Best TWAS P=5.3e-48 · Best GWAS P=2.8e-52 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | C18orf25 | 0.15 | 0.08 | enet | 11 | 0.06 | 2.7e-04 | -14.46 | -14.6 | 5.3e-48 | 0.96 | 0.07 | 0.88 | TRUE |
| 2 | GTEx | Nerve Tibial | C18orf25 | 0.14 | 0.00 | enet | 30 | 0.03 | 5.8e-03 | 0.37 | 5.5 | 4.7e-08 | -0.22 | 0.12 | 0.06 | TRUE |
| 3 | METSIM | Adipose | ATP5A1 | 0.03 | 0.04 | lasso | 12 | 0.03 | 4.4e-05 | 7.69 | -7.7 | 1.8e-14 | 0.44 | 0.95 | 0.01 | FALSE |
| 4 | NTR | Blood | C18orf25 | 0.06 | 0.06 | enet | 23 | 0.06 | 1.6e-19 | -15.17 | 14.3 | 2.0e-46 | -0.94 | 0.01 | 0.99 | FALSE |
| 5 | YFS | Blood | ATP5A1 | 0.14 | 0.16 | lasso | 18 | 0.17 | 2.3e-54 | 7.69 | -6.3 | 3.5e-10 | 0.39 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ATP5A1 | 0.02 | 0.02 | lasso | 1 | 0.02 | 1.2e-04 | 7.69 | -7.7 | 1.5e-14 | 0.45 | 0.56 | 0.06 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C18orf25 | 0.03 | 0.03 | lasso | 3 | 0.02 | 2.5e-03 | -11.07 | -12.2 | 1.9e-34 | 0.77 | 0.08 | 0.65 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C18orf25 | 0.04 | 0.01 | blup | 54 | 0.03 | 2.3e-04 | 2.78 | -10.4 | 2.2e-25 | 0.77 | 0.02 | 0.80 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | HAUS1 | 0.15 | 0.00 | blup | 39 | 0.01 | 2.0e-01 | 1.98 | -8.8 | 1.9e-18 | 0.62 | 0.01 | 0.40 | FALSE |