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chr19:53,922,287-55,427,510

Best TWAS P=7.19e-10 · Best GWAS P=2.84e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	TMC4	0.19	0.19	lasso	4	0.17	1.4e-13	-5.3	5.4	5.2e-08	0.03	0.07	0.93	FALSE
2	GTEx	Artery Aorta	TMC4	0.23	0.05	lasso	5	0.06	2.0e-04	-5.3	5.2	1.8e-07	0.04	0.13	0.72	FALSE
3	GTEx	Artery Tibial	TMC4	0.17	0.07	lasso	6	0.13	3.9e-10	3.5	5.4	7.1e-08	0.06	0.35	0.65	FALSE
4	GTEx	Brain Caudate basal ganglia	CTD-3093M3.1	0.57	-0.01	lasso	13	0.01	1.3e-01	2.8	5.1	2.7e-07	0.16	0.05	0.13	FALSE
5	GTEx	Brain Cortex	TMC4	0.28	0.26	lasso	4	0.24	2.8e-07	-5.3	5.5	3.3e-08	0.04	0.09	0.75	FALSE
6	GTEx	Brain Frontal Cortex BA9	TMC4	0.44	0.10	enet	20	0.09	1.9e-03	-5.3	5.6	1.8e-08	0.12	0.12	0.54	FALSE
7	GTEx	Breast Mammary Tissue	TMC4	0.23	0.17	lasso	5	0.17	3.8e-09	-5.3	5.2	1.5e-07	0.03	0.09	0.90	FALSE
8	GTEx	Esophagus Mucosa	TMC4	0.47	0.50	lasso	2	0.50	1.9e-38	-5.3	5.3	1.4e-07	0.04	0.07	0.93	FALSE
9	GTEx	Esophagus Muscularis	TMC4	0.23	0.17	lasso	3	0.16	9.9e-10	-5.3	5.3	1.1e-07	0.02	0.08	0.92	FALSE
10	GTEx	Heart Atrial Appendage	TMC4	0.33	0.18	lasso	4	0.28	9.2e-13	3.5	5.2	2.4e-07	0.01	0.29	0.71	FALSE
11	GTEx	Heart Left Ventricle	TMC4	0.38	0.24	lasso	6	0.25	1.6e-13	-5.3	5.3	9.2e-08	0.02	0.08	0.92	FALSE
12	GTEx	Muscle Skeletal	TMC4	0.25	0.26	enet	21	0.26	1.1e-25	-5.3	5.8	7.3e-09	0.03	0.07	0.93	TRUE
13	GTEx	Nerve Tibial	PRPF31	0.17	0.08	lasso	6	0.10	9.2e-08	-4.7	5.3	9.9e-08	0.03	0.51	0.44	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	TMC4	0.45	0.28	lasso	6	0.26	3.0e-14	-5.3	5.3	1.2e-07	0.04	0.07	0.93	FALSE
15	GTEx	Spleen	TMC4	0.46	0.14	enet	17	0.26	3.0e-07	-5.2	5.5	3.8e-08	0.03	0.15	0.53	FALSE
16	GTEx	Whole Blood	TMC4	0.27	0.25	lasso	7	0.28	1.6e-25	-5.3	5.8	8.7e-09	0.02	0.07	0.93	FALSE
17	NTR	Blood	LILRA3	0.30	0.34	enet	10	0.35	1.0e-116	5.9	-6.2	7.2e-10	-0.97	0.00	1.00	TRUE
18	YFS	Blood	LILRA3	0.67	0.60	bslmm	410	0.72	0.0e+00	5.9	-5.7	1.4e-08	-0.89	0.00	1.00	FALSE
19	YFS	Blood	MBOAT7	0.08	0.02	enet	26	0.05	5.5e-16	-2.3	5.5	3.1e-08	0.09	0.49	0.50	FALSE
20	YFS	Blood	TMC4	0.13	0.14	bslmm	409	0.16	6.0e-49	-5.3	5.4	7.8e-08	0.00	0.08	0.92	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMC4	0.03	0.03	blup	7	0.03	1.2e-04	-4.0	5.2	1.7e-07	0.03	0.00	0.84	FALSE
22	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMC4	0.11	0.08	lasso	1	0.08	2.4e-05	-5.2	5.2	2.2e-07	-0.01	0.00	0.98	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	PRPF31	0.07	0.01	enet	6	0.03	1.0e-03	-5.2	5.3	1.1e-07	0.05	0.00	0.96	FALSE