Hub : Traits :

Ovarian Cancer

472 significantly associated models · 42 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	176721984	177234702	2	1	9.1e-14	3.5e-14	3.4e-03	85	HOXD9
2	3	155768424	157456920	3	3	4.4e-20	1.1e-38	5.7e-16	61	LINC00886 LOC100287227
3	8	81971745	83365154	1	1	1.0e-10	1.3e-09	3.3e-01	97	CHMP4C
4	10	21087485	22724472	2	1	4.5e-09	4.9e-10	3.7e-02	89	MLLT10
5	15	90800449	92187978	1	1	6.6e-08	8.4e-08	2.0e-01	94	RCCD1
6	17	42774693	47357969	27	2	2.5e-14	9.3e-14	2.5e-03	84	HOXB-AS1 PLEKHM1
7	19	16643043	18117646	5	3	1.8e-10	8.1e-17	4.6e-05	76	ANKLE1 GTPBP3 OCEL1
8	21	35795370	36339264	1	1	1.9e-07	1.0e-06	3.9e-02	82	CLIC6

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Hair/balding pattern: Pattern 4	8.13	1	1	2.2	0.00	1.0000	PLEKHM1
Breast Cancer	6.62	5	4	8.9	0.64	0.2455	ANKLE1 MLLT10 OCEL1 PLEKHM1 RCCD1
Blood Red Count	5.37	3	3	6.7	0.00	1.0000	HOXB-AS1 HOXD9 PLEKHM1
Lung FVC	5.32	4	4	8.9	0.98	0.0220	CLIC6 HOXB-AS1 MLLT10 PLEKHM1
Forced vital capacity (FVC), Best measure	5.31	4	2	4.4	0.97	0.0049	HOXB-AS1 LOC100287227 MLLT10 PLEKHM1
Forced vital capacity (FVC)	4.92	5	1	2.2	0.97	0.0013	GTPBP3 HOXB-AS1 LOC100287227 MLLT10 PLEKHM1
Forced expiratory volume in 1-second (FEV1), Best measure	4.88	3	1	2.2	0.99	0.0113	HOXB-AS1 LOC100287227 PLEKHM1
Forced expiratory volume in 1-second (FEV1)	4.73	3	1	2.2	0.00	1.0000	HOXB-AS1 LOC100287227 PLEKHM1
Relative age of first facial hair	4.56	1	1	2.2	0.00	1.0000	PLEKHM1
Sensitivity / hurt feelings	4.45	1	1	2.2	0.00	1.0000	PLEKHM1
Medication: Paracetamol	4.42	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Hair/balding pattern: Pattern 3	4.36	1	1	2.2	0.00	1.0000	PLEKHM1
Medication: Paracetamol	4.32	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.03	1	1	2.2	0.00	1.0000	PLEKHM1
Neuroticism	3.99	1	1	2.2	0.00	1.0000	PLEKHM1
Neuroticism (Nagel 2018)	3.97	1	1	2.2	0.00	1.0000	PLEKHM1
Peak expiratory flow (PEF)	3.90	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Relative age voice broke	3.46	1	1	2.2	0.00	1.0000	PLEKHM1
Headache pain in last month	3.43	1	1	2.2	0.00	1.0000	PLEKHM1
Neuroticism score	3.35	1	1	2.2	0.00	1.0000	PLEKHM1
Average weekly champagne plus white wine intake	3.31	1	0	0.0	0.00	1.0000	PLEKHM1
Impedance of arm (left)	3.18	5	3	6.7	0.23	0.7134	ANKLE1 HOXD9 MLLT10 OCEL1 PLEKHM1
Heel T-Score	3.15	7	5	11.1	0.25	0.5818	ANKLE1 CHMP4C HOXD9 LINC00886 LOC100287227 OCEL1 PLEKHM1
Depressed Affect (Nagel 2018)	3.12	1	1	2.2	0.00	1.0000	PLEKHM1
Medication for pain relief, constipation, heartburn	3.00	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Breast cancer (self-reported)	3.00	1	0	0.0	0.00	1.0000	MLLT10
Neuroticism (2016)	2.98	1	1	2.2	0.00	1.0000	PLEKHM1
Worry too long after embarrassment	2.95	1	0	0.0	0.00	1.0000	PLEKHM1
Impedance of arm (right)	2.93	5	2	4.4	0.27	0.6623	ANKLE1 HOXD9 MLLT10 OCEL1 PLEKHM1
Mood swings	2.86	1	1	2.2	0.00	1.0000	PLEKHM1
Hand grip strength (right)	2.81	3	1	2.2	0.00	1.0000	HOXB-AS1 MLLT10 PLEKHM1
Hand grip strength (left)	2.80	2	1	2.2	0.00	1.0000	HOXB-AS1 PLEKHM1
Leg fat percentage (right)	2.74	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Frequency of tenseness / restlessness in last 2 weeks	2.73	1	1	2.2	0.00	1.0000	PLEKHM1
Leg fat percentage (left)	2.73	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Bilateral oophorectomy (both ovaries removed)	2.71	1	0	0.0	0.00	1.0000	MLLT10
Waist circumference	2.68	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Worry (Nagel 2018)	2.65	1	1	2.2	0.00	1.0000	PLEKHM1
Number of operations (self-reported)	2.62	1	0	0.0	0.00	1.0000	MLLT10
Systolic blood pressure, automated reading	2.57	1	0	0.0	0.00	1.0000	PLEKHM1
Handedness (chirality/laterality): Left-handed	2.57	1	0	0.0	0.00	1.0000	PLEKHM1
Waist Hip Ratio (WHR)	2.56	2	1	2.2	0.00	1.0000	LOC100287227 PLEKHM1
Impedance of whole body	2.53	4	2	4.4	0.49	0.5150	ANKLE1 HOXD9 OCEL1 PLEKHM1
Leg fat mass (right)	2.40	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Leg fat mass (left)	2.34	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Body mass index (BMI)	2.33	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Nervous feelings	2.32	1	1	2.2	0.00	1.0000	PLEKHM1
Heel bone mineral density (BMD) T-score, automated (right)	2.31	2	0	0.0	0.00	1.0000	LINC00886 LOC100287227
Ever unenthusiastic/disinterested for a whole week	2.31	1	0	0.0	0.00	1.0000	PLEKHM1
Pain experienced in last month	2.31	1	0	0.0	0.00	1.0000	PLEKHM1
Mouth/teeth dental problems: Mouth ulcers	2.30	1	1	2.2	0.00	1.0000	PLEKHM1
Qualifications: A levels/AS levels or equivalent	2.28	1	0	0.0	0.00	1.0000	PLEKHM1
Medication: Ibuprofen (e.g. Nurofen)	2.27	1	0	0.0	0.00	1.0000	PLEKHM1
Number of treatments/medications taken	2.24	1	1	2.2	0.00	1.0000	MLLT10
Medication: Blood pressure	2.24	1	1	2.2	0.00	1.0000	PLEKHM1
Heel bone mineral density (BMD) T-score, automated (left)	2.23	1	0	0.0	0.00	1.0000	LINC00886
Sitting height	2.18	3	1	2.2	0.98	0.0159	LOC100287227 MLLT10 PLEKHM1
Diabetes diagnosed by doctor	2.16	1	0	0.0	0.00	1.0000	RCCD1
Ever had hysterectomy (womb removed)	2.15	1	0	0.0	0.00	1.0000	MLLT10
Asthma	2.15	2	0	0.0	0.00	1.0000	LOC100287227 MLLT10
Medication: Ibuprofen	2.12	1	0	0.0	0.00	1.0000	PLEKHM1
Body fat percentage	2.07	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
BMI	2.04	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Hearing difficulty/problems with background noise	2.02	1	0	0.0	0.00	1.0000	PLEKHM1
Fed-up feelings	1.98	1	1	2.2	0.00	1.0000	PLEKHM1
Trunk fat percentage	1.95	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Arm fat percentage (left)	1.94	2	2	4.4	0.00	1.0000	LOC100287227 MLLT10
Hip circumference	1.93	1	1	2.2	0.00	1.0000	MLLT10
Maternal smoking around birth	1.88	1	0	0.0	0.00	1.0000	MLLT10
Past tobacco smoking	1.87	1	0	0.0	0.00	1.0000	MLLT10
Irritability	1.87	1	1	2.2	0.00	1.0000	PLEKHM1
Hair/balding pattern: Pattern 2	1.85	1	0	0.0	0.00	1.0000	PLEKHM1
Arm fat-free mass (left)	1.84	5	1	2.2	0.56	0.3226	ANKLE1 GTPBP3 HOXD9 MLLT10 OCEL1
Arm fat percentage (right)	1.83	2	1	2.2	0.00	1.0000	LOC100287227 MLLT10
Arm fat-free mass (right)	1.83	5	1	2.2	0.56	0.3211	ANKLE1 GTPBP3 HOXD9 MLLT10 OCEL1
Whole body fat mass	1.83	1	1	2.2	0.00	1.0000	MLLT10
Smoking status: Previous	1.83	1	0	0.0	0.00	1.0000	MLLT10
Asthma (self-reported)	1.83	1	0	0.0	0.00	1.0000	LOC100287227
Number of live births	1.82	1	0	0.0	0.00	1.0000	PLEKHM1
Qualifications: College or University degree	1.82	2	1	2.2	0.00	1.0000	MLLT10 PLEKHM1
Arm fat mass (left)	1.80	1	1	2.2	0.00	1.0000	MLLT10
Arm predicted mass (left)	1.80	5	1	2.2	0.57	0.3192	ANKLE1 GTPBP3 HOXD9 MLLT10 OCEL1
Smoking Status	1.79	1	1	2.2	0.00	1.0000	MLLT10
Worrier / anxious feelings	1.79	1	1	2.2	0.00	1.0000	PLEKHM1
Arm predicted mass (right)	1.77	4	1	2.2	0.51	0.4947	GTPBP3 HOXD9 MLLT10 OCEL1
Chronotype (morning person)	1.76	1	0	0.0	0.00	1.0000	LOC100287227
Trunk fat mass	1.76	1	1	2.2	0.00	1.0000	MLLT10
Number of self-reported non-cancer illnesses	1.76	1	0	0.0	0.00	1.0000	MLLT10
Arm fat mass (right)	1.74	1	1	2.2	0.00	1.0000	MLLT10
Primary Biliary Cirrhosis	1.69	1	0	0.0	0.00	1.0000	PLEKHM1
Systolic Blood Pressure	1.67	2	1	2.2	0.00	1.0000	HOXB-AS1 PLEKHM1
Alcohol intake frequency.	1.67	1	1	2.2	0.00	1.0000	PLEKHM1
Trunk fat-free mass	1.66	4	2	4.4	0.98	0.0235	ANKLE1 GTPBP3 HOXD9 OCEL1
Trunk predicted mass	1.64	4	2	4.4	0.98	0.0215	ANKLE1 GTPBP3 HOXD9 OCEL1
Respiratory disease	1.63	1	0	0.0	0.00	1.0000	LOC100287227
Pulse rate, automated reading	1.63	1	0	0.0	0.00	1.0000	ANKLE1
High blood pressure	1.62	1	0	0.0	0.00	1.0000	MLLT10
Miserableness	1.61	1	1	2.2	0.00	1.0000	PLEKHM1
Breastfed as a baby	1.60	1	0	0.0	0.00	1.0000	CHMP4C
Hypertension (Self-reported)	1.59	1	0	0.0	0.00	1.0000	MLLT10
Diastolic blood pressure, automated reading	1.59	1	1	2.2	0.00	1.0000	MLLT10
Guilty feelings	1.58	1	0	0.0	0.00	1.0000	PLEKHM1
Vascular/heart problems diagnosed by doctor	1.58	1	0	0.0	0.00	1.0000	MLLT10
Lung FEV1/FVC ratio	1.54	3	1	2.2	0.00	1.0000	LINC00886 MLLT10 PLEKHM1
Weight	1.51	1	1	2.2	0.00	1.0000	MLLT10
Standing height	1.49	3	3	6.7	0.98	0.0239	GTPBP3 LOC100287227 PLEKHM1
Whole body water mass	1.49	4	1	2.2	0.97	0.0257	ANKLE1 GTPBP3 HOXD9 OCEL1
Impedance of leg (right)	1.48	2	0	0.0	0.00	1.0000	HOXD9 PLEKHM1
Whole body fat-free mass	1.47	4	0	0.0	0.98	0.0227	ANKLE1 GTPBP3 HOXD9 OCEL1
Suffer from 'nerves'	1.46	1	0	0.0	0.00	1.0000	PLEKHM1
Overall health rating	1.46	1	0	0.0	0.00	1.0000	MLLT10
Basal metabolic rate	1.45	4	0	0.0	0.52	0.4753	ANKLE1 GTPBP3 MLLT10 OCEL1
Birth weight	1.41	1	0	0.0	0.00	1.0000	LOC100287227
Verbal and Numeric Reasoning (VNR)	1.39	1	0	0.0	0.00	1.0000	PLEKHM1
Height	1.38	5	5	11.1	0.97	0.0010	ANKLE1 GTPBP3 LOC100287227 OCEL1 PLEKHM1
Blood Platelet Count	1.37	3	2	4.4	0.00	1.0000	HOXB-AS1 PLEKHM1 RCCD1
Blood Eosinophil Count	1.32	1	1	2.2	0.00	1.0000	PLEKHM1
Impedance of leg (left)	1.31	1	0	0.0	0.00	1.0000	PLEKHM1
Frequency of depressed mood in last 2 weeks	1.30	1	0	0.0	0.00	1.0000	PLEKHM1
Loneliness, isolation	1.25	1	0	0.0	0.00	1.0000	PLEKHM1
Intelligence (Savage-Jansen 2018)	1.22	1	0	0.0	0.00	1.0000	PLEKHM1
Leg predicted mass (right)	1.17	1	0	0.0	0.00	1.0000	GTPBP3
Leg fat-free mass (right)	1.16	2	0	0.0	0.00	1.0000	GTPBP3 OCEL1
Leg predicted mass (left)	1.13	2	0	0.0	0.00	1.0000	GTPBP3 MLLT10
Leg fat-free mass (left)	1.12	2	0	0.0	0.00	1.0000	GTPBP3 MLLT10
Depression (Nagel 2018)	1.08	1	0	0.0	0.00	1.0000	PLEKHM1
Allergy	0.99	1	0	0.0	0.00	1.0000	LOC100287227
Comparative height size at age 10	0.97	1	1	2.2	0.00	1.0000	PLEKHM1
Blood White Count	0.86	1	1	2.2	0.00	1.0000	PLEKHM1
Cardiovascular Disease	0.83	1	0	0.0	0.00	1.0000	MLLT10
Tanning	0.48	1	0	0.0	0.00	1.0000	LOC100287227
Hair Pigment	0.28	2	1	2.2	0.00	1.0000	HOXB-AS1 PLEKHM1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	4	0.866	1.7
GTEx	Brain Cortex	7	0.676	1.6
GTEx	Brain Frontal Cortex BA9	8	0.864	1.6
GTEx	Brain Hippocampus	5	0.951	1.6
GTEx	Brain Nucleus accumbens basal ganglia	7	0.808	1.6
GTEx	Brain Putamen basal ganglia	5	0.800	1.6
GTEx	Cells EBV-transformed lymphocytes	9	0.632	1.6
GTEx	Uterus	6	1.056	1.6
GTEx	Vagina	6	0.943	1.6
GTEx	Artery Coronary	9	0.759	1.5
GTEx	Brain Caudate basal ganglia	5	0.542	1.5
GTEx	Brain Hypothalamus	4	0.677	1.5
GTEx	Breast Mammary Tissue (Male)	8	0.670	1.5
GTEx	Colon Sigmoid	7	0.478	1.5
GTEx	Esophagus Gastroesophageal Junction	9	0.622	1.5
GTEx	Liver	4	0.557	1.5
GTEx	Ovary	6	0.659	1.5
GTEx	Spleen	9	0.637	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	4	0.781	1.5
GTEx	Adipose Visceral Omentum	6	0.294	1.4
GTEx	Adrenal Gland	6	0.412	1.4
GTEx	Artery Aorta	10	0.336	1.4
GTEx	Brain Cerebellar Hemisphere	7	0.470	1.4
GTEx	Breast Mammary Tissue	7	0.354	1.4
GTEx	Breast Mammary Tissue (Female)	8	0.486	1.4
GTEx	Cells Transformed fibroblasts	11	0.262	1.4
GTEx	Colon Transverse	9	0.435	1.4
GTEx	Esophagus Mucosa	12	0.361	1.4
GTEx	Esophagus Muscularis	11	0.340	1.4
GTEx	Heart Atrial Appendage	7	0.443	1.4
GTEx	Heart Left Ventricle	7	0.457	1.4
GTEx	Pancreas	8	0.490	1.4
GTEx	Pituitary	5	0.448	1.4
GTEx	Prostate	4	0.479	1.4
GTEx	Skin Not Sun Exposed Suprapubic	9	0.366	1.4
GTEx	Stomach	7	0.481	1.4
GTEx	Testis	11	0.348	1.4
GTEx	Thyroid	14	0.350	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	4	0.363	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	4	0.582	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	6	0.375	1.4
GTEx	Adipose Subcutaneous	10	0.286	1.3
GTEx	Artery Tibial	5	0.133	1.3
GTEx	Brain Cerebellum	8	0.403	1.3
GTEx	Lung	12	0.417	1.3
GTEx	Muscle Skeletal	13	0.449	1.3
GTEx	Nerve Tibial	10	0.231	1.3
GTEx	Skin Sun Exposed Lower leg	12	0.330	1.3
GTEx	Whole Blood	6	0.301	1.3
NTR	Blood	4	0.166	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	4	0.241	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	5	0.113	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	4	0.193	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	5	0.488	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	5	0.183	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	7	0.170	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	3	0.271	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	6	0.204	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	4	0.159	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	5	0.300	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	4	0.301	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	3	0.431	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	3	0.280	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	6	0.355	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	3	0.234	1.3
METSIM	Adipose	2	0.043	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	4	0.195	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	5	0.116	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	10	0.216	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	6	0.116	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.1