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chr6:124,741,508-128,307,725

Best TWAS P=1.93e-29 · Best GWAS P=7.18e-35 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
41	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RSPO3	0.02	0.03	blup	60	0.02	1.3e-03	10.6	11.3	1.9e-29	0.92	0.24	0.46	TRUE
25	GTEx	Testis	NCOA7	0.18	0.03	enet	16	0.09	7.5e-05	-6.4	9.7	4.2e-22	-0.05	0.05	0.64	TRUE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	HDDC2	0.08	0.09	blup	63	0.10	8.0e-11	8.5	-8.4	2.9e-17	0.01	0.01	0.99	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CENPW	0.04	0.06	lasso	10	0.06	2.4e-07	-8.1	8.1	7.4e-16	0.14	0.24	0.76	TRUE
16	GTEx	Heart Atrial Appendage	CENPW	0.17	0.01	enet	15	0.06	1.8e-03	-8.0	7.6	2.9e-14	0.11	0.05	0.16	TRUE
4	GTEx	Artery Aorta	HDDC2	0.18	0.08	enet	25	0.10	4.8e-06	3.5	-6.5	1.1e-10	0.05	0.03	0.97	TRUE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HDDC2	0.19	0.15	lasso	2	0.15	1.5e-06	4.9	-6.4	1.7e-10	0.03	0.03	0.93	TRUE
30	YFS	Blood	HEY2	0.02	0.01	blup	322	0.01	3.0e-04	-3.2	-5.5	4.0e-08	0.07	0.30	0.06	TRUE
47	The Cancer Genome Atlas	Thyroid Carcinoma	TPD52L1	0.08	0.03	blup	110	0.03	1.0e-03	-2.8	5.4	7.1e-08	0.02	0.17	0.33	TRUE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	RSPO3	0.02	0.02	blup	60	0.02	2.8e-04	11.5	11.2	3.8e-29	0.93	0.01	0.98	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	RSPO3	0.06	0.02	blup	60	0.04	9.3e-05	10.6	10.1	3.4e-24	0.74	0.10	0.66	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	HDDC2	0.32	0.20	enet	38	0.22	2.3e-12	9.1	-9.6	1.4e-21	0.04	0.00	1.00	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	HDDC2	0.53	0.69	lasso	6	0.70	4.0e-127	9.1	-8.9	4.8e-19	0.03	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	HDDC2	0.23	0.15	lasso	5	0.14	2.5e-11	9.1	-8.9	6.8e-19	0.02	0.00	1.00	FALSE
11	GTEx	Colon Transverse	HDDC2	0.24	0.17	enet	28	0.16	3.9e-08	9.1	-8.9	7.4e-19	0.05	0.00	1.00	FALSE
6	GTEx	Artery Tibial	HDDC2	0.22	0.12	lasso	5	0.10	2.4e-08	9.1	-8.8	1.3e-18	0.03	0.00	1.00	FALSE
17	GTEx	Heart Left Ventricle	HDDC2	0.40	0.18	lasso	7	0.22	1.0e-11	9.1	-8.8	2.0e-18	0.03	0.00	1.00	FALSE
19	GTEx	Muscle Skeletal	HDDC2	0.28	0.17	lasso	8	0.18	1.9e-17	9.1	-8.7	2.5e-18	0.02	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	HDDC2	0.09	0.13	lasso	4	0.12	3.5e-12	9.1	-8.6	8.8e-18	0.03	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HDDC2	0.12	0.09	enet	11	0.10	7.7e-05	8.5	-8.5	1.5e-17	0.04	0.01	0.99	FALSE
5	GTEx	Artery Aorta	TPD52L1	0.17	0.08	lasso	10	0.07	1.7e-04	8.5	8.4	5.6e-17	-0.03	0.02	0.96	FALSE
26	GTEx	Thyroid	HDDC2	0.25	0.11	lasso	6	0.16	2.0e-12	9.1	-8.3	6.8e-17	0.04	0.00	1.00	FALSE
14	GTEx	Esophagus Muscularis	HDDC2	0.42	0.19	lasso	10	0.25	2.7e-15	9.1	-8.3	7.5e-17	0.02	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	HDDC2	0.05	0.02	blup	65	0.02	9.3e-04	8.5	-8.2	1.7e-16	0.02	0.03	0.96	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	HDDC2	0.36	0.23	lasso	11	0.26	6.6e-10	8.5	-8.1	5.2e-16	0.04	0.02	0.98	FALSE
22	GTEx	Skin Sun Exposed Lower leg	HDDC2	0.28	0.20	enet	30	0.26	1.2e-21	9.1	-8.0	9.6e-16	0.04	0.00	1.00	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	HDDC2	0.24	0.00	lasso	9	-0.01	6.1e-01	9.1	-8.0	1.8e-15	0.02	0.02	0.85	FALSE
8	GTEx	Brain Cortex	HDDC2	0.21	0.07	lasso	5	0.08	3.3e-03	9.1	-7.9	2.0e-15	0.04	0.02	0.83	FALSE
10	GTEx	Colon Sigmoid	HDDC2	0.44	0.25	lasso	8	0.22	2.9e-08	9.1	-7.9	2.7e-15	0.04	0.00	1.00	FALSE
13	GTEx	Esophagus Mucosa	HDDC2	0.38	0.16	lasso	8	0.22	6.4e-15	9.1	-7.8	5.6e-15	0.03	0.00	1.00	FALSE
7	GTEx	Artery Tibial	TPD52L1	0.15	0.02	lasso	5	0.04	4.1e-04	5.9	7.8	9.2e-15	-0.02	0.27	0.61	FALSE
24	GTEx	Stomach	HDDC2	0.31	0.10	enet	33	0.14	2.0e-07	9.1	-7.7	1.1e-14	0.07	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	HDDC2	0.09	0.05	blup	65	0.09	1.2e-10	3.3	-7.6	2.5e-14	0.03	0.04	0.96	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HDDC2	0.09	0.06	blup	62	0.05	6.7e-04	8.5	-7.5	5.8e-14	0.03	0.02	0.92	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CENPW	0.04	0.05	lasso	5	0.05	2.6e-06	-8.1	7.5	7.5e-14	0.11	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	CENPW	0.04	0.06	blup	35	0.05	9.2e-07	-8.0	7.5	7.6e-14	0.12	0.02	0.98	FALSE
28	METSIM	Adipose	HDDC2	0.10	0.08	blup	459	0.08	1.5e-12	3.5	-7.5	8.4e-14	0.03	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HDDC2	0.15	0.09	enet	18	0.16	2.0e-19	3.5	-7.4	1.9e-13	0.04	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	HDDC2	0.05	0.04	blup	65	0.04	1.5e-08	8.5	-7.3	3.6e-13	0.01	0.09	0.91	FALSE
18	GTEx	Lung	HDDC2	0.26	0.10	enet	18	0.19	2.4e-14	9.1	-7.1	1.3e-12	0.02	0.00	1.00	FALSE
27	GTEx	Whole Blood	HDDC2	0.12	0.04	enet	17	0.10	6.6e-10	9.1	-7.0	2.1e-12	0.02	0.01	0.99	FALSE
15	GTEx	Heart Atrial Appendage	HDDC2	0.26	0.10	enet	32	0.08	1.9e-04	9.1	-7.0	3.1e-12	0.03	0.00	0.99	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HDDC2	0.05	0.05	enet	14	0.07	1.5e-08	8.5	-6.6	3.1e-11	0.07	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	HINT3	0.04	0.02	enet	7	0.02	2.6e-05	-6.4	-6.5	8.5e-11	0.01	0.01	0.99	FALSE
31	YFS	Blood	RNF146	0.01	0.00	bslmm	323	0.00	4.8e-02	0.8	-6.4	1.4e-10	-0.35	0.04	0.25	FALSE
23	GTEx	Spleen	HDDC2	0.54	0.18	enet	36	0.26	2.2e-07	3.5	-5.7	1.5e-08	0.06	0.03	0.90	FALSE
20	GTEx	Nerve Tibial	HDDC2	0.21	0.00	enet	19	0.02	9.2e-03	9.1	-5.4	6.0e-08	-0.01	0.00	0.98	FALSE