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chr18:51,100,222-52,540,420

Best TWAS P=2.94e-13 · Best GWAS P=3.64e-14 conditioned to 0.00272

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Cerebellar Hemisphere	POLI	0.48	0.38	lasso	7	0.34	1.3e-09	5.8	-5.4	7.5e-08	-0.68	0.47	0.48	FALSE
2	GTEx	Breast Mammary Tissue (Male)	POLI	0.31	0.35	lasso	3	0.32	4.5e-08	5.8	-5.8	6.4e-09	-0.67	0.08	0.88	FALSE
3	GTEx	Cells Transformed fibroblasts	POLI	0.46	0.36	enet	18	0.36	9.9e-28	5.8	-6.6	5.4e-11	-0.77	0.99	0.01	FALSE
4	GTEx	Colon Transverse	POLI	0.24	0.26	lasso	4	0.25	4.5e-12	5.8	-5.2	1.6e-07	-0.65	0.82	0.18	FALSE
5	GTEx	Testis	POLI	0.32	0.25	lasso	4	0.23	1.4e-10	5.8	-5.2	2.0e-07	-0.65	0.93	0.07	FALSE
6	GTEx	Vagina	POLI	0.22	0.11	enet	16	0.17	9.3e-05	6.7	-5.2	2.3e-07	-0.73	0.03	0.74	FALSE
7	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	POLI	0.18	0.12	lasso	3	0.11	8.2e-10	5.8	-5.8	5.5e-09	-0.68	0.96	0.04	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	POLI	0.11	0.11	lasso	4	0.11	2.1e-22	5.8	-5.6	2.2e-08	-0.69	0.99	0.01	FALSE
9	The Cancer Genome Atlas	Colon Adenocarcinoma	POLI	0.13	0.07	blup	43	0.06	3.3e-04	7.6	-7.0	2.7e-12	-0.77	0.00	0.99	FALSE
10	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLI	0.16	0.13	lasso	3	0.13	2.0e-14	5.8	-6.3	3.9e-10	-0.72	0.91	0.09	FALSE
11	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POLI	0.18	0.16	enet	4	0.16	1.4e-17	5.8	-5.9	3.1e-09	-0.72	0.99	0.01	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	POLI	0.20	0.17	lasso	6	0.18	3.6e-20	5.8	-5.4	7.0e-08	-0.64	0.99	0.01	FALSE
13	The Cancer Genome Atlas	Lung Adenocarcinoma	POLI	0.08	0.07	blup	43	0.08	7.1e-10	5.8	-7.3	2.9e-13	-0.78	0.10	0.90	TRUE
14	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	POLI	0.11	0.07	blup	43	0.09	4.5e-10	5.8	-7.3	3.5e-13	-0.81	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POLI	0.23	0.15	lasso	4	0.16	6.0e-11	5.8	-7.0	1.9e-12	-0.86	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POLI	0.20	0.17	lasso	4	0.14	1.6e-06	5.8	-6.1	9.5e-10	-0.72	0.06	0.92	FALSE
17	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	POLI	0.27	0.16	enet	23	0.16	8.8e-07	5.8	-5.5	2.9e-08	-0.70	0.05	0.92	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLI	0.16	0.17	lasso	7	0.17	3.5e-17	5.8	-5.7	1.2e-08	-0.71	0.98	0.02	FALSE
19	The Cancer Genome Atlas	Rectum Adenocarcinoma	POLI	0.20	0.03	blup	43	0.05	3.3e-02	5.8	-6.5	8.4e-11	-0.59	0.01	0.13	FALSE
20	The Cancer Genome Atlas	Soft Tissue Sarcoma	POLI	0.10	0.07	lasso	2	0.06	2.7e-04	5.8	-5.9	3.7e-09	-0.68	0.10	0.16	FALSE
21	The Cancer Genome Atlas	Stomach Adenocarcinoma	POLI	0.13	0.11	enet	5	0.11	1.8e-08	5.8	-5.9	3.2e-09	-0.67	0.92	0.08	FALSE
22	The Cancer Genome Atlas	Testicular Germ Cell Tumors	POLI	0.14	0.05	lasso	3	0.04	1.1e-02	5.8	-5.2	2.2e-07	-0.65	0.06	0.26	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	POLI	0.24	0.28	lasso	2	0.28	7.3e-27	5.8	-5.8	6.0e-09	-0.67	0.99	0.01	FALSE