Best TWAS P=7.72e-09 · Best GWAS P=5.94e-19 conditioned to 5.11e-20
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | FAM35A | 0.19 | 0.05 | enet | 10 | 0.03 | 5.4e-02 | 4.9 | -5.5 | 3.4e-08 | -0.06 | 0.02 | 0.69 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | NUTM2D | 0.19 | 0.09 | lasso | 6 | 0.08 | 8.3e-07 | 4.9 | -5.4 | 8.0e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 3 | METSIM | Adipose | FAM35A | 0.29 | 0.27 | lasso | 4 | 0.27 | 2.3e-40 | -5.6 | -5.2 | 2.2e-07 | -0.05 | 0.00 | 1.00 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FAM22A | 0.02 | 0.03 | lasso | 2 | 0.03 | 6.6e-04 | -5.6 | -5.6 | 2.2e-08 | -0.05 | 0.00 | 0.96 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FAM35A | 0.04 | 0.02 | enet | 4 | 0.01 | 1.0e-02 | -5.6 | -5.8 | 7.7e-09 | -0.04 | 0.00 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | FAM35A | 0.16 | 0.13 | lasso | 3 | 0.12 | 2.3e-05 | -5.6 | -5.5 | 3.6e-08 | -0.06 | 0.00 | 0.99 | FALSE |