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chr16:10,646,170-12,426,645

Best TWAS P=1.29e-11 · Best GWAS P=1.19e-09 conditioned to 0.381

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RMI2	0.49	0.43	bslmm	534	0.57	4.4e-84	-5.4	-5.3	1.1e-07	0.81	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	RMI2	0.10	0.06	lasso	5	0.07	1.9e-06	-5.1	-5.8	5.2e-09	0.49	0.27	0.72	FALSE
3	GTEx	Adipose Visceral Omentum	RMI2	0.23	0.16	enet	16	0.14	6.6e-08	3.5	-6.6	5.4e-11	0.65	0.08	0.91	FALSE
4	GTEx	Adrenal Gland	RMI2	0.24	0.12	lasso	7	0.15	5.2e-06	-5.4	-5.9	4.4e-09	0.82	0.01	0.98	FALSE
5	GTEx	Artery Aorta	RMI2	0.30	0.11	lasso	5	0.17	1.3e-09	-5.2	-6.5	6.9e-11	0.73	0.02	0.98	FALSE
6	GTEx	Artery Coronary	RMI2	0.32	0.14	lasso	6	0.12	9.9e-05	-5.1	-6.5	1.0e-10	0.50	0.10	0.88	FALSE
7	GTEx	Artery Tibial	RMI2	0.27	0.11	enet	27	0.21	1.4e-16	-5.1	-6.8	1.3e-11	0.77	0.07	0.93	TRUE
8	GTEx	Brain Caudate basal ganglia	RMI2	0.46	0.22	enet	19	0.24	1.2e-07	-5.4	-6.0	2.5e-09	0.85	0.01	0.99	FALSE
9	GTEx	Brain Cortex	RMI2	0.55	0.15	enet	10	0.17	2.3e-05	-5.4	-5.9	4.5e-09	0.90	0.02	0.98	FALSE
10	GTEx	Breast Mammary Tissue	RMI2	0.37	0.25	lasso	7	0.21	3.5e-11	-5.4	-6.0	2.2e-09	0.90	0.04	0.96	FALSE
11	GTEx	Breast Mammary Tissue (Male)	RMI2	0.32	0.15	enet	25	0.10	2.9e-03	-6.1	-6.2	7.6e-10	0.73	0.01	0.90	FALSE
12	GTEx	Colon Sigmoid	RMI2	0.30	0.09	enet	11	0.12	6.2e-05	-5.4	-5.4	5.3e-08	0.92	0.01	0.99	FALSE
13	GTEx	Heart Left Ventricle	RMI2	0.24	0.09	lasso	6	0.12	6.2e-07	-4.8	-5.5	3.1e-08	0.59	0.09	0.90	FALSE
14	GTEx	Muscle Skeletal	RMI2	0.28	0.12	lasso	11	0.20	2.1e-19	-5.1	-5.8	5.4e-09	0.68	0.24	0.76	FALSE
15	GTEx	Muscle Skeletal	LITAF	0.39	0.19	enet	30	0.21	1.9e-20	5.2	-5.7	1.4e-08	0.27	0.13	0.87	TRUE
16	GTEx	Nerve Tibial	RMI2	0.50	0.24	enet	35	0.38	5.9e-28	4.1	-5.6	2.4e-08	0.78	0.83	0.17	FALSE
17	GTEx	Ovary	RMI2	0.48	0.26	lasso	9	0.20	1.2e-05	-6.1	-6.7	2.7e-11	0.94	0.00	0.99	FALSE
18	GTEx	Pituitary	RMI2	0.52	0.18	enet	6	0.32	6.6e-09	-5.4	-5.4	5.4e-08	0.95	0.01	0.98	FALSE
19	GTEx	Prostate	RMI2	0.35	0.09	lasso	2	0.16	1.1e-04	-4.8	-6.0	2.3e-09	0.52	0.08	0.37	FALSE
20	GTEx	Uterus	RMI2	0.54	0.02	enet	20	0.04	6.4e-02	4.1	-6.7	1.5e-11	0.58	0.04	0.67	FALSE
21	METSIM	Adipose	RMI2	0.20	0.18	lasso	8	0.26	3.0e-38	-5.4	-5.9	3.4e-09	0.83	0.10	0.90	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	RMI2	0.46	0.49	bslmm	510	0.58	1.5e-92	-5.4	-5.5	4.6e-08	0.82	0.07	0.93	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	C16orf75	0.35	0.24	lasso	7	0.37	2.7e-40	-4.6	-5.3	9.5e-08	0.69	0.75	0.25	FALSE