Hub : Traits :

Ovarian Cancer

472 significantly associated models · 42 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	176721984	177234702	2	1	9.1e-14	3.5e-14	3.4e-03	85	HOXD9
2	3	155768424	157456920	3	3	4.4e-20	1.1e-38	5.7e-16	61	LINC00886 LOC100287227
3	8	81971745	83365154	1	1	1.0e-10	1.3e-09	3.3e-01	97	CHMP4C
4	10	21087485	22724472	2	1	4.5e-09	4.9e-10	3.7e-02	89	MLLT10
5	15	90800449	92187978	1	1	6.6e-08	8.4e-08	2.0e-01	94	RCCD1
6	17	42774693	47357969	27	2	2.5e-14	9.3e-14	2.5e-03	84	HOXB-AS1 PLEKHM1
7	19	16643043	18117646	5	3	1.8e-10	8.1e-17	4.6e-05	76	ANKLE1 GTPBP3 OCEL1
8	21	35795370	36339264	1	1	1.9e-07	1.0e-06	3.9e-02	82	CLIC6

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Depressed Affect (Nagel 2018)	3.12	1	1	2.2	0.00	1.0000	PLEKHM1
Depression (Nagel 2018)	1.08	1	0	0.0	0.00	1.0000	PLEKHM1
Intelligence (Savage-Jansen 2018)	1.22	1	0	0.0	0.00	1.0000	PLEKHM1
Neuroticism (Nagel 2018)	3.97	1	1	2.2	0.00	1.0000	PLEKHM1
Worry (Nagel 2018)	2.65	1	1	2.2	0.00	1.0000	PLEKHM1
Verbal and Numeric Reasoning (VNR)	1.39	1	0	0.0	0.00	1.0000	PLEKHM1
Breast Cancer	6.62	5	4	8.9	0.64	0.2455	ANKLE1 MLLT10 OCEL1 PLEKHM1 RCCD1
Neuroticism (2016)	2.98	1	1	2.2	0.00	1.0000	PLEKHM1
Primary Biliary Cirrhosis	1.69	1	0	0.0	0.00	1.0000	PLEKHM1
Blood Eosinophil Count	1.32	1	1	2.2	0.00	1.0000	PLEKHM1
Blood Platelet Count	1.37	3	2	4.4	0.00	1.0000	HOXB-AS1 PLEKHM1 RCCD1
Blood Red Count	5.37	3	3	6.7	0.00	1.0000	HOXB-AS1 HOXD9 PLEKHM1
Blood White Count	0.86	1	1	2.2	0.00	1.0000	PLEKHM1
Heel T-Score	3.15	7	5	11.1	0.25	0.5818	ANKLE1 CHMP4C HOXD9 LINC00886 LOC100287227 OCEL1 PLEKHM1
BMI	2.04	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Height	1.38	5	5	11.1	0.97	0.0010	ANKLE1 GTPBP3 LOC100287227 OCEL1 PLEKHM1
Waist Hip Ratio (WHR)	2.56	2	1	2.2	0.00	1.0000	LOC100287227 PLEKHM1
Systolic Blood Pressure	1.67	2	1	2.2	0.00	1.0000	HOXB-AS1 PLEKHM1
Smoking Status	1.79	1	1	2.2	0.00	1.0000	MLLT10
Cardiovascular Disease	0.83	1	0	0.0	0.00	1.0000	MLLT10
Respiratory disease	1.63	1	0	0.0	0.00	1.0000	LOC100287227
Lung FEV1/FVC ratio	1.54	3	1	2.2	0.00	1.0000	LINC00886 MLLT10 PLEKHM1
Lung FVC	5.32	4	4	8.9	0.98	0.0220	CLIC6 HOXB-AS1 MLLT10 PLEKHM1
Neuroticism	3.99	1	1	2.2	0.00	1.0000	PLEKHM1
Chronotype (morning person)	1.76	1	0	0.0	0.00	1.0000	LOC100287227
Hair Pigment	0.28	2	1	2.2	0.00	1.0000	HOXB-AS1 PLEKHM1
Tanning	0.48	1	0	0.0	0.00	1.0000	LOC100287227
Hand grip strength (left)	2.80	2	1	2.2	0.00	1.0000	HOXB-AS1 PLEKHM1
Number of treatments/medications taken	2.24	1	1	2.2	0.00	1.0000	MLLT10
Sensitivity / hurt feelings	4.45	1	1	2.2	0.00	1.0000	PLEKHM1
Frequency of depressed mood in last 2 weeks	1.30	1	0	0.0	0.00	1.0000	PLEKHM1
Relative age of first facial hair	4.56	1	1	2.2	0.00	1.0000	PLEKHM1
Ever had hysterectomy (womb removed)	2.15	1	0	0.0	0.00	1.0000	MLLT10
Systolic blood pressure, automated reading	2.57	1	0	0.0	0.00	1.0000	PLEKHM1
Impedance of leg (right)	1.48	2	0	0.0	0.00	1.0000	HOXD9 PLEKHM1
Leg fat-free mass (left)	1.12	2	0	0.0	0.00	1.0000	GTPBP3 MLLT10
Trunk fat percentage	1.95	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Hand grip strength (right)	2.81	3	1	2.2	0.00	1.0000	HOXB-AS1 MLLT10 PLEKHM1
Maternal smoking around birth	1.88	1	0	0.0	0.00	1.0000	MLLT10
Fed-up feelings	1.98	1	1	2.2	0.00	1.0000	PLEKHM1
Relative age voice broke	3.46	1	1	2.2	0.00	1.0000	PLEKHM1
Bilateral oophorectomy (both ovaries removed)	2.71	1	0	0.0	0.00	1.0000	MLLT10
Heel bone mineral density (BMD) T-score, automated (left)	2.23	1	0	0.0	0.00	1.0000	LINC00886
High blood pressure	1.62	1	0	0.0	0.00	1.0000	MLLT10
Sitting height	2.18	3	1	2.2	0.98	0.0159	LOC100287227 MLLT10 PLEKHM1
Body mass index (BMI)	2.33	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Impedance of leg (left)	1.31	1	0	0.0	0.00	1.0000	PLEKHM1
Leg predicted mass (left)	1.13	2	0	0.0	0.00	1.0000	GTPBP3 MLLT10
Trunk fat mass	1.76	1	1	2.2	0.00	1.0000	MLLT10
Waist circumference	2.68	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Past tobacco smoking	1.87	1	0	0.0	0.00	1.0000	MLLT10
Nervous feelings	2.32	1	1	2.2	0.00	1.0000	PLEKHM1
Frequency of tenseness / restlessness in last 2 weeks	2.73	1	1	2.2	0.00	1.0000	PLEKHM1
Hearing difficulty/problems with background noise	2.02	1	0	0.0	0.00	1.0000	PLEKHM1
Hair/balding pattern: Pattern 2	1.85	1	0	0.0	0.00	1.0000	PLEKHM1
Forced vital capacity (FVC)	4.92	5	1	2.2	0.97	0.0013	GTPBP3 HOXB-AS1 LOC100287227 MLLT10 PLEKHM1
Heel bone mineral density (BMD) T-score, automated (right)	2.31	2	0	0.0	0.00	1.0000	LINC00886 LOC100287227
Ever unenthusiastic/disinterested for a whole week	2.31	1	0	0.0	0.00	1.0000	PLEKHM1
Allergy	0.99	1	0	0.0	0.00	1.0000	LOC100287227
Neuroticism score	3.35	1	1	2.2	0.00	1.0000	PLEKHM1
Weight	1.51	1	1	2.2	0.00	1.0000	MLLT10
Impedance of arm (right)	2.93	5	2	4.4	0.27	0.6623	ANKLE1 HOXD9 MLLT10 OCEL1 PLEKHM1
Arm fat percentage (right)	1.83	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Trunk fat-free mass	1.66	4	2	4.4	0.98	0.0235	ANKLE1 GTPBP3 HOXD9 OCEL1
Hip circumference	1.93	1	1	2.2	0.00	1.0000	MLLT10
Worrier / anxious feelings	1.79	1	1	2.2	0.00	1.0000	PLEKHM1
Hair/balding pattern: Pattern 3	4.36	1	1	2.2	0.00	1.0000	PLEKHM1
Number of live births	1.82	1	0	0.0	0.00	1.0000	PLEKHM1
Forced expiratory volume in 1-second (FEV1)	4.73	3	1	2.2	0.00	1.0000	HOXB-AS1 LOC100287227 PLEKHM1
Qualifications: A levels/AS levels or equivalent	2.28	1	0	0.0	0.00	1.0000	PLEKHM1
Asthma	2.15	2	0	0.0	0.00	1.0000	LOC100287227 MLLT10
Medication: Ibuprofen (e.g. Nurofen)	2.27	1	0	0.0	0.00	1.0000	PLEKHM1
Forced expiratory volume in 1-second (FEV1), Best measure	4.88	3	1	2.2	0.99	0.0113	HOXB-AS1 LOC100287227 PLEKHM1
Impedance of arm (left)	3.18	5	3	6.7	0.23	0.7134	ANKLE1 HOXD9 MLLT10 OCEL1 PLEKHM1
Arm fat mass (right)	1.74	1	1	2.2	0.00	1.0000	MLLT10
Trunk predicted mass	1.64	4	2	4.4	0.98	0.0215	ANKLE1 GTPBP3 HOXD9 OCEL1
Standing height	1.49	3	3	6.7	0.98	0.0239	GTPBP3 LOC100287227 PLEKHM1
Breastfed as a baby	1.60	1	0	0.0	0.00	1.0000	CHMP4C
Hair/balding pattern: Pattern 4	8.13	1	1	2.2	0.00	1.0000	PLEKHM1
Peak expiratory flow (PEF)	3.90	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Medication: Paracetamol	4.32	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Headache pain in last month	3.43	1	1	2.2	0.00	1.0000	PLEKHM1
Birth weight	1.41	1	0	0.0	0.00	1.0000	LOC100287227
Forced vital capacity (FVC), Best measure	5.31	4	2	4.4	0.97	0.0049	HOXB-AS1 LOC100287227 MLLT10 PLEKHM1
Body fat percentage	2.07	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Leg fat percentage (right)	2.74	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Arm fat-free mass (right)	1.83	5	1	2.2	0.56	0.3211	ANKLE1 GTPBP3 HOXD9 MLLT10 OCEL1
Worry too long after embarrassment	2.95	1	0	0.0	0.00	1.0000	PLEKHM1
Qualifications: College or University degree	1.82	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Medication for pain relief, constipation, heartburn	3.00	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Medication: Ibuprofen	2.12	1	0	0.0	0.00	1.0000	PLEKHM1
Whole body fat mass	1.83	1	1	2.2	0.00	1.0000	MLLT10
Leg fat mass (right)	2.40	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Arm predicted mass (right)	1.77	4	1	2.2	0.51	0.4947	GTPBP3 HOXD9 MLLT10 OCEL1
Pulse rate, automated reading	1.63	1	0	0.0	0.00	1.0000	ANKLE1
Alcohol intake frequency.	1.67	1	1	2.2	0.00	1.0000	PLEKHM1
Comparative height size at age 10	0.97	1	1	2.2	0.00	1.0000	PLEKHM1
Suffer from 'nerves'	1.46	1	0	0.0	0.00	1.0000	PLEKHM1
Overall health rating	1.46	1	0	0.0	0.00	1.0000	MLLT10
Hypertension (Self-reported)	1.59	1	0	0.0	0.00	1.0000	MLLT10
Smoking status: Previous	1.83	1	0	0.0	0.00	1.0000	MLLT10
Whole body fat-free mass	1.47	4	0	0.0	0.98	0.0227	ANKLE1 GTPBP3 HOXD9 OCEL1
Leg fat-free mass (right)	1.16	2	0	0.0	0.00	1.0000	GTPBP3 OCEL1
Arm fat percentage (left)	1.94	2	2	4.4	0.00	1.0000	LOC100287227 MLLT10
Handedness (chirality/laterality): Left-handed	2.57	1	0	0.0	0.00	1.0000	PLEKHM1
Mood swings	2.86	1	1	2.2	0.00	1.0000	PLEKHM1
Loneliness, isolation	1.25	1	0	0.0	0.00	1.0000	PLEKHM1
Diabetes diagnosed by doctor	2.16	1	0	0.0	0.00	1.0000	RCCD1
Mouth/teeth dental problems: Mouth ulcers	2.30	1	1	2.2	0.00	1.0000	PLEKHM1
Breast cancer (self-reported)	3.00	1	0	0.0	0.00	1.0000	MLLT10
Asthma (self-reported)	1.83	1	0	0.0	0.00	1.0000	LOC100287227
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.03	1	1	2.2	0.00	1.0000	PLEKHM1
Whole body water mass	1.49	4	1	2.2	0.97	0.0257	ANKLE1 GTPBP3 HOXD9 OCEL1
Leg predicted mass (right)	1.17	1	0	0.0	0.00	1.0000	GTPBP3
Arm fat mass (left)	1.80	1	1	2.2	0.00	1.0000	MLLT10
Number of self-reported non-cancer illnesses	1.76	1	0	0.0	0.00	1.0000	MLLT10
Average weekly champagne plus white wine intake	3.31	1	0	0.0	0.00	1.0000	PLEKHM1
Miserableness	1.61	1	1	2.2	0.00	1.0000	PLEKHM1
Guilty feelings	1.58	1	0	0.0	0.00	1.0000	PLEKHM1
Medication: Blood pressure	2.24	1	1	2.2	0.00	1.0000	PLEKHM1
Medication: Paracetamol	4.42	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Basal metabolic rate	1.45	4	0	0.0	0.52	0.4753	ANKLE1 GTPBP3 MLLT10 OCEL1
Leg fat percentage (left)	2.73	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Arm fat-free mass (left)	1.84	5	1	2.2	0.56	0.3226	ANKLE1 GTPBP3 HOXD9 MLLT10 OCEL1
Number of operations (self-reported)	2.62	1	0	0.0	0.00	1.0000	MLLT10
Irritability	1.87	1	1	2.2	0.00	1.0000	PLEKHM1
Diastolic blood pressure, automated reading	1.59	1	1	2.2	0.00	1.0000	MLLT10
Vascular/heart problems diagnosed by doctor	1.58	1	0	0.0	0.00	1.0000	MLLT10
Pain experienced in last month	2.31	1	0	0.0	0.00	1.0000	PLEKHM1
Impedance of whole body	2.53	4	2	4.4	0.49	0.5150	ANKLE1 HOXD9 OCEL1 PLEKHM1
Leg fat mass (left)	2.34	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Arm predicted mass (left)	1.80	5	1	2.2	0.57	0.3192	ANKLE1 GTPBP3 HOXD9 MLLT10 OCEL1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	10	0.286	1.3
GTEx	Adipose Visceral Omentum	6	0.294	1.4
GTEx	Adrenal Gland	6	0.412	1.4
GTEx	Artery Aorta	10	0.336	1.4
GTEx	Artery Coronary	9	0.759	1.5
GTEx	Artery Tibial	5	0.133	1.3
GTEx	Brain Caudate basal ganglia	5	0.542	1.5
GTEx	Brain Cerebellar Hemisphere	7	0.470	1.4
GTEx	Brain Cerebellum	8	0.403	1.3
GTEx	Brain Cortex	7	0.676	1.6
GTEx	Brain Frontal Cortex BA9	8	0.864	1.6
GTEx	Brain Hippocampus	5	0.951	1.6
GTEx	Brain Hypothalamus	4	0.677	1.5
GTEx	Brain Nucleus accumbens basal ganglia	7	0.808	1.6
GTEx	Brain Putamen basal ganglia	5	0.800	1.6
GTEx	Breast Mammary Tissue	7	0.354	1.4
GTEx	Breast Mammary Tissue (Male)	8	0.670	1.5
GTEx	Breast Mammary Tissue (Female)	8	0.486	1.4
GTEx	Cells EBV-transformed lymphocytes	9	0.632	1.6
GTEx	Cells Transformed fibroblasts	11	0.262	1.4
GTEx	Colon Sigmoid	7	0.478	1.5
GTEx	Colon Transverse	9	0.435	1.4
GTEx	Esophagus Gastroesophageal Junction	9	0.622	1.5
GTEx	Esophagus Mucosa	12	0.361	1.4
GTEx	Esophagus Muscularis	11	0.340	1.4
GTEx	Heart Atrial Appendage	7	0.443	1.4
GTEx	Heart Left Ventricle	7	0.457	1.4
GTEx	Liver	4	0.557	1.5
GTEx	Lung	12	0.417	1.3
GTEx	Muscle Skeletal	13	0.449	1.3
GTEx	Nerve Tibial	10	0.231	1.3
GTEx	Ovary	6	0.659	1.5
GTEx	Pancreas	8	0.490	1.4
GTEx	Pituitary	5	0.448	1.4
GTEx	Prostate	4	0.479	1.4
GTEx	Skin Not Sun Exposed Suprapubic	9	0.366	1.4
GTEx	Skin Sun Exposed Lower leg	12	0.330	1.3
GTEx	Small Intestine Terminal Ileum	4	0.866	1.7
GTEx	Spleen	9	0.637	1.5
GTEx	Stomach	7	0.481	1.4
GTEx	Testis	11	0.348	1.4
GTEx	Thyroid	14	0.350	1.4
GTEx	Uterus	6	1.056	1.6
GTEx	Vagina	6	0.943	1.6
GTEx	Whole Blood	6	0.301	1.3
METSIM	Adipose	2	0.043	1.2
NTR	Blood	4	0.166	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.1
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	4	0.241	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	5	0.113	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	4	0.363	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	4	0.193	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	4	0.582	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	5	0.488	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	5	0.183	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	7	0.170	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	4	0.195	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	5	0.116	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	3	0.271	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	6	0.204	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	4	0.159	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	6	0.375	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	5	0.300	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	4	0.301	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	10	0.216	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	3	0.431	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	3	0.280	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	6	0.355	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	3	0.234	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	6	0.116	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	4	0.781	1.5