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chr10:45,174,519-46,691,610

Best TWAS P=3.06e-41 · Best GWAS P=2.5e-96 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	GTEx	Esophagus Muscularis	ZFAND4	0.07	0.03	enet	4	0.05	3.4e-04	-14.61	-13.5	3.1e-41	0.02	0.05	0.80	TRUE
22	GTEx	Esophagus Gastroesophageal Junction	ZFAND4	0.14	0.03	enet	11	0.06	4.7e-03	-10.91	-11.8	3.3e-32	-0.02	0.13	0.25	TRUE
59	The Cancer Genome Atlas	Thyroid Carcinoma	ANUBL1	0.06	0.03	blup	37	0.05	1.3e-05	-10.76	-11.6	2.7e-31	0.01	0.07	0.32	TRUE
23	GTEx	Esophagus Mucosa	FAM21C	0.21	0.08	lasso	6	0.07	2.8e-05	-10.91	10.6	2.3e-26	-0.02	0.26	0.65	TRUE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	MARCH8	0.05	0.00	blup	50	0.02	5.4e-03	0.78	-9.1	1.4e-19	0.02	0.01	0.37	TRUE
4	GTEx	Artery Aorta	MARCH8	0.09	0.04	lasso	4	0.03	6.2e-03	-10.87	-8.9	5.0e-19	0.06	0.07	0.56	TRUE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	AGAP4	0.04	0.00	blup	37	0.02	3.4e-03	6.04	-8.9	8.1e-19	-0.04	0.01	0.23	TRUE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	C10orf10	0.06	0.02	blup	56	0.03	2.1e-04	-4.21	7.0	2.9e-12	0.24	0.07	0.22	TRUE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ALOX5	0.05	0.03	enet	3	0.02	3.2e-03	-1.96	6.3	3.4e-10	0.00	0.41	0.02	TRUE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	MARCH8	0.08	0.04	blup	49	0.04	2.1e-05	-14.71	-13.3	2.5e-40	-0.03	0.02	0.98	FALSE
37	GTEx	Skin Sun Exposed Lower leg	MARCH8	0.10	0.04	lasso	10	0.04	2.0e-04	-13.66	-13.0	1.2e-38	0.03	0.02	0.97	FALSE
39	GTEx	Stomach	MARCH8	0.18	0.03	lasso	4	0.04	4.2e-03	-14.61	-12.6	1.6e-36	0.05	0.03	0.74	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	MARCH8	0.18	0.11	enet	6	0.14	2.7e-08	-10.91	-12.4	2.2e-35	0.04	0.05	0.94	FALSE
42	GTEx	Testis	FAM21C	0.16	0.12	lasso	3	0.14	8.4e-07	-10.91	12.3	6.9e-35	-0.01	0.06	0.90	FALSE
38	GTEx	Skin Sun Exposed Lower leg	FAM21C	0.12	0.09	lasso	8	0.11	3.8e-09	-10.72	12.2	3.2e-34	-0.01	0.59	0.41	FALSE
10	GTEx	Brain Cerebellar Hemisphere	FAM21C	0.20	0.09	lasso	2	0.04	4.0e-02	-10.91	11.9	6.7e-33	0.04	0.04	0.47	FALSE
12	GTEx	Brain Cerebellum	FAM21C	0.25	0.16	lasso	4	0.14	7.0e-05	-10.91	11.8	3.1e-32	0.01	0.06	0.65	FALSE
28	GTEx	Heart Atrial Appendage	ZFAND4	0.40	0.25	enet	22	0.32	3.6e-15	-10.91	-11.7	1.4e-31	-0.03	0.94	0.06	FALSE
27	GTEx	Heart Atrial Appendage	MARCH8	0.14	0.06	lasso	11	0.03	1.9e-02	-10.87	-11.6	5.1e-31	0.02	0.03	0.94	FALSE
43	GTEx	Testis	ZFAND4	0.12	0.08	lasso	5	0.07	5.3e-04	-10.87	-11.4	2.6e-30	0.03	0.20	0.63	FALSE
8	GTEx	Artery Tibial	ZFAND4	0.06	0.00	enet	6	0.00	3.4e-01	6.23	-11.4	3.9e-30	-0.09	0.05	0.39	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	FAM21C	0.22	0.12	lasso	3	0.06	2.8e-03	-10.72	11.2	4.1e-29	0.00	0.22	0.07	FALSE
40	GTEx	Stomach	FAM21C	0.22	0.05	enet	11	0.10	1.2e-05	-10.91	11.1	1.0e-28	0.03	0.08	0.28	FALSE
11	GTEx	Brain Cerebellum	MARCH8	0.17	0.03	enet	13	0.10	9.1e-04	5.20	11.1	1.4e-28	-0.01	0.06	0.49	FALSE
31	GTEx	Lung	MARCH8	0.21	0.12	enet	17	0.19	1.1e-14	-14.71	-11.0	6.2e-28	0.06	0.02	0.98	FALSE
30	GTEx	Heart Left Ventricle	ZFAND4	0.27	0.35	lasso	3	0.34	8.3e-19	-10.91	-10.9	1.1e-27	0.01	1.00	0.00	FALSE
15	GTEx	Breast Mammary Tissue (Male)	FAM21C	0.18	0.05	lasso	6	0.09	5.0e-03	-10.91	10.9	1.7e-27	-0.02	0.05	0.40	FALSE
7	GTEx	Artery Tibial	FAM21C	0.39	0.15	lasso	7	0.15	1.1e-11	-10.91	10.8	2.7e-27	-0.01	1.00	0.00	FALSE
32	GTEx	Muscle Skeletal	FAM21C	0.19	0.06	lasso	8	0.06	2.1e-06	-10.91	10.7	1.1e-26	-0.01	0.90	0.04	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MARCH8	0.04	0.00	blup	49	0.01	2.2e-02	-14.71	-10.5	6.7e-26	0.04	0.01	0.84	FALSE
46	GTEx	Thyroid	FAM21C	0.15	0.06	lasso	5	0.05	1.9e-04	-10.91	10.3	7.9e-25	-0.02	0.53	0.20	FALSE
2	GTEx	Adipose Subcutaneous	FAM21C	0.37	0.06	enet	30	0.17	4.6e-14	0.92	10.2	2.0e-24	0.06	0.84	0.15	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	FAM21C	0.28	0.00	enet	12	0.07	1.7e-04	-10.72	10.2	2.3e-24	0.00	0.17	0.26	FALSE
6	GTEx	Artery Coronary	ZFAND4	0.17	0.00	enet	15	0.01	1.4e-01	-10.37	-10.0	1.0e-23	-0.03	0.04	0.31	FALSE
45	GTEx	Thyroid	MARCH8	0.16	0.08	lasso	6	0.09	3.9e-07	-10.91	-9.8	1.9e-22	0.03	0.75	0.21	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	AGAP4	0.06	0.02	blup	37	0.03	2.7e-04	6.30	-9.7	3.1e-22	-0.01	0.03	0.15	FALSE
14	GTEx	Breast Mammary Tissue	FAM21C	0.25	0.18	enet	17	0.22	2.1e-11	-10.91	9.6	8.2e-22	-0.06	0.80	0.20	FALSE
17	GTEx	Cells Transformed fibroblasts	MARCH8	0.13	0.01	enet	19	0.05	6.8e-05	-1.29	-9.1	7.8e-20	0.04	0.04	0.92	FALSE
29	GTEx	Heart Left Ventricle	MARCH8	0.13	0.04	lasso	9	0.06	4.7e-04	-10.91	-9.1	9.6e-20	0.06	0.02	0.97	FALSE
16	GTEx	Breast Mammary Tissue (Female)	FAM21C	0.16	0.09	lasso	2	0.11	3.0e-04	-10.91	8.9	3.8e-19	-0.03	0.04	0.22	FALSE
24	GTEx	Esophagus Mucosa	ZFAND4	0.09	0.00	enet	18	0.03	5.4e-03	3.72	-8.8	1.1e-18	-0.05	0.12	0.10	FALSE
48	GTEx	Whole Blood	FAM21C	0.18	0.05	lasso	7	0.09	6.7e-09	0.92	8.7	2.7e-18	-0.03	0.74	0.09	FALSE
3	GTEx	Adrenal Gland	FAM21C	0.37	-0.01	enet	32	0.16	1.7e-06	-10.91	8.4	3.1e-17	0.07	0.06	0.16	FALSE
9	GTEx	Brain Cerebellar Hemisphere	MARCH8	0.25	0.19	lasso	5	0.23	1.3e-06	5.84	8.3	6.7e-17	0.06	0.64	0.14	FALSE
18	GTEx	Cells Transformed fibroblasts	ZFAND4	0.24	0.22	lasso	9	0.24	4.3e-18	6.18	-8.2	1.8e-16	-0.08	1.00	0.00	FALSE
34	GTEx	Nerve Tibial	ZFAND4	0.05	0.02	lasso	5	0.03	6.1e-03	6.07	-7.8	4.8e-15	-0.06	0.37	0.05	FALSE
33	GTEx	Nerve Tibial	FAM21C	0.28	0.05	enet	37	0.13	2.6e-09	-10.91	7.3	2.1e-13	0.00	0.53	0.07	FALSE
20	GTEx	Colon Transverse	AGAP4	0.17	0.05	enet	24	0.09	5.8e-05	2.52	-7.1	1.3e-12	-0.08	0.12	0.49	FALSE
41	GTEx	Stomach	AGAP4	0.20	0.10	enet	17	0.14	2.9e-07	6.72	-7.0	2.3e-12	-0.07	0.74	0.12	FALSE
25	GTEx	Esophagus Muscularis	FAM21C	0.39	0.06	enet	43	0.12	1.3e-07	-10.91	7.0	2.6e-12	0.00	0.05	0.93	FALSE
49	NTR	Blood	ALOX5	0.01	0.00	blup	338	0.00	1.1e-02	-4.46	-6.8	1.1e-11	0.01	0.07	0.02	FALSE
44	GTEx	Testis	CTGLF10P	0.31	0.12	lasso	8	0.16	8.6e-08	0.92	6.8	1.5e-11	-0.04	0.68	0.24	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	MARCH8	0.32	0.02	lasso	4	0.02	1.1e-01	-1.29	-6.7	1.8e-11	0.08	0.05	0.17	FALSE
5	GTEx	Artery Aorta	FAM21C	0.23	0.00	enet	16	0.01	7.6e-02	-0.77	6.1	1.1e-09	0.05	0.04	0.36	FALSE
19	GTEx	Colon Transverse	FAM21C	0.25	0.02	enet	29	0.11	8.3e-06	-10.72	5.8	4.8e-09	0.00	0.05	0.15	FALSE
50	YFS	Blood	MARCH8	0.28	0.02	enet	36	0.11	2.3e-33	1.93	-5.7	1.5e-08	0.00	1.00	0.00	FALSE
1	GTEx	Adipose Subcutaneous	ALOX5	0.11	0.02	enet	12	0.06	1.9e-05	-1.37	-5.6	2.5e-08	-0.05	0.52	0.02	FALSE
47	GTEx	Thyroid	AGAP4	0.29	0.23	enet	26	0.29	2.8e-22	2.52	-5.3	1.4e-07	-0.09	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AGAP4	0.13	0.01	enet	8	0.00	2.1e-01	1.72	-5.2	2.2e-07	-0.03	0.01	0.19	FALSE