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chr10:89,997,495-92,230,837

Best TWAS P=4.17e-15 · Best GWAS P=2.81e-12 conditioned to 0.422

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
36	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ37201	0.21	0.06	enet	4	0.08	1.0e-03	-6.9	7.8	4.2e-15	-0.81	0.00	0.81	TRUE
21	YFS	Blood	ACTA2	0.71	0.69	enet	55	0.72	0.0e+00	6.9	-7.0	2.2e-12	0.03	0.00	1.00	TRUE
37	The Cancer Genome Atlas	Thyroid Carcinoma	KIF20B	0.05	0.02	enet	6	0.03	1.0e-03	-6.9	-7.6	2.5e-14	0.79	0.00	0.96	FALSE
18	NTR	Blood	ACTA2	0.04	0.04	lasso	3	0.04	4.9e-12	6.9	-6.9	4.6e-12	0.02	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FLJ37201	0.19	0.14	lasso	3	0.14	8.4e-17	-6.9	6.9	4.7e-12	-0.92	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	PANK1	0.04	0.05	lasso	2	0.03	2.6e-04	-6.9	-6.9	6.4e-12	0.90	0.00	0.98	FALSE
31	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FLJ37201	0.14	0.08	lasso	2	0.08	3.9e-06	-6.9	6.9	6.7e-12	-0.90	0.00	1.00	FALSE
5	GTEx	Brain Caudate basal ganglia	FAS	0.72	0.47	enet	9	0.40	9.9e-13	-5.9	6.8	1.1e-11	-0.01	0.01	0.99	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	FAS	0.38	0.20	enet	36	0.24	3.4e-07	-5.9	6.8	1.1e-11	-0.03	0.01	0.98	FALSE
13	GTEx	Nerve Tibial	FAS	0.24	0.14	lasso	5	0.18	1.7e-12	6.9	-6.8	1.1e-11	0.02	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAS	0.57	0.54	enet	20	0.59	4.8e-89	6.9	6.8	1.2e-11	-0.02	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ37201	0.19	0.11	enet	9	0.10	6.2e-20	-6.9	6.7	2.7e-11	-0.90	0.00	1.00	FALSE
7	GTEx	Brain Hippocampus	FAS	0.72	0.29	enet	45	0.34	1.0e-08	6.9	6.6	3.7e-11	-0.01	0.00	0.98	FALSE
22	YFS	Blood	FAS	0.14	0.07	bslmm	548	0.10	5.5e-32	-5.9	-6.6	3.7e-11	0.05	0.03	0.97	FALSE
4	GTEx	Artery Tibial	KIF20B	0.05	0.02	enet	8	0.02	7.0e-03	5.5	-6.6	4.5e-11	0.16	0.16	0.63	FALSE
3	GTEx	Adipose Subcutaneous	FAS	0.34	0.16	enet	22	0.25	1.1e-20	-5.9	-6.5	6.4e-11	0.05	0.03	0.97	FALSE
10	GTEx	Breast Mammary Tissue (Female)	FAS	0.25	0.19	lasso	6	0.15	3.3e-05	6.3	-6.5	9.1e-11	0.03	0.01	0.98	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	FAS	0.47	0.42	enet	30	0.48	2.5e-70	6.9	6.2	4.0e-10	-0.01	0.00	1.00	FALSE
19	NTR	Blood	FAS	0.04	0.03	enet	20	0.03	7.9e-10	6.9	-6.2	5.0e-10	0.01	0.00	1.00	FALSE
12	GTEx	Muscle Skeletal	FAS	0.20	0.07	lasso	10	0.07	1.1e-07	-5.9	-6.2	6.5e-10	0.02	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	PANK1	0.05	0.02	blup	83	0.03	8.9e-04	-2.9	-6.2	6.6e-10	0.68	0.02	0.81	FALSE
9	GTEx	Brain Putamen basal ganglia	RP11-399O19.9	0.40	0.17	lasso	3	0.20	2.2e-05	6.9	6.0	2.3e-09	0.00	0.01	0.98	FALSE
15	GTEx	Testis	KIF20B	0.13	0.10	lasso	5	0.09	5.9e-05	5.8	-5.9	3.8e-09	0.30	0.70	0.18	FALSE
25	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FLJ37201	0.09	0.09	enet	5	0.07	1.7e-04	-3.9	5.9	4.1e-09	-0.66	0.05	0.82	FALSE
17	METSIM	Adipose	FAS	0.28	0.21	enet	13	0.28	3.9e-42	6.9	-5.9	4.5e-09	0.02	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	KIF20B	0.16	0.09	blup	75	0.11	9.5e-07	-3.9	-5.8	4.8e-09	0.58	0.39	0.56	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ37201	0.04	0.02	enet	15	0.01	2.1e-02	-3.9	5.8	7.6e-09	-0.72	0.02	0.84	FALSE
6	GTEx	Brain Cortex	FAS	0.45	0.25	lasso	5	0.25	1.3e-07	6.9	5.7	9.4e-09	-0.01	0.00	1.00	FALSE
16	GTEx	Testis	PANK1	0.24	0.12	lasso	4	0.07	7.6e-04	5.6	5.7	9.9e-09	-0.33	0.25	0.30	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAS	0.03	0.03	enet	3	0.03	6.1e-04	4.2	5.7	1.2e-08	-0.01	0.01	0.98	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KIF20B	0.05	0.03	lasso	5	0.02	7.4e-04	-6.9	-5.7	1.3e-08	0.85	0.00	0.98	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLJ37201	0.08	0.04	blup	41	0.06	1.8e-05	-3.9	5.5	3.0e-08	-0.66	0.18	0.81	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	FAS	0.05	0.01	blup	87	0.02	1.6e-03	5.8	5.5	3.1e-08	-0.06	0.01	0.98	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	FAS	0.03	0.00	blup	87	0.01	3.0e-02	-2.0	-5.5	4.7e-08	0.09	0.01	0.31	FALSE
11	GTEx	Esophagus Muscularis	FAS	0.20	0.06	enet	31	0.05	5.0e-04	6.3	-5.4	5.9e-08	0.02	0.00	0.99	FALSE
35	The Cancer Genome Atlas	Rectum Adenocarcinoma	PANK1	0.18	0.05	blup	83	0.10	2.1e-03	-6.8	-5.2	1.8e-07	0.74	0.01	0.64	FALSE
14	GTEx	Skin Sun Exposed Lower leg	FAS	0.12	0.01	lasso	7	0.02	3.8e-03	-3.8	-5.2	2.1e-07	0.00	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIF20B	0.03	0.02	blup	75	0.01	1.0e-02	5.3	-5.2	2.3e-07	0.20	0.13	0.10	FALSE