.87	2.8
GTEx	Pancreas	14	0.86	2.3
GTEx	Pituitary	19	1.71	2.5
GTEx	Prostate	15	1.81	2.7
GTEx	Skin Not Sun Exposed Suprapubic	31	1.26	2.5
GTEx	Skin Sun Exposed Lower leg	41	1.13	2.5
GTEx	Small Intestine Terminal Ileum	4	0.87	2.2
GTEx	Spleen	21	1.49	2.7
GTEx	Stomach	18	1.24	2.6
GTEx	Testis	36	1.14	2.4
GTEx	Thyroid	44	1.10	2.4
GTEx	Uterus	8	1.41	2.5
GTEx	Vagina	13	2.05	2.7
GTEx	Whole Blood	33	1.66	3.0
METSIM	Adipose	49	1.06	2.4
NTR	Blood	32	1.33	2.8
ROSMAP	Brain Pre-frontal Cortex	40	0.91	2.2
YFS	Blood	44	0.95	2.5
CommonMind	Brain Pre-frontal Cortex	44	0.82	2.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	19	1.15	2.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	37	0.84	2.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	11	1.00	2.4
The Cancer Genome Atlas	Colon Adenocarcinoma	18	0.87	2.4
The Cancer Genome Atlas	Esophageal Carcinoma	6	0.87	2.1
The Cancer Genome Atlas	Glioblastoma Multiforme	10	0.98	2.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	26	0.95	2.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	30	0.73	2.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	18	0.88	2.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	43	1.00	2.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	12	1.08	2.2
The Cancer Genome Atlas	Lung Adenocarcinoma	28	0.95	2.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	26	1.04	2.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	18	1.13	2.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	17	1.02	2.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	15	1.13	2.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	40	0.86	2.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	11	1.58	2.8
The Cancer Genome Atlas	Soft Tissue Sarcoma	9	0.84	2.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	8	1.50	2.6
The Cancer Genome Atlas	Stomach Adenocarcinoma	19	1.13	2.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	11	0.86	2.3
The Cancer Genome Atlas	Thyroid Carcinoma	47	0.91	2.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	5	0.98	2.3