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chr20:17,251,370-18,666,258

Best TWAS P=4.95e-10 · Best GWAS P=8.38e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Esophagus Muscularis	MGME1	0.24	0.17	lasso	4	0.16	1.1e-09	6.1	-6.2	5.0e-10	-0.99	0.00	1.00	TRUE
21	The Cancer Genome Atlas	Stomach Adenocarcinoma	C20orf72	0.19	0.14	lasso	5	0.14	2.5e-10	6.0	-6.2	5.3e-10	-0.97	0.00	1.00	FALSE
9	GTEx	Nerve Tibial	MGME1	0.15	0.16	lasso	4	0.14	4.3e-10	6.1	-6.1	8.3e-10	-1.00	0.00	1.00	FALSE
1	GTEx	Adipose Subcutaneous	MGME1	0.19	0.15	lasso	3	0.14	2.5e-11	6.1	-6.1	9.2e-10	-1.00	0.00	1.00	FALSE
4	GTEx	Artery Tibial	MGME1	0.19	0.11	lasso	2	0.09	9.3e-08	6.1	-6.1	9.9e-10	-1.00	0.00	1.00	FALSE
6	GTEx	Esophagus Mucosa	MGME1	0.20	0.10	lasso	2	0.07	3.0e-05	6.0	-6.1	1.2e-09	-0.98	0.00	1.00	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C20orf72	0.10	0.07	lasso	3	0.07	1.1e-08	6.0	-6.0	1.6e-09	-0.96	0.00	1.00	FALSE
3	GTEx	Artery Aorta	MGME1	0.19	0.14	lasso	3	0.14	2.4e-08	6.0	-6.0	2.7e-09	-0.97	0.00	1.00	FALSE
2	GTEx	Adipose Visceral Omentum	MGME1	0.22	0.09	enet	6	0.09	3.4e-05	6.1	-5.9	3.5e-09	-0.95	0.00	1.00	FALSE
20	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C20orf72	0.42	0.27	lasso	3	0.27	7.9e-08	6.0	-5.9	4.6e-09	-0.94	0.00	1.00	FALSE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	C20orf72	0.17	0.13	enet	9	0.13	2.9e-14	6.1	-5.8	4.9e-09	-0.95	0.00	1.00	FALSE
5	GTEx	Cells Transformed fibroblasts	MGME1	0.19	0.14	enet	14	0.17	9.4e-13	6.1	-5.8	5.7e-09	-0.90	0.00	1.00	FALSE
10	GTEx	Whole Blood	MGME1	0.11	0.11	lasso	3	0.12	4.7e-11	6.0	-5.8	8.1e-09	-0.94	0.00	1.00	FALSE
8	GTEx	Lung	MGME1	0.18	0.16	lasso	3	0.18	6.8e-14	6.0	-5.7	9.4e-09	-0.94	0.00	1.00	FALSE
18	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C20orf72	0.15	0.10	lasso	5	0.09	1.4e-04	6.0	-5.7	1.2e-08	-0.93	0.00	0.97	FALSE
11	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C20orf72	0.15	0.09	enet	11	0.11	2.1e-09	4.7	-5.7	1.4e-08	-0.70	0.07	0.93	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	C20orf72	0.17	0.09	blup	58	0.10	1.7e-10	6.1	-5.6	2.1e-08	-0.79	0.00	1.00	FALSE
13	The Cancer Genome Atlas	Glioblastoma Multiforme	C20orf72	0.24	0.08	blup	58	0.12	1.8e-04	6.0	-5.6	2.3e-08	-0.83	0.00	0.96	FALSE
17	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C20orf72	0.12	0.01	blup	58	0.05	1.9e-03	6.0	-5.3	1.4e-07	-0.77	0.00	0.90	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	C20orf72	0.11	0.01	enet	5	0.04	1.8e-03	6.0	-5.2	1.7e-07	-0.83	0.00	0.97	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C20orf72	0.16	0.09	blup	58	0.12	1.0e-13	6.1	-5.2	1.8e-07	-0.78	0.00	1.00	FALSE