Best TWAS P=4.17e-15 · Best GWAS P=2.81e-12 conditioned to 0.422
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAS | 0.57 | 0.54 | enet | 20 | 0.59 | 4.8e-89 | 6.9 | 6.8 | 1.2e-11 | -0.02 | 0.00 | 1.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | FLJ37201 | 0.19 | 0.14 | lasso | 3 | 0.14 | 8.4e-17 | -6.9 | 6.9 | 4.7e-12 | -0.92 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | FAS | 0.34 | 0.16 | enet | 22 | 0.25 | 1.1e-20 | -5.9 | -6.5 | 6.4e-11 | 0.05 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Artery Tibial | KIF20B | 0.05 | 0.02 | enet | 8 | 0.02 | 7.0e-03 | 5.5 | -6.6 | 4.5e-11 | 0.16 | 0.16 | 0.63 | FALSE |
| 5 | GTEx | Brain Caudate basal ganglia | FAS | 0.72 | 0.47 | enet | 9 | 0.40 | 9.9e-13 | -5.9 | 6.8 | 1.1e-11 | -0.01 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Brain Cortex | FAS | 0.45 | 0.25 | lasso | 5 | 0.25 | 1.3e-07 | 6.9 | 5.7 | 9.4e-09 | -0.01 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Brain Hippocampus | FAS | 0.72 | 0.29 | enet | 45 | 0.34 | 1.0e-08 | 6.9 | 6.6 | 3.7e-11 | -0.01 | 0.00 | 0.98 | FALSE |
| 8 | GTEx | Brain Nucleus accumbens basal ganglia | FAS | 0.38 | 0.20 | enet | 36 | 0.24 | 3.4e-07 | -5.9 | 6.8 | 1.1e-11 | -0.03 | 0.01 | 0.98 | FALSE |
| 9 | GTEx | Brain Putamen basal ganglia | RP11-399O19.9 | 0.40 | 0.17 | lasso | 3 | 0.20 | 2.2e-05 | 6.9 | 6.0 | 2.3e-09 | 0.00 | 0.01 | 0.98 | FALSE |
| 10 | GTEx | Breast Mammary Tissue (Female) | FAS | 0.25 | 0.19 | lasso | 6 | 0.15 | 3.3e-05 | 6.3 | -6.5 | 9.1e-11 | 0.03 | 0.01 | 0.98 | FALSE |
| 11 | GTEx | Esophagus Muscularis | FAS | 0.20 | 0.06 | enet | 31 | 0.05 | 5.0e-04 | 6.3 | -5.4 | 5.9e-08 | 0.02 | 0.00 | 0.99 | FALSE |
| 12 | GTEx | Muscle Skeletal | FAS | 0.20 | 0.07 | lasso | 10 | 0.07 | 1.1e-07 | -5.9 | -6.2 | 6.5e-10 | 0.02 | 0.01 | 0.99 | FALSE |
| 13 | GTEx | Nerve Tibial | FAS | 0.24 | 0.14 | lasso | 5 | 0.18 | 1.7e-12 | 6.9 | -6.8 | 1.1e-11 | 0.02 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | FAS | 0.12 | 0.01 | lasso | 7 | 0.02 | 3.8e-03 | -3.8 | -5.2 | 2.1e-07 | 0.00 | 0.01 | 0.99 | FALSE |
| 15 | GTEx | Testis | KIF20B | 0.13 | 0.10 | lasso | 5 | 0.09 | 5.9e-05 | 5.8 | -5.9 | 3.8e-09 | 0.30 | 0.70 | 0.18 | FALSE |
| 16 | GTEx | Testis | PANK1 | 0.24 | 0.12 | lasso | 4 | 0.07 | 7.6e-04 | 5.6 | 5.7 | 9.9e-09 | -0.33 | 0.25 | 0.30 | FALSE |
| 17 | METSIM | Adipose | FAS | 0.28 | 0.21 | enet | 13 | 0.28 | 3.9e-42 | 6.9 | -5.9 | 4.5e-09 | 0.02 | 0.00 | 1.00 | FALSE |
| 18 | NTR | Blood | ACTA2 | 0.04 | 0.04 | lasso | 3 | 0.04 | 4.9e-12 | 6.9 | -6.9 | 4.6e-12 | 0.02 | 0.00 | 1.00 | FALSE |
| 19 | NTR | Blood | FAS | 0.04 | 0.03 | enet | 20 | 0.03 | 7.9e-10 | 6.9 | -6.2 | 5.0e-10 | 0.01 | 0.00 | 1.00 | FALSE |
| 20 | ROSMAP | Brain Pre-frontal Cortex | FAS | 0.47 | 0.42 | enet | 30 | 0.48 | 2.5e-70 | 6.9 | 6.2 | 4.0e-10 | -0.01 | 0.00 | 1.00 | FALSE |
| 21 | YFS | Blood | ACTA2 | 0.71 | 0.69 | enet | 55 | 0.72 | 0.0e+00 | 6.9 | -7.0 | 2.2e-12 | 0.03 | 0.00 | 1.00 | TRUE |
| 22 | YFS | Blood | FAS | 0.14 | 0.07 | bslmm | 548 | 0.10 | 5.5e-32 | -5.9 | -6.6 | 3.7e-11 | 0.05 | 0.03 | 0.97 | FALSE |
| 23 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FLJ37201 | 0.08 | 0.04 | blup | 41 | 0.06 | 1.8e-05 | -3.9 | 5.5 | 3.0e-08 | -0.66 | 0.18 | 0.81 | FALSE |
| 24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ37201 | 0.19 | 0.11 | enet | 9 | 0.10 | 6.2e-20 | -6.9 | 6.7 | 2.7e-11 | -0.90 | 0.00 | 1.00 | FALSE |
| 25 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FLJ37201 | 0.09 | 0.09 | enet | 5 | 0.07 | 1.7e-04 | -3.9 | 5.9 | 4.1e-09 | -0.66 | 0.05 | 0.82 | FALSE |
| 26 | The Cancer Genome Atlas | Colon Adenocarcinoma | KIF20B | 0.16 | 0.09 | blup | 75 | 0.11 | 9.5e-07 | -3.9 | -5.8 | 4.8e-09 | 0.58 | 0.39 | 0.56 | FALSE |
| 27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FLJ37201 | 0.04 | 0.02 | enet | 15 | 0.01 | 2.1e-02 | -3.9 | 5.8 | 7.6e-09 | -0.72 | 0.02 | 0.84 | FALSE |
| 28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KIF20B | 0.05 | 0.03 | lasso | 5 | 0.02 | 7.4e-04 | -6.9 | -5.7 | 1.3e-08 | 0.85 | 0.00 | 0.98 | FALSE |
| 29 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FAS | 0.03 | 0.03 | enet | 3 | 0.03 | 6.1e-04 | 4.2 | 5.7 | 1.2e-08 | -0.01 | 0.01 | 0.98 | FALSE |
| 30 | The Cancer Genome Atlas | Lung Adenocarcinoma | FAS | 0.03 | 0.00 | blup | 87 | 0.01 | 3.0e-02 | -2.0 | -5.5 | 4.7e-08 | 0.09 | 0.01 | 0.31 | FALSE |
| 31 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FLJ37201 | 0.14 | 0.08 | lasso | 2 | 0.08 | 3.9e-06 | -6.9 | 6.9 | 6.7e-12 | -0.90 | 0.00 | 1.00 | FALSE |
| 32 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAS | 0.05 | 0.01 | blup | 87 | 0.02 | 1.6e-03 | 5.8 | 5.5 | 3.1e-08 | -0.06 | 0.01 | 0.98 | FALSE |
| 33 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KIF20B | 0.03 | 0.02 | blup | 75 | 0.01 | 1.0e-02 | 5.3 | -5.2 | 2.3e-07 | 0.20 | 0.13 | 0.10 | FALSE |
| 34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PANK1 | 0.05 | 0.02 | blup | 83 | 0.03 | 8.9e-04 | -2.9 | -6.2 | 6.6e-10 | 0.68 | 0.02 | 0.81 | FALSE |
| 35 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PANK1 | 0.18 | 0.05 | blup | 83 | 0.10 | 2.1e-03 | -6.8 | -5.2 | 1.8e-07 | 0.74 | 0.01 | 0.64 | FALSE |
| 36 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FLJ37201 | 0.21 | 0.06 | enet | 4 | 0.08 | 1.0e-03 | -6.9 | 7.8 | 4.2e-15 | -0.81 | 0.00 | 0.81 | TRUE |
| 37 | The Cancer Genome Atlas | Thyroid Carcinoma | KIF20B | 0.05 | 0.02 | enet | 6 | 0.03 | 1.0e-03 | -6.9 | -7.6 | 2.5e-14 | 0.79 | 0.00 | 0.96 | FALSE |
| 38 | The Cancer Genome Atlas | Thyroid Carcinoma | PANK1 | 0.04 | 0.05 | lasso | 2 | 0.03 | 2.6e-04 | -6.9 | -6.9 | 6.4e-12 | 0.90 | 0.00 | 0.98 | FALSE |