Hub : Traits :

Ovarian Cancer

472 significantly associated models · 42 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 176721984 177234702 2 1 9.1e-14 3.5e-14 3.4e-03 85 HOXD9
2 3 155768424 157456920 3 3 4.4e-20 1.1e-38 5.7e-16 61 LINC00886 LOC100287227
3 8 81971745 83365154 1 1 1.0e-10 1.3e-09 3.3e-01 97 CHMP4C
4 10 21087485 22724472 2 1 4.5e-09 4.9e-10 3.7e-02 89 MLLT10
5 15 90800449 92187978 1 1 6.6e-08 8.4e-08 2.0e-01 94 RCCD1
6 17 42774693 47357969 27 2 2.5e-14 9.3e-14 2.5e-03 84 HOXB-AS1 PLEKHM1
7 19 16643043 18117646 5 3 1.8e-10 8.1e-17 4.6e-05 76 ANKLE1 GTPBP3 OCEL1
8 21 35795370 36339264 1 1 1.9e-07 1.0e-06 3.9e-02 82 CLIC6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 3.12 1 1 2.2 0.00 1.0000 PLEKHM1
Depression (Nagel 2018) 1.08 1 0 0.0 0.00 1.0000 PLEKHM1
Intelligence (Savage-Jansen 2018) 1.22 1 0 0.0 0.00 1.0000 PLEKHM1
Neuroticism (Nagel 2018) 3.97 1 1 2.2 0.00 1.0000 PLEKHM1
Worry (Nagel 2018) 2.65 1 1 2.2 0.00 1.0000 PLEKHM1
Verbal and Numeric Reasoning (VNR) 1.39 1 0 0.0 0.00 1.0000 PLEKHM1
Breast Cancer 6.62 5 4 8.9 0.64 0.2455 ANKLE1 MLLT10 OCEL1 PLEKHM1 RCCD1
Neuroticism (2016) 2.98 1 1 2.2 0.00 1.0000 PLEKHM1
Primary Biliary Cirrhosis 1.69 1 0 0.0 0.00 1.0000 PLEKHM1
Blood Eosinophil Count 1.32 1 1 2.2 0.00 1.0000 PLEKHM1
Blood Platelet Count 1.37 3 2 4.4 0.00 1.0000 HOXB-AS1 PLEKHM1 RCCD1
Blood Red Count 5.37 3 3 6.7 0.00 1.0000 HOXB-AS1 HOXD9 PLEKHM1
Blood White Count 0.86 1 1 2.2 0.00 1.0000 PLEKHM1
Heel T-Score 3.15 7 5 11.1 0.25 0.5818 ANKLE1 CHMP4C HOXD9 LINC00886 LOC100287227 OCEL1 PLEKHM1
BMI 2.04 2 1 2.2 0.00 1.0000 LOC100287227 MLLT10
Height 1.38 5 5 11.1 0.97 0.0010 ANKLE1 GTPBP3 LOC100287227 OCEL1 PLEKHM1
Waist Hip Ratio (WHR) 2.56 2 1 2.2 0.00 1.0000 LOC100287227 PLEKHM1
Systolic Blood Pressure 1.67 2 1 2.2 0.00 1.0000 HOXB-AS1 PLEKHM1
Smoking Status 1.79 1 1 2.2 0.00 1.0000 MLLT10
Cardiovascular Disease 0.83 1 0 0.0 0.00 1.0000 MLLT10
Respiratory disease 1.63 1 0 0.0 0.00 1.0000 LOC100287227
Lung FEV1/FVC ratio 1.54 3 1 2.2 0.00 1.0000 LINC00886 MLLT10 PLEKHM1
Lung FVC 5.32 4 4 8.9 0.98 0.0220 CLIC6 HOXB-AS1 MLLT10 PLEKHM1
Neuroticism 3.99 1 1 2.2 0.00 1.0000 PLEKHM1
Chronotype (morning person) 1.76 1 0 0.0 0.00 1.0000 LOC100287227
Hair Pigment 0.28 2 1 2.2 0.00 1.0000 HOXB-AS1 PLEKHM1
Tanning 0.48 1 0 0.0 0.00 1.0000 LOC100287227
Hand grip strength (left) 2.80 2 1 2.2 0.00 1.0000 HOXB-AS1 PLEKHM1
Number of treatments/medications taken 2.24 1 1 2.2 0.00 1.0000 MLLT10
Sensitivity / hurt feelings 4.45 1 1 2.2 0.00 1.0000 PLEKHM1
Frequency of depressed mood in last 2 weeks 1.30 1 0 0.0 0.00 1.0000 PLEKHM1
Relative age of first facial hair 4.56 1 1 2.2 0.00 1.0000 PLEKHM1
Ever had hysterectomy (womb removed) 2.15 1 0 0.0 0.00 1.0000 MLLT10
Systolic blood pressure, automated reading 2.57 1 0 0.0 0.00 1.0000 PLEKHM1
Impedance of leg (right) 1.48 2 0 0.0 0.00 1.0000 HOXD9 PLEKHM1
Leg fat-free mass (left) 1.12 2 0 0.0 0.00 1.0000 GTPBP3 MLLT10
Trunk fat percentage 1.95 2 1 2.2 0.00 1.0000 MLLT10 PLEKHM1
Hand grip strength (right) 2.81 3 1 2.2 0.00 1.0000 HOXB-AS1 MLLT10 PLEKHM1
Maternal smoking around birth 1.88 1 0 0.0 0.00 1.0000 MLLT10
Fed-up feelings 1.98 1 1 2.2 0.00 1.0000 PLEKHM1
Relative age voice broke 3.46 1 1 2.2 0.00 1.0000 PLEKHM1
Bilateral oophorectomy (both ovaries removed) 2.71 1 0 0.0 0.00 1.0000 MLLT10
Heel bone mineral density (BMD) T-score, automated (left) 2.23 1 0 0.0 0.00 1.0000 LINC00886
High blood pressure 1.62 1 0 0.0 0.00 1.0000 MLLT10
Sitting height 2.18 3 1 2.2 0.98 0.0159 LOC100287227 MLLT10 PLEKHM1
Body mass index (BMI) 2.33 2 1 2.2 0.00 1.0000 LOC100287227 MLLT10
Impedance of leg (left) 1.31 1 0 0.0 0.00 1.0000 PLEKHM1
Leg predicted mass (left) 1.13 2 0 0.0 0.00 1.0000 GTPBP3 MLLT10
Trunk fat mass 1.76 1 1 2.2 0.00 1.0000 MLLT10
Waist circumference 2.68 2 1 2.2 0.00 1.0000 LOC100287227 MLLT10
Past tobacco smoking 1.87 1 0 0.0 0.00 1.0000 MLLT10
Nervous feelings 2.32 1 1 2.2 0.00 1.0000 PLEKHM1
Frequency of tenseness / restlessness in last 2 weeks 2.73 1 1 2.2 0.00 1.0000 PLEKHM1
Hearing difficulty/problems with background noise 2.02 1 0 0.0 0.00 1.0000 PLEKHM1
Hair/balding pattern: Pattern 2 1.85 1 0 0.0 0.00 1.0000 PLEKHM1
Forced vital capacity (FVC) 4.92 5 1 2.2 0.97 0.0013 GTPBP3 HOXB-AS1 LOC100287227 MLLT10 PLEKHM1
Heel bone mineral density (BMD) T-score, automated (right) 2.31 2 0 0.0 0.00 1.0000 LINC00886 LOC100287227
Ever unenthusiastic/disinterested for a whole week 2.31 1 0 0.0 0.00 1.0000 PLEKHM1
Allergy 0.99 1 0 0.0 0.00 1.0000 LOC100287227
Neuroticism score 3.35 1 1 2.2 0.00 1.0000 PLEKHM1
Weight 1.51 1 1 2.2 0.00 1.0000 MLLT10
Impedance of arm (right) 2.93 5 2 4.4 0.27 0.6623 ANKLE1 HOXD9 MLLT10 OCEL1 PLEKHM1
Arm fat percentage (right) 1.83 2 1 2.2 0.00 1.0000 LOC100287227 MLLT10
Trunk fat-free mass 1.66 4 2 4.4 0.98 0.0235 ANKLE1 GTPBP3 HOXD9 OCEL1
Hip circumference 1.93 1 1 2.2 0.00 1.0000 MLLT10
Worrier / anxious feelings 1.79 1 1 2.2 0.00 1.0000 PLEKHM1
Hair/balding pattern: Pattern 3 4.36 1 1 2.2 0.00 1.0000 PLEKHM1
Number of live births 1.82 1 0 0.0 0.00 1.0000 PLEKHM1
Forced expiratory volume in 1-second (FEV1) 4.73 3 1 2.2 0.00 1.0000 HOXB-AS1 LOC100287227 PLEKHM1
Qualifications: A levels/AS levels or equivalent 2.28 1 0 0.0 0.00 1.0000 PLEKHM1
Asthma 2.15 2 0 0.0 0.00 1.0000 LOC100287227 MLLT10
Medication: Ibuprofen (e.g. Nurofen) 2.27 1 0 0.0 0.00 1.0000 PLEKHM1
Forced expiratory volume in 1-second (FEV1), Best measure 4.88 3 1 2.2 0.99 0.0113 HOXB-AS1 LOC100287227 PLEKHM1
Impedance of arm (left) 3.18 5 3 6.7 0.23 0.7134 ANKLE1 HOXD9 MLLT10 OCEL1 PLEKHM1
Arm fat mass (right) 1.74 1 1 2.2 0.00 1.0000 MLLT10
Trunk predicted mass 1.64 4 2 4.4 0.98 0.0215 ANKLE1 GTPBP3 HOXD9 OCEL1
Standing height 1.49 3 3 6.7 0.98 0.0239 GTPBP3 LOC100287227 PLEKHM1
Breastfed as a baby 1.60 1 0 0.0 0.00 1.0000 CHMP4C
Hair/balding pattern: Pattern 4 8.13 1 1 2.2 0.00 1.0000 PLEKHM1
Peak expiratory flow (PEF) 3.90 2 1 2.2 0.00 1.0000 MLLT10 PLEKHM1
Medication: Paracetamol 4.32 2 1 2.2 0.00 1.0000 MLLT10 PLEKHM1
Headache pain in last month 3.43 1 1 2.2 0.00 1.0000 PLEKHM1
Birth weight 1.41 1 0 0.0 0.00 1.0000 LOC100287227
Forced vital capacity (FVC), Best measure 5.31 4 2 4.4 0.97 0.0049 HOXB-AS1 LOC100287227 MLLT10 PLEKHM1
Body fat percentage 2.07 2 1 2.2 0.00 1.0000 LOC100287227 MLLT10
Leg fat percentage (right) 2.74 2 1 2.2 0.00 1.0000 LOC100287227 MLLT10
Arm fat-free mass (right) 1.83 5 1 2.2 0.56 0.3211 ANKLE1 GTPBP3 HOXD9 MLLT10 OCEL1
Worry too long after embarrassment 2.95 1 0 0.0 0.00 1.0000 PLEKHM1
Qualifications: College or University degree 1.82 2 1 2.2 0.00 1.0000 MLLT10 PLEKHM1
Medication for pain relief, constipation, heartburn 3.00 2 1 2.2 0.00 1.0000 MLLT10 PLEKHM1
Medication: Ibuprofen 2.12 1 0 0.0 0.00 1.0000 PLEKHM1
Whole body fat mass 1.83 1 1 2.2 0.00 1.0000 MLLT10
Leg fat mass (right) 2.40 2 1 2.2 0.00 1.0000 LOC100287227 MLLT10
Arm predicted mass (right) 1.77 4 1 2.2 0.51 0.4947 GTPBP3 HOXD9 MLLT10 OCEL1
Pulse rate, automated reading 1.63 1 0 0.0 0.00 1.0000 ANKLE1
Alcohol intake frequency. 1.67 1 1 2.2 0.00 1.0000 PLEKHM1
Comparative height size at age 10 0.97 1 1 2.2 0.00 1.0000 PLEKHM1
Suffer from 'nerves' 1.46 1 0 0.0 0.00 1.0000 PLEKHM1
Overall health rating 1.46 1 0 0.0 0.00 1.0000 MLLT10
Hypertension (Self-reported) 1.59 1 0 0.0 0.00 1.0000 MLLT10
Smoking status: Previous 1.83 1 0 0.0 0.00 1.0000 MLLT10
Whole body fat-free mass 1.47 4 0 0.0 0.98 0.0227 ANKLE1 GTPBP3 HOXD9 OCEL1
Leg fat-free mass (right) 1.16 2 0 0.0 0.00 1.0000 GTPBP3 OCEL1
Arm fat percentage (left) 1.94 2 2 4.4 0.00 1.0000 LOC100287227 MLLT10
Handedness (chirality/laterality): Left-handed 2.57 1 0 0.0 0.00 1.0000 PLEKHM1
Mood swings 2.86 1 1 2.2 0.00 1.0000 PLEKHM1
Loneliness, isolation 1.25 1 0 0.0 0.00 1.0000 PLEKHM1
Diabetes diagnosed by doctor 2.16 1 0 0.0 0.00 1.0000 RCCD1
Mouth/teeth dental problems: Mouth ulcers 2.30 1 1 2.2 0.00 1.0000 PLEKHM1
Breast cancer (self-reported) 3.00 1 0 0.0 0.00 1.0000 MLLT10
Asthma (self-reported) 1.83 1 0 0.0 0.00 1.0000 LOC100287227
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.03 1 1 2.2 0.00 1.0000 PLEKHM1
Whole body water mass 1.49 4 1 2.2 0.97 0.0257 ANKLE1 GTPBP3 HOXD9 OCEL1
Leg predicted mass (right) 1.17 1 0 0.0 0.00 1.0000 GTPBP3
Arm fat mass (left) 1.80 1 1 2.2 0.00 1.0000 MLLT10
Number of self-reported non-cancer illnesses 1.76 1 0 0.0 0.00 1.0000 MLLT10
Average weekly champagne plus white wine intake 3.31 1 0 0.0 0.00 1.0000 PLEKHM1
Miserableness 1.61 1 1 2.2 0.00 1.0000 PLEKHM1
Guilty feelings 1.58 1 0 0.0 0.00 1.0000 PLEKHM1
Medication: Blood pressure 2.24 1 1 2.2 0.00 1.0000 PLEKHM1
Medication: Paracetamol 4.42 2 1 2.2 0.00 1.0000 MLLT10 PLEKHM1
Basal metabolic rate 1.45 4 0 0.0 0.52 0.4753 ANKLE1 GTPBP3 MLLT10 OCEL1
Leg fat percentage (left) 2.73 2 1 2.2 0.00 1.0000 LOC100287227 MLLT10
Arm fat-free mass (left) 1.84 5 1 2.2 0.56 0.3226 ANKLE1 GTPBP3 HOXD9 MLLT10 OCEL1
Number of operations (self-reported) 2.62 1 0 0.0 0.00 1.0000 MLLT10
Irritability 1.87 1 1 2.2 0.00 1.0000 PLEKHM1
Diastolic blood pressure, automated reading 1.59 1 1 2.2 0.00 1.0000 MLLT10
Vascular/heart problems diagnosed by doctor 1.58 1 0 0.0 0.00 1.0000 MLLT10
Pain experienced in last month 2.31 1 0 0.0 0.00 1.0000 PLEKHM1
Impedance of whole body 2.53 4 2 4.4 0.49 0.5150 ANKLE1 HOXD9 OCEL1 PLEKHM1
Leg fat mass (left) 2.34 2 1 2.2 0.00 1.0000 LOC100287227 MLLT10
Arm predicted mass (left) 1.80 5 1 2.2 0.57 0.3192 ANKLE1 GTPBP3 HOXD9 MLLT10 OCEL1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 10 0.286 1.3
GTEx Adipose Visceral Omentum 6 0.294 1.4
GTEx Adrenal Gland 6 0.412 1.4
GTEx Artery Aorta 10 0.336 1.4
GTEx Artery Coronary 9 0.759 1.5
GTEx Artery Tibial 5 0.133 1.3
GTEx Brain Caudate basal ganglia 5 0.542 1.5
GTEx Brain Cerebellar Hemisphere 7 0.470 1.4
GTEx Brain Cerebellum 8 0.403 1.3
GTEx Brain Cortex 7 0.676 1.6
GTEx Brain Frontal Cortex BA9 8 0.864 1.6
GTEx Brain Hippocampus 5 0.951 1.6
GTEx Brain Hypothalamus 4 0.677 1.5
GTEx Brain Nucleus accumbens basal ganglia 7 0.808 1.6
GTEx Brain Putamen basal ganglia 5 0.800 1.6
GTEx Breast Mammary Tissue 7 0.354 1.4
GTEx Breast Mammary Tissue (Male) 8 0.670 1.5
GTEx Breast Mammary Tissue (Female) 8 0.486 1.4
GTEx Cells EBV-transformed lymphocytes 9 0.632 1.6
GTEx Cells Transformed fibroblasts 11 0.262 1.4
GTEx Colon Sigmoid 7 0.478 1.5
GTEx Colon Transverse 9 0.435 1.4
GTEx Esophagus Gastroesophageal Junction 9 0.622 1.5
GTEx Esophagus Mucosa 12 0.361 1.4
GTEx Esophagus Muscularis 11 0.340 1.4
GTEx Heart Atrial Appendage 7 0.443 1.4
GTEx Heart Left Ventricle 7 0.457 1.4
GTEx Liver 4 0.557 1.5
GTEx Lung 12 0.417 1.3
GTEx Muscle Skeletal 13 0.449 1.3
GTEx Nerve Tibial 10 0.231 1.3
GTEx Ovary 6 0.659 1.5
GTEx Pancreas 8 0.490 1.4
GTEx Pituitary 5 0.448 1.4
GTEx Prostate 4 0.479 1.4
GTEx Skin Not Sun Exposed Suprapubic 9 0.366 1.4
GTEx Skin Sun Exposed Lower leg 12 0.330 1.3
GTEx Small Intestine Terminal Ileum 4 0.866 1.7
GTEx Spleen 9 0.637 1.5
GTEx Stomach 7 0.481 1.4
GTEx Testis 11 0.348 1.4
GTEx Thyroid 14 0.350 1.4
GTEx Uterus 6 1.056 1.6
GTEx Vagina 6 0.943 1.6
GTEx Whole Blood 6 0.301 1.3
METSIM Adipose 2 0.043 1.2
NTR Blood 4 0.166 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.1
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 2 0.037 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 4 0.241 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 5 0.113 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 4 0.363 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 4 0.193 1.3
The Cancer Genome Atlas Esophageal Carcinoma 4 0.582 1.4
The Cancer Genome Atlas Glioblastoma Multiforme 5 0.488 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 5 0.183 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 7 0.170 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 4 0.195 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 5 0.116 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 3 0.271 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 6 0.204 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 4 0.159 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 6 0.375 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 5 0.300 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 4 0.301 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 10 0.216 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 3 0.431 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 3 0.280 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.187 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 6 0.355 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 3 0.234 1.3
The Cancer Genome Atlas Thyroid Carcinoma 6 0.116 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 4 0.781 1.5