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chr19:49,252,989-51,176,055

Best TWAS P=2.52e-33 · Best GWAS P=2.35e-30 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RCN3	0.03	0.01	blup	31	0.02	4.7e-03	8.05	12.0	2.5e-33	0.65	0.03	0.39	TRUE
32	GTEx	Skin Sun Exposed Lower leg	PRRG2	0.23	0.18	lasso	3	0.21	1.3e-17	11.50	11.5	1.2e-30	0.96	0.00	1.00	TRUE
6	GTEx	Brain Cerebellar Hemisphere	PRR12	0.27	0.12	lasso	5	0.10	2.0e-03	11.30	11.0	3.4e-28	0.93	0.02	0.82	TRUE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	PRR12	0.04	0.02	blup	30	0.03	7.1e-03	8.99	10.6	3.2e-26	0.89	0.02	0.50	TRUE
33	GTEx	Skin Sun Exposed Lower leg	NOSIP	0.13	0.12	lasso	1	0.11	3.2e-09	7.50	7.5	6.6e-14	0.68	0.78	0.22	TRUE
19	GTEx	Esophagus Mucosa	RPS11	0.14	0.08	lasso	3	0.08	7.0e-06	6.98	-6.5	7.7e-11	-0.46	0.82	0.01	TRUE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ALDH16A1	0.07	0.03	blup	45	0.05	9.9e-07	2.16	6.2	4.8e-10	0.02	0.71	0.02	TRUE
23	GTEx	Liver	PRR12	0.44	0.19	lasso	7	0.16	2.8e-05	3.69	5.5	3.2e-08	0.51	0.20	0.71	TRUE
8	GTEx	Brain Putamen basal ganglia	CTB-33G10.6	0.21	0.02	enet	7	-0.01	4.5e-01	2.58	5.2	1.8e-07	0.34	0.04	0.19	TRUE
22	GTEx	Liver	PRRG2	0.23	0.10	lasso	2	0.12	3.1e-04	11.40	11.7	2.0e-31	0.96	0.00	0.98	FALSE
40	METSIM	Adipose	PRR12	0.06	0.06	enet	10	0.06	9.4e-09	11.30	11.4	4.0e-30	0.96	0.00	1.00	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	PRRG2	0.05	0.05	lasso	2	0.02	1.9e-02	11.40	-11.4	4.5e-30	-0.97	0.00	0.91	FALSE
28	GTEx	Nerve Tibial	PRR12	0.20	0.18	lasso	3	0.17	7.4e-12	11.30	11.4	5.3e-30	0.97	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	PRR12	0.04	0.03	lasso	4	0.02	1.1e-05	10.20	11.4	6.6e-30	0.84	0.03	0.95	FALSE
3	GTEx	Adipose Subcutaneous	PRR12	0.11	0.10	lasso	1	0.09	1.0e-07	11.30	11.3	2.0e-29	0.97	0.01	0.99	FALSE
7	GTEx	Brain Cerebellum	PRR12	0.36	0.33	lasso	6	0.31	6.8e-10	11.30	11.3	2.0e-29	0.95	0.01	0.99	FALSE
20	GTEx	Esophagus Muscularis	PRR12	0.19	0.16	lasso	3	0.16	6.4e-10	11.30	11.2	4.6e-29	0.96	0.01	0.99	FALSE
24	GTEx	Lung	PRR12	0.13	0.11	lasso	2	0.10	5.8e-08	11.30	11.1	2.1e-28	0.96	0.01	0.99	FALSE
4	GTEx	Artery Aorta	PRR12	0.21	0.13	lasso	5	0.15	7.6e-09	10.40	11.0	2.5e-28	0.92	0.01	0.99	FALSE
41	YFS	Blood	FCGRT	0.05	0.01	lasso	4	0.02	9.8e-07	6.98	-11.0	4.2e-28	-0.55	0.36	0.52	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRRG2	0.06	0.10	lasso	5	0.09	1.3e-05	10.20	11.0	6.1e-28	0.85	0.02	0.96	FALSE
13	GTEx	Colon Sigmoid	FCGRT	0.26	0.06	lasso	6	0.03	2.2e-02	10.30	-10.9	1.1e-27	-0.81	0.15	0.37	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRR12	0.03	0.00	blup	30	0.01	1.1e-02	11.40	10.6	2.1e-26	0.87	0.01	0.76	FALSE
30	GTEx	Pancreas	PRR12	0.19	0.17	lasso	2	0.16	3.8e-07	11.30	10.6	3.6e-26	0.93	0.01	0.98	FALSE
2	GTEx	Adipose Subcutaneous	FCGRT	0.12	0.03	enet	18	0.04	2.2e-04	7.06	-10.4	2.0e-25	-0.58	0.29	0.25	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	RCN3	0.02	0.01	blup	31	0.01	1.1e-02	8.40	-10.4	2.6e-25	-0.67	0.02	0.44	FALSE
58	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PRRG2	0.11	0.09	lasso	1	0.06	4.1e-03	10.20	10.2	2.5e-24	0.76	0.02	0.34	FALSE
56	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRR12	0.03	0.00	blup	30	0.01	2.1e-02	3.69	9.5	1.7e-21	0.83	0.01	0.68	FALSE
15	GTEx	Colon Transverse	FCGRT	0.20	0.16	lasso	4	0.16	3.7e-08	8.15	-9.3	1.6e-20	-0.49	0.97	0.02	FALSE
43	YFS	Blood	NOSIP	0.15	0.13	lasso	8	0.13	1.6e-40	6.77	9.3	1.7e-20	0.68	1.00	0.00	FALSE
21	GTEx	Esophagus Muscularis	CTB-33G10.11	0.09	0.00	lasso	4	0.00	2.7e-01	7.71	9.2	4.1e-20	0.86	0.01	0.89	FALSE
18	GTEx	Esophagus Mucosa	PRR12	0.23	0.11	lasso	6	0.21	3.2e-14	3.69	8.8	1.0e-18	0.80	0.03	0.97	FALSE
27	GTEx	Nerve Tibial	FCGRT	0.17	0.17	enet	8	0.19	1.7e-13	8.30	-8.8	1.4e-18	-0.45	1.00	0.00	FALSE
11	GTEx	Cells Transformed fibroblasts	PRR12	0.14	0.06	enet	14	0.10	4.5e-08	11.30	8.6	8.4e-18	0.76	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	ALDH16A1	0.07	0.06	blup	45	0.07	3.8e-08	2.07	8.4	5.4e-17	0.20	0.98	0.00	FALSE
17	GTEx	Colon Transverse	RCN3	0.18	0.10	lasso	4	0.06	6.8e-04	8.15	-8.3	7.4e-17	-0.39	0.53	0.05	FALSE
39	GTEx	Whole Blood	RCN3	0.18	0.12	lasso	5	0.10	7.4e-10	8.30	-8.3	1.3e-16	-0.37	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRR12	0.09	0.03	lasso	6	0.06	4.0e-04	3.69	8.2	2.1e-16	0.74	0.01	0.86	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	IRF3	0.04	0.03	enet	7	0.03	4.0e-04	8.33	8.1	6.4e-16	0.64	0.12	0.58	FALSE
9	GTEx	Breast Mammary Tissue	PRR12	0.23	0.09	lasso	6	0.11	3.3e-06	3.52	8.0	1.3e-15	0.73	0.02	0.98	FALSE
16	GTEx	Colon Transverse	PRR12	0.27	0.09	enet	8	0.16	4.7e-08	3.69	8.0	1.3e-15	0.73	0.20	0.80	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FCGRT	0.05	0.04	enet	14	0.04	5.0e-06	6.98	-7.9	4.0e-15	-0.58	0.66	0.25	FALSE
38	GTEx	Whole Blood	FCGRT	0.08	0.05	lasso	3	0.03	1.1e-03	8.30	-7.7	1.0e-14	-0.38	0.22	0.32	FALSE
44	YFS	Blood	RCN3	0.17	0.12	bslmm	347	0.13	8.0e-41	8.27	-7.7	1.1e-14	-0.35	1.00	0.00	FALSE
10	GTEx	Breast Mammary Tissue (Male)	PRR12	0.41	0.29	lasso	5	0.24	2.5e-06	3.52	7.6	2.7e-14	0.69	0.02	0.91	FALSE
29	GTEx	Nerve Tibial	RPS11	0.19	0.14	enet	15	0.14	4.8e-10	6.98	-7.5	8.1e-14	-0.41	1.00	0.00	FALSE
35	GTEx	Thyroid	IRF3	0.13	0.08	lasso	3	0.05	5.1e-05	7.02	7.2	7.6e-13	0.57	0.36	0.27	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS11	0.03	0.01	enet	11	0.01	1.5e-02	8.45	-7.2	8.1e-13	-0.52	0.01	0.70	FALSE
42	YFS	Blood	IRF3	0.24	0.12	lasso	4	0.13	3.3e-40	7.02	7.1	9.3e-13	0.60	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	RPS11	0.08	0.10	lasso	2	0.09	2.8e-07	6.98	-7.1	1.0e-12	-0.44	0.96	0.00	FALSE
26	GTEx	Muscle Skeletal	RPS11	0.13	0.10	lasso	2	0.08	1.2e-08	6.98	-7.0	2.2e-12	-0.44	1.00	0.00	FALSE
34	GTEx	Testis	IRF3	0.28	0.17	lasso	6	0.15	3.9e-07	7.00	6.9	5.6e-12	0.60	0.77	0.16	FALSE
45	YFS	Blood	RPL13A	0.45	0.19	enet	53	0.34	1.8e-115	8.45	6.3	3.3e-10	0.43	1.00	0.00	FALSE
31	GTEx	Skin Sun Exposed Lower leg	FCGRT	0.15	0.08	enet	18	0.08	2.6e-07	8.30	-6.0	1.7e-09	-0.16	0.99	0.00	FALSE
25	GTEx	Muscle Skeletal	PIH1D1	0.10	0.07	enet	14	0.05	8.3e-06	2.21	5.9	3.0e-09	0.16	0.79	0.14	FALSE
5	GTEx	Artery Aorta	RPL13A	0.22	0.00	lasso	3	0.00	6.4e-01	1.44	5.9	4.7e-09	0.29	0.04	0.08	FALSE
14	GTEx	Colon Sigmoid	PRR12	0.20	0.01	lasso	8	0.00	4.9e-01	11.40	5.6	1.9e-08	0.69	0.03	0.52	FALSE
37	GTEx	Vagina	SIGLEC16	0.63	-0.01	enet	26	-0.01	7.0e-01	0.19	5.5	2.9e-08	0.10	0.06	0.07	FALSE
36	GTEx	Thyroid	PRR12	0.47	0.34	lasso	5	0.40	3.5e-32	3.52	5.4	6.9e-08	0.53	1.00	0.00	FALSE