Best TWAS P=1.83e-10 · Best GWAS P=8.08e-17 conditioned to 4.61e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Left Ventricle | OCEL1 | 0.44 | 0.18 | lasso | 7 | 0.40 | 6.0e-23 | -3.8 | -5.1 | 2.8e-07 | 0.34 | 0.92 | 0.07 | FALSE |
| 2 | GTEx | Muscle Skeletal | ABHD8 | 0.16 | 0.07 | lasso | 5 | 0.09 | 4.5e-09 | 4.1 | -5.5 | 5.0e-08 | 0.54 | 0.52 | 0.48 | FALSE |
| 3 | GTEx | Nerve Tibial | ANKLE1 | 0.16 | 0.16 | lasso | 3 | 0.15 | 4.5e-11 | -6.4 | -6.4 | 1.8e-10 | 0.72 | 0.98 | 0.02 | TRUE |
| 4 | GTEx | Thyroid | ANKLE1 | 0.10 | 0.03 | lasso | 5 | 0.02 | 5.9e-03 | -6.4 | -6.0 | 1.7e-09 | 0.68 | 0.17 | 0.16 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GTPBP3 | 0.24 | 0.09 | lasso | 3 | 0.12 | 9.4e-13 | 1.8 | 5.5 | 4.3e-08 | -0.50 | 0.85 | 0.15 | TRUE |
| 6 | The Cancer Genome Atlas | Stomach Adenocarcinoma | OCEL1 | 0.18 | 0.08 | blup | 53 | 0.11 | 1.4e-08 | -6.4 | -5.4 | 6.5e-08 | 0.53 | 0.04 | 0.96 | TRUE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C19orf62 | 0.13 | 0.11 | lasso | 6 | 0.10 | 1.9e-04 | -6.4 | 5.8 | 5.8e-09 | -0.65 | 0.04 | 0.83 | FALSE |