Best TWAS P=1.01e-09 · Best GWAS P=7.61e-11 conditioned to 2.42e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | SNHG7 | 0.37 | 0.10 | lasso | 6 | 0.27 | 2.5e-08 | -2.2 | 5.6 | 2.1e-08 | 0.02 | 0.15 | 0.18 | FALSE |
| 2 | GTEx | Colon Transverse | SEC16A | 0.13 | 0.04 | lasso | 4 | 0.05 | 2.5e-03 | 5.4 | -5.2 | 2.5e-07 | -0.08 | 0.16 | 0.06 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | INPP5E | 0.13 | 0.12 | lasso | 2 | 0.10 | 3.5e-05 | 5.4 | -5.4 | 7.6e-08 | -0.05 | 0.26 | 0.21 | FALSE |
| 4 | GTEx | Nerve Tibial | INPP5E | 0.13 | 0.17 | enet | 10 | 0.14 | 3.7e-10 | 5.0 | -5.2 | 1.7e-07 | -0.08 | 0.89 | 0.11 | FALSE |
| 5 | GTEx | Pancreas | SEC16A | 0.28 | 0.10 | enet | 16 | 0.16 | 4.1e-07 | 5.4 | -5.6 | 1.9e-08 | -0.13 | 0.67 | 0.25 | FALSE |
| 6 | GTEx | Pituitary | INPP5E | 0.21 | 0.24 | lasso | 3 | 0.14 | 1.8e-04 | 5.3 | 5.3 | 1.0e-07 | 0.07 | 0.27 | 0.08 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SDCCAG3 | 0.05 | 0.01 | blup | 61 | 0.01 | 7.9e-04 | 5.4 | -5.8 | 5.9e-09 | -0.05 | 0.00 | 0.92 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEC16A | 0.02 | 0.00 | blup | 69 | 0.01 | 1.0e-03 | 5.3 | -6.1 | 1.0e-09 | -0.03 | 0.01 | 0.95 | TRUE |