Best TWAS P=4.95e-10 · Best GWAS P=8.38e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MGME1 | 0.19 | 0.15 | lasso | 3 | 0.14 | 2.5e-11 | 6.1 | -6.1 | 9.2e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | MGME1 | 0.22 | 0.09 | enet | 6 | 0.09 | 3.4e-05 | 6.1 | -5.9 | 3.5e-09 | -0.95 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Aorta | MGME1 | 0.19 | 0.14 | lasso | 3 | 0.14 | 2.4e-08 | 6.0 | -6.0 | 2.7e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Tibial | MGME1 | 0.19 | 0.11 | lasso | 2 | 0.09 | 9.3e-08 | 6.1 | -6.1 | 9.9e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | MGME1 | 0.19 | 0.14 | enet | 14 | 0.17 | 9.4e-13 | 6.1 | -5.8 | 5.7e-09 | -0.90 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Esophagus Mucosa | MGME1 | 0.20 | 0.10 | lasso | 2 | 0.07 | 3.0e-05 | 6.0 | -6.1 | 1.2e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Esophagus Muscularis | MGME1 | 0.24 | 0.17 | lasso | 4 | 0.16 | 1.1e-09 | 6.1 | -6.2 | 5.0e-10 | -0.99 | 0.00 | 1.00 | TRUE |
| 8 | GTEx | Lung | MGME1 | 0.18 | 0.16 | lasso | 3 | 0.18 | 6.8e-14 | 6.0 | -5.7 | 9.4e-09 | -0.94 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Nerve Tibial | MGME1 | 0.15 | 0.16 | lasso | 4 | 0.14 | 4.3e-10 | 6.1 | -6.1 | 8.3e-10 | -1.00 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Whole Blood | MGME1 | 0.11 | 0.11 | lasso | 3 | 0.12 | 4.7e-11 | 6.0 | -5.8 | 8.1e-09 | -0.94 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C20orf72 | 0.15 | 0.09 | enet | 11 | 0.11 | 2.1e-09 | 4.7 | -5.7 | 1.4e-08 | -0.70 | 0.07 | 0.93 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | C20orf72 | 0.11 | 0.01 | enet | 5 | 0.04 | 1.8e-03 | 6.0 | -5.2 | 1.7e-07 | -0.83 | 0.00 | 0.97 | FALSE |
| 13 | The Cancer Genome Atlas | Glioblastoma Multiforme | C20orf72 | 0.24 | 0.08 | blup | 58 | 0.12 | 1.8e-04 | 6.0 | -5.6 | 2.3e-08 | -0.83 | 0.00 | 0.96 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C20orf72 | 0.10 | 0.07 | lasso | 3 | 0.07 | 1.1e-08 | 6.0 | -6.0 | 1.6e-09 | -0.96 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C20orf72 | 0.16 | 0.09 | blup | 58 | 0.12 | 1.0e-13 | 6.1 | -5.2 | 1.8e-07 | -0.78 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C20orf72 | 0.17 | 0.13 | enet | 9 | 0.13 | 2.9e-14 | 6.1 | -5.8 | 4.9e-09 | -0.95 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C20orf72 | 0.12 | 0.01 | blup | 58 | 0.05 | 1.9e-03 | 6.0 | -5.3 | 1.4e-07 | -0.77 | 0.00 | 0.90 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C20orf72 | 0.15 | 0.10 | lasso | 5 | 0.09 | 1.4e-04 | 6.0 | -5.7 | 1.2e-08 | -0.93 | 0.00 | 0.97 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C20orf72 | 0.17 | 0.09 | blup | 58 | 0.10 | 1.7e-10 | 6.1 | -5.6 | 2.1e-08 | -0.79 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | C20orf72 | 0.42 | 0.27 | lasso | 3 | 0.27 | 7.9e-08 | 6.0 | -5.9 | 4.6e-09 | -0.94 | 0.00 | 1.00 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C20orf72 | 0.19 | 0.14 | lasso | 5 | 0.14 | 2.5e-10 | 6.0 | -6.2 | 5.3e-10 | -0.97 | 0.00 | 1.00 | FALSE |