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chr6:129,638,583-131,163,098

Best TWAS P=3.04e-18 · Best GWAS P=1.2e-18 conditioned to 0.0351

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	L3MBTL3	0.20	0.08	lasso	4	0.09	1.1e-07	-7.4	-8.7	5.3e-18	0.87	0.22	0.78	FALSE
2	GTEx	Adipose Visceral Omentum	L3MBTL3	0.14	0.12	lasso	2	0.15	2.8e-08	-7.4	-8.4	3.0e-17	0.89	0.05	0.95	FALSE
3	GTEx	Breast Mammary Tissue	L3MBTL3	0.31	0.25	lasso	7	0.23	2.8e-12	-7.4	-8.2	1.7e-16	0.85	0.21	0.79	FALSE
4	GTEx	Breast Mammary Tissue	RP11-73O6.3	0.27	0.22	lasso	9	0.22	1.5e-11	-7.4	-8.2	2.0e-16	0.82	0.24	0.76	FALSE
5	GTEx	Breast Mammary Tissue (Male)	L3MBTL3	0.31	0.24	lasso	6	0.23	5.5e-06	-7.4	-8.1	6.0e-16	0.87	0.06	0.78	FALSE
6	GTEx	Breast Mammary Tissue (Male)	RP11-73O6.3	0.33	0.17	lasso	4	0.12	1.3e-03	-7.4	-7.8	7.8e-15	0.80	0.04	0.74	FALSE
7	GTEx	Breast Mammary Tissue (Female)	L3MBTL3	0.30	0.13	lasso	5	0.14	4.5e-05	-5.8	-8.2	1.7e-16	0.84	0.02	0.95	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RP11-73O6.3	0.29	0.08	lasso	5	0.10	5.7e-04	-7.7	-8.5	1.8e-17	0.87	0.02	0.94	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	L3MBTL3	0.28	0.08	lasso	10	0.03	4.4e-02	-7.4	-8.4	3.9e-17	0.90	0.02	0.93	FALSE
10	GTEx	Colon Transverse	L3MBTL3	0.27	0.13	lasso	8	0.20	8.0e-10	-7.4	-8.5	1.4e-17	0.86	0.04	0.96	FALSE
11	GTEx	Colon Transverse	RP11-73O6.3	0.19	0.09	lasso	2	0.06	1.2e-03	-7.4	-7.8	5.2e-15	0.81	0.03	0.95	FALSE
12	GTEx	Esophagus Mucosa	L3MBTL3	0.26	0.18	lasso	2	0.23	2.7e-15	-7.7	-8.1	6.2e-16	0.82	0.94	0.06	FALSE
13	GTEx	Lung	L3MBTL3	0.37	0.34	lasso	4	0.38	4.1e-30	-7.4	-8.3	6.7e-17	0.88	0.89	0.11	FALSE
14	GTEx	Lung	RP11-73O6.3	0.15	0.08	lasso	5	0.12	2.2e-09	-7.4	-8.5	2.0e-17	0.90	0.02	0.98	FALSE
15	GTEx	Nerve Tibial	L3MBTL3	0.30	0.23	lasso	4	0.22	2.3e-15	-7.4	-8.0	1.4e-15	0.83	0.98	0.02	FALSE
16	GTEx	Pancreas	L3MBTL3	0.32	0.17	lasso	4	0.23	4.4e-10	-7.4	-8.2	3.4e-16	0.85	0.12	0.88	FALSE
17	GTEx	Pituitary	L3MBTL3	0.45	0.31	lasso	8	0.29	5.1e-08	-5.8	-7.6	3.9e-14	0.72	0.20	0.77	FALSE
18	GTEx	Pituitary	RP11-73O6.3	0.48	0.07	lasso	7	0.16	8.2e-05	-5.8	-5.8	5.2e-09	0.55	0.16	0.64	FALSE
19	GTEx	Prostate	L3MBTL3	0.35	0.27	lasso	5	0.17	5.9e-05	-7.4	-7.9	3.2e-15	0.83	0.03	0.90	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	L3MBTL3	0.26	0.12	lasso	4	0.12	4.0e-07	-6.0	-7.5	4.2e-14	0.79	0.18	0.81	FALSE
21	GTEx	Skin Sun Exposed Lower leg	L3MBTL3	0.25	0.25	lasso	9	0.24	1.4e-19	-7.4	-8.1	7.7e-16	0.82	0.95	0.05	FALSE
22	GTEx	Small Intestine Terminal Ileum	L3MBTL3	0.37	0.20	lasso	4	0.17	1.3e-04	-7.4	-7.8	6.8e-15	0.80	0.03	0.84	FALSE
23	GTEx	Spleen	L3MBTL3	0.64	0.34	enet	14	0.48	6.4e-14	-7.7	-8.7	3.0e-18	0.91	0.06	0.94	TRUE
24	GTEx	Spleen	RP11-73O6.3	0.45	0.43	enet	21	0.42	7.7e-12	-7.7	-7.6	3.2e-14	0.83	0.41	0.58	FALSE
25	GTEx	Stomach	L3MBTL3	0.36	0.18	enet	27	0.20	1.1e-09	-8.8	-8.1	8.0e-16	0.89	0.00	1.00	FALSE
26	GTEx	Stomach	RP11-73O6.3	0.21	0.12	lasso	6	0.06	5.9e-04	-8.8	-8.4	2.9e-17	0.95	0.00	0.98	FALSE
27	GTEx	Testis	L3MBTL3	0.41	0.22	lasso	8	0.30	9.2e-14	-7.4	-7.3	3.7e-13	0.71	0.15	0.85	FALSE
28	GTEx	Thyroid	L3MBTL3	0.40	0.39	enet	9	0.43	2.8e-35	-7.4	-8.6	8.5e-18	0.90	0.90	0.10	FALSE
29	GTEx	Thyroid	RP11-73O6.3	0.18	0.15	lasso	3	0.20	2.3e-15	-8.3	-8.6	1.1e-17	0.91	0.02	0.98	FALSE
30	GTEx	Whole Blood	L3MBTL3	0.22	0.20	lasso	9	0.20	5.1e-18	-7.4	-7.8	5.6e-15	0.82	0.93	0.07	FALSE
31	GTEx	Whole Blood	RP11-73O6.3	0.15	0.06	lasso	8	0.04	1.1e-04	-7.4	-7.5	5.6e-14	0.81	0.03	0.94	FALSE
32	METSIM	Adipose	L3MBTL3	0.13	0.12	enet	22	0.12	4.8e-18	-7.7	-7.5	4.9e-14	0.74	0.74	0.26	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	L3MBTL3	0.14	0.07	blup	609	0.08	3.8e-10	-7.4	-7.2	7.5e-13	0.69	0.04	0.96	FALSE
34	YFS	Blood	L3MBTL3	0.28	0.22	blup	614	0.27	1.2e-88	-7.7	-6.8	1.3e-11	0.73	0.97	0.03	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	L3MBTL3	0.06	0.01	blup	114	0.04	4.0e-03	-7.7	-7.7	1.5e-14	0.76	0.07	0.52	FALSE